정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

豚肉의 鹽漬保存法에 關한 硏究

鄭承鏞 진주농과대학 1969 진주농과대학 연구논문집 Vol.- No.8

1. 養畜農家에 있어서 食生活改善의 一助로서 簡便한 方法인 鹽漬에 依한 豚肉의 保存法과 그 實際 利用性에 關하여 實驗 한바 그 結果를 要約하면 다음과 같다. 2. 鹽漬에 依한 保存은 豚肉의 15% 相當量 以上의 食鹽을 使用한 것은 30日以上 60日까지 長期間 保存할 수 있었다. 3. 豚肉의 15% 相當量 以上의 食鹽을 使用한 鹽漬 豚肉은 家庭에서 各種調理에 利用可能 하다는것을 알 수 있었다. 1. This experiment was carried out to investigate the storage and utility of pork by salting method, which is convinient for healthy dietary life in live-stock farm. 2. In the preservation pork treated with salt amounting to 15% and over of pork weight(salt-sprinkling method) was available for 30-60 days. 3. Pork treated with salt amounting to 15% and over of pork weight was available for all sorts of cooking at home.

1997~2000년에 발생된 황사에 관한 연구

정용승,김학성,낫짜가도르지 엘,적데어 디,첸 수잰 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

Joint monitoring of yellow sand (YS) phenomena occurred from 1997 to 2000 was carried out. It was found that the YS in source regions occurred in any time during the year, while the severe dust storms occurred frequently from March to May after the spring thaw. Wind erosion occurred usually with wind greater than about 8 ms^-1 in the source region in any seasons. However, severe YS phenomenon found to occur with wind greater than 15 ms^-1 at least for 3 hours or more. In source regions, YS occurred over 60∼120 days per year. In Korea, YS was found to occur 8∼12 cases per year with 12-22 YS days. It was recorded that maximum concentrations of TSP were 989∼1396 ㎍ m^-3 with PM10 values of 861∼996 ㎍ m^-3 and with the lowest visibility of 1.4∼1.6km. In Mongolia, however, it was observed that the number of dusty days decreased due to the increase in rainy days.

음식쓰레기의 감량화 및 적정관리 방안

정재춘,이재웅,한용희,탁성제 연세대학교 보건과학연구소 1998 보건과학논집 Vol.8 No.-

말쥐치기름 및 들깨기름의 攝取가 高콜레스테롤 食餌 흰쥐의 血淸 및 肝臟의 脂質成分에 미치는 影響

鄭承鏞,朴畢淑,徐孟姬,姜晋順,禹靜淑 慶尙大學校 1985 論文集 Vol.24 No.1

Hypercholesterolemic male rats of Sprague Dawley, divided into six groups, were fed for 3 weeks with the diets containing several different oils of 10,0, the mixtures of 5% perilla oil and 5% other oils. The concentration of the lipid peroxide, T-cholesterol, phospholipid and triglyceride in the serum and liver were measured along with the HDL-cholesterol concentration of the serum. The results were as follows: 1. The concentration of LPO in the serum of the rats fed with lO% perilla oil, with 5% perilla oil+5% lard and with 5% perilla oil+5% file fish oil was higher than those with any other oils. The concentration of that was significantaly high in the liver of the rats fed with 10% perilia oil, while it was considerably low with 10% olive oil. 2. The concentration of T-cholesterol in the serum of the rats fed with 10% perilla oil, with 10% file fish oil and with 5% perilla oil+5% file fish oil was lower than those with any other oils. 3. The concentration of HDL-cholesterol was low in the serum of the rats fed with 10% perilla oil, while it was high with 5% perilla oil+5% file fish oil and with 10% file fish oil. The concen tration of that for the T-cholesterol in the serum of the rats fed with 10% file fish oil and with 5% perilla oil+5% file fish oil was much higher than those with any other oils. 4. The concentration of T-cholesterol in the liver of the rats fed with 10% perilla oil was high, while it was low with 10f file fish oil and with any other oils. 5. The concentration of PL and TG in the serum of the rats fed with 10% perilla oil and with 10% file fish oil was lower than those with any other oils, but it was lower in the liver of the rats fed with 10% perilla oil than the mixtures of perilla oil and with 10% file fish oil.

청원-청주지역에서 관측된 시정 장애 현상

정용승 한국교원대학교 환경과학연구소 1998 환경연구논문집 Vol.- No.4

In Chongwon of central Korea, daily measurements of visibility at 09 LST have been made since 1990. Observations of low visibility reduction, 7㎞, associated with the occurrence of fog, mist and haze are recorded for 6 years. According to observed data, an increase in the low visibility days is related to an increase in anthropogenic air pollutants and water vapour in the study area. Also, the occurrence of fog, mist and haze in much related to the influence of local, regional and synoptic meteorology. In Chongwon, we commonly observe the typical historical type of London fog and mist. Discussion on a satellite observation of sea fog and advection is also included. In the present study, chemical analyses of fog, mist, haze and frost are carried out. The annual mean values of pH are 5.33 for 1995 (44 days) and 5.47 for 1996 (45 days), respectively. The lowest pH value of all fog and mist samples in 4.03. The pH values less than 5.6 are 65.9% of all samples for 1995 and 53.3% for 1996. Data obtained during 1994∼95 have indicated that there are abundant contents of nitrates and sulphates in fog and mist samples. This suggest the availability of condensation nuclei of anthropogenic origins in the rural atmosphere.

악성 종양을 지닌 환자의 복수에서의 염색체 분석

류승완,정기용,김대광 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.5

구속된 비행 청소년들의 특성 및 석방 후 6개월간 재범여부와 관련된 변인

정선주,김원식,고승희,구영진,김홍창,서동혁 대한소아ㆍ청소년정신의학회 1999 소아청소년정신의학 Vol.10 No.2

한국에서 관측된 산성강수와 대륙적인 중국의 대기오염 이동

정용승,김학성,박기현 한국교원대학교 환경과학연구소 2002 환경연구논문집 Vol.- No.7

1990년부터 청원(KHN)의 농촌기역에서 산성강우가 관측되었다. 청원의 10년 관측과 함께 다른 6개의 배경 관측소에서도 강우가 채집 및 분석되었다. 산성비는 전 관측에서 자주 발생되었다. KHN 에서는 다른 10년의 강수량 가중평균 VWM 값이 4.67이고 산술평균 값은 5.09이다. 일반적으로, 봄 철 황사가 발생될 때 pH 값이 높았으며, 여름철에는 비교적 중성 값을 보였다. 다른 계절에는 산성 강수가 대개 기류와 관련되었으며, 중국의 중부와 남부지방에서 오는 기류와 저기압은 한반도에서 낮은 pH 값을 발생시켰다. 1996년부터 인공위성을 이용 동아시아 대기오염의 장거리 이동을 모니터링하고 있으며, 황해를 지나 한반도에 이동되는 대기오염의 장거리 이동 사례를 많이 수집하였다. 한국의 산성비는 중국의 발원지로부터 공기의 지나온 분석, 산성 안개와 박무도 논의 되었다. Acid rain at a rural site in Chongwon(KHN), central Korea has been under observation since 1990. To substantiate the 10-year observations, rain samples from six other sites were also collected and analyzed. Results show that acid rain occurred frequently at all sites, At KHN, seasonal and annual variability of pH values had a 10-year VWM value of 4.67 and an arithmetic mean value of 5.09, In general, a high value of pH occurred during springtime when the occurrence of yellow sand (dust) was prevalent in East Asia; during summer, heavy rain usually contained neutral pH values. During other seasons, the degree of acidic precipitation usually coincided with certain air flows. Most frequently, air flows and cyclones coming from south and central China often resulted in precipitation with low pH values observed in Korea. Using daily satellite observations from 1996, we have also been monitoring the large-scale transport of air pollutants over East Asia. Many samples of long-range transport of air pollutants (LRTAP) were obtained when they were crossing the Yellow Sea and moving over the Korean Peninsula. Cases of acid rain in Korea clearly correlate wth the LRTAP from source regions in China. In this study, results of air-parcel trajectory, plus acid fog and mist analysis are discussed.

자동차 잡음환경 고립단어 음성인식에서의 VTS와 PMC의 성능비교

정용주,이승우 한국음성과학회 2003 음성과학 Vol.10 No.3

There has been many research efforts to overcome the problems of speech recognition is noisy conditions. Among the noise-robut speech recognition methods, model-based adaptation approaches have been shown quite effective. Particularly, the PMC (parallel model combination) method is very popular and ha been shown to give considerably improved recognition results compared with the conventional methods. In this paper, we experimented with the VTS (vector Taylor series) algorithm, which is also based on the model parameter transformation but has not attracted much interests of the researchers in this area. To verify the effectiveness of it, we employed the algorithm in the continuous density HMM (Hidden Markov Model). We compared the performance of the VTS algorithm with the PMC method and could see that the it gave better results than the PMC method.