대장내시경검사의 전처치로서 항콜린제 사용에 관한 연구 : 전향적, 이중맹검법으로

박경남,한동수,이민호,최호순,박준용,손주현,이오영,함준수,전용철,송승찬,기춘석,윤병철,이종희 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.3

Background: Use of antispasmodic medication prior to colonoscopy is controversial but someone believes antispasmodic may improve visualization of colonic mucosa and ease colonoscope insertion. So, we designed a study to assess the effect of premedication with the antispasmodic, hyoscine-N-butyl bromide(Buscopan') on the performance of colonoscopy. Methods: This study was prospective, double blinded, randomized, controlled study, One hundred three consecutive patients were randomized to receive intravenous buscopan lml(n=52) or placebo(n=51) combined with our standard initial medication(me- peridine 50 mg and midazolam 2 mg). Insertion of colonoscopy was timed, and 100 mm visual analogue scales (VAS) were used for asscssing difficulty of procedure, colonic motility, frequency of positional change, frequency of external compression, difficulty of assistance and degree of discomfort experienced by the patients. Results: There were no significant differences of intubation time between buscopan group(mean time, 7.23 min., range 2~15) and placebo group(7.07 min., range 3-25), (p=0.83) and withdrawal time between buscopan group (6.46 min., range 2-22) and placebo group(6.76 min., range 2 25), (p=0.69). Also, there was no significant differences in intubation time between males and females(buscopan; males 7.00 min., females 7.60 min., p=0.34, placebo; males 7.0~5 min., females 7.08 min., p 0.44). The VAS scores checked by endoscopist(p=0.29), assistant(p=0.32) and patient (p=0.15) were not significantly different in both groups. There were no significant differences in intubation time, VAS scores nf endoscopist, assistant, and patients. Conclusion: Premedication with intravenous bu.opan has no advantage on colonoscopy procedure. Use of antispasmodic medication prior to colonoscopy was not considered as recommendable agent.

아임계수 추출에 의한 홍삼 추출물의 진세노사이드 조성 및 이화학적 특성

이주미(Joo-Mi Lee),고민정(Min-Jung Ko),정명수(Myong-Soo Chung) 한국식품과학회 2015 한국식품과학회지 Vol.47 No.6

홍삼의 신규 추출 방법으로 아임계수 추출(subcritical water extraction, SWE)을 적용하여 홍삼 추출물의 이화화적 특성 및 진세노사이드 추출 특성을 조사함으로써 최적 아임계수 추출 조건을 결정하고 기존 추출 방법과 비교함으로써 산업적 이용 효율을 평가하였다. 아임계수 추출에 의한 홍삼 추출물의 당도, 고형분 함량, 색차 및 탁도는 추출 온도가 높아지고 추출 시간이 길어질수록 증가하였고 pH는 낮아졌으며, 조 사포닌은 120℃, 20분에서 최대였다. TLC 및 HPLC 분석 결과, 총 및 극성 진세노사이드 농도는 120℃, 20분에서 최대였고 홍삼 특유의 저극성 진세노사이드 Rg3, Rh1 등은 150℃, 15분에서 최대 농도였다. 또한 최적 아임계수 추출과 열수, 에탄올 및 메탄올을 용매로 환류 냉각 추출하여 비교한 결과, 저극성 진세노사이드의 추출 이행률은 150℃, 15분의 아임계수 추출에서 가장 높았고 특히 Rg3는 3.5-5배, Rh1은 2-2.5배의 높은 농도로 나타났다. 홍삼의 특이 사포닌으로 극미량 존재하는 Rg3 및 Rh1은 강력한 항암 효과 등이 보고되면서 최근 화학적, 물리적, 생물학적 방법에 의한 전환 연구가 활발히 진행되고 있으나 낮은 선택성과 생산성의 저하, 부 반응으로 인한 환경 공해 및 대량 생산의 한계 등으로 산업적 적용에 제약이 존재하여 왔다. 본 연구에서는 아임계 상태에서의 물의 특성 변화를 이용한 아임계수 추출을 적용하여 홍삼으로부터 특히 저극성 진세노사이드의 선택적 추출 및 전환에 효과적인 대체 기술로서 가능성을 확인하였다. Red ginseng was treated by subcritical water extraction (SWE) whose two parameters were the extraction temperature (105-150℃) and time (5-20 min) under a high pressure. The oBrix value, solid content, color difference, and turbidity of the red ginseng extract increased with increasing extraction time and temperature, while the pH decreased. The total concentration of ginsenosides in the red ginseng extract was maximal at 120℃ and 20 min. The concentrations of ginsenosides Rg3 and Rh1 were maximal at 150oC and 15 min. The concentrations of Rg3 and Rh1 were respectively 3.5- 5 times and 2-2.5 times higher than those treated by conventional extraction methods with hot water, ethanol, and methanol. SWE is a particularly effective method for the selective extraction of less-polar ginsenosides such as Rg3 which is well known to exert strong anticancer effects.

알코올이 Dynamic Posturography에 미치는 영향

이진춘,고의경,장민호,이병주,백무진,노환중,왕수건,전경명 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

Free Paper Presentation : OS-111 ; The Effects of Dexmedetomidine for Sleep in Critically Ill Patients: Pilot Study

( Se Joong Kim ),( Jin Soo Min ),( Ji Soo Park ),( Yeon Joo Lee ),( Jong Sun Park ),( Ho Il Yoon ),( Jae Ho Lee ),( Choon Taek Lee ),( Young Jae Cho ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-

Background: Many critically ill patients in the intensive care unit (ICU) experience sleep disruption and delirium. For the sedation of these patients, dexmedetomidine is one of commonly recommended sedatives because of its pharmacokinetic merit. This pilot study was undertaken to identify the effects of dexmedetomidine for sleep and delirium in critically ill patients. Methods: This prospective study was conducted in medical ICU of a tertiary referral hospital. Dexmedetomidine was administered with the maintenance dose of 0.4-0.7μg/kg/hr and adjusted by Richmond Agitation Sedation Scale score of 0 to -2. Portable polysomnography was performed in the ICU over 24 hour to assess the quantity and quality of sleep. The confusion assessment method for ICU was used for detection of delirium. Results: Total 9 patients were enrolled. Median age was 77.0 (Range: 61-90) and 3 patients experienced delirium. Median total sleep time was 283 (IQR: 56-739) min. The majority of sleep was stage 1 (median 208 [IQR: 56-356] min) and 2 (median 75 [IQR: 7-396] min) with absent REM and stage 3 sleep. The dose of dexmedetomidine was not associated with total sleep time, stage 1 and stage 2 sleep (all P>0.05). However, the patients with delirium was administered higher dose of dexmedetomidine than ones without delirium (0.67μg/kg/hr vs 0.33μg/kg/hr, P=0.006). Conclusions: Although proper sedation was met with dexmedetomidine, the quantity and quality of sleep in critically ill patients were poor. Further study is required for the promotion of good sleep and the prevention of delirium in ICU patients.

개의 췌도분리에서 췌장의 팽창과 콜라겐 분해요소

이상훈,김성주,박정환,김종성,오승훈,한진수,정인경,양태영,김동준,김광원,이문규,민용기,이명식,정재훈,함종렬 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.2

Backgrounds: One of the main problems conditioning the outcome of islet transplantation is the ability to separate a sufficient number of viable islets with preserved function. Islet purification is critically affected by all of the isolation stages. Thus, it is necessary to set up the standard isolation method that islets are separate well from acinar without compromising islet yield and viability. Methods: Twenty three adult mongrel dogs were used for the experiment of total pancreatectomy with islet isolation. The islets were properly isolated by a modified Recordi method. The obtained islets were further purified by centrifugation on discontinuous gradients using cell separation system (Model 2991, Cobe, Lakewood Colo). We evaluated islet number (islet equivalent number, 150 um equivalents/kg of recipient body weight, IEq/kg), purity, cell volume, viabilty, recovery rate, and comparison of outcome according to the isolation conditions. Results: 1) The mean of islet numbers before purification were 13543±9431Eq/kg, digestion times were 13.8±2.6 min., digestion temperature was 37.4±0.2℃, purity was 59.7?.0%, viability was 90.0±2.1%, cell volume was 4.7±1.1 mL, islet number after purification were 4064±361 IEq/kg, and recovery rate was 29±2.9%. 2) Isolated islet numbers were different according to the degree of pancreas distension with collagenase, digestion temperature, and digestion time. 3) The best conditions for islet isolation were above 37.5℃ in temperature at recirculation of collagenase, within 12 min in digestion time and well distended pancreas with collagenase. 4) According to multiple regression adjusted by variable factors, the degree of pancreas distension with collagenase and digestion time were independently associated factors for successful islet isolation. Conclusions: In this study, we concluded that the degree of pancreas distension with collagenase and digestion time were independent factors for successful islet isolation and the best conditions for islet isolation were above 37.5℃ in temperature at recirculation of collagenase, within 12 min in digestion time and well distended pancreas with collagenase.

레거시 시스템 이해 도구를 위한 효율적인 코볼 코드 분석기 설계 및 구현

주상현,임동기,정민수 慶南大學校 附設 工業技術硏究所 2003 硏究論文集 Vol.21 No.2

최근 컴퓨팅 환경이 변화함에 따라 현재 운용되고 있는 레거시 시스템을 새로운 환경에서도 운용할 수 있도록 시스템을 현대화하는 연구가 활발히 진행되고 있다. 특히 소프트웨어 재사용 기술과 함께 컴포넌트 기술이 개발, 보급됨에 따라 기존 시스템을 컴포넌트로 변환하거나 연계하는 방법들이 연구되고 있다. 그러나, 레거시 시스템은 중요성과 안정성으로 인해서 쉽게 새로운 시스템으로 전환하기가 쉽지가 않다. 그래서, 레거시 시스템의 현대화를 위해서 재개발, 변환, 래핑 등의 다양한 방법을 사용해서 새로운 시스템 환경에서 사용 가능하게 한다. 이 방법을 사용함으로써 신뢰성과 안정성을 향상시킬 수 있게 된다. 본 논문에서 추출정보, 플로우 그래프, 프로그램 콜 그래프, 패러그래프 플로우 그래프 등에서 사용될 핵심변수와 패턴 식별을 위한 레거시 시스템과 릴레이션 방지 기술을 가진 효율적인 코볼 코드 분석기를 소개한다. Computing environment is changing much recently Legacy system should be executed in new environment. Modernization research of system is progressing so that can be executed in these environment. According to the development and supply of the component technology and software reuse technology. We are studied and interested in conversion and connection of component methods. But the importance of legacy system, it is hard to convert by easily new system. Make use of legacy system just as it is using methods of redevelopment, transformation, wrapping etc. It is available in new system environment and improve trustability and stability. In this paper, we introduce a legacy system and design a efficient cobol code analyzer which has a redundant relation preventing technology to create core variable and pattern discernment that is used to abstraction information and flow graph, program call graph, paragraph flowing graph etc.

혼화재 종류별 온도 변화에 따른 콘크리트의 응결 및 강도발현 특성

주은희,손명수,차천수,한민철,김성수,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objective the paper is to investigate the physical and mechanical properties of concrete incorporating mineral admixtures. For setting properties, at low curing temperature, setting time of concrete with mineral admixture is delayed compared with that of plain concrete. But, use of cement kiln dust(CKD) has a desirable effect on reducing setting retard under low curing temperature. For compressive strength, concrete with FA and BS have low strength at early stage compared with that of plain concrete under low curing temperature. However, the use of CKD resulted in an enhancement of compressive strength at early stage under low curing temperature, and exhibited a similar level of compressive strength with plain concrete. For this reason, use of CKD in cold weather concreting has positive effect on strength development at low curing temperature under early age.

자연대류를 고려한 전력용 변압기의 2차원 온도분포 해석

민경조,김중경,한성진,주수원 東亞大學校附設 情報技術硏究所 2005 情報技術硏究所論文誌 Vol.13 No.1

Recently, the efficiency of power transformer is improved and the size is becoming smaller. So, it is very important that temperature characteristics of the transformer should be estimated and predicted precisely. This paper deals with the temperature distribution of power transformer by simplified 2-D hybrid mesh model. The temperature distribution was obtained by CFD algorithm considering natural convection. Heat sources are calculated first by magnetic field analysis based on F.E.M. and are used as the input data for thermal field problem based on computational fluid dynamics (CFD) algorithm. The calculated temperature distribution of the simplified 2-D power transformer model shows good results in accuracy as well as in computing time.

양파의 껍질 및 육질 추출물이 CCl₄투여 흰쥐의 지질과산화적 손상에 미치는 영향

이재민,정수현,조정순,서형주,정승태 明知大學校 自然科學硏究所 1997 자연과학논문집 Vol.15 No.-

CCl₄투여한 흰쥐에서 양파껍질과 양파육질 추출물의 항산화 효과를 알아보기 위해 SOD활성도 측정을 이용한 유리 라디칼 소거능, 과산화지질(Malondialdehyde, MDA),GOT, GTP를 측정한 결과 CCl₄ 투여로 증가된 IC 값(cytochrome C 환원의 50%의 저해 함량) 은 양파껍질과 육질 추출물에 의해 유의하게 감소되었다. MDA함량은 양파껍질 추출물에 의해 그 함량이 유의하게 감소되었다. 또한 혈청내 GOT와 GTP의 함량도 역시 양파껍질과 육질추출물에 의해 감소되었다. Using the CCl₄-induced hepatotxicity in rats as model system, superoxide radical scavenging activities by SOD(Super oxide dismutase), TBA-reactants(MDA) contents, GOT acd GPT were measured for antiaxidative activity in onion peel and onion flesh. The results were summarized as follows, IC (Inhibition concentration of 50% cytochrom Creduction)values which were increased with intra peritoneal injection of CCl₄were siginificantly decreased by the extracts from onion peel and onion flesh. The contents of MDA(malon dialdehyde) in liver were increased CCl₄ injection whereas the contents were siginificantly decreaed with the extracts from onion peel and were slightly decreased with the extracts from onion flesh. The contents of GOT and GPT in serum were also decreased with the extracts from onion flesh. The contents of GOT and GPT in serum were also decreased with the extracts from onion peel and onion flesh.

국산 체외 충격파 쇄석기의 음향학적 특성 평가

최민주,이종수,김성삼,조성찬,양형석,손종수,천원기 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

In the study we measured and evaluated the acoustical property of a domestic spark gap type extracorporeal shock wave lithotripsy (ESWL). Altering the discharging medium between the electrodes of the shock wave generator (water, 1% an 10% NaCl electrolyte), we measured shock waveforms and sound pressure level (SPL). For the shock waves produced using the discharging medium, water, it was seen that the shock wave peak pressure went up to 70 MPa, and the SPL was in the range of 90 - 100 dB. As the concentration of NaCl increased in the electrolyte. the SPL did not change much and was shown to increase correlation with the discharging voltage. In the case of the discharging medium. 10% NaCl electrolyte, it was found that the shock amplitudes varied in a narrow range when being high in the concentration of NaCl and were large when being high in discharging voltages. While the stone fragmentation was in process, we measured the acoustic emission and compared their spectral properties.