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The aim of this experiments was to investigate the effects of Chinese magnolia vine water extract on the renal function, plasma renin activity, plasma levels of aldosterone and atrial natriuretic peptide in rats. The results of this study were as follows; 1. Water balance decreased significantly after administration with Chinese magnolia vine extracts (0.2 ml/200 g of body weight). 2. Urine volume increased significantly after administration with Chinese magnolia vine extracts. 3. Urinary excretion of sodium increased significantly after administration with Chinese magnolia vine extracts. 4. Urinary excretion of creatinine increased significantly after administration with Chinese magnolia vine extracts (0.2 ml/200 g of body weight). 5. Plasma levels of atrial natriuretic peptide decreased significantly after administration with Chinese magnolia vine extracts (0.1 ml/200 g of body weight). 6. Plasma levels of aldosterone decreased significantly after administration with Chinese magnolia vine extracts (0.2 ml/200 g of body weight).
The purpose of this research was to investigate the effects of Salviae miltiorrhizae Radix water extract (SRE) on immune response in BALB/c mice. SRE (1,000 mg/kg) was administered p.o. once a day for 5 days. SRE increased the cell viability of murine thymocytes in vivo and in vitro, but did not affect the mitochondrial transmembrane potential and the subpopulation of murine thymocytes. SRE suppressed the production of nitric oxide and the activity of phagocytosis of murine peritoneal macrophages in vitro and in vivo. These results suggest that SRE enhances the specific immune response via the increase of cell viability in thymocytes.
Antitumor and antimetastatic effects of holyessing were studied. Cytotoxicity against various cancer cell lines, antiadhesion, Huvec cell proliferation, pulmonary colonization, and T/C% to S-180 and immunomodulatory effect were evaluated, respectively. The results were summarized as follows; HE exhibited significant cytotoxicity against Raw cell, B16-BL6 and Sk-Mel-2 cell in 1.0% conc. but didn't exhibit cytotoxicity against L929, HT-1080 and A549 cell. HE inhibited adhesion of HT1080 cell to complex extracellular matrix. And also inhibited the proliferation of HUVEC cell in dose-dependent manner. The T/C% was 113% in HE treated group in animal study with S-180. In pulmonary colonization assay by B16-F10, a number of colonies in the lungs were decreased but insignificantly. By FACS analysis, T cell and T-helper cell were significantly increased in HE treated group. From above results it was concluded that HE could be usefully applied for the prevention and treatment of cancer.
Spatholobus suberectus belonging to the family Leguminosae has been used in Oriental medicine for promoting blood circulation, removing blood stasis, tonifying the blood, relaxing tendons, stopping internal bleeding and eliminating dampness. This study investigates whether the water extracts of S. suberectus induce apoptotic cell death in Jurkat T-acute lymphoblastic leukemia (ALL) cells. Cell viability of Jurkat cells was inhibited in a concentration-dependent manner by S. suberectus, as measured by cell morphology. The capability of S. suberectus to induce apoptosis was associated with proteolytic cleavage of specific target protein such as poly (ADP-ribose) polymerase protein suggesting the possible involvement of caspases. The purpose of this study is also to investigate the effect of S. suberectus on cell cycle progression. G1 checkpoint related gene products (cyclin D1, cyclin dependent kinase 4. retinoblastoma, E2F1) were decreased in their protein levels in a dose-dependent manners after treatment of the extract. These results indicate that the increase of apoptotic cell death by S. suberectus may be due to the inhibition of cell cycle progression in wild type p53-lacking Jurkat cells.
Citri Reticulatae Viride Pericarpium(CRVP) have been used in oriental medicine for many centuries as a therapeutic agent for soothing the liver and regulating the circulation of qi(疏肝理氣), and promoting digestion and removing stagnated food (消積化滯). The effects of CRVP extract on the cerebral hemodynamics in ischemic cerebrovascular pathologic-model is not known. Therefor, this study was designed to investigate the pharmacological effects of CRVP extract on the cerebral ischemia using modern techniques, and further to provide the possibility of scientification of oriental medicine. The changes of regional cerebral blood flow(rCBF) was determinated by Laser-Doppler Flowmetry(LDF), and the changes of pial arterial diameter were determinated by video microscopy methods and video analyzer. The results were as follows ; Both the methylene chloride fraction and the hexane fraction of CRVP dose-dependently improved the altered cerebral hemodynamics of cerebral ischemic animal by increasing rCBF and pial arterial diameter. It is suggested that CRVP has an antiischemic effect through the improvement of ischemic cerebral hemodynamics, and that in future further development of main effective constituent in CRVP can provide a novel therapeutic strategy for cerebral ischemia.
To evaluate the effect of Kamisaganmahwang-tang(KSMT)vto the allergy studies were done experimentally. The IgE level induced by LPS was decreased in KSMT extract feeding group compared with control group. In the cross regulation pattern between Th1 and Th2, the INF-γ from Th1 was increased, but the changes of IL4, IL10, IL12, IL13 expression levels are smaller than INF-γ. These results indicated KSMT extracts can produce the high level induction INF-γ. This study suggest that KSMT may act as antagonist to the Th2 and B cell for IgE production.
The purpose of this study is to examine the effects of Jeodang-tang on the dermal temperature and blood clotting system in dextran-treated rats. Forty male Sprague- Dawley rats, around 200g of B.W., were divided into normal, control, sample A and sample B group. Normal and control groups were orally administrated with saline, sample A and sample B with threefold and fivefold of liquid extract of Jeodang-tang respectively. One hour after, control, sample A and sample B groups were injected with 0.7㎖ of 15% dextran solution into caudal vein. One and two hours after the dextran injection, dermal tempature were measured with using Digital Infrared Thermal Imaging. Three hours after the dextran injetion, blood samples were collected, and then platelets, fibrinogen, prothrombin time(PT) and activated partial thromboplastin time(APTT) were measured.
This study was carried out for the purpose of knowing the effect from anti-allergic action of B cells and the mast cells of the BALB/c mouse by the abstraction from a Magnolia flos (OMF). In order to know what the effect of controlling an extraction from Magnolia flos (OMF) and about the expression of CD23 in the IC-2 cells (mouse mast precursor cells that was dependent on IL-3). We then analyzed it from the flow cytometry on the increase and the divorce of the B cells activated by anti-CD40, rHRF. We also examined the effect of OMF on proliferation of the B cells by 3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and nitric oxide (NO). The results are as follows : 1. According to inspection of the inhibitory effect of OMF on the cell proliferation of B cells, OMF reduced cell proliferation of B cells significantly. 2. We knew that results by the effect of OMF on the expression of CD23 in the IC-2 mast cells. We knew that reducing expression of CD23 was caused by OMF contained a large quantity. And OMF had an effect on the expression of CD23, and on the expression of the CD23 by the OMF but it was related to CD40 and rHRF. 3. According to our inspection of the effect on expression of IgE by OMF, OMF reduced the anti-IgE significantly but didn't reduced the IL-4 release of B cells stimulated by anti-CD40, rHRF. 4. OMF enhanced NO production in the B cells stimulated by the anti-CD40, rHRF. 5. According to inspection of effect on IC-2 cells by OMF, we found that OMF reduced histamine release stimulated by B cells and anti-CD40, rHRF.
This experimental study was carried out to develop a new prescription to exert the antitumor and antimetastatic activity. For this aim the effect of solvent fractions of Kamisamryungbaekchul-san(加味蔘笭白朮散: KSRBS) was studied experimentally. KSRBS was made into water extract(WE) and other solvent fractions(ethyl acetate(EA), ethylether(EE), butanol(BU), hexane(HA) to perform cytotoxity effect, DNA topoisomerase Ⅰ inhibition, cell adhesion assay, cell invasion assay, CAM assay and B16BL6 pulmonary colonization in vivo and in vitro. On cytotoxicity, the solvent fractions inhibiting over 50% cell growth were EA against A549 and SK-MEL-2, EE against B16-F10 and SK-MEL-2, BU against SK-MEL-2 and HA against A549, B16-F10 and SK-MEL-2 at the concentration of 0.1mg/㎖ or more. On cell adhesion the solvent fractions inhibiting over 50% of cell adhesion to extracellular matrix were EA, EE, HA and BU against A549 and SK-OV-3. Solvent fractions such as HA, EA effectively inhibited cell invasion of HT1080 into transwell filter up to 69-94% at over 50 ㎍/㎖. On CAM assay WE, HA and BU disrupted CAM to 50%, 60% and 60% respectively. They also inhibited pulmonary colonization by B16BL6. From these results it was concluded that fractions of KSRBS had antitumor and antimetastatic effects suggesting its application for the prevention and treatment of cancer.