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N/A Thirty five cases of hepatic encephalopathy which were admitted to Chosun University Hospital from August 1982 to August 1983 were studied in the view of electroencephalography alteration and plasma ammonia level in relation to neuropsychiatric changes. The results were as follows; 1) There was a significant difference between abnormal EEG (Grade A-E), neuropsychiatric sigs (grade I-IV) and normal state in plasma ammonia level (p<0.01) 2) There was a significant correlation between neuropsychiatric signs and EEG changes with a correlation coefficient of 0.81 (p<0.01). 3) EEG finding and severity of neuropsychiatric signs tend to he altered plasma ammonia level, but there was no significant correlation (p>0.1), 4) Usually, typical triphasic wave tended to rise as a severity of neuropsychiatric signs increased. 5) These suggested that EEG study was beneficial in early diagnosis and identification for process of hepatic encephalopathy.
N/A Recent studies have shown that atrial natriuretic peptide, which is a thrird factor that is important in electrolytes and volume homeostasis, is increased or decreased in patients with liver cirrhosis that complicate ascites or not. For further evaluation about levels and effects of circulating ANP in liver cirrhosis author measured simultaneously the plasma concentracion of α-hANP, renin activity, aldosterene by radioimmunoassay and 24-hour urine sodium levels in series of 22 patients with liver cirrhosis, and compared these values with those obtained in 18 normal controls. The results were as follows: 1) The plasma levels of α-hANP (pg/ml) in normal controls (18 cases), cirrhotics without ascites (10 cases), and cirrhotics with ascites (12 cases) were 71.56+-9.35, 73.62+-8.72, and 60.88+-8.60 respectively: and those of cirrhotics with ascites were significantly decreased(p<0.01). 2) In cirrhotics with ascites, plasma renin activity (ng/ml/hr) and plasma aldosterone levels (pg/ml) were 8.52+-2.70 and 303.50+-48.52 respectively and were significantly increased, as compared to those in the normal controls and cirrhotics without ascites(p<0.001). 3) There was no significant correltation between plasma α-hANP levels and renin activity in normal controls and cirrhotic patients (r= 0.45). 4) There was no significant correlation between plasma α-hANP levels and 24h excretion of sodium in normal controls and cirrhotic patients (r=0.225).
N/A Serum gastrin and group 1 pepsinogen levels were checked by radioimmunoassay in 97 subjects. They consisted of 28 healthy control subjects, 10 patients with gastric ulcer, 14 with doudenal ulcer, 15 with chronic gastritis and 30 with gastric cancer. Postoperative serum gastrin and pepsinogen 1 levels were evaluated in 8 patients among the gastric cancers. The following results were obtained; 1) The mean levels of fasting serum gastrin and PG 1 of patients with gastric ulcer did not show any differences as compared with normal control groups. 2) The patients with doudenal ulcer showed significantly higher mean levels of fasting serum PG 1 as compared with normal control(p<0.001). 3) The patients with chronic gastritis had not significant relationship between the mean levels of fasting serum gastrin as compared with normal control, but mean serum PG 1 values revealed some elevated state (p<0.001). 4) Patients with gastric cancer had significantly lower mean levels of fasting serum gastrin as compared with normal control(p<0.025). 5) Gastric resection was performed in 8 patients among gastric cancer, and serum gastrin and PG 1 levels were compared preoperatively and postoperatively. Gastrin levels were significantly reduced after gastrectomy. It was concluded that serum gastrin and PG 1 may be valuable in diagnosis of peptic ulcer, especially doudenal ulcer and may be useful as subclinical marker for gastric cancer.