Infliximab으로 호전된 장관 증상없이 발생한 구강-안면 크론병

정보용 ( Bo Yong Jung ),이석호 ( Suck Ho Lee ),정승규 ( Seung Kyu Chung ),이창균 ( Chang Kyun Lee1 ),이태훈 ( Tae Hoon Lee ),정일권 ( Il Kwun Chung ),김선주 ( Sun Joo Kim ),조현득 ( Hyun Deuk Cho ) 대한소화기학회 2012 대한소화기학회지 Vol.59 No.6

Crohn`s disease is a chronic inflammatory bowel disease that can involve the whole gastrointestinal tract. The orofacial manifestation of Crohn`s disease, which is rare, can develop irrespective of intestinal involvement. These orofacial lesions are often misdiagnosed as simple oral ulcers. Corticosteroids are the mainstay of therapy for orofacial Crohn`s disease. However, infliximab, the chimeric monoclonal antibody to tumor necrosis factor-α, is now considered as a primary treatment because of the disease`s relatively high rate of steroid resistance. We present a case of deep oral ulcer and periorbital swelling in a 65-year-old woman. She was diagnosed with intestinal Crohn`s disease 7 years ago, which was in remission after treatment with an immunosuppressive agent (azathioprine). The patient was given the diagnosed with orofacial Crohn`s disease and successfully treated with infliximab. (Korean J Gastroenterol 2012;59:437-440)

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

정상 관동맥을 가진 심장 점액종 환자에서 발생한 급성 심근 경색증 1예

이정민,이현승,전은정,윤호중,정욱성,오용석,김철민,김재형,최규보,홍순조,이교영,심상인 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

프로야구 選手契約의 法理에 관한 小考

李淸助,金甫炫 東亞大學校 法學硏究所 2003 東亞法學 Vol.- No.33

고려수지요법을 이용한 손 마사지가 항암 화학요법을 받는 암 환자의 오심·구토 및 식욕부진에 미치는 효과

이현숙,성기월,손보경,김지선,이혜정,이순영 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The purpose of this study was to examine the effect of hand massage through Korean hand acupuncture therapy on nausea, vomiting and anorexia induced by chemotherapy in cancer patients. Method: Subjects consisted of 40 patients with cancer who were hospitalized and had chemotherapy at D university hospital in D city, Korea. These subject were assigned randomly to a hand massage throght Korean Hand Acupuncture Therapy (experimental group: n=20, control group: n=20). The data were collected from April 1 to September 15 in 2005. All the patients were assessed for their nausea, womiting and anorexia; Nausea and vomiting were measured with Rhodes INVR(index of Nausea, Vomiting by Rhodes and McDaniel) and Anorexia was measured with VAS(Visual Analogue Scale). As an experimental treatment, the hand massage through Korean Hand Acupuncture Therapy was applied three times a day for three consecutive days. The data were collected at the time of 4 hours before the start of chemotherapy, 24hours and 48hours after hand massage respectively. The data were analyzed with SPSS/WIN 11.5 program using frequency, percentage, χ²-test, t-test, repeated Measures ANOVA. Reslt: Severity of nausea and vomiting in hand massage through Korean Hand Acupuncture Therapy group was significantly less than of control group(F=28.10, P=.000). Severity of anorexia in hand massage through Korean Hand Acupuncture Therapy group was also significantly less than that of control group(F=31.24, P=.000). Conclusion: Hand massage through Korean Hand Acupuncture Therapy is effective for relieving patients' nausea, vomiting and anorexia during chemotherapy. Therefore, it is proposed that hand massage through Korean Hand Acupuncture Therapy can be applied as a supportive as a supportive nursing arbitration method to relieve naussa, vomiting and anorexia in patients who are getting chemotherapy.

W(110) 표면에 CO의 흡착

이경희,유위량,한현석,부진효,이순보,곽현태 성균관대학교 기초과학연구소 1998 論文集 Vol.49 No.-

The interaction of CO with W(110) surface was investigated through LEED, TDS, and photoelectron spectroscopy using synchrotron radiation under UHV condition. After CO saturation at RT, two desorption states, called α and β , were observed at about 400 and 1150 K in thermal desorption spectra, respectively. The kinetics of 3-CO followed the first order kinetics, indicating the existence of molecular CO on W(110) surface. This is contrary to the previous results. The O 1s BE(binding energy) of CO adsorbed on W(110) surface at room temperature was 529.9 eV. On the other hand, the O 1s BE of β-CO after heating to 900 K was different from that of oxygen adsorbed W(110) surface, suggesting a different adsorption state. According to the UP valence band spectra, we observed two peaks at near -10.7 eV (4σ) and -7.0 eV (5σ+1π), indicating the molecular adsorption of CO at room temperature. Furthermore we could see the 4σ peak at the various photon energy and elevated temperatures. Comparing the energy separation, Δ(4σ-1π) , between 4σ and 1π UP peaks of chemisorbed CO, we found that an increased separation reflects an decreased C-O bond strength. Therefore on the basis of TDS and photoelectron spectroscopy, we could suggest that β state of CO on W(110) may not be dissociated and has an adsorption geometry of lying-down mode.

집적화된 실리콘 압력센서의 출력전압 보상파라미터 추출 및 그 특성

이보나,김건년,박효덕,신상모,이경탁,김찬,권혁채,이상조,박현주 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1

An integrated silicon pressure sensor has been designed, fabricated and tested. The signal conditioning circuits were designed to include calibration and temperature compensation of output voltage through trimming of diffusion and ion-implanted resistors. Before trimming of resistors, the compensation parameters such as pressure sensitivity, temperature coefficient of pressure sensitivity, temperature coefficient of piezoresistors and pressure sensitivity of piezoresistors were measured. Then offset voltage, span, and temperature coefficients of offset voltage and span were calibrated by trimming of resistors. The measured output voltage met our design specification and simulation value above room temperature. But, the measured output voltage at -30°C deviated from our design specification and simulation value because the offset voltages were found to vary randomly as a function of temperature.

여자 체조 이단평행봉 연기에 대한 분석

이보선,박순호,이필영,최정현 龍仁大學校 體育科學硏究所 2001 體育科學硏究論叢 Vol.11 No.1

The purpose of the study is to help Korean women gymnasts get better grades in the international sports arena by understanding the world trends in this field based on the analyses of performances in the parallel bars, the weakest event among the four Korean women's gymnastic events. Value, connection value by which bonus points can be obtained, and start value were analyzed, excluding demerit marks in general performances, impressions, and art. The results of the study are as follows. In the analysis of value, the top four athletes implemented more parts than the average level while the four Korean athletes achieved less than the average level. According to the analysis of value parts D and E, the top four athletes received an average of 0.675 bonus points while the Koreans got 0.15, showing a great difference among them. The analysis of connection value by which bonus points can be obtained also showed stark contrast between the top four athletes and the Koreans marking bonus points of 0.50 and 0.075, respectively. The average start value of the top four athletes was 9.95, 0.925 higher than that of the Korean athletes of 9.025, which can be considered as a big difference. It is suggested that Korean athletes should focus on conducting high level of value parts and connection value to make greater achievements in the international sports arena, considering general demerit points were not included in this study. They are also needed to be confident in order to act to the best of their abilities.

PEO가 첨가된 원형관 난류운동에서의 마찰저항 감소 측정

이동원,김신,현명택,천원기,이보안 濟州大學校 工科大學 産業技術硏究所 1998 尖端技術硏究所論文集 Vol.9 No.2

The drag reduction by polymer additive is a well-known phenomenon and has been widely studied due to its high usefulness. In this study. in order to obtain the fundamental data on the drag reduction by polymer additive. we measured the friction factors in the polymer added turbulent flow through a circular pipe for Reynolds number ranging 10000∼50000. As Polymer additive, PEO (polyethylene oxide : molecular weight 4×10의 6제곱)was used. We also performed the experiments varying the concentration of PEO from 3 to 24 wppm to investigate the effect of the PEO concentration on the drag reduction. We observed more than 25% drag reduction under the above experimental conditions and the most effective drag reduction was found at 6 wppm (31% drag reduction).