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첨단 과학의 발전에 따른 질병 발생에 관한 병태생리의 이해와 새로운 치료약제의 도입에도 불구하도 알레르기 질환은 최근 20년 사이에 전세계적으로 증가하고 있는 추세이다. 국내에서도 암, 만성 성인병과 더불어 국민의 3대 만성 질환의 하나이고 소아에서는 이제 가장 흔한 만성 질환으로 알려져 있다. 1972년 대한알레르기학회가 창립되고 1981년 '알레르기' 학회 잡지가 발간되면서 알레르기 질환의 발생, 진단, 치료, 예방 등에 대한 관심이 증가하여 알레르기 여러 분야에서 논문들이 활발하게 보고되기 시작하였으며 여러 가지 학술활동 및 환자와 가족들을 위한 알레르기 교육이 시작되었다. 그러나 이러한 활동은 주로 알레르기 전문 클리닉이 설치되어 있는 병원들에 내원한 환자들을 대상으로 시행되었기 때문에 알레르기 질환의 증가 추세와 비교할 때 부족한 감이 있었다. 이에 대책으로 대한 천식 및 알레르기학회는 대한 소아알레르기 및 호흡기학회와 공동으로 1999년 5월 15일부터 21일까지 1주간을 제1회 알레르기주간으로 제정하고 다가오는 21세기에는 알레르기 질환의 발병을 줄이기 위하여 알레르기 예방을 위한 "7대 권장사항"을 채택하였다 (Table.1). 이는 알레르기질환의 발볍에 영향응 미치는 인자들 중 학문적으로 그 중요성이 널리 인정된 것들을 국내의 상황에 맞게 채택하였다. 이에 이러한 캠페인의 전체적인 필요성과 각 항목의 선정 배경을 밝히고자 한다.
김미영 ( Mi Yeong Kim ),강민규 ( Min Gyu Kang ),이서영 ( Suh Young Lee ),강성윤 ( Sung Yoon Kang ),심은진 ( Eun Jin Shim ),정재우 ( Jae Woo Jung ),강혜련 ( Hye Ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2011 천식 및 알레르기 Vol.31 No.3
Background: Cashew (Anacardium) is a tree nut allergen which can induce severe symptoms, including anaphylaxis. However, only a few cases of tree nut allergies have been reported in Korea and Japan. We experienced a case of cashew allergy. Case History: A-27-year-old female patient presented with facial urticaria, lip edema, conjunctiva injection, nausea, vomiting, and voice change after eating cashew. The patient suffered from recurrent symptoms after eating food containing cashew. Results: We measured specific immunoglobulin E (IgE) to various tree nuts in serum using the Pharmacia CAP system and confirmed a marked increase of serum specific IgE to cashew and pistachio. However, allergic reactions occurred only after ingestion of cashew. Conclusion: We report a case of cashew allergy confirmed by the typical clinical history and specific IgE test. (Korean J Asthma Allergy Clin Immunol 2011;31:215-218)
이수영 ( Soo Young Lee ),김경원 ( Kyun Won Kim ),이현희 ( Hyun Hee Lee ),임대현 ( Dae Hyun Lim ),정혜리 ( Hae Lee Chung ),김성원 ( Sung Won Kim ),이소연 ( So Yeon Lee ),양은석 ( Eun Seok Yang ),이정민 ( Jeong Min Lee ),김규언 ( Ky 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.3
Background: Incidence and severity of childhood food allergy increased during the past 2 decades and that pediatric emergency department visits and death occurring due to food-induced anaphylaxis also increased in Western countries. Methods: To evaluate the incidence and clinical characteristics of pediatric emergency department visits due to severe forms of food allergy in Korea, data were collected from 305 with urticaria, angioedema or anaphylaxis of 78,889 children aged ≤18 or younger than 18 years who visited the emergency departments between of 9 hospitals in 8 cities in Korea June 2008 and March 2009. The incidence and clinical characteristics of childhood food allergy were evaluated using the detailed medical records. Results: Of 78,889 children, 169 (0.214%) showed food-related systemic urticaria, angioedema or anaphylaxis. Of the 57 children with anaphylaxis, 36 of which (63.16%) were food-related. The incidence of food-related anaphylaxis was 4.56 per 10,000 pediatric emergency department visits. Cutaneous symptoms (92.8%) were the most common anaphylaxis followed by cardiovascular (29.82%), gastrointestinal (28.07%), and respiratory symptoms (24.56%). The most common offending food allergen was fish, followed by cow`s milk, other seafoods, chicken, pork, egg, walnut, pupa, peanut, beef and buckwheat. There were no cases of death from anaphylaxis in this study. Conclusion: This is the first study to evaluate the incidence of pediatric emergency department visits and severity of childhood food allergy in Korea. The causative food allergens and clinical characteristics of pediatric emergency department visits due to food allergy in Korean children have been surveyed.
RAST has been used frequently as a test to detect specific IgE for the diagnosis of atopic allergic diseases. But many reports have shown that RAST is correlated well with allergy skin test and not better than the latter in its significance for confirming causative allergens. The purpose of this study is to know whether RAST can detect the patients who could not be detected by allergy skin test. 108 cases who had asthma like symptoms and shown negative or equivocal reactions to D. farinae or D. pteronyssinus by allergy skin test as a screc.,'ng test were performed RAST with about 10 allergens which are frequently positive in Korean children including house dust mite allergen. In cases who were positive by RAST, allergy skin test with same allergens were performed and the results were analyzed. The results obtained from this study were as fol- lows: 1. Ninty-nine cases(91.6%) were negative to house dust mite allergen and only 9 cases(8.4%) showed equivocal or positive reactions to same allergen by RAST. 2. Seven out of 9 cases who had equivocal or positive reactions to house dust mite by RAST were per- formed allergy skin test with same allergen as a follow-up study. The result of allergy skin test on house dust mite was correlated very well with RAST. The possibility of correlation with RAST on the other 2 cases who had not performed allergy skin test were also discussed. 3. Twenty-one allergens other than house dust mite were equivocal or positive reactions by RAST. Allergy skin tests were performed with same allergens on these cases. Seven allergens (cat hair in 5 cases, house dust and ragweed in each case) were negative by allergy skin test. Therefore, it can be concluded that detection of house dust mite allergen by allergy skin test in the diagnosis of atopic respiratory diseases is reliable method because skin test is correlated very well with RAST. But it is recommendable to perform allergy skin test more than once in suspicious cases in diagnosis.
김성렬 ( Sung-ryeol Kim ),김수정 ( Sujeong Kim ),김세훈 ( Sae-hoon Kim ),박종숙 ( Jong-sook Park ),박혜정 ( Hye Jung Park ),서동인 ( Dong In Suh ),심다운 ( Da Woon Sim ),양민석 ( Min Suk Yang ),이재현 ( Jae-hyun Lee ),이화영 ( Hwa 대한천식알레르기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.1
An allergy skin test is used to diagnose certain allergies by identifying sensitized allergens. In other words, it is a test for patients who are already sensitized to certain allergens. Because of the prevailing perception that beta-lactam allergy can be dangerous and potentially lethal, the intradermal test has long been routinely performed before use to screen beta-lactam allergy in Korea. The prevalence of penicillin allergy is estimated to be 1% to 2%. However, only 14% of the subjects with perceived penicillin allergy is considered to have true penicillin allergy. Moreover, it is difficult to justify performing a skin test on subjects who are very unlikely to be sensitized to beta-lactam, such as those who never used beta-lactam or never experienced allergy after previous use of beta-lactam. Therefore, allergists recommend beta-lactam skin testing in those who have allergy after the use of beta-lactam. Nevertheless, many hospitals in Korea are conducting routine skin tests on patients regardless of a history of beta-lactam allergy, which are not clinically validated but consume considerable human and material resources. False-positive results can consequently result in inappropriate labeling of beta-lactam allergy, leading to the unnecessary restriction of medication prescriptions and the increase in medical expenses. Herein, the drug allergy working group affiliated with the Korean Academy of Asthma, Allergy, and Clinical Immunology announces an expert opinion on the preuse beta-lactam skin test for subjects without a history of beta-lactam allergy based on the objective evidence from the literature and clinical relevance. (Allergy Asthma Respir Dis 2022;10:3-8)
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한천식알레르기학회(구 대한알레르기학회) 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children`s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
Purpose: Kiwi fruit allergy in children has scarcely been reported. This study focused on the clinical characteristics of kiwi fruit allergy and value of kiwi specific Immunoglobulin E (IgE) antibodies in Korean children. Methods: The study was based on a data analysis of 18 patients, who were diagnosed with clinical kiwi fruit allergy at Ajou University Hospital from June 2005 to June 2012. Clinical details were collected by medical history and telephone survey. Sera from all children were analyzed for kiwi specific IgE (ImmunoCAP) and patients with negative result were further evaluated by an enzyme linked immunosorbentassay test (ELISA) using our own made kiwi fruit extracts. Results: The subjects were 10 male and 8 female with a median aged 25 months. Twelve out of 18 (66.7%) were diagnosed with angioedema or urticaria, 4 (22.2%) were diagnosed with oral allergy syndrome, 1 was presented with dyspnea, and 1 was diagnosed with anaphylaxis. Oral route of exposure (88.9%) was most common and majority of patients (88.9%) experienced clinical symptoms at the first exposure to kiwi fruit. Six out of 12 patients with urticaria showed negative result in specific IgE by ImmunoCAP, but specific IgE were detected in 2 of 6 by ELISA with our own made kiwi extract. Conclusion: Systemic reactions to kiwi fruit were common in Korean children, and the symptoms were frequently developed at the first time of exposure. Additional diagnostic methods would be needed for evaluation of IgE sensitization in kiwi allergic patients with negative result by ImmunoCAP. (Allergy Asthma Respir Dis 1?1):73-78, 2013)Allergy Asthma Respir Dis 1(1):73-78, 2013)