정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

강화되는 총인 방류수 수질기준을 만족하는 친환경 저에너지형 MBR 개발

유하나 ( Ha Na Yu ),나유미 ( Yu Mee Na ),최훈창 ( Hun Chang Choi ),이동진 ( Dong Jin Lee ),윤희성 ( Hee Sung Yoon ),황윤영 ( Yun Young Hwang ),김연국 ( Youn Kook Kim ) 한국물환경학회 ( 구 한국수질보전학회 ) 2012 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2012 No.-

Isolation and characterization of a novel H9N2 influenza virus in Korean native chicken farm.

Lee, Yu-Na,Lee, Dong-Hun,Park, Jae-Keun,Lim, Tae-Hyun,Youn, Ha-Na,Yuk, Seong-Su,Lee, Youn-Jeong,Mo, In-phil,Sung, Haan-Woo,Lee, Joong-Bok,Park, Seung-Yong,Choi, In-Soo,Song, Chang-Seon American Association of Avian Pathologists [etc.] 2011 Avian diseases Vol.55 No.4

<P>An outbreak of avian influenza, caused by an H9N2 low-pathogenic avian influenza virus (AIV), occurred in a chicken farm and caused severe economic losses due to mortality and diarrhea. AIV was isolated and identified in a sample from an affected native Korean chicken. Genetic analysis of the isolate revealed a high sequence similarity to genes of novel reassortant H9N2 viruses isolated from slaughterhouses and live bird markets in Korea in 2008 and 2009. Animal challenge studies demonstrated that the replication kinetics and pathogenicity of the isolate were considerably altered due to adaptation in chickens. Vaccine protection studies indicated that commercial vaccine was not able to prevent virus shedding and clinical disease when chickens were challenged with the isolate. These results suggest that the novel H9N2 virus possesses the capacity to replicate efficiently in the respiratory system against vaccination and to cause severe disease in domestic chickens. The results also highlight the importance of appropriate updating of vaccine strains, based on continuous surveillance data, to prevent the possibility of a new H9N2 epidemic in Korea.</P>

Continuing evolution and interspecies transmission of influenza viruses in live bird markets in Korea.

Lee, Hyun-Jeong,Kwon, Ji-Sun,Lee, Dong-Hun,Lee, Yu-Na,Youn, Ha-Na,Lee, Youn-Jeong,Kim, Min-Chul,Jeong, Ok-Mi,Kang, Hyun-Mi,Kwon, Jun-Hun,Lee, Joong-Bok,Park, Seung-Yong,Choi, In-Soo,Song, Chang-Seon American Association of Avian Pathologists [etc.] 2010 Avian diseases Vol.54 No.1

<P>Live bird markets (LBMs) provide an ideal environment for the evolution and interspecies transfer of avian influenza viruses (AIVs). In this study, we analyzed AIVs present in LBMs in Korea during the winter seasons of 2006-08. Sixty-five AIVs that belong to four hemagglutination (HA) subtypes ofAIV (H3, H4, H6, and H9) were isolated from 644 pooled tissue or swab samples collected in LBMs. Most H9 subtypes of AIVs were isolated from Galliformes (chickens, silky fowls, pheasants, and guinea fowls), and other subtypes were isolated from Anseriformes (Pekin ducks and mallards). In addition, we obtained a single H3N2 virus from nasal swabs of dogs sold in LBMs, and the virus was genetically identical to the canine influenza virus (CIV) isolated from pet dogs in Korea. Phylogenetic analysis suggests that the Korean H9N2 viruses prevalent in chickens have provided their gene segments to AIVs circulating in ducks. These gene transfers facilitated reassortment events among AIVs and likely generated the ancestors of CIV in Korea. An animal challenge study using chickens, quail, mice, and dogs had shown that the H4 and H6 subtypes could replicate in mice and that some H4 and H6 viruses could replicate in chickens without preadaptation. In addition, two H3 subtype viruses (H3N2 and H3N8) induced interstitial pneumonia that accompanied clinical signs and seroconversion in dogs. Our findings indicate that the newly evolved AIVs have been continuously generated by reassortment in ducks, and these reassortments could result in expanding the host range of AIVs.</P>

Preparation of a Vibrio vulnificus Vaccine with Immunogenicity and Protective Efficacy

( Na Gyong Lee,Sang Bo Jung,Bo Young Ahn,Young Gi Kim,Je Hak Kim,Youn Ha Lee,Wan Jae Park,Hyun Su Kim ) 한국미생물생명공학회 1997 Journal of microbiology and biotechnology Vol.7 No.6

A Case of Superior Mesenteric Vein and Portal Vein Thrombosis Associated with Normal Delivery Presented by Acute Pancreatitis

Na, Youn Ju,Kang, Min Jung,Jung, Ji Min,Ha, Chang Yoon,Jung, Hae Sun,Baik, Su Jung,Yi, Sun Young 이화여자대학교 의과학연구소 2008 EMJ (Ewha medical journal) Vol.31 No.1

급성 췌장염의 가장 흔한 원인은 술과 담석으로 알려져 있다. 간정맥과 장간막 정맥의 혈전을 동반한 급성 췌장염은 임신이나 분만 뒤에 드물게 발견될 수 있다. 임신 전에 복부 손상, 자가면역성질환, 혈전의 과거력의 없었던 28세 여자 환자가 정상 분만 후에 계속되는 우상복부 통증을 주소로 내원하였다. 복부 전산화 단층촬영술에서 혈전은 호전되었으나 해면상 정맥 형성은 진행하였다. 이에 정상 분만 뒤에 급성 췌장염을 동반한 복부정맥혈전의 1예를 보고하는 바이다.

Toothwise Fault Identification for a Planetary Gearbox Based on a Health Data Map

Ha, Jong M.,Park, Jungho,Na, Kyumin,Kim, Yunhan,Youn, Byeng D. IEEE 2018 IEEE transactions on industrial electronics Vol.65 No.7

<P>Vibration-based fault diagnosis of a planetary gearbox is challenging due to the revolving planet gears inducing modulation of vibration signals. For accurate fault diagnosis, researchers have suggested that vibration signals should be extracted by window function when the planet gears are positioned under the sensor. However, vibration modulation characteristics can be affected by operational and geometrical uncertainties. Thus, fault-related features can be inadvertently discarded when the window function is employed. Alternatively, periodicity analysis of anomalies can be employed with the entire vibration signal without the use of window function. However, it is challenging in a planetary gearbox because the fault-related features are also modulated. This paper proposes a health data map for toothwise fault identification in a planetary gearbox. In the proposed approach, samplewise health data are aligned in the domains of a pair of gear teeth of the planetary gearbox. The proposed approach represents the health state of every pair of gear teeth, while making it possible to isolate the location of any faulty teeth in the gears. For demonstration of the proposed method, two case studies are presented: an analytical model and a 2-kW testbed. The results suggest that the proposed method performs well even under unexpected vibration modulation characteristics.</P>

Epigenetic modification of α-N-acetylgalactosaminidase enhances cisplatin resistance in ovarian cancer

Ha, Ye-Na,Sung, Hye Youn,Yang, San-Duk,Chae, Yun Ju,Ju, Woong,Ahn, Jung-Hyuck The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1

Although cisplatin is one of the most effective antitumor drugs for ovarian cancer, the emergence of chemoresistance to cisplatin in over 80% of initially responsive patients is a major barrier to successful therapy. The precise mechanisms underlying the development of cisplatin resistance are not fully understood, but alteration of DNA methylation associated with aberrant gene silencing may play a role. To identify epigenetically regulated genes directly associated with ovarian cancer cisplatin resistance, we compared the expression and methylation profiles of cisplatin-sensitive and -resistant human ovarian cancer cell lines. We identified ${\alpha}$-N-acetylgalactosaminidase (NAGA) as one of the key candidate genes for cisplatin drug response. Interestingly, in cisplatin-resistant cell lines, NAGA was significantly down-regulated and hypermethylated at a promoter CpG site at position +251 relative to the transcriptional start site. Low NAGA expression in cisplatin-resistant cell lines was restored by treatment with a DNA demethylation agent, indicating transcriptional silencing by hyper-DNA methylation. Furthermore, overexpression of NAGA in cisplatin-resistant lines induced cytotoxicity in response to cisplatin, whereas depletion of NAGA expression increased cisplatin chemoresistance, suggesting an essential role of NAGA in sensitizing ovarian cells to cisplatin. These findings indicate that NAGA acts as a cisplatin sensitizer and its gene silencing by hypermethylation confers resistance to cisplatin in ovarian cancer. Therefore, we suggest NAGA may be a promising potential therapeutic target for improvement of sensitivity to cisplatin in ovarian cancer.

Biliary Disorders/Pancreatic Disorders : Primary Adenosquamous Cell Carcinoma Of Pancreas With Duodenal Invasion Misdiagnosed With Same Duodenal Cancer

( Youn Ju Na ),( Ki Nam Shim ),( Tae Hun Kim ),( Sung Ae Jung ),( Kwon Yoo ),( Il Hwan Moon ),( Kyu Won Chung ),( Min Jung Kang ),( Ji Min Jung ),( Chang Yun Ha ),( Hae Sun Jung ),( Su Jung Baik ),( H 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The most common pancreatic cancer is adenocarcinoma. Primary adenosquamous cell carcinoma of the pancreas is very rare and aggressive. We reported a case of adenosqumous cell carcinoma of pancreas. Results: A 46-year-old man presented with a 3-month history of dyspepsia and weight loss of 7 kg. He had no history of disease. On admission, the pulse rate was 70/min, the respiration rate was 20/minutes, blood pressure was 130/80 mmHg. There was no jaundice. Physical examinations showed direct tenderness on the right upper quadrant area on the abdomen. But rebound tenderness and Murphy`s sign was abscent. There were slightly elevated 170 U/L of amylase, elevated 338 U/L of lipase. But among tumor makers, especially CA 19-9 was elevated to 566.7 U/mL. The other lab test was normal. Gastroduodenoscopy showed hard ulceroinfiltrative mass with yellowish exudates and easy touch bleeding in second portion of duodenum. At that we considered it as primary duodenal cancer. Biopsy of duodenum showed adenosquamous cell carcinoma. Abdominal computed tomography showed 7.1 x 6.3 cm sized heterogeneous enhancing mass in pancreatic head portion. Main pancreatic duct was dilatation due to mass. Pancreatic mass was invaded into duodenum wall, gastric antrum and gastroduodenal artery encasement. Fine needle biopsy cytology of the pancreatic mass revealed adenosquamous cell carcinoma with anaplastic type. We concluded that an adenosquamous cell carcinoma of pancreas was invaded into duodenal mucosa with ulceration. Conclusions: We report a rare case with primary pancreatic adenosquamous cell carcinoma with duodenal invasion.

MMPP is a novel VEGFR2 inhibitor that suppresses angiogenesis via VEGFR2/AKT/ERK/NF-κB pathway

( Na-yeon Kim ),( Hyo-min Park ),( Jae-young Park ),( Uijin Kim ),( Ha Youn Shin ),( Hee Pom Lee ),( Jin Tae Hong ),( Do-young Yoon ) 생화학분자생물학회 2024 BMB Reports Vol.57 No.5

Many types of cancer are associated with excessive angiogenesis. Anti-angiogenic treatment is an effective strategy for treating solid cancers. This study aimed to demonstrate the inhibitory effects of (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol (MMPP) in VEGFA-induced angiogenesis. The results indicated that MMPP effectively suppressed various angiogenic processes, such as cell migration, invasion, tube formation, and sprouting of new vessels in human umbilical vein endothelial cells (HUVECs) and mouse aortic ring. The inhibitory mechanism of MMPP on angiogenesis involves targeting VEGFR2. MMPP showed high binding affinity for the VEGFR2 ATP-binding domain. Additionally, MMPP improved VEGFR2 thermal stability and inhibited VEGFR2 kinase activity, suppressing the downstream VEGFR2/AKT/ERK pathway. MMPP attenuated the activation and nuclear translocation of NF-κB, and it down-regulated NF-κB target genes such as VEGFA, VEGFR2, MMP2, and MMP9. Furthermore, conditioned medium from MMPP-treated breast cancer cells effectively inhibited angiogenesis in endothelial cells. These results suggested that MMPP had great promise as a novel VEGFR2 inhibitor with potent anti-angiogenic properties for cancer treatment via VEGFR2/AKT/ERK/NF-κB signaling pathway. [BMB Reports 2024; 57(5): 244-249]