성인에서 발생한 발진성 가성 혈관종증

서상희 ( Sang Hee Seo ),장호선 ( Ho Sun Jang ),목혜수 ( Hye Soo Mok ),김성준 ( Sung Jun Kim ),김병수 ( Byung Soo Kim ),김문범 ( Moon Bum Kim ),오창근 ( Chang Keun Oh ),권경술 ( Kyung Sool Kwon ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.8

Background: Eruptive pseudoangiomatosis (EPA) is a rare, benign, spontaneously regressing childhood exanthem. It is characterized by the sudden onset of several bright red angioma-like papules surrounded by pale halos with a distinct histopathology from true angiomas. Objective: This study was performed to evaluate the clinical and histopathologic characteristics of EPA occuring in adults. Methods: Ten adult patients who visited Pusan National University Hospital and Mok Hye-SooㆍJang Ho-Sun Dermatology Clinic from March 2005 to September 2006 were evaluated. We prospectively evaluated the sex, age, onset season, past medical history including immunosuppressive abnormalities, systemic disorders and other diseases including allergies. We also investigated the relations of mosquito biting, patients` occupations and outdoor activities to occurrence of EPA. In addition, simultaneous occurrence in family members, the clinical, histopathologic, laboratory findings, disease courses and responses to treatment were evaluated. Based on medical records, photographs and pathologic slides, we retrospectively diagnosed another 20 EPA patients suspected as insect bite from October 2003 to March 2005. The same questions were inquired as for the 10 patients who prospectively underwent evaluation. Results: In the study, female predominance (76.7%) was observed and the average age of onset was 54.2 years. Interestingly, there was no child patient during the period of study. Multiple, 2∼5 mm sized, red angiomatous papules surrounded by pale halos occurred on exposed areas such as the arms (86.7%), legs (50%), and face (46.7%), although it could also occur to a non-exposed area. EPA occuring in adults usually appeared in summer (80%). The mean disease duration was 3.4 weeks. Although EPA spontaneously regressed, it had the potential of recurrence (46.7%). Histopathologic findings showed dilated dermal blood vessels without the evidence of increase in numbers, and perivascular lymphocytes infiltration. Inside the lumen of dermal blood vessels, plump endothelial cells were found. Conclusion: EPA occuring in adults usually happened to exposed sites in summer, so it can be misdiagnosed as insect bite. We suggest that dermatologists should be concerned about EPA in adults and conduct further investigation to have a better understanding of the disease. (Korean J Dermatol 2007;45(8):797∼803)

여학생 동복 하의 착용시의 생리반응과 주관적 착용감

권수애,오미경,강미영,송혜원,박진채,권리현 충북대학교 교육 ·생활연구소 생활과학연구센터 2002 생활과학연구논총 Vol.5 No.-

In this study, physiological responses and subjective sensations were investigated depending on various high school girls' lower cloth uniform in winter. Four healthy young women were selected, and they wore same underwear and jacket. The types of lower cloth were tight skirt+stocking, flared skirt+stocking, tight skirt+legings+socks, flared skirt+legings+socks, and slacks+socks. The results were as follows: 1) The effect of the type of lower cloth in winter on the skin temperature, humidity inside clothing and subjective sensations were significant. 2) It is desirable for high school girls to wear slacks in winter, Since physiological responses and subjective sensations of slacks are superior to those of skirts. 3) It is desirable for high school girls to wear flared skirt, legings, socks in winter, Since insulation and subjective sensations of flared skirts are superior to those of tight skirts.

생쥐 뇌 N-type 칼슘 채널 α1B Subunit의 cDNA Cloning

권혜수,조경혜 서울여자대학교 자연과학연구소 1997 자연과학연구논문집 Vol.8 No.-

생체내에서 칼슘이온은 이차 정보전달자의 하나로서 생체현상을 조절하는 매우 중요한 물질중의 하나이다. 칼슘 이온의 유입은 주로 전압의존형 칼슘 채널에 의하여 이루어지며 막 홍분성, 효소활성, 호르몬 분비, 근육수축, 신경 전달물질의 전달 등의 세포내 다양한 기능을 조절한다. 이 전압 의존형 칼슘 채널은 그 전기생리학적, 약리학적 특성에 따라 4가지 타입(L-, P-, N-, T- type)으로 구분된다. 이중에서도 신경계에 특이적으로 분포하여 미성숙 뉴런의 이동이나 신경 전달 물질의 분비에 중요한 역할을 하는 N-타입 칼슘 채널의 연구가 많이 이루어지고 있다. 각 칼슘채널을 이루는 4개의 subunit 중에서 칼슘의 유입을 조절하는 역할을 담당하는 al subunit의 연구는 중요하며 활발히 진행되고 있다. 이미 알려진 흰쥐나 토끼의 N-타입 칼슘 채널과 마찬가지로 생쥐에서도 신경특이적인 N-타입 칼슘 채널의 역할이 중요하리라고 보여진다. 따라서 본 연구에서는 아직 완전하게 cDNA가 클론 되어있지 않은 생쥐의 뇌를 시료로 하여 cDNA를 합성한 후 rbB-I을 탐침으로 사용하여 검색하여 3가지의 클론을 얻었다. 그리고 클론 각각이 가지고 있는 insert를 restriction mapping으로 확인한 후 제한효소의 반응위치를 이용, 유전자 조작을 거듭하여 생쥐 N-타입 칼슘 채널 alB subunit cDNA의 full clone을 얻어ㅐㄴ었다. 그 발현양상은 Northern blotting을 이용하여 조직별, 발생별로 연구되어야 하고 그외 돌연변이를 이용한 기능연구 등이 수행되어야 하겠다. Influx of calcium through voltage-dependent calcium channels plays a vital role in the regulation of a variety of cellular functions, including muscle contraction, axonal outgrowth, hormone release, and neurotransmitter release. On the basis of electrophysiological and pharmacological properties, at least four types of calcium channel (designated T-, L-, N-, and P-type) have been distinguished and each type is composed of 4 or 5 subunits(??, ??, ??, ??, and ??). The ?? subunit of each type has been a focus of research since it controls the entry of calcium ions. Among the four major types of calcium channels, N-type calcium channels are unipue in that they are found specifically in neurons, have been correlated with control of neurotransmitter release, and are blocked by ??-conotoxin. Recently, many studies of N-type calcium channels have been done and are progressing. Mouse N-type ??B subunit is expected to play an essential role in migration of immature neurons and neurotransmitter release in considering the roles of rat and rabbit N-type ??B subunit. In this study, mouse brain cDNA library was prepared and screened with rbB-I DNA rpobe. Through gene manipulation, we obtained full-length cDNA clone of the ??B subunit of mouse N-type calcium channel. And through Northern boltting of mouse tissues and mutagenesis studies, we will study how the N-type ??B subunits of mouse are expressed and regulated.

연상단어 순위로 본 정신질환자의 죽음의식에 관한 연구

권혜진,이소우 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.1

The purpose of this study was to explore the death consciousness of 60 psychiatric patients hospitalized in the 3 general hospitals with similar therapeutic environments in Seoul by means of free word association method. 10 words identified to be most frequently associated with death in the Kwon's study in 1980 were used in this study. 5 hypotheses were formed to achieve the objectives of the study. It's major findings are an follows; 1. In this study suicide topped the list of the 10 words followed by 'Disease', 'Graves', 'Emptiness', 'Incurable Disease', Frustration', 'Death', 'Disaster', 'Grief', and 'Darkness' in the responses of the psychiatric patients. The first hypothesis was found statistically significant and therefore, was verified. 2. No difference statistically significant was found in the order of frequencies in the patients' association of words related to 'death' by sex or age. 3. However, there was statistically significant difference in the order of frequencies in the patients' association of words by dignosis. Schizophrenic patients associated 'death' most frequently with emptiness and neurotic patients with 'incurable disease' while in the case of psychoneurotic patients, 'suicide' topped the list. Therefore the fourth hypothesis was verified. 4. There was a statistically significant difference by behavior characteristics, and the fifth hypothesis was denied.

한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

안경착용자의 안경착용에 대한 이미지 연구 : Q-방법론적 연구 Q-methodological Approach

정수정,정혜경,김경희,권혜진 韓國學校保健學會 1999 韓國學校保健學會誌 Vol.12 No.1

This study attempts to identify the self-image of eyeglass wearers with Q-methodology. Preliminary Q-statements were collected through personal and telephone interviews and based in consultation with reference books, eyeglass wearers, an optician and an oculist. Finally,34 Q-samples were seleted. The results were analyzed by a Q-factor with a PC QUANL Program. The sell-image of eyeglass wearers were found to revolve around three types: Type 1. They feel that eyeglasses have a negative inf1uence on image and that they uncomfortable. In addition, other people have a negative bias toward people who wear eyeglasses. As a result of these negative prejudices and inconveniences, there is a tendency to wear contact lens or have laser operations. Type 2. They feel less uncomfortable comparatively', when explained that classes can help improve their image. When explained as a fashion accessory, negative prejudices almost disappeared. Type 3. They show a positive reaction when explained that spectacles are also rosed for sight protection. However, they are sensitive to changes in their complexion as a result of eyeglass wear and place much importance in the design of glass frames. The significance of this study is to suggest basic data for a mediation device that improve the image of eyeglass wearers discovery and analysis of these three types.

Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성

정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3

목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.

호산구성 간농양 54예의 임상상

강혜련,권혁수,송우정,이상민,김태범,박혜경,장윤석,김윤근,조상헌,민경업,김유영 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

새로운 Baculoviurs 전이벡터를 이용한 Escherichia coli β-galactosidase 유전자의 발현

우수동,김우진,김혜성,진병래,강석권 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

국내에서 분리된 BmNPV를 이용하여 제작된 새로운 전이벡터 pBmKSK1에 외래 유전자로서 E. coli lacZ 유전자를 클로닝하고 재조합 바이러스를 제작하였다. 재조합 바이러스에 대하여 Southern blotting 분석을 실시하여 lacZ 유전자의 존재를 확인하였으며, 재조합 바이러스가 접종된 세포의 SDS-PAGE 및 Western blotting 분석을 통하여 β-galactosidase의 발현을 확인하였다. 재조합 바이러스의 발현효율을 누에 세포주 및 유충에서 비교 조사한 결과, 유충에서 더욱 높은 발현량을 보임을 확인하였다. To investigate the expression efficiency of new transfer vector of Bombyx mori nuclear polyhedrosis virus (BmNPV), Escherichia coli lacZ gene was inserted into new transfer vector pBmKSK1, under the control of polyhedrin promoter and expressed in BmN-4 cells coninfected with transfer vector pBmKSK1-LacZ and vild type BmNPV genome, and analysed by Southern blotting. The expression of β-galactosidase was characterized by SDS-PAGE, Western blotting and β-galactosidase activity assay. The results showed that the level of expression in silkworn larvae was higher than that of BmN-4 cells.

일부 흡연 대학생의 지각된 스트레스와 흡연실태에 대한 상관관계 연구

강초록,권시내,권혜림,박수경,송인혜,오해인,이미지,한승아,황선아,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

In spite of the seriousness of smoking harm has been developed these days. the increase of national smoking rate and that the people in the twenties are especially leading the rise of national smoking rate is an important issue of national health. Smoking of the university students can occur health problem and cause loss of manpower and expenses in their social activity period. So then the actual state for prevention of smoking and development of a program to prohibit smoking has to be seized urgently and starting with the study of the realities of university students, the effort to find a related fluent of smoking has to be studied. Related to this, the purpose of this study is to seize the general characteristics of smoking university students and to find out the relationship between perceived stress and smoking status among smoking university students. In addition, by collating the relationship between perceived stress and smoking status among smoking university students we have the purpose to furnish the basal data of stress care, the best way to cope with stress through group training and the plan for nursing implementation to decrease the smoking rate. For this study, a survey was conducted for 204 smoking university students of 13 universities in Seoul from 9th of May to 16th of May, 2003. The collected data was analyzed by t-test, Pearson Correlation and ANOVA in the statistical packages SPSS/PC. Major findings of this study are as follows; 1. Of the 204 respondents 85.4% of them were male and 14.6% of them were female. The average age of the sample was 23.19 years old and 41.8% of them were in senior, 21.4% in junior, 16.9% in sophomore, 19.9% in freshman grade. The major motivation to start smoking was 'because of curiosity'(33.8%) and the first smoking experience was at 'senior high school' (41.9%) and at 'college' (41.9%). 2 The highest scored stress factor of smoking university students were stresses about school work. 3. 72.7% had experience to quit smoking at least one or more times. Most of the reason to keep on smoking was 'short will to quit'(51.0%) and the smoking place was usually at 'school' (41.4%). Most respondents for the number ofsmoking friends were '5 people and above' (73.2%). 4. There was a negative relationship between the general characteristics and the entire perceived stress, however, there was a positive relationship between the general characteristics and the perceived stress in 4 categories which is 'sex distinction', 'major of study', 'residence form' and' inmate'. 5. There was a negative relationship between the general characteristics and the entire smoking status, however, there was a positive relationship between the general characteristics and the smoking status in 2 categories which is 'presence of hobby' and 'number of smoking friends'. 6. There was a negative relationship between the perceived stress and the smoking status. Through this study we have seized the relationship between the general characteristics, perceived stress and the smoking status of smoking university students. There was a positive relationship between some of the general characteristics with the perceived stress and the smoking status of smoking university students. Also there was a negative relationship between the perceived stress and the smoking status.