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        • KCI등재

          우울증에서 Wellbutrin SR의 사용

          정한용,김양래 대한정신약물학회 2005 대한정신약물학회지 Vol.16 No.1

          This article discusses the mechanism of action of Wellbutrin(bupropion) and relates the drug's neuropharmacologic effects to its clinical efficacy and side effect profiles. The preclinical and clinical data show that bupropion acts via dual inhibition of norepinephrine and dopamine reuptake and is devoid of clinically significant serotonergic effects or direct effects on postsynaptic receptors. With respect to treatment of depression, these catecholaminergic effects of bupropion tended to produce more robust effects on anhedonia/positive affect. Augmenting or switching antidepressants with bupropion has become an increasingly common strategy in the treatment of resistant depression. Bupropion has been suggested for the treatment of bipolar depression , because of its efficacy and a lower risk of inducing switches to hypomania or mania. Clinically, SR formulation, side effects are infrequent and benign, would be used without a risk of seizure in dose up to 400mg/day.

        • KCI등재

          DSM-III에 의한 불면증에 관한 연구 : 정신과 외래환자를 대상으로

          정한용,이대희,신동균 대한신경정신의학회 1985 신경정신의학 Vol.24 No.3

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          This investigation was based on the study of 247 Psychiatric patients with insomnia of at least 1 month’s duration, who had visited at the Department of Neuropsychiatry, Korea University Haewha Hospital from January 1983 to December 1983. The results were as follows; 1. There were 101 men ar.d 146 wcmen with the mean age of 38. 9 years. They had occupied 40.4 percent of all psychiatric patients in the same period. 2. The most common diagnoses were, in order, -affective, somatoform , anxiety, schizophrenic, -compulsive personality, and passive-aggressive perscalrity disorder. Also abcut one half of them were in the anxious or fearful cluster. 3. In the duration of insomnia, more than one half had been suffering from insomnia for at least 12 months and there were no statistical significances among diagnoses except subtypes of affective disorder. 4. Difficulty falling asleep was the most common type in this investigation. Difficulty falling asleep was more common in bipolar disorder, mania; V codes; schizophrenic; dysthymic; and compulsive personality disorder, whereas difficulty staying asleep was more common in major depression and bipolar disorder, depressed. 5. Twenty-one patients had axis III diagnoses and also they had axis I diagnosis as principal diagnosis. 6. In the MMPI results, the scales most elevated were, in order, hypochondriasis, conversion hysteria, depression and psychasthenia. These findings suggested that various factors such as somatic concern, depression, anxiety, fear, and obsession were correlated with insomnia.

        • KCI등재후보

          급성 조증 입원환자에 대한 항정신병약물의 처방 경향

          정한용,이소영,전용호 대한정신약물학회 2004 대한정신약물학회지 Vol.15 No.1

          Objective: Antipsychotic drugs are known to be effective in reducing psychotic symptoms and behavioral disruptions, and are mainly used during the first few days of acute manic phases of bipolar disorders. The purpose of this study was to investigate the use patterns of antipsychotics in the treatment of acute bipolar manic patients in a university hospital in Korea during the last decade. Methods: To track the use of antipsychotics from 1990 through 2000, a retrospective chart review was conducted by reviewing the medical records of bipolar disorder inpatients at the department of psychiatry, Soonchunhyang Medical Center in Seoul and Chunan. The following data were collected (1) demographic data, (2) history of bipolar disorder, (3) length of hospital stay, and (4) drug titration records of all prescribed antipsychotic medications. Results: Of the 138 total subjects, 98.5% had been treated with more than one antipsychotics combined with a mood stabilizer for at least one week. Chlorpromazine was found to be the preferred antipsychotic between 1990 and 1995. However, preference of high-potency antipsychotics, such as haloperidol, to low-potency antipsychotics for bipolar disorder patients was observed between 1995 and 2000. The prescription percentage of atypical antipsychotics increased to 16.3% in 2000. The overall mean prescribed daily chlorpromazine equivalents was 669.9mg/day (SD=514.3). Conclusion: In spite of unfavorable side effects and an established guideline for the usage of antipsychotics for bipolar disorder, most bipolar manic inpatients have been prescribed adjunctive antipsychotics at relatively high dosages. The results imply a need to reduce the discrepancy between daily clinical practice and recommended guidelines in the treatment of bipolar patients.

        • KCI등재

          외상성 뇌손상 환자에서 Amantadine의 치료적 효과 : 2증례 및 고찰

          정한용,이소영,김양래,Jung, Han Yong,Lee, Soyoung Irene,Kim, Yang Rae 대한생물정신의학회 2001 생물정신의학 Vol.8 No.1

          We reported two cases of amantadine treatment in traumatic brain injury patients and reviewed the literature of amantadine treatment of those patients. Problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficit could occur following traumatic brain injury or other types of acquired brain injury. This report described results of amantadine using in two patients with this type of symptom profile. Patients received neuropsychiatric examination as well as BPRS and Barthel index. These patients were improved, respectively from 57 point to 82 point(case 1), from 85 to 94(case 2) in Barthel index, and from 66 point to 35 point(case 1), from 55 to 32 point(case 2) in BPRS. These two patients did not reveal any other adverse effect. The rationale for using amantadine were discussed. 두부 외상을 받은 환자는 여러 가지 다양한 병태생리학적인 과정을 통해 뇌손상을 받으며 이로 인해 다양한 신경정신과적인 장애를 나타낸다. 두부외상을 받은 두 명의 환자에서 이에 대한 약물학적인 접근으로 amantadine을 사용하였고 증세의 호전을 경험하였다. 이에 대한 이론적인 근거로는 amantadine은 전연접(presynaptic)과 후연접(postsynaptic)에서 도파민 신경전달(dopamine neurotransmission)을 증진시켜 인지기능과 전두엽 기능장애에서 발생되는 특징적인 정신 행동학적인 증상을 호전시키고, NMDA 수용체 길항제(NMDA receptor antagonist)로 작용하여 흥분성 독성물질(excitotoxic substrate)에 의한 이차적인 신경손상을 차단하는 신경보호제(neuroprotective agent)로 작용한다. 이와 같이 amantadine은 급성과 만성 외상성 뇌손상 환자 모두에서 나타나는 인지, 기분과 행동장애의 치료에 효과적이고 안전하며 비싸지 않은 가격으로 사용될 수 있을 것으로 사료된다. 또한 이 영역에서 더욱 많은 대조군 연구가 필요하고, 나아가서 외상성 뇌손상 환자의 인지기능 호전을 위한 약물학적인 개입에 관한 연구가 필요할 것으로 사료된다.

        • KCI등재

          외상성 뇌 손상 환자의 신경정신과 영역 치료

          정한용,Jung, Han Yong 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

          The neuropsychiatric sequelae of traumatic brain injury are effects on complex aspect of cognition, emotion and behavior. They include problems with attention and arousal, concentration, executive function, intellectual changes, memory inpairments, personality changes, affective disorders, anxiety disorders, psychosis, apathy, aggression, and irritability. There are many useful therapeutic approaches available for people who have been brain injuries. Although a multifactioral, multidisciplinary, collaborative approach to treatment is proposed, for purposes of exposition the author have divided treatment into psychopharmacological, cognitive, behavioral, psychological, and social interventions.

        • Antipsychotic Drug Use Patterns for In-hospital Treatment of Bipolar Disorder Patients Across A 10-Year Span

          정한용,이소영,Yong-Ho Jun 대한정신약물학회 2003 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.1 No.1

          Antipsychotic drugs are known to be effective in reducing psychotic symptoms and behavioral disruptions, and are mainly used during the first few days of acute manic phases of bipolar disorders. The purpose of this study was to investigate the use patterns of antipsychotics in the treatment of acute bipolar manic patients in a university hospital in Korea during the last decade. To track the use of antipsychotics from 1990 through 2000, a retrospective chart review was conducted by reviewing the medical records of bipolar disorder inpatients at the department of psychiatry, Soonchunhyang Medical Center in Seoul and Chunan. The following data were collected; 1) demographic data, 2) history of bipolar disorder, 3) length of hospital stay, and 4) drug titration records of all prescribed psychotropic medications. Of the 139 total subjects, 98.5% had been treated with more than one antipsychotics combined with a mood stabilizer for at least one week. Chlorpromazine was found to be the preferred antipsychotic between 1990 and 1995. However, preference of high-potency antipsychotics, such as haloperidol, to low-potency antipsychotics for bipolar disorder patients was observed between 1995 and 2000. The prescription percentage of atypical antipsychotics increased to 16.3% in 2000. The overall mean prescribed daily chlorpromazine equivalents was 669.9 mg/day(SD=514.3). In spite of unfavorable side effects and an established guideline for the usage of antipsychotics for bipolar disorder, most bipolar manic inpatients have been prescribed adjunctive antipsychotics at relatively high dosages. The results imply a need to reduce the discrepancy between daily clinical practice and recommended guidelines in the treatment of bipolar patients.

        • KCI우수등재

          보강용 이상구조 지오텍스타일의 점탄성 거동에 관한 연구

          정한용,장경호,Jeong, Han-Yong,Jang, Gyeong-Ho 한국섬유공학회 1998 한국섬유공학회지 Vol.35 No.1

          By use of thermal bonding method, 2-phase geotextile composed of bonded and nonbonded parts for reinforcement was made from a needle punched polypropylene nonwoven to analyze the viscoelastic behaviors. The yield strain of 2-phase geotextiles is lower than that of simply needle punched geotextile and this is due to the increase of stiffness by uniform distributions of bonded parts. The interpretation of stress relaxation behaviors of 2-phase gootextile was based on Schapery's theory. The equilibrium state of stress relaxations approached to 10 sec independent of additional strains, and relaxation times existed within the range of 10 sec. The strain function, h(e), was divided into elastic and plastic regions and the transition between these regions occurred at 15∼25% strain ranges. Finally, the relaxation behavior of bonded parts was governed by (∞) and the behavior of unbonded parts was governed by (0)- (∞).

        • KCI등재

          외상성 뇌손상환자에서 Amantadine의 사용

          정한용,김양래,Jung, Han Yong,Kim, Yang Rae 대한생물정신의학회 2000 생물정신의학 Vol.7 No.1

          Avariety of symptoms can occur following traumatic brain injury(TBI) or other types of acquired brain injury. These symptoms can include problems with short-term memory, attention, planning, problem solving, impulsivity, disinhibition, poor motivation, and other behavioral and cognitive deficit. These symptoms may respond to certain drugs, such as dopaminergic agents. Amantadine may protect patients from secondary neuronal damage after brain injury as a effect of NMDA receptor antagonists and may improve functioning of brain-injured patients as a dopaminergic agonist. Clinically, based on current evidence, amantadine may provide a potentially effective, safe, and inexpensive option for treating the cognitive, mood, and behavioral disorders of individuals with brain injury. The rationales for using amantadine are discussed, and pertinent literatures are reviewed.

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