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민경업 대한알레르기학회 1999 천식 및 알레르기 Vol.19 No.5
첨단 과학의 발전에 따른 질병 발생에 관한 병태생리의 이해와 새로운 치료약제의 도입에도 불구하도 알레르기 질환은 최근 20년 사이에 전세계적으로 증가하고 있는 추세이다. 국내에서도 암, 만성 성인병과 더불어 국민의 3대 만성 질환의 하나이고 소아에서는 이제 가장 흔한 만성 질환으로 알려져 있다. 1972년 대한알레르기학회가 창립되고 1981년 '알레르기' 학회 잡지가 발간되면서 알레르기 질환의 발생, 진단, 치료, 예방 등에 대한 관심이 증가하여 알레르기 여러 분야에서 논문들이 활발하게 보고되기 시작하였으며 여러 가지 학술활동 및 환자와 가족들을 위한 알레르기 교육이 시작되었다. 그러나 이러한 활동은 주로 알레르기 전문 클리닉이 설치되어 있는 병원들에 내원한 환자들을 대상으로 시행되었기 때문에 알레르기 질환의 증가 추세와 비교할 때 부족한 감이 있었다. 이에 대책으로 대한 천식 및 알레르기학회는 대한 소아알레르기 및 호흡기학회와 공동으로 1999년 5월 15일부터 21일까지 1주간을 제1회 알레르기주간으로 제정하고 다가오는 21세기에는 알레르기 질환의 발병을 줄이기 위하여 알레르기 예방을 위한 "7대 권장사항"을 채택하였다 (Table.1). 이는 알레르기질환의 발볍에 영향응 미치는 인자들 중 학문적으로 그 중요성이 널리 인정된 것들을 국내의 상황에 맞게 채택하였다. 이에 이러한 캠페인의 전체적인 필요성과 각 항목의 선정 배경을 밝히고자 한다.
소아천식환자에 대한 RAST 및 알레르기 피부검사의 진단적 가치 평가
이기영 대한천식알레르기학회 1987 천식 및 알레르기 Vol.7 No.2
RAST has been used frequently as a test to detect specific IgE for the diagnosis of atopic allergic diseases. But many reports have shown that RAST is correlated well with allergy skin test and not better than the latter in its significance for confirming causative allergens. The purpose of this study is to know whether RAST can detect the patients who could not be detected by allergy skin test. 108 cases who had asthma like symptoms and shown negative or equivocal reactions to D. farinae or D. pteronyssinus by allergy skin test as a screc.,'ng test were performed RAST with about 10 allergens which are frequently positive in Korean children including house dust mite allergen. In cases who were positive by RAST, allergy skin test with same allergens were performed and the results were analyzed. The results obtained from this study were as fol- lows: 1. Ninty-nine cases(91.6%) were negative to house dust mite allergen and only 9 cases(8.4%) showed equivocal or positive reactions to same allergen by RAST. 2. Seven out of 9 cases who had equivocal or positive reactions to house dust mite by RAST were per- formed allergy skin test with same allergen as a follow-up study. The result of allergy skin test on house dust mite was correlated very well with RAST. The possibility of correlation with RAST on the other 2 cases who had not performed allergy skin test were also discussed. 3. Twenty-one allergens other than house dust mite were equivocal or positive reactions by RAST. Allergy skin tests were performed with same allergens on these cases. Seven allergens (cat hair in 5 cases, house dust and ragweed in each case) were negative by allergy skin test. Therefore, it can be concluded that detection of house dust mite allergen by allergy skin test in the diagnosis of atopic respiratory diseases is reliable method because skin test is correlated very well with RAST. But it is recommendable to perform allergy skin test more than once in suspicious cases in diagnosis.
성인 비아토피 호흡기알레르기 환자에서 혈청 총 IgE와 신체질량지수의 관계
이지호 ( Ji Ho Lee ),리원연 ( Won Yeon Lee ),용석중 ( Suk Joong Yong ),신계철 ( Kye Chul Shin ),이선녕 ( Shun Nyung Lee ),이석정 ( Seok Jeong Lee ),김종환 ( Chong Whan Kim ),정세현 ( Sae Hyun Jung ),정예령 ( Ye Ryung Jung ),김상하 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.4
Background: Serum total IgE levels are increased in some obese patients with nonatopic respiratory allergy. It has not yet been fully determined a significant relationship between total IgE and body mass index (BMI) in nonatopic patients. We sought to examine the relationship between total IgE and BMI in patients with nonatopic respiratory allergy. Methods: We retrospectively reviewed 468 patietns with nonatopic asthma or allergic rhinitis without sensitization to 33 aeroallerens out of the 1,596 patients wirh respiratory allergic diseases who visitied Wonju Christian Hospital between June 2005 and July 2007. Nonatopy was determined by negative skin prick test results for all of the aeroallergens. Patients with were excluded from the study total IgE levels of >500 IU/mL because such levels were more frequently associated with other causes. Results: There were 468 patients with nonatopy and total IgE levels of <500 IU/mL (169 males and 299 females). The mean total IgE levels were 41.0 IU/mL in female patients with underweight (BMI<18.5 kg/m2), 64.6 IU/mL in those with normal weight (18.5≤BMI<23 kg/m2), 78.9 IU/mL in those with overweight (23≤BMI<25 kg/m2), and 85.5 IU/mL in those with obesity (BMI≥25 kg/m2). The mean total IgE levels were significantly higher in female patients with obesity or overweight than in those without (83.4 versus 61.8 IU/mL, P=0.036). There were no significant difference in serum total IgE levels according to BMI in male patients. Conclusion: Obesity may be a contributor to increased total IgE levels in female patients with nonatopic respiratory allergy. (Korean J Asthma Allergy Clin Immunol 2011; 31:288-294)
계란 알레르기 환아에서 인플루엔자 백신 접종의 안정성에 대한 연구
장수진 ( Soo Jin Chang ),설인숙 ( In Suk Sol ),김윤희 ( Yoon Hee Kim ),이희선 ( Hee Seon Lee ),한윤기 ( Yoon Ki Han ),박현빈 ( Hyun Bin Park ),김민정 ( Min Jung Kim ),김경원 ( Kyung Won Kim ),손명현 ( Myung Hyun Sohn ),김규언 ( Ky 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4
Purpose: Although influenza vaccine contains some residual egg protein (ovalbumin), recent studies have been reported that the influenza vaccine is even safe for patients with egg allergy. The object of this study was to assess the safety of influenza vaccination and estimate the risk factors of allergic reactions to influenza vaccination in children with egg allergy. Methods: The medical records of 108 children were reviewed retrospectively, those were diagnosed as egg allergy at Department of Pediatrics in Severance Children`s Hospital between January 2006 and December 2011. All of them were vaccinated with very low ovalbumin concentration (≤0.12 μg/mL). Patients were vaccinated in graded doses by the international guideline. Subjects without allergic reactions to influenza vaccine among egg allergy patients were recruited as control subjects. Results: Only 12 subjects of patients had adverse reactions to influenza vaccination. There were no significant relationships between adverse reactions to influenza vaccine and their own history of other allergy, history of breast feeding or graded vaccination. The egg allergy symptoms or egg-specific IgE levels were not associated with adverse reactions to influenza vaccination. Conclusion: These results show that patients with egg allergy may have adverse reactions with influenza vaccine, but severe adverse reactions are rare as general population. Therefore, the patients with egg allergy can be safe vaccinated with influenza vaccine, regardless of severity of allergic reaction after egg ingestion or methods of vaccination.
( Motohiro Ebisawa ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.3
In October 2005, we released Food Allergy Management Guideline 2005. To cover food allergy from infancy to adulthood, the project committee included not only pediatric researchers, but also internists, dermatologists, and otolaryngologists. The guideline concept was to utilize the data accumulated by the National Food Allergy Research Group, to be plain and as short as a pamphlet, and to be released on internet. The most glowing argument was about relation between infantile atopic dermatitis and food allergy, and how it should be treated in the guideline. To avoid neither overvaluation nor undervaluation, fastidious care was given to the denotation. With the definition of infantile atopic dermatitis associated with food allergy, both dermatologic and pediatric members of the project committee finally came to agreement, which was a landmark between dermatologists and pediatricians in Japan. The guideline explains fundamentals with the least paragraphs and with tables and figures as many as possible. Flowcharts are made largely as a composition in the parts of diagnosis and treatment. I really hope that this guideline is useful for Korean doctors involved in food allergy and that quality of life of food allergy patients and their parents are improved. (Korean J Asthma Allergy Clin Immunol 2006;26:177-185)