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Streptozotocin 유발성 당뇨백서에서 해당효소에 대한 Phlorizin의 효과
배학연,정회상,박유환,전용준,이승일,문철웅,양성훈,이병래 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.15 No.1
In glycolysis, the reactions catalyzed by hexokinase, Phosphofructokinase, and pyruvate kinase are lally irreversible; hence they would be expected to have regulatory as well as catalytic roles. They ilso adaptive in a number of physiological states, and although the molecular mechanisms controlling adaptations are largely unknown, dietary and hormonal stimuli serve as environmental factors lating enzyme levels in vivo. The present study was undertaken to examine the effects of phlorizin, a blocker of renal tubular ose reabsorption, on the activities of glucokinase, hexokinase, and pyruvate kinase in the liver and nrocytes of streptozotocin (STZ) diabetic rats. The levels of plasma glucose and insulin and the activities of glycolytic enzymes were measured onchird day after phlonzin treatment in normal and STZ diabetic rats and the results were as follows. 1. Plasma glucose levels were reduced by 14.35%(P<0.05) in normal rats and by 39.38% (p<0.01) in STZ diabetic rats. 2. Plasma insulin levels were reduced by 45.6% (P<0.05) in normal rats and by 58.2% (P<0.01) in STZ diabetic rats. 3. On the third day after phlorizin treatment, hepatic glucokinase and pyruvate kinase activities in normal rats were reduced by approximately 56% (P<0.01) and 43% (P<0.01) respectively, and erythrocyte hexokinase and pyruvate kinase activities were reduced by approximately 18% (P<0.05) and 22% (P<0.01) respectively, In STZ diabetic rat shepatic glucokinase and pyruvate kina activities were reduced by approximately 52% (P<0.01) and 22% (P<0.01) respectively, a erythrocyte hexokmase and pyruvate kinase activities were reduced by approximately 4% and 3 respectively. Thus the overall decreases of the levels of plasma glucose and insulin and the activity of glycoly enzymes were observed on the third day after phlorizin treatment in normal and STZ diabetic ra These alterations in the enzyme activity with phlorizin treatment were shown to be a result of reducinsulin levels, and the smaller decrease in enzyme actvity in STZ diabetic rats than in normal rats thought to be probably due to the reduced response to changes in insulin levels at near basal levels enzyme activity.
배학연,오종찬,김상용,최동현,김정인,김경남,김진화,이범주 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.4
Multiple sclerosis is an autoimmune disorder, which may be associated with other rheumatologic or endocrine diseases induced by autoantibodies. Hashimoto's thyroiditis is also an organ-specific autoimmune disorder, and its association with multiple sclerosis during interferon therapy has been reported. Cases of Hashimoto's thyroiditis with multiple sclerosis are very rare. Herein is reported our experience of a 27 year-old woman who presented with general weakness, cold intolerance and progressive muscle weakness. She had been treated with levothyroxine due to subclinical hypothyroidism, which rather aggravated the symptom. In a CSF analysis, the myelin basic protein level was above 10 ng/dL and that of the IgG and the IgG index were 135 mg/dL and 7.8, respectively. In a brain MRI, demyelinating lesions in the left middle pontocerebellar junction and right subcortex were shown. She was diagnosed with multiple sclerosis, and the symptom improved after glucocorticoid and levothyroxine therapy. Herein is reported the first Korean case of Hashimoto's thyroiditis associated with multiple sclerosis. 저자들은 감각 및 근력저하를 주소로 내원한 27세 여자에서 하시모토 갑상선염과 다발성 경화증이 함께 동반된 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.
배학연,Bae, Hak-Yeon 사단법인 한국당뇨협회 2005 당뇨 Vol.183 No.-
당뇨병 치료 중 많은 환자들이 지나치게 혈당을 낮추는 데에만 신경을 쓰는 경우가 있다. 하지만 우리 몸의 건강유지를 위해서는 적절한 수치의 혈당유지가 중요하다. 당뇨병 치료과정에서 발생할 수 있는 저혈당과 그에 대한 처치 및 예방법의 인식은 또 다른 안전한 당뇨병 치료의 길을 알려 줄 것이다.
배학연 ( Hak Yeon Bae ) 대한내과학회 2011 대한내과학회지 Vol.80 No.6
Managing type 2 diabetes has become more complex as pharmacotherapy has expanded. Therapies for type 2 diabetes can be divided into drugs facilitating supply of endogenous insulin or those enhancing insulin actions. Successful treatment of type 2 diabetes combines approaches to lifestyle modification frequently in conjunction with use of pharmacologic therapy. The dual aspects of type 2 diabetes, insulin resistance and insulin deficiency, are important factors in therapy selection and the subsequent reponse to therapy. Most patients have gradually increasing needs for additional therapy. Some patients require combination pharmacologic therapy at the time of initial treatment, especially if they have a markedly elevated HbA1c. We describes combination pharmacologic therapy in type 2 diabetes, recent evidence and opinions on sequences for type 2 diabetes. (Korean JMed 2011;80:643-648)
OFDM 기반 유비쿼터스 광대역 서비스를 위한 단일화된 시간영역 채널추정기법
배학연(Hag-Youn Bae),서정욱(Jeong-Wook Seo),김동구(Dong-Ku Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
OFDM 기반 광대역 무선접속 시스템들을 통해 유비쿼터스 서비스를 제공받기 위해서는 SDR (Software Defined Radio)과 같은 공통의 플랫폼이 필요하다. [1]. 본 논문에서는 이러한 플랫폼을 구성하기 위한 채널추정기법으로 단일화된 시간영역 채널추정기를 제안한다. 제안한 기법은 기존의 시간영역 채널추정기법의 전처리 과정에 Wiener 필터를 사용함으로써 파일럿 위치와 할당방식에 관계없이 추정기법을 단일화할 수 있으며 우수한 성능을 제공할 수 있다.
OFDM 기반 유비쿼터스 광대역 서비스를 위한 분산된 시공간 부호화에 의한 성능 향상에 관한 연구
배학연(Hag-Youn Bae),서정욱(Jeong-Wook Seo),김동구(Dong-Ku Kim) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11
When Virtual Antenna Arrays(VAA) create a set as a clusters(Included Source, Destination, Relay terminals) among many mobile terminals with a single antenna in order to get a diversity gain in each teminals, it can be included bad condition mobile terminals with a different pilot subcarriers allocation i.e. pilot initial position, pilot spacing. In these cases, the BER performance will be severly degraded by interpolation errors[2]. In order to solve these problem, We proposed a method of the performance improvement by the distributed space-time coding for OFDM-based ubiquitous broadband access.