신장이식 환자에서 HCMV 항원혈증 검사의 임상적 유용성

김탁,성흥섭,박관태,김송철,김성한,최상호,김양수,우준희,박수길,한덕종,이상오 대한감염학회 2009 감염과 화학요법 Vol.41 No.2

Background : This study was performed to determine the cut-off value and the predictability of symptomatic human cytomegalovirus (HCMV) infection according to the peak value of HCMV antigenemia assay in kidney transplant recipients. Materials and Methods : We reviewed the results of HCMV antigenemia assay (Chemicon, CA, USA) in patients who received kidney transplantation at our institution from May 2003 through May 2008, and investigated the existence and the type of HCMV infection by the medical record review. Patients who underwent the test only once during the episode or those who received ganciclovir for more than 48hrs before the test were excluded. The receiver-operator characteristic curve was drawn and the point showing maximum likelihood ratio (LR) was chosen as the cut-off value of symptomatic HCMV infection. Results : A total of 689 episodes were screened and 134 episodes were enrolled. Thirty-three (24.6%) episodes were symptomatic HCMV infection, 23 (17.2%) episodes were associated with HCMV syndrome, and 10 (7.5%) episodes were tissue-invasive diseases. The maximum LR was 7.5 (95% confidence interval, 4.014.2) and the cut-off value was 29.5 cells/200,000 WBC. The sensitivity, specificity, Positive predictive value, and negative predictive value were 66.7%, 91.1%, 71.0%, and 89.3%, respectively. Conclusions : The cut-off value of symptomatic HCMV infection by the peak value of HCMV antigenemia assay in our study was similar with previous results, although the sensitivity was relatively low.

강원도 화천군 수달(Lutra lutra) 서식지의 식생 구조

서형수 ( Hyung Soo Seo ),신영섭 ( Young Seob Shin ),이경은 ( Kyung Eun Lee ),김윤미 ( Yoon Mi Kim ),전미나 ( Mina Jeon ),남택우 ( Taek Woo Nam ),한성용 ( Sung Yong Han ),정연숙 ( Yeonsook Choung ) 한국하천호수학회 2014 생태와 환경 Vol.47 No.special

In order to determine whether vegetation would be one of the factors for the selection of otter home range, vegetation structure and other potential factors were studied in Hwacheon, Korea. Thirteen sites, otter’s activity found and not found, were investigated in North Han River and connected tributary streams of Hwacheon-gun. Three types of vegetation were classified by cluster analysis, which is short grass, tall grass and shrub type. Vegetation zone of each channel is composed of either one type, or mosaic of tall grass and shrub type. Short grass type is common in Lake Paro and upper North Han-river where water level is highly variable throughout a year. Therefore, annual species such as Persicaria nodosa, Fimbristylis dichotomam and Chenopodium ficifolium are the most dominant. Shrub type is common at the downstream sites of Jichon stream and along mainstream of North Han River down Lake Paro. A shrub species, Salix koreensis, is the most common. Tall grass type is dominant occupying the most vegetation zone of the tributary channels. Phragmites japonica is absolutely dominant. Due to its dense cover, a few plant species are co-existed. Otter activity was found in all three vegetation types and no marked activity was found at some sites of tall grass type. There is no difference in species composition and physiognomy between tall grass sites with and without otter activity, while it shows significant difference in fish availability between two groups. Overall we found that home range of otters in the region is along the mainstream and downstream of tributary streams with high fish availability in all vegetation types and in various human activity levels.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

用寒遠寒과 用熱遠熱에 대한 考察 : 六元正紀大論에서

채영진,신창환,임현택,여성원,한성규,이재원,정헌영,금경수 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Five elements motion and six kinds of natural factors influence not only human disease but also difference of medicine effect. Because the climate of summer is very hot, that is easy to increase the properties of hot medicines, a doctor must be careful to use it in summer. Also the climate of winter is very cold, that is easy to increase the properties of cold medicines, a doctor must be careful to use it in winter. But in the certain conditions to use diaphoretics or purgatives, in spite of that regulation a doctor can use them.

큐빅 다이아몬드의 에너지 밴드 측정

한성원,홍진수,배형철 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

Photonic band gaps(PBG) are investigated for cubic diamond composed of dielectric spheres and air spheres. It was found that PBGs exist in both cases. PBGs lie between the 2nd-3rd, 8th-9th and 14th-15th band for dielectric spheres and the 2th-3th band for air spheres.

알코올 발효성 야생 효모, Kodamaea ohmeri S-2 의 막걸리 발효특성

한상민, 이종수 배재대학교 자연과학연구소 2018 自然科學論文集 Vol.29 No.1

본 연구는 알코올 발효능이 우수한 Kodamaea ohmeri S-2의 균학적 특성과 막걸리 발효 조건을 조사하였다. Kodamaea ohmeri S-2는 계란 모양으로 자낭포자를 생성하였으며 50% 포도당과 15% NaCl을 함유한 yeast extract-peptone-dextrose (YPD)배지에서 생육하는 내당성이며 호염성 야생 효모이었다. Kodamaea ohmeri S-2를 YPD배지에 2일간 배양액을 주모로 증자미와 35% 입국과 150% 물이 혼합된 술밑에 5% 첨가한 후 25℃로 10일간 발효시켰을 때 가장 많은 5.70%의 에탄올을 생성하였고 7일 발효시킨 막걸리의 항고혈압 활성 안지오텐신 전환효소 저해활성이 52..1%로 가장 높았다. The goal of this study were to elucidate microbiological characteristics of ethanol–fermenting wild yeast, Kodamaea ohmeri S-2 and further to optimize its makgeolli fermentation condition. Kodamaea ohmeri S-2 was oval shape and formed asospore. The S-2 yeast was also sugar tolerant and halotorerant yeast which grew in 50% glucose and 15% NaCl-containing YPD medium, respectively. Maximal 5.70% ethanol content was obtained when a mixture of cooked rice, 150% water and 35% Ipguk for cooked rice was fermented by 5% Kodamaea ohmeri S-2 culture broth at 25℃ for 10 days. Antihypertensive angiotensin I-converting enzyme inhibitory activity of the makgeolli from fermentation for 7 days by Kodamaea ohmeri S-2 was showed 52.1%.

fcc(face-centered cubic) structure의 에너지 밴드 측정

한성원,홍진수,배형철 순천향대학교 기초과학연구소 2011 순천향자연과학연구 논문집 Vol.17 No.2

Photonic band gaps(PBGs) are investigated for face-centered cubic structure composed of dielectric spheres and air spheres. It was found that PBGs exist for both cases. PBGs lie between the 6th-7th and 13th-14th for dielectric spheres and the 8th-9th for air spheres.

忠南傳說의 特性硏究

韓相壽 牧園大學校 1980 論文集 - 牧園大學校 Vol.3 No.-

Chungnam District, where once located the capital town of Baikjai, is well known for the old culture area. Had been near the border of Seoul, the capital town was not only one of the highly favoured places which abound with chronicle and great great kings but also an important place of transportation. A great many legerds, as the history of culture and legend bears witness, have been occurred and handed down in the long settled capital town. Chungnam has many and various legends with the historic background. But the most important thing is to const-ruct the systematic context of the fragmentary legends and to assess their originality or value. The author have attempt to gather 551 kinds of legend which remains very nearly in its original state and to find out some characters among them. First of all, there is something characteristic about these legends that have the pessi-mism of the Baikjainian people, not merely from the lost town, but from their idea of old grandeur. Secondly, the most of legends commemorate the great king's achieveme-nts and the revolutionary events which we may call their historical idea. Thirdly, it is the confucian idea that has been kept up with their traditional way of life. Fourthly, they are deeply concerned with Buddhism as a means of recognizing the ultimate nature of reality. The four points of view are not mutually contradictory, but closely combined. Thus, we can say that such an organic union came from the deeprooted historical or regional background, and as a consequence, formed a specific feature quite different from the legends of any other towns.

효율적인 차량 동역학 해석을 위한 부분 시스템 합성 기법

한종규,김성수 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.2

A subsystem synthesis method has been proposed for an efficient dynamic analysis of vehicle systems which consist of several subsystems. This method enables the analyst to solve equations of motion for a chassis and for each subsystem separately. Therefore, it is efficient that several small size equations of motion for a chassis and subsystems are separately solved, instead of solving relatively large size equations of motion for the whole vehicle system. Computational efficiency of the proposed method has been also investigated theoretically through the operational counting method. In order to show the effectiveness of the method, a SLA(Short-Long Arm) suspension subsystem of a military vehicle has been synthesized to form equations of motion for 1/4 car and 1/2 car models.

HSC 기둥의 내진성능에 대한 횡보강근의 효과

한병찬,황선경,성수용,정수영 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1

In seismic-resistant design of buildings of ductile frame, the possibility of formation of plastic hinge at column end demands sufficient member ductility. The paper summarizes results of an experimental study of reinforced concrete columns with high-strength materials and subjected to simulated seismic loadings. The experimental program consisted of 6, approximately one-third-scale, rectilinearly confined, high-strength reinforced concrete columns with concrete compressive strengths of approximately 700kgf/cm2. The primary variables of the testing program were the volumetric ratio, spacing, and configuration of transverse reinforcement. Experimental results indicate as follows : 1.There is no expectation of improved effectiveness of deformability by the types of transverse reinforcement when using high yielding strength transverse reinforcement. 2.When using high yielding strength transverse reinforcement, it is possible to widen the spacing that are designed based on seismic provision of ACI 318-89 and get an appropriate deformability as well. 3.The significant parameter to determine the deformability is the spacing of transverse reinforcement in the HSC columns.