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통년성 알레르기성 비염에 있어서의 흡입성 알레르겐의 역학적 연구
민경업,김유영,강석영 대한천식알레르기학회 1983 천식 및 알레르기 Vol.2 No.2
To evaluate the causative allergens epidemiologically, we performed skin tests with 126 inhalant' allergens in 349 cases of perennial allergic'rhinitis concentrating special interest on the patients living plsce, age and serum total IgE level. 1) The 20 most common inhal ant allergens and their positive rates were house dust 49.6 % Dermatophagoides farinae 50.3% D, pteronyssinus 49.0%, hay dust 20.9%, straw dust 18.6 %, mixed threshing 12.0 %, chrysanthemum pollen 10.9 % mugwort pollen 9. 5%, golden rod pollen 8.6 %, dahlia pollen 7.4%, aster pollen 7. 2%, dandelion pollen 6.6 %, catfur 18.3 %, dog hair 18.1%, rabbitfur 11.7%, horse hair 6.3%, cowdander 6.0%, house fly 15.5%, mosquito 13.2% and silk 7. 7%. 2) Positive reaction rate to D. farinae was higher in urban dweller (54.8 %) than rural. Contrarily, positive reaction rate to house fly was higher in rural dweller(35.7%) than urban. Those were statistically significant. Other allergns did not show any significsnt di fference between urban sndrural dweller. 3) Positive reaction rates to six allergens(house dust, D. farinae, D. pteronyssinus, dog hair, catfur, and rabbit fur) were higher in patients who were under the sge of 30 years or had increased total serum IgE levels than not. Other allergens showed no significant difference according to the age or total serum IgE level.
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쥐의 복강비반세포로부터의 Calcium Inopfore A23187에 의한 히스타민 유추
민경업,김유영,최강원 대한천식알레르기학회 1989 천식 및 알레르기 Vol.9 No.3
Calcium ions mediate essential role on the release of histamine from mast cells of various origin. Caleium ionophore exerts its effect by inducing influx of calcium ions into the mast cells in a dose dependent pattern. However, there are rare study about the effect of high calcium ion and calcium ionophore concentrations. To investigate the effects of high concentrations of these chemicals, the authors releaeed histamine from rat peritoneal mast cells in the presence of various concentraions of calciumion and calcium ionophore A23187. The releaaed hiatamine was assayed using automated fluorospectrometry In the presence of low concentration of calciuum ions, the release of histamine was proportional to the concentration of calcium ionophore. But the release of histamine was inhibited in the presence of high calcium ion and calcium ionophore. In conclusion, the calcium ions have dual effects on the calcium ionophore- induced histamine release from rat peritoneal mast cells.
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민경업,반준우,이병재,손지웅,이상록,김윤근,지영구,윤호주,조상헌,이명현,김유영 대한천식알레르기학회 1997 천식 및 알레르기 Vol.17 No.3
Background: Exercise induced asthma (EIA) can be demonstrated by exercise in 70 75% patients with bronchial asthma. The mech anisms by which the airway heat and water loss after exercise may cause bronchoconstriction is not clear. Eosinophils are major effector cells in airway allergic inflammationin bronchial asthma, and eosinophil cationic protein (ECP), which is released by activated eosinophil, may be the index of eosinophil activation. However it is unknown whether the eosinophil is activated in the development of EIA. Objective. We evaluated the hypothesis that the activation of eosinophils is important on the development of EIA. Methods'. We performed exercise challenges (free running for 6 minutes) in 21 asthmatics, who consist of 13 patients with EIA (EIA group) and 8 asthmatics without EIA (control group), and measured FEV1 and FVC, peripheral blood eosinophil counts, and the serum ECP concentrations before and after the exer- cise challenges. Results'. The average fall of FEV1 in EIA and control was 29.3+4.8%, and 7.9+1.3%, respectively. There was no significant difference of basal peripheral blood eosinophils (303 /mm+ 54 versus 275/mm+ 67) and basal serum ECP concentrations (31.2ng/ml+ 7.1 versus 39.2ng/m) +8.7) between EIA and control groups. However serum ECP levels were signiqicantly increased ast 30 minutes ofter execise (45+ 9.4 ng/ml) Than that before execise, but were not in control group. By the ways, the peripheral blood eosinophils after exercise were not significantly different from that before exercise in EIA and control groups. Conclusion.' It is suggested that. The activation of eosinophil is related to the development of EIA.
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