칠복음(七福飮)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)

최공한,박승택,류도곤,최민호,엄상섭,허진영,강성도,고정수,서의석,성은경,조남수,이춘우,황일택,선성규,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Um, Sang-Sub,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Sou, Eui-Suk,Sung, Yeun-Ky 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay 2. GO, a oxygen radical, increased lipid peroxidation and the amount of LDH. 3. CBY have efficacy of decreasing lipid peroxidation. 4. CBY have efficacy of decreasing the amount of LOH. From the above results, It is concluded that Chilbokyeum has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeum is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeum should be complemented.

석창포(石菖蒲) 전탕액(煎湯液)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)

최공한,박승택,류도곤,최민호,허진영,강성도,고정수,양상철,성은경,조남수,이춘우,서의석,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Yang, Sang-cheal,Sung, Yeun-Kyung,Cho, Nam-Su,L 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay. 2. GO, a oxygen radical, decreased the amount of neurofilaments and total protein. 3. AR have efficacy of increasing the amount of neurofilament. 4. AR have efficacy of increasing the amount of total protein. From the above results, It is concluded that AR has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And AR is thought to have certain pharmacological effects on controlling over aging. Further clinical study of this pharmacological effects of AR should be complemented.

심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

BioSMACK: a Linux Live CD for genome-wide association analyses

( Chang Bum Hong ),( Young Jin Kim ),( Sang Hoon Moon ),( Young Ah Shin ),( Min Jin Go ),( Dong Joon Kim ),( Jong Young Lee ),( Yoon Shin Cho ) 생화학분자생물학회 2012 BMB Reports Vol.45 No.1

Recent advances in high-throughput genotyping technologies have enabled us to conduct a genome-wide association study (GWAS) on a large cohort. However, analyzing millions of single nucleotide polymorphisms (SNPs) is still a difficult task for researchers conducting a GWAS. Several difficulties such as compatibilities and dependencies are often encountered by researchers using analytical tools, during the installation of software. This is a huge obstacle to any research institute without computing facilities and specialists. Therefore, a proper research environment is an urgent need for researchers working on GWAS. We developed BioSMACK to provide a research environment for GWAS that requires no configuration and is easy to use. BioSMACK is based on the Ubuntu Live CD that offers a complete Linux-based operating system environment without installation. Moreover, we provide users with a GWAS manual consisting of a series of guidelines for GWAS and useful examples. BioSMACK is freely available at http://ksnp.cdc. go.kr/biosmack. [BMB reports 2012; 45(1): 44-46]

연령대별 요추 추간판탈출증 환자의 요근과 척추주위근 단면적에 대한 분석

공덕현 ( Deok Hyun Kong ),배광호 ( Kwang Ho Bae ),고호연 ( Ho Yeon Go ),강명진 ( Myung Jin Kang ),김준수 ( Jun Su Kim ),양기영 ( Kee Young Yang ),이재훈 ( Jae Hoon Lee ),은영준 ( Young Jun Eun ) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.4

Objectives :This study was designed to evaluate the correlation of the cross-sectional areas(CSA) of paraspinalis(iliocostalis lumborum, multifidus, longissimus thoracis parts lumborum) and psoas muscle and sex, age, change of the VAS(visual analogue scale) and past history of chronic low back pain in patients suffering from HIVD(herniation of intervertebral disc). Methods :Medical records of 140 subjects with HIVD were retrospectively reviewed. The MRI(magnetic resonance imaging) findings on the patients were scanned and analyzed by PiView program to find the paraspinal and psoas muscle CSA and were evaluated by the correlation of sex, age, change of the VAS, and past history of chronic low back pain. Results :There was significant difference between groups in male and female, young-adults age and middle age, middle age and old age, young-adults age and old age. But the correlation of the paraspinal and psoas muscle CSA and past history of chronic low back pain were partially significant. On the other hand, the correlation of the paraspinal and psoas muscle CSA and change of the VAS were not significant. Conclusions :These results suggest that the cross-sectional areas(CSA) of paraspinalis and psoas muscle have relevance to sex and age.

근대문학의 주변부적 표상과 임노월

고영진 배재대학교 주시경교양교육연구소 2019 대학교양교육연구 Vol.4 No.1

임노월이 1920년 문단에 데뷔해서 1925년 절필할 때까지 짧은 기간 우리 근대문학에 남긴 궤적에 대한 가장 설득력 있는 접근법은 ‘개인주의와 유미주의’로 함의된다. 임노월은 당시 지주계급 유학생들과 다름없이 일본에서 예술과 철학을 전공했고, 이때 접한 오스카 와일드의 예술론을 바탕으로 시, 소설, 평론, 대화, 수필을 남겼다. 임노월은 이런 창작 태도 를 스스로 ‘신개인주의’로 설명하였고, 나름의 논리를 갖추려 노력했고, 바로 그 이유 때문 에 주변부적 표상이 되었다. 본고는 임노월의 기술을 전반적으로 재독하면서 그가 남긴 주변부적 표상의 진의를 살 피고, 그 과정에서 그의 예술 활동의 전제가 된, 1920년대의 문학공간을 입체적으로 재구성 하고자 하는데 궁극적인 목적이 있다. 특히 그의 연애소설들은 모두 비극적 연애를 기본적 인 서사 구조로 하고 있는데, 이에 대한 재독은 포스트모더니즘의 시기에 와서야 그 의미를 실천할 수 있게 된 ‘개인’적 낭만성의 첫 장면을 확인하는 일이 될 수도 있다. 이를 위해 본고는 그에게 드러난 주변부적 표상을 화해하지 못하는 ‘일상’, 새롭고 완벽한 지향점, 작 품 전반에 나타나는 감정의 수사로 나눠 살펴보았다. 이를 통해 그가 구성한 주변부적 표상은 중심부에 진입하지 못한 소외된 것이 아니라, 중심부와 충돌하면서 구성되었다는 것을 알 수 있었다. 이 지점에서 임노월은 근대공간의 다양성을 드러내는 소품으로 소환되는 것에서 멈추지 않고 우리의 근대와 근대문학을 입체 적으로 구조화하는 주요한 키를 잡게 된다. 우리는 뻔뻔하고 노골적인 그를 통해 여전히 문학이, 소설이 할 수 있는 것은 무엇인가라는 질문을 계속할 수 있게 되었다 The most persuasive approach to the trajectory left in our modern literature for a short period until Rim No-wol’s debut in 1920 and his compilation in 1925 is referred to as ‘individualism and estheticism’. Rim No-wol majored in arts and philosophy in Japan, as well as foreign students at the time, and left poetry, novels, criticism, dialogues and essays based on Oscar Wilde’s artistic theory at this time. Rim No-wol explains this creative attitude as ‘New individualism’ and tried to establish his own logic, and for that very reason he became a peripheral representation. The purpose of this article is to reconstruct the literary space in the 1920s, which is the premise of his artistic activities in the process, in order to reconfigure the literary space in three dimensions. In particular, his romantic novels all have tragic romance as the basic narrative structure, and the re-reading of this may be the first scene of ‘personal’ romanticism that has come into being in the postmodern period . For this purpose, this study divided into ‘daily life’ that can not reconcile the peripheral representation manifestations revealed to him, the new and perfect point of view, and the investigation of emotions in the first Through this, it was found that the peripheral representation figures that he composed were composed not by marginality that did not enter the center, but by collision with the center. At this point, Rim No-wol does not stop from being recalled as a props that reveal the diversity of modern space, but it is the key to structuring our modern and modern literature in three dimensions. We are able to continue to ask the question of what literature is capable of, and what novels are still, through the blatant and explicit.

다중센서 환경에서 공중표적 데이타의 연계

정진영,우영운,고봉홍,김재희,홍인표,조동래 연세대학교 산업기술연구소 1994 논문집 Vol.26 No.2

In the system using one sensor, to describe accurate situation or conclude from information of one source in difficult. Moreover, sensor noise degrades the belief of decision. Multisensor information system, however, can increase the belief of date by imploying more than one source of information simultaneously. Another advantage of the system is that it can accomplish its task with other sources of information when one source malfunctions. In this paper, we implemented data association methods to identity moving flight targets using distance, probability theory, Dempster-Shafter theory for the low level process in the information fusion system. Data association is to classify information from various sources into data groups depending for the same flight object. Times and errors of these data association methods are analyzed.

鹽化物含有 콘크리트의 透水係數와 鐵筋腐蝕 性狀

김영수,진유동,문양고 釜山大學校生産技術硏究所` 1998 生産技術硏究所論文集 Vol.54 No.-

염화물함유 콘크리트의 투수성과 철근부식에 미치는 영향을 규명하기 위해 염화물 함유량을 0, 0.3, 0.6㎏/㎥으로 변화시키고 W/C비를 0.4, 0.45, 0.5, 0.6으로 변화시킨 상태에서 투수계수, 철근 부식면적율, 압축강도, 슬럼프, S.E.M에 의한 미세구조를 보통 콘크리트, fly ash 혼입 콘크리트, AE 혼입 콘크리트와 비교하여 다음과 같은 결론을 얻었다. 1) 콘크리트 투수계수는 W/C비 또는 염화물 함유량이 클수록 증가하였다. W/C비 0.5까지는 투수계수의 증가폭이 크지 않으나 W/C비 0.65에서는 염화물 혼입 및 보통 콘크리트의 투수계수가 크게 증가하여 W/C비가 염화물 함유량 보다는 특수성에 더 큰 영향인자임을 알 수 있었다. 2) 철근부식 면적율은 투수계수와 마찬가지로 W/C비 또는 염화물 함유량이 클수록 증가하였다. W/C비 0.65에서 보통 콘크리트의 투수계수는 염화물 혼입시와 유사하나 철근부식 면적율은 현격히 작은 결과를 나타내 투수계수의 증가에 따라 철근부식 면적율이 반드시 비례하여 커지는 것은 아님을 알 수 있었다. 3) 플라이애쉬 및 AE감수제를 혼입하면 콘크리트 투수계수 및 철근부식 면적율이 크게 감소하여 밀실화 효과가 우수하였으며, 피복두께를 2㎝에서 3㎝로 증가 시키면 염화물 및 혼화재 혼입 유무에 관계없이 철근부식 면적율은 모두 감소하였다. The purpose of this paper is to investigate the coeffecient of permeability and the properties of corrosion of steel in concrete containing chloride. For this purpose, the experiments for the permeability and the rate of corrosion area by selecting factors and levels such as chloride content, W/C and admixture were executed. The major results are as follows. 1) The coefficient of permeability was increased with increasing chloride is higher than that of plain concrete. 3) The permeability and the rate of corrosion area in concrete containing fly ash and AE water reducer is lower than that of plain concrete and concrete containing chloride at the same W/C 4) The rate of corrosion area was decreased with increasing covering depth from 2㎝ to 3㎝.

강의 수소취화에 대한 국부영역에서의 수소의 거동(Ⅰ) : 지연파괴의 수소집적에 미치는 응력 및 소성변형의 영향

이영호,이진우,배명일,고준빈,이규천 충남대학교 산업기술연구소 2001 산업기술연구논문집 Vol.16 No.1

Hydrogen embrittlement cause decrease of it's mechanical properties during hydrogen dissolved in steels. Many mechanisms of hydrogen concentration researches have done, but it is not clearly known yet. In this study the effect of plastic deformation and external stress on mechanism of hydrogen concentration by high temperature hydro-genation treatment were investigated. The main results are as follow : 1)For short time fracture process, a defect rate of chemical potential energy is an important factor on hydrogen concentration for delayed fracture of steel processed with high temperature hydrogen. 2)For long time fracture process, the important element is long range diffusion of hydrogen due to the rate of effective hydrogen density and plastic deformation. 3)hydrogen concentration as plastic deformation vary in proportion to slope of plastic deformation. 4)Hydrogen concentration due to the effect of external stress, but this effect is limited in short range. 5)External stress is an acceleration element for delayed fracture of steel.