황색종 잎담배 (N. tabacum L.)의 유기산과 숙도에 관한 연구

이문수,김찬호 한국연초학회 1984 한국연초학회지 Vol.6 No.1

The changes of contents of organic acids in flue-cured tobacco leaves depending on stalk position and maturity viz immature, mature and overmature were studied in 1982-83. Among them, particularly, the leaves harvested at mature stage have the lowest amounts of oxalic and citric acids in smoking or cutter leaves but the acid contents has increased during the overmature. The linolenic acid content tended to be lower with increase of maturity.

연약지반(VII)

이문수,김영남 한국지반공학회 1996 지반 : 한국지반공학회지 Vol.12 No.5

진행성 위암으로 오인된 조기위암 천공 1예

이문수,김성용,오상현,채만규,정일권,백무준,박경규,김창호,조무식,Lee Moon Soo,Kim Sung Yong,Oh Sang Hyun,hCae Man Kyu,Chung Il Kwon,Baek Moo Jun,Park Kyung Kyu,Kim Chang Ho,Cho Moo Sik 대한위암학회 2001 대한위암학회지 Vol.1 No.1

An exceedingly rare case of perforated early gastric cancer is reported. A 68-year-old man developed peritonitis due to perforation of early gastric cancer. An emergency radical operation was performed and was followed by an uneventful recovery. Histologic examination of the surgical specimen showed type III early gastric cancer composed of a signet ring cell carcinoma. Five years after surgery, the patients was alive with no evidence of tumor recurrence. The rarity of this complication in early gastric cancer is discussed, and a review of the literature is presented.

Sociotropic Threat and Tolerance on Minorities - The Mediating Effects of Subjective Well-being, Trust in Government and Society -

이문수 (사)위기관리이론과실천 2023 Crisisonomy Vol.19 No.7

This study aims to fill the theoretical gap of why an anxiety about indefinite one(s) causes intolerance on minorities. It hypothesizes the mediating role of subjective well-being, trust in government and society on the relationship between sociotropic threat and tolerance on minorities. In other words, an anxiety about indefinite one(s) reduces individuals’ subjective well-being, trust in government and society, and the reduced subjective well-being, trust in government and society affect tolerance on minorities negatively. The statistical analysis result confirms the mediating effects of subjective well-being, trust in government and society. On the other hand, the statistical analysis result shows that the direct effects of sociotropic threat are insignificant. That is, Sociotropic threat cannot affect tolerance on minorities without the mediating variables. This study is significant in that it identifies how safety issues can affect tolerance on minorities.

Nutritional Management in Gastric Cancer Patients

이문수 대한위암학회 2003 대한위암학회지 Vol.3 No.4

위선암에서 FHIT 유전자 발현이상의 임상적 의의

이문수,김태윤,조규석,채만규,김성용,백무준,이상한,박경규,김창호,송옥평,조무식,Lee, Moon-Soo,Kim, Tae-Yun,Cho, Gyu-Seok,Chae-Man-Kyu,Kim, Sung-Yong,Baek-Moo-Jun,Lee, Sang-Han,Park, Kyung-Kyu,Kim, Chang-Ho,Song-Ok-Pyung,Cho, Moo-Sik 대한위암학회 2003 대한위암학회지 Vol.3 No.1

Purpose: Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric cancer were examined to determine whether the FHIT gene is actually a frequent target for alteration during gastric carcinogenesis. Materials and Methods: To correlate DNA and RNA lesions of the FHIT gene with the effect on FHIT protein expression, in 40 gastric cancers, we investigated the FHIT gene for loss of heterozygisity (LOH), aberrant transcripts, and protein expression. Results: Allelic loss at D3S1300 was detected in 7 of 38 ($19\%$) informative cases. Aberrant transcripts were observed in 20 of 40 ($50\%$) cases. Significant reduction of FHIT protein expression was observed in 22 of 40 ($55\%$) cases. Aberrant FHIT transcription was shown to be associated with loss of FHIT protein expression. However, aberrent FHIT transcripts themselves were not associated with any clinicopathological parameters, such as age, sex, tumor site, or clinical stage. Moreover, there was no association between the presence of LOH at D3S1300 and the expression of aberrant FHIT transcripts. Conclusion: The high frequency of aberrant FHIT transcripts, the significant rate of LOH at D3S1300, and the altered expression of the FHIT protein indicate that alterations of the FHIT gene can play an important role in gastric carcinogenesis.

Polyamine Stimulation of arcA Expression in Escherichia coli

이문수,김영식,SeonYoungPark,MyungHunChoi,BoMinKim,SeongUkKang,KuiJooLee,이종호 한국미생물학회 2002 The journal of microbiology Vol.40 No.4

The effects of two natural polyamines (putrescine and spermidine) on the synthesis of ArcA, a response regulator of the Arc two-component signal transduction system, were studied using an E. coli mutant deficient in polyamine biosynthesis. Endogenous polyamine deficiency of the mutant resulted in marked reduction in the ArcA level determined by Western blot analysis. Putrescine supplement to the growth medium effectively increased the ArcA level of the mutant in a concentration-dependent manner. Spermidine also stimulated the ArcA level in the mutant to a greater degree than putrescine. Expression of arcA'::lacZ operon fusion in the mutant was stimulated 6-fold and 10-fold by putrescine and spermidine at a 1mM concentration, respectively, indicating that the stimulatory effect of the polyamines on ArcA synthesis is due to transcriptional induction, and that spermidine is a more potent arcA inducer than putrescine. The polyamine-dependent arcA'::lacZ induction was growth-phase-dependent and independent of either arcA or fnr which are two regulators involved in anaerobic stimulation of the ArcA level. These results suggested that putrescine and spermidine polyamines may be potential intracellular signal molecules in the control of arcA expression, and thereby may play an important role in cellular metabolism. The effects of two natural polyamines (putrescine and spermidine) on the synthesis of ArcA, a response regulatorof the Arc two-component signal transduction system, were studied using an E. coli mutant deficientin polyamine biosynthesis. Endogenous polyamine deficiency of the mutant resulted in markedreduction in the ArcA level determined by Western blot analysis. Putrescine supplement to the growthmedium effectively increased the ArcA level of the mutant in a concentration-dependent manner. Spermidinealso stimulated the ArcA level in the mutant to a greater degree than putrescine. Expressionof arcA'::lacZ operon fusion in the mutant was stimulated 6-fold and 10-fold by putrescine and spermidineat a 1mM concentration, respectively, indicating that the stimulatory effect of the polyamineson ArcA synthesis is due to transcriptional induction, and that spermidine is a more potent arcAinducer than putrescine. The polyamine-dependent arcA'::lacZ induction was growth-phase-dependentand independent of either arcA or fnr which are two regulators involved in anaerobic stimulation ofthe ArcA level. These results suggested that putrescine and spermidine polyamines may be potentialintracellular signal molecules in the control of arcA expression, and thereby may play an important rolein cellular metabolism.

천공성 위암의 수술 방법과 치료 결과

이문수,채만규,김태윤,조규석,김성용,백무준,정일권,박경규,김창호,송옥평,조무식,Lee, Moon-Soo,Chae, Man-Kyu,Kim, Tae-Yun,Cho, Gyu-Seok,Kim, Sung-Yong,Baek-Moo-Jun,Chung-Il-Kwon,Park, Kyung-Kyu,Kim, Chang-Ho,Song-Ok-Pyung,Cho, Moo-Sik 대한위암학회 2002 대한위암학회지 Vol.2 No.2

Purpose: Perforated gastric cancer (PGC) is rare and occurs in $1\∼4\%$ of all gastric cancers. Possible dissemination of tumor cells at the time of perforation of the gastric carcinoma has been a matter of concern. The intraoperative determination of what kind of operation should be done and how extensive the lymphnode dissection should be still remains controversial. The purpose of this study is to evaluate the factors influencing the survival and to determine the optimal treatment for PGC. Materials and Methods: A total of 42 patients were operated on for a perforated gastric carcinoma at Soonchunhyang University Chunan Hospital from 1983 to 2000. the age and the sexes of the patients, the location of perforation, the diameter of perforation, the histologic type of the tumor, the depth of wall invasion, the absence or presence of lymph node metastasis / distant metastasis, the stage of disease, the type of operation, and the outcomes were examined. Statistically significant differences were analyzed by using Fisher's exact test. Results: The stage distributions according to the UICC classification were 1 case of stage I, 6 cases of stage II, 17 cases of stage III, and 11 cases of stage IV. An emergency gastrectomy was done in 26 patients ($61.9\%$), with a 5-yr survival rate of $44\%$. The survival of patients was significantly influenced by the depth of wall invasion, the lymphnode metastasis, distant metastasis, the stage of disease, and the type of operation. Conclusions: an emergency gastrectomy is the treatment of choice for most patients with resectable PGC. Choosing more a optimistic surgical approach for potentially curative cases of PGC should be one way to increase the patient's survival rate.

Duvatrienediol의 열변성화합물의 분리 및 확인

이문수,이운철,곽재진,Rhee, Moon-Soo,Lee, Un-Cheoul,Kwag, Jae-Jin 한국연초학회 1987 한국연초학회지 Vol.9 No.2

$\alpha$, $\beta$-4.8.13-Duvatriene-1, 3-diols was identified as the major component of diterponoid extracted from Nicotiana Tabacum L. The isolated duvatriendiol was thermolyged at 300'c under a stream of nitrogen. The approximately 20 compounds were separated from the thermolyzates and the 9 compounds of them were identified with GC/MS. However, the thermolyzates identified in this study differed in distribution from the products under the condition of a different temperature or photooxidation.

斜面安定에 대하여

李汶樹 全南大學校 農漁村開發硏究所 1981 農業科學技術硏究 Vol.16 No.2

This paper treats the calculation method for the factor of safety in the soil slope Gravitational and seepage forces tend to cause instability in natural slopes formed by excavation and in the slopes of embankments and earth dams. The most important types of slope failure are illustrated in Fig. 9.1. In rotational slips the shape of the failure surface in section may be a circular arc or a non-circular curve. In general, circular slips are associated with homogeneous soil conditions and noncircular slips with non-homogeneous conditions. Translational and compound slips occur where the form of the failure surface is influenced by the presence of an adjacent stratum is at a relatively shallow depth below the surface of the slope: the failure surface tends to be plane and roughly parallel to the slope. Compound slips usually occur where the adjacent stratum is at greater depth, the failure surface consisting of curved and plane sections. In this paper, comparisons among several methods for the factor of safety are performed under the assumtion of the circular arc on slip surface. The results obtained are as follows. 1. Any method underestimates the facfor of safety compared with the accurate solution. So the result is safe. 2. The assumtion that the shape of slip surface is a circular arc can be in common use with little error, even in case that the shape is not a circular one.