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한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계
여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2
Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.
국내 유통 식품용 플라스틱 기구 및 용기, 포장의 중금속 위해도 평가
이경연,김형수,장대용,구예지,이승하,여혜빈,윤지수,임경민,최재윤 한국포장학회 2022 한국포장학회지 Vol.28 No.3
중금속은 첨가제 성분이나 오염으로 인해 식품용 플라스 틱 기구 및 용기, 포장 제품에 유입되어 식품을 통해 인체 로 노출될 수 있다. 따라서 본 연구에서는 독성을 가진 7종 의 중금속(납, 카드뮴, 니켈, 크롬, 안티몬, 구리, 망간)을 선 정하고 국내 유통되는 16재질 137개 제품들에서의 이행량 을 파악하여 위해도 평가를 수행하였다. 대상 검체들은 4% 초산을 식품모사용매(70oC, 30분)로 적용하여 이행시험을 수행하였다. 동시분석을 위해 유도결합플라즈마 질량분석법 (ICP-MS)을 적용했으며 선형성, 검출 한계(LOD), 정량 한 계(LOQ), 회수율, 정밀도를 측정하고 확장불확도를 산출하 여 정량결과의 신뢰성을 확보하였다. 모니터링 결과, 전체 적으로 불검출 (ND) ~ 8.76 ± 11.87 μg/L의 수준으로 검출되 었으며, 대부분이 평균 1 μg/L 미만의 미량으로 확인되었다. 또한 안티몬이 PET 재질에서 다른 재질들에 비해 통계적 으로 유의하게 높게(p < 0.05) 측정되었다. 마지막으로 위해 도를 평가한 결과, 국내 유통되는 제품들의 중금속들은 인 체안전기준 대비 모두 안전한 수준으로 유지되고 있는 것을 확인하였다. Heavy metals can be intentionally or unintentionally introduced into plastic food utensils, containers, and packaging (PFUCP) as additives or contaminants, which can be ingested with food by humans. Here, seven-heavy metals (lead, cadmium, nickel, chromium, antimony, copper, and manganese) with toxicity concerns were selected, and risk assessment was done by establishing their migration from 137 PFUCP products made of 16 materials distributed in Korea. Migration of heavy metals was examined by applying 4% acetic acid as a food simulant (70oC, 30 minutes) to the PFUCP products. Inductively coupled plasma mass spectrometry (ICP-MS) was employed for the analysis of migrated heavy metals, and the reliability of quantitative results was confirmed by checking linearity, LOD, LOQ, recovery, precision, and expanded uncertainty. As a result of monitoring, heavy metals were detected at a level of non-detection to 8.76 ± 11.87 μg/L and most of the heavy metals investigated were only detected at trace amounts of less than 1 μg/ L on average. However, antimony migrated from PET products was significantly higher than other groups. Risk assessment revealed that all the heavy metals investigated were safe with a margin of exposure above 311. Collectively, we demonstrated that heavy metals migrated from PFUCP products distributed in Korea appear to be within the safe range.