부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

스티븐스의 시에 나타난 색깔의 의미 : 실재와 상상력

서만순,김현생 啓明專門大學 産業開發硏究所 2001 啓明硏究論叢 Vol.19 No.1

월라스 스티븐스는 자신의 작품에 인간의 상상력과 물리적 실재와의 관계를 규명하고자 노력한 시인이다. 상상력과 실재와의 관계 규명을 위해 시의 가시화를 시도하였는데 시인의 이러한 실험은 그림과 시, 나아가 색깔이 주는 의미와 느낌을 언어로 표현하고자 하였다. 시인의 작품에 등장하는 다양한 회화적 기법과 실재 화가의 이름은 이를 뒷받침하고 있다. 상상력을 표현하는데 있어 파랑을 상징적 색깔로 차용하였으며 실재를 표현하는데 초록을 상징적 색깔로 택하였다. 이와 같은 시인의 색깔의 차용과 상징의 이용은 언어가 나타내는 한계를 절감한 결과이다. 색깔은 명암과 농도에 따라 그 표현 가능성은 거의 무한하다. 시인이 노린 효과는 자신의 시에서 언어가 색깔만큼 다양하게 다채롭게 의미되고 있다. 상상력과 실재의 분리는 결국 무의미하며 그 둘이 결합될 때에 '물 자체'라는 실재에 접근 가능하다. 보험사 부사장으로 또 시인으로 두 가지 역할을 훌륭하게 수행하였던 스티븐스로서는 시에서 상상력과 실재의 추구와 그 결합을 이끌어 내고자 하였던 것은 당연한 귀결로 여겨진다. Wallace Stevens' poetry is chiefly concerned with the relation of man's imagination to his physical reality. Reality, characteristically, as he has symbolized by the 'green,' is often transfigured and changed when acted upon by man's imagination. The transfiguration of reality, that is imagination, is represented by 'blue.' Throughout his works. the poet tries to pursue reality as being "Things Itself and imagination as being "metamorphosis" of reality. Stevens explores mans many ways of interpreting his physical reality, and considers how one might apply to chaos through the use of one's imaginative power. The problem of belief is resolved by the belief in a poetry which celebrates life here and now and which takes the place of God or gods. Stevens excelled in two roles that of poet and of surety bonds expert, and throughout his life. he performed admirably in both capacities. To create a meaningful order out of the interplay of reality and the imagination was one of Stevens' basic poetic themes. In 'blue' and 'green' he seems to have found an almost perfectly balanced representation of reality and the imagination. In an evolving poetic process which explores man's consciousness, he juxtaposes possibilities, plays variations on ideas, poses alternative, and finally arrives at synthesis of contradictory elements: reality and imagination, chaos and order Key Words.' imagination, reality, color, blue, green, 'Thing Itself.

연구논문 : 아마로 사용실태 및 향 선호도

김장순 ( Jang Soon Kim ),이종렬 ( Jong Ryol Lee ),박천만 ( Chun Man Park ) 한국미용학회 2006 한국미용학회지 Vol.12 No.3

The purpose of this study is to offer fundamental data for establishing a theory on aroma therapy by understanding Korean use and preference of aroma. The subjects of the study were 130 skin care specialists who worked for skin care salons and 410 general people in Daegu. The study was carried out through a questionnaire and inhalation test. The data were collected from September 1, 2003 to October 1, 2003. The result were as follows : 1. The rate of people who had experienced aroma less than 3 times was 40.5%. The rate of people who had not experienced aroma was 26.1%, who had experienced aroma massage was 33%, and who had inhaled aroma was 47.5%. The people who were older, wealthy, female, married, graduated from college were more experienced aroma(p<0.0l) and housewives in the thirties had more opportunities of experiencing aroma than other subjects. 2. General people preferred aroma Orange(66.3%) the most among 8 essential oils used in the test. The second preference was blended oil with Rosemary, Geranium and Lemon(26.1%). The third preference was the Lavender(25.8%). The order of preference in skin care specialists was Orange(83.3%), Lavender (48.8%), blended oil with Rosemary, Geranium and Lemon(42.9%), and blended oil with Lavender, Sandalwood, Ylangylang and Mandarin(26.2%). Both general people and skin care specialists disliked Teatree the most. 3. Lavender was more preferred by women than men (p<0.05) and Teatree was more preferred by men than women(p<0.0l). In particular, people in thirties liked Lavender the most(p<0.01). Teatree(p<0.001) and Sandalwood (p<0.05) were more preferred by married people than unmarried people. 4. The more educated people were, the more they liked the blended oil with Rosemary, Geranium, and Lemon(p<0.01). Housewives preferred Lavender(p<0.001) and Frankincense(p<0.05) and workers preferred Teatree(p<0. 001) and Sandalwood(p<0.05). As people were not healthy, they tended to prefer Teatree(p<0. 01) As people experienced essential oil, aroma massage and aroma inhalation more, they preferred Lavender and Frankincense. 5. Women`s average score was higher than men`s(women : 4.58, men: 4.18, total score: 6.0). Younger people more preferred aroma than older people(p<0.05). 6. 51.3% of specialists answered they used aroma for skin care less than one time a day, 35.7% of them used 2 or 3 times a day. 29.6% of specialists answered that the biggest difficulty in their work was the lack of knowledge of aroma. The next one was relationship with co-workers and pay(20.4%) and overwork was 13.9% 7. 37.3% of specialists had got massages 10~20 times from a skin care specialist and 31.7% of them had got massages less than 10 times. About experiencing aroma in everyday life, 42.9% of them experienced aroma 10~20 times and 28.6% of then experienced less then 10 times. 8. Generally, the more experienced people liked Lavender, Teatree, Sandalwood and Frankincense(p<0.05). 9. As a result of the survey on the specialists` preference, preferred oils were Lavender(22.4%), Rosemary (13.4%), Rose(10.1%), Jasmine(9.2%) and Orange(8.4%). Unpleasant oils were Teatree(16.0%), Yiangyiang(13.6%), Peppermint(9.9%) and Patchouli(8.6%). The specialists used Lavender the most (67.6%) in aroma therapy and used Rosemary(6.5%), Teatree(5.6%) and Peppermint(4.6%). In conclusion, the subjects` experience and knowledge of aroma were not high, and there was difference in preferences of aroma by their ages, gender, education, occupations, and experiences. However, both general people and the specialists had a difficulty in aroma use due to the lack of knowledge of aroma. So, if we apply aroma therapy to patients in consideration of their preferences, the best result will be expected. A systemic aroma education program for specialists is needed as soon as possible.

단무지 공장에서 발생한 질식 사고의 원인과 방사선학적 소견: 중례보고 및 가스분석 결과

박충기,김만구,김흥철,안범규,박만수,황우철,최철순,강익원 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

목 적:단무지 공장에서 질식사고를 일으켰던 가스의 종류를 알아내고, 이러한 가스중독의 방서선학적 소견을 소개하기 위하여 본 연구를 하였다. 대상 및 방법:단무지 공장에서 발생한 질식 사고자 3예중 생존자 1예를 대상으로 단순흥부X-선검사와 CT 소견을 분석하였으며, 가스의 종류를 알아내기 위하여 단무지를 유리병에 넣어 발생된 가스를 가스크로마토그래픽을 이용하여 분석하였다. 결 과:단무지 공장에서 발생한 질식사고자중 생존한 1명의 방사선학적 검사에서 신속히 호전되는 폐경결(consolidation)을 볼 수 있었으며 이는 폐부종의 소견임을 알 수 있었다. 협기성 상태에서 단무지를 담은 유리병의 상층부 가스를 실험 분석한 결과 이산화탄소, 에칠알코올이 다량으로 검출되었으나 독성가스는 주로 황화수소이였다. 결 론:단무지 공장의 질식 사고자에서 폐방사선학적 소견은 폐경결을 보이는 폐부증으로서 이는 실험을 통해 단무지에서 발생되는 유독가스인 황화수소 때문임을 입증하였다. Purpose: To identify the main toxic gas released from salted radish in rice bran(Dan-M-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Materials and Methods: Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analized by using the gas chromatography. Results: The radiographlc examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consolidations in both lung. The headapace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Conclusion: Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.

서브시퀀스 매칭을 위한 효과적인 후처리 기법

김상욱,김만순,박정일 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-

Subsequence matching, which consists of index searching and post-processing steps, is an operation that finds those subsequences whose changing patterns are similar to that of a given query sequence from a time-series database. This paper discusses optimization of post-processing for subsequence matching. The common problem occurred in post-processing of previous methods is to compare the candidate subsequence with the query sequence for discarding false alarms whenever each candidate subsequence appears during index searching. This makes a sequence containing candidate subsequences to be accessed multiple times from disk, and also have a candidate subsequence to be compared with the query sequence multiple times. These redundancies cause the performance of subsequence matching to degrade seriously. In this paper, we propose a new optimal method for resolving the problem. The proposed method stores all the candidate subsequences returned by index searching into a binary search tree, and performs post-processing in a batch fashion after finishing the index searching. By this method, we are able to completely eliminate the redundancies mentioned above. For verifying the performance improvement effect of the proposed method, we perform extensive experiments using a real-life stock data set. The results reveal that the proposed method achieves 55 times to 156 times speedup over the previous methods.

종격동 종괴를 의심케한 우대동맥궁 1례

김만우,백학연,정춘해,장경식,홍순표,조건국,김종진 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

Developmental anomalies of the aortic arch, commonly known as vascular rings, are relatively rare congenital vascular anomalies which can compress the trachea and esophagus. One routine chest film of a patient who was checked and hepatoma-diagnosed in Internal Medicine, Chosun University Hospital left the room for doubt of mediastinal mass. But no subjective symptoms for the mass was told by the patient. This is to report our experience of a patient having right side aortic arch with aberrant left subclavian artery, as proved by diagnosis, but none of congenital heart disease. This right side aortic arch with aberrant left subclavian artery is the most frequent type among right aortic arch, the anomaly of which is usually detected from the incidental suspicion for mediastinal mass at routine chest film; because no symptoms are accompanied therewith.

이미지 데이터베이스를 위한 정보 검색 시스템의 설계 및 구현

김만순,오세봉,김미연,민은미,박미영,정문숙,문현수,김상욱 강원대학교 정보통신연구소 2002 정보통신논문지 Vol.6 No.-

This paper presents design and implementation of an information retrieval system for a large volue of an image database. Our system supports three kinds of queries: attribute-based queries, keyword-based queries, and color-based queries. The attribute-based query is the most-typical query that finds target images based on their attribute values. The keyword-based query is to find target images by referring to their description information their attribute values. Finally, the color-based query is to search for target images by comparing the colors of a query image with those of images in the database. In this paper, we presents the system architecture and approaches adopted in our system for supporting the above three queries effectively and efficiently. We also discuss the user interface of our system that enables users to manipulate our system easily and conveniently.

알코올에 의한 α-Tocopherol이 혈액성분에 미치는 영향

김영순,이상한,김창세,조만희 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

This study was done in order to observe the effects of ethanol and a-tocopherol on the serum ALP, BUN and uric acid concentrations. The white Sprague-Dawley rats were classified with 4-grops : 0.9% NaCl administration was group A control, 25% ethanol administration for the each 5, 10 and 15 days was group B(Bl, B2 and B3), 25% ethanol administration for the each 5, 10 and 15 days and 50% a-tocopherol for the 2 and 7 days administration was group C (Cl and C2) and 50% a-tocopherol pretreated for the each 5, 10 and 16 days and 25% ethanol for the 2, 7 and the 10 days administration was group D(Dl, D2 and D3) The following results were obtained. 1. The changes of serum ALP activity was significantly increased in ethanol treated group. The group C and D was decreased. 2. The changes of serum BUN concentration between each group were not significant and however B2, B3, C2 and Dl was significantly increased. 3. The changes of serum uric acid concentration between each group were not significant. However group Cl and Dl was slightly decreased patterns.

임신중 알코올 섭취에 의한 기형 유발기전에 관한 연구

김소희,김순선,이규식,손경희,곽승준,채수영,안상미,허만욱,박귀례 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

임신중에 만성적으로 음주한 산모의 태아는 중추신경계 손상으로 인한 특징적인 이상증상인 소두증 정신발육장애 등 태아 알코을 증후군(fetal alcoho3 syndrome, F,LSB이 나타나는 것으로 알려져 있으냐 분자생물학적 측면에서의 유발기전은 명확하게 밝혀져 있지 않다. 든 연구예서는 in vitro 단기 발생독성시험법 중 하나인 전배자배양댑을 사용하여 랫드 배자의 )1관 발생기에 알코을 및 알코올의 주 군사 체인 아세트알데히드를 처리하여 기형 유발 여부를 관찰하였다. 또한 이들 물질의 기형 유발 기전을 규명하고자 microarray 깡법으로 발현이 변화되는 유전자를 검색하였으며, 알코을 처리로 발현이 변후 되는 유전자의 정확한 확인을 위하여 northern blot analysis 실시 중이다. 임신 9.5일의 랫드 배자에 0.1, 0.5, 1.0% 에란올을 처리하였을 때 성장부진, 뒤틀리거나 꼬렬라진 꼬리, open caudal neura tube, open neural tube, 불완전찬 반전, 불규칙적이고 비정상적인 체절과 짧은 꼬리 등의 이상이 나티났다. 임신 9.5일의 랫드 배자에 Sr10-4, 8.3×10-4, 2.SxIO-3% 아세트알데히드를 처리시 래antois caudal neura3 tube의 발달저해, somite 수 감소, 꺽인 꼬리 등의 이상이 나타났다. Control과 에탄을 처리한 배자로부터 total RNA를 추출하고 poll· A--RNA를 분리한 후, reverse transcriptase를 사용하여 C?3 혹은 Cl·5 형광염료로 tag된 nucleotide로 표지된 probe를 만들어 등량을 시판중인 'toxicotogy chip'의 틴991개의 CDNA 형태의 유전자와 hybr겨iaation시켰다. 에탄을 처리에 의해 'serum deprivation response' gene등의 발현이 유도되었으며, 'rat transcription factor MaflmRNA'등의 발현은 저해되었다. It is reported that alcohol drinking by pregnant mothers often leads to abnormal fetal development including fetal alcohol syndrome(FAS) in both humans and experimental animals. The FAS is characterized by prenatal and postnatal growth retardation, distinct craniofacial dysmorphology, and central nervous system dysfunctions such as mental retardation. However, molecular mechanisms for FAS is not completely elucidated as yet. In this study, developmental toxicity of ethanol and its metabolite, acetaldehyde were evaluated using whole embryo culture. In addition genes inducing FAS were investigated by the technique of cDNA microarray. Embryos treated with ethanol showed growth retardation, abnormal tail torsion, open neural tube, open caudal neural tube and abnormal somite at concentrations of 0.1∼0.5%. Also embryos treated with acetaldehyde showed growth retardation including allantois, open caudal neural tube, reduction number of somite and abnormal tail torsion at concertrations of 5×10^(-4)∼2.5×10^(-3)%. RNAs from embryos of control and ethanol treatment were reverse transcribed into cDNA tagged with Cy3 or Cy5 and hybridized with cDNA probe of rat in 'toxicology chip'. Ethanol 0.5% treatment resulted in alteration in expression of several genes including 'serum deprivation response', 'Cide-b' and 'check point suppressor 1'. Northern blot analysis is conducted for identification of genes related to FAS.