대한천식알레르기학회 설하면역요법 진료지침

류광희,지혜미,이화영,강성윤,김경훈,김주희,박경희,박소영,성명순,이영수,양은애,민진영,하은교,이상민,이용원,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한만용,최정희,신유섭,한두희,대한천식알레르기학회 면역요법/알레르겐연구팀,Gwanghui Ryu,Hye Mi Jee,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3

Allergen immunotherapy (AIT) has been used for over a century and has been demonstrated to be effective in treating patients with various allergic diseases. AIT allergens can be administered through various routes, including subcutaneous, sublingual, intra-lymphatic, oral, or epicutaneous routes. Sublingual immunotherapy (SLIT) has recently gained clinical interest, and it is considered an alternative treatment for allergic rhinitis (AR) and asthma. This review provides an overview of the current evidence-based studies that address the use of SLIT for treating AR, including (1) mechanisms of action, (2) appropriate patient selection for SLIT, (3) the current available SLIT products in Korea, and (4) updated information on its efficacy and safety. Finally, this guideline aims to provide the clinician with practical considerations for SLIT.

대한천식알레르기학회 알레르기 면역요법 진료지침

이화영,강성윤,김경훈,김주희,류광희,민진영,박경희,박소영,성명순,이영수,양은애,지혜미,하은교,신유섭,이상민,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한두희,한만용,이용원,최정희,대한천식알레르기학회 면역요법/알레르겐연구팀,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,Ju Hee Kim,Gwanghui Ryu,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3

Allergen immunotherapy (AIT) is a causative treatment of allergic diseases in which allergen extracts are regularly administered in a gradually escalated doses, leading to immune tolerance and consequent alleviation of allergic diseases. The need for uniform practice guidelines in AIT is continuously growing as the number of potential candidates for AIT increases and new therapeutic approaches are tried. This updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT, published in 2010, proposes an expert opinion by specialists in allergy, pediatrics, and otorhinolaryngology. This guideline deals with the basic knowledge of AIT, including mechanisms, clinical efficacy, allergen standardization, important allergens in Korea, and special consideration in pediatrics. The article also covers the methodological aspects of AIT, including patient selection, allergen selection, schedule and doses, follow-up care, efficacy measurements, and management of adverse reactions. Although this guideline suggests the optimal dosing schedule, an individualized approach and modifications are recommended considering the situation for each patient and clinic.

아토피피부염이 영유아의 식품알레르기 자연경과에 미치는 영향

박지선 ( Ji Sun Park ),문순정 ( Soon Jeong Moon ),임대현 ( Dae Hyun Lim ),장해지 ( Hae Ji Jang ),황선영 ( Sun Young Hwang ),박윤성 ( Yoon Sung Park ),김정희 ( Jeong Hee Kim ) 대한천식알레르기학회 2017 Allergy Asthma & Respiratory Disease Vol.5 No.5

Purpose: There have been studies showing that food allergy plays a role in the pathogenesis of atopic dermatitis. However, there have been few studies about the effect of atopic dermatitis on remission of food allergy. Thus, this study aimed to evaluate the dif-ference in remission according to the presence of atopic dermatitis in infants and young children with milk or egg allergy. Methods: A retrospective study was performed on 109 infants and young children with IgE-mediated food allergy in a tertiary hos-pital. They divided into food allergy with atopic dermatitis (FA with AD) and without atopic dermatitis (FA without AD). Results: In the milk allergy group, initial milk-specific IgE levels were 21.16±27.98 kU_A/L and 11.36±22.88 kU_A/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of milk allergy at 36 months of age were 64.9% and 90.0%, respectively, in FA with AD and FA without AD. In the egg allergy groups, initial egg-specific IgE levels were 34.48±36.72 kU_A/L and 15.66±28.60 kU_A/L, respectively, in FA with AD and FA without AD under 12 months of age. The remission rates of egg allergy at 36 months of age were 61.2% and 90.0% in children with FA with AD and FA without AD. Conclusion: Atopic dermatitis may play an important role in the natural history of food allergy in infants. Different strategies are needed for the management of food allergy in young children with atopic dermatitis. (Allergy Asthma Respir Dis 2017;5:256-261)

사과 알레르기 환자들의 임상적 특성과 원인 알레르겐의 규명

조현주 ( Hyun Joo Cho ),김주희 ( Joo Hee Kim ),최길순 ( Gil Soon Choi ),김정은 ( Jeong Eun Kim ),예영민 ( Young Min Ye ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2010 천식 및 알레르기 Vol.30 No.2

Background: Hypersensitivity to Rosaceae fruits, especially apple, is often associated with birch pollinosis. As the sensitization to pollens has increased, apple allergy is more prevalent. However, the immunologic mechanism has not yet been evaluated in Korean adult patients. Objective: This study was conducted to characterize the clinical features of apple allergy and to identify its IgE- binding components. Method: Ten patients having apple allergy were enrolled. Skin prick tests to common allergens and pollens were performed. Serum specific IgE to apple was measured by ELISA, and IgE-binding components of apple allergen were identified by IgE immunoblot analysis.Result: Most patients showed positive responses to alder/ birch pollens by skin prick tests and high serum levels of specific IgE to apple by ELISA. The IgE-binding component of apple allergen with a molecular weight of 17 kDa was identified by IgE immunoblot in most patients. There was no significant difference in the level of specific IgE to apple between the patient group having oral allergy syndrome and the other group with additional systemic symptoms. Conclusion: We confirmed that apple allergy can develop in pollen-sensitized patients because a 17-kDa allergen is assumed as Mal d 1 which shares a common allergenic determinant with Bet v 1 of birch pollen. (Korean J Asthma Allergy Clin Immunol 2010;30:116-122)

대한 소아알레르기 호흡기학회 창립 30년 - 소아알레르기 분야 연구 활동의 발자취(1945-1981년)

김규언 ( Kyu Earn Kim ) 대한천식알레르기학회 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S

연제 및 초록 - 심포지움 : 제11회 국제알레르기학회에 다녀와서 ; 기생충과 동물 알레르기

주정균 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1982 대한알레르기학회학술대회 Vol.2 No.2

한국 소아 식품알레르기의 연구 현황과 과제

안강모 ( Kangmo Ahn ) 대한천식알레르기학회 2018 Allergy Asthma & Respiratory Disease Vol.6 No.S

Food allergy is an immune-mediated adverse reaction that occurs mainly by consumption of food. Some of the children with food allergies have mild symptoms like urticaria and pruritus, while others manifest fatal symptoms like anaphylaxis. Many cases develop in infants and children, and disappear spontaneously over time. The prevalence of food allergy is known to be up to 6% of children and 3%-4% of adults. Growing concern is that prevalence of food allergy seems to be increasing. The prevalence, common allergens and natural course of food allergy vary according to the race, age, eating habits, and unknown factors. In Korea, many researchers have reported regional data on food allergy for comparison with those of foreign countries. Awareness is increasing and food labelling is being established to help people avoid allergenic foods. In the future, monitoring of prevalence and common food allergens at regular intervals is needed to make appropriate policies for children with food allergy. There are still lack of data on pathogenesis, natural course and clinical trials of immunotherapy in Korean children. In addition, it is necessary to form a consensus on primary prevention of food allergy by early exposure to allergenic foods. Further regional studies should be performed to expand our understanding of food allergy and to lead to proper management for Korean children with food allergy. (Allergy Asthma Respir Dis 2018;6 Suppl 1:S44-51)

연제 및 초록 - 심포지움 : 제11회 국제알레르기학회에 다녀와서 ; 제11회 국제 알레르기 학회 회의장과 학회운영에 관하여

변해원 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1982 대한알레르기학회학술대회 Vol.2 No.2

연제 및 초록 - 심포지움 : 제11회 국제알레르기학회에 다녀와서 ; 피부 알레르기

김정원 대한천식 및 알레르기학회 ( 구 대한알레르기학회 ) 1982 대한알레르기학회학술대회 Vol.2 No.2

대한천식알레르기학회 알레르기비염 진료지침: 파트 2. 비약물치료의 업데이트

박상철 ( Sang Chul Park ),정수지 ( Soo Jie Chung ),최정희 ( Jeong-hee Choi ),이용주 ( Yong Ju Lee ),양현종 ( Hyeon-jong Yang ),박도양 ( Do-yang Park ),김동규 ( Dong-kyu Kim ),이일환 ( Il Hwan Lee ),김수환 ( Soo Whan Kim ),김도현 ( 대한천식알레르기학회 2023 Allergy Asthma & Respiratory Disease Vol.11 No.3

Allergic rhinitis is the most common chronic disease worldwide. Various upper airway symptoms lower quality of life, and due to the recurrent symptoms, multiple treatments are usually attempted rather than one definitive treatment. There are alternatives to medical (medication-based) and nonmedical treatments. A guideline is needed to understand allergic rhinitis and develop an appropriate treatment plan. We have developed guidelines for medical treatment based on previous reports. The current guidelines herein are associated with the “KAAACI Evidence-Based Guidelines for Allergic Rhinitis in Korea, Part 1: Update in pharmacotherapy” in which we aimed to provide evidence-based recommendations for the medical treatment of allergic rhinitis. Part 2 focuses on nonpharmacological management, including allergen-specific immunotherapy, subcutaneous or sublingual immunotherapy, nasal saline irrigation, environmental management strategies, companion animal management, and nasal turbinate surgery. The evidence to support the treatment efficacy, safety, and selection has been systematically reviewed. However, larger controlled studies are needed to elevate the level of evidence to select rational non-medical therapeutic options for patients with allergic rhinitis. (Allergy Asthma Respir Dis 2023;11:126-134)