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서영욱,이상숙,이태성,차순도,권경익,이정호 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.4
The nuclear accumulation of p53 protein is known to correspond with mutation of p53 tumor supressor gene. To investigate the relationship between clinico-pathologic features and expression of p53 mutations, 65 cases of primary cervical carcinoma were analysed by an immunohistochemieal method using monoclonal antibody of p53. Immunostaining demonstrated various nuclear stinings of cancer cells in 48.4% of squamous cell carcinoma(51.9% in large cell carcinoma and 25,0% in small cell carcinomas) and 23.5% of adenocarcinoma(p$lt;0.05) No differences in clinical stage and p53 positivity were found. There was no significant correlation between p53 positive cases and status of recurrence. This data suggests that p53 mutation plays an important role in carcinogenesis of the cervical cancer. The nuclear accumulation of P53 protein is not correlated with the disease progression and prognosis.
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