한국산 날치과(Beloniformes , Exocoetidae)어류 5 종의 분류학적 재검토

김종만,김진구,유정화,조선형,명정구,강충배,김용억 한국어류학회 2001 韓國魚類學會誌 Vol.13 No.2

Taxonomic review of the five flyingfishes, Parexocoetus mento (Valenciennes), Cheilopogon agoo (Temminck et Schlegel), Cheilopogon heterurus doederleini (Steindachner), Cheilopogon cyanopterus (Valenciennes), Hirundichthys oxycephalus (Bleeker) were carried out based on samples collected from the South sea and around sea of Jeju Island of Korea from 1996 to 1998. Parexocoetus mento (Valenciennes) and Cheilopogon cyanopterus (Valenciennes) were revealed as the unrecorded species in Korea, which were named as "Men-to-hwang-nal-chi" and "Ki-geom-nal-chi" respectively. Parexocoetus mento is differed from P. barchypterus in having no chin barbels in juveniles, and Cheilopogon cyanopterus is distinguished from C. agoo in the branched form of pectoral fin rays and from C. heterurus doederleini in the numbers of the dorsal fin ray and the color of pectoral fins.

시험관내에서 당화시킨 인슐린의 생체내 활성

김성완,김성연,조보연,이홍규,고창순,민헌기,이문규,김철희,민용기,장학철,정대원,배철민 대한당뇨병학회 1990 Diabetes and Metabolism Journal Vol.14 No.2

Mycobacterium Avium - in tracellulare Complex 와 M . Fortuitum 에 의한 폐항산균증(肺抗酸菌症) 3예

김상재,홍수표,배길한,김성진,진병환,정충모 대한미생물학회 1982 大韓微生物學會誌 Vol.17 No.1

Two cases of pulmonary disease in a 54 year-old female and a 70 year-old male patient due to Mycobacterium avium-intracellulare complex (MAIC) and a case of pulmonary infection in a 69 year-old male patient due to M fortuitum (MF) were found recently in this institute. All three patients bad a long history of anti-tuberculous chemotherapy because they were initially diagnosed as pulmonary tuberculosis. A 70 year-old male patient infected with MAIC had an unsuccessful chemotherapy history of isoniazid (INH), para-aminosalicylic acid (PAS) and streptomycin (SM) with an incomplete, temporary, symptomatic improvement, for three years since 1964 when he was first diagnosed as pulmonary tuberculosis on physical examination. A 54 year-old female patient infected with MAIC also had an unsuccessful chemotherapy history with the various anti-tuberculous drugs since 1958. Both patients discharged large number of MAIC in their sputum specimens for at least more than one year, but no M tuberculosis at all. A 69 year-old male patient infected with MF was diagnosed as moderately advanced pulmonary tuberculsis in 1977. Combined chemotherapy with INH+PAS+pyrazinamide (PZA) improved his clinical symptoms, however, his chest radiograph was deteriorated again in 1980 one year after he stopped therapy. Therefore he started chemotherapy again with INH+ethionamide (TH)+cycloserine(CS) but no improvement was noticed. MF was cultured from his sputum in August 1983 and he continuously discharged the same baeilli until last examination of January l982. Whether all three patients were initially infected with nontuberculous mycobacteria or complicated with predisposing tuberculosis was not clear because there were no reliable bacteriological Examination records.

다이캐스팅한 SiC 입자강화 알루미늄 복합재료의 피로균열 전파특성

김송희,윤여범,이기호,오준도,주희위,이지환 대한금속재료학회(대한금속학회) 1998 대한금속·재료학회지 Vol.36 No.8

This study is to investigate the effect of load ratio on fatigue crack of die-cast SiC particulate aluminum composites. Fundamental fatigue crack propagation tests were performed with sub-sized C-T specimens at a load ratio of 0.1, 0.3 and 0.5 respectively. Crack closure measurements were conducted for explaning the effect of load ratio on fatigue crack growth. The experimental results showed that the fatigue crack growth rate increases with the load ratio, especially at near threshold. The composite reinforced with 20 vol.% SiC particles was better in fatigue crack growth resistance than that with 10 vol.% SiC particles. Through the measurement of Kop and ΔK at various R ratios the concept of effective stress intensity factor range ratio. U was reviewed to evaluate the stress ratio effect on fatigue crack growth. Relationships between U and variables such as ΔK and R were obtained empirically so that we could predict ΔK_(eff) that is of critical importance for the prediction of fatigue crack propagation rate.

제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

400 계열 스테인레스 스틸 분말을 사용한 ABS Sensor Ring 개발

임종국,양현수,김경환,곽창섭 한국산업안전학회 1998 한국안전학회지 Vol.13 No.3

ABS sensor ring has been manufactured by P/M method using 400 series ferrite stainless steel. The results are as following: It is supposedly sufficient to use for control computer due to good experimental results of magnetic characteristics. Compared with sensor ring made by iron, 400 series ferrite stainless steel has shown a good corrosion resistance without an addition surface treatment. Thus the decreasing production process has been obtained. As a result of hardness and tensile test, 400 series ferrite stainless steel shown a good endurance when it is combined to C/V joint, and has a good hardness properties endurable to sand and pebble impact.

만성신부전증에서 혈청 CEA치에 관한 연구

이정상,신영태,정순일,고창순,김성권,표희정,권인순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1979년 3월부터 1980년 10월까지 서울대학교병원내과에 입원하여 만성신부전증으로 진단받고 혈액투석요법을 받지 않은 환자 15예, 혈액투석요법을 시행중인 환자 39예 및 신장이식술을 받고 신장능이 호전된 환자 23예에서 혈청 CEA치를 방사면역측정법으로 측정하여 정상대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 정상 성인 65명의 혈청 CEA치의 범위는 1.0∼4.3 ng/ml이었으며 평균은 1.6±0.66 ng이었다. 2) 혈액투석요법을 시행치 않은 만성신부전증 환자 15예의 혈청 CEA치는 0.3∼8.3 ng/ml이었고 평균은 3.6±2.10 ng/ml로써 정상대조군에 비하여 유의하게 증가되어 있었다(p$lt;0.001). 3) 혈액투석요법으로 치료중인 만성신부전증 환자 39예의 혈청 CEA치는 0.7∼6.7 ng/ml로 평균이 3.0±1.52 ng/ml이며, 정상대조군에 비하여 유의하게 상승되어 있으나(p$lt;0.001), 혈액투석을 받지 않은 환자군과는 유의한 차이가 없었다. 4) 신이식 환자 23예의 혈청 CEA치의 분포는 1.8∼10.8 ng/ml이고 평균은 3.8±1.96 ng/ml로 역시 정상대조군에 비하여 유의하게 증가되어 있으나(p$lt;0.001), 만성신부전증 환자군과는 유의한 차이가 없었다. 5) 이상의 혈청 CEA치가 정상범위 이상으로 상승된 49명��환자중 이학적 소견이나 검사소견상 악성종양은 발견되지 않았다. The serum CEA levels were measured by radioimmunoassay technique in 15 patients with chronic renal failure, who were not treated with hemodialysis, in 39 patients under hemodialysis and in 23 patients who received renal transplantation. The results were compared with those in 65 normal adults and the following results were obtained. 1) Serum CEA concentrations in 65 normal adults were in the range of 1.0 to 4.3 ng/ml with a mean value of 1.6±0.66 ng/ml. 2) Serum CEA concentrations in 15 chronic renal failure patients who were not treated with hemodialysis, were in the range of 0.3 to 8.3 ng/ml with a mean value of 3.6±2.10 ng/m1 which was significantly higher than those of normal controls(P$lt;0.001). 3) Serum CEA concentrations in 39 chronic renal failure patients under hemodialysis were also much higher than normal controls(p$lt;0.001), but not significantly different from those of the patients who were not under hemodialysis(P$gt;0.05). 4) In 23 patients who received renal transplantation, serum CEA levels were snificantly higher than normal controls(P$lt;0.001), but not significantly different from those of chronic renal failure patients.

갑상선자극 호르몬 분비에 대한 Dopaminergic Control에 관한 연구

이정상,이문호,고창순,김응진,김명덕 대한핵의학회 1978 핵의학 분자영상 Vol.12 No.2

1978년 4월부터 1978년 8월사이에 서울대학교병원 내과에 내원하였던 원발성 갑상선기능저하증 환자 9명과 일반신체검사 및 갑상선기능검사상 전혀 이상이 발견되지 않은 의과대학생 6명과 수련의 1명 총 16명을 대상으로 Dopamine 수용체를 선택적으로 차단하는 Metoclopramide와 Dopamine 수용체를 선택적으로 자극하는 Bromergocryptine(CB-154)을 각각 혹은 함께 투여해서 다음과 같은 결과를 얻었다. 1) Metoclopramide(Moxolonⓡ) 10mg을 정맥으로 주사했을때 원발성 갑상선기능저하증 환자들에서는 투여후 20분에 말초혈액에서 갑상선자극호르몬이 통계학적으로 유의하게 증가되었으며, 60분에도 계속 증가되었다. 그 이후 180분까지 계속 증가된 장태를 유대했으며, 중증보다 경증에서 더욱 현저하게 증가되어 나타났다. 그러나 정상인에서는 이러한 증가가 나타나지 않았다. 2) Bromergocryptine(CB-154)을 2mg 경구투여했을때 원발성 갑상선기능저하증 환자들에서는 투여후 120분에 말초혈액에서 갑상선자극호르몬이 현저하게 감소되었고, 240분 및 360분까지 계속 감소되었으며, 중증보다 경증에서 더욱 현저하게 감소되어 나타났다. 그러나 정상인에서는 이러한 감소가 나타나지 않았다. 3) Bromergocryptine(CB-154) 2mg을 경구투여한 후 120분에 Metoclopramide(Moxolonⓡ) 10mg을 정맥 주사했을때 원발성 갑상선기능저하증 환자들에서는 Bromergocryptine을 투여한 후 120분에 말초혈액에서 갑상선자극호르몬이 감소했으며, Metoclopramid를 투여한 후에 약간 증가하는 추세였으나, Metoclopramide를 단독으로 투여했을 때와 같은 현저한 증가는 나타나지 않았으며, 정상인들에서는 Bromergocryptine 및 Metoclopramide를 투여했을때 뚜렷한 증가나 감소는 보이지 않았다. 4) 생리식염수 2ml를 정맥주사했을 때 원발성 갑상선기능저하증 환자들 및 정상인들에서 갑상선자극호르몬이 말초혈액에서 뚜렷한 증가 내지 감소는 보이지 않았다. 5) Metoclopramide와Bromergocryptine을 각각 혹은 함께 투여했을때 및 생리염수를 투여했을 때 혈중 Triiodothyronine 및 Thyroxine치는 각각의 기저치들에 비해 통계학적으로 유의한 증가나 감소를 보이지 않았다. 이상의 결과에서 갑상선자극호르몬의 분비가 Dopaminergic Control을 받는다는 사실을 알 수 있었다. 본 연구를 실시함에 있어 물심양면으로 협조해주신 동아제약에 사의를 표하는 바이다. To e1ucidate the depaminergic control of T.S.H. secretion, we analized the pattern of T.S.H secretion in seven normal controls and nine primary hypothyroid subjects, before and after single or combined administration of specific dopaminergic receptor blocker, metoclopramide, and specific depaminergic receptor stimulant, bromergocryptine (CB-154). The results obtained were as follows: 1) There was a significant rise in T.S.H. levels after intravenous injection of metocioramide(10mg) in hypothyroid subjects. But there was no significant rise in T.S.H. levels in normal controls. The T.S.H. response to metoclopramide varied considerably, being large in mild cases and small in severely hypothyroid subjects. 2) There was a significant fall in T.S.H. levels after oral administration of bromergocryptine(2mg) in hypothyroid subjects, but there was no significant fall in T.S.H. levels in normal controls. 3) There was no significant fluctuation in T.S.H. levels after combined administration of both metoclopramide and bromergocrytine. 4) There was no significant fluctuation in T.S.H. levels after intravenous injection of normal saline(2ml) in both hypothyroid and normal subjects. 5) There was no significant change in serum T3 and T4 after administration of metoclopramide and bromergocryptine respectively and serially. These data support the fact that there is a dopaminergic control in the secretioI1 of T.S.H. in the human.

아급성 갑상선염의 임상적 고찰

홍기석,고창순,정준기,이홍규,김삼용,석창호,박성회,김용일 대한핵의학회 1978 핵의학 분자영상 Vol.12 No.2

저자들은 서울대학교 병원 내과에서 108례의 갑상선 침생검을 시행하여 8례(7.9%)의 아급성갑상선염을 진단할 수 있었다. 이를 임상경과, 갑상선기능 등으로 본 임상단계와 비교한 결과 다음과 같은 결론을 얻었다. Czernick 등이 시도하였던 임상단계와 침생검의 조직소견이 비교적 잘 대응하였다. 임상경과가 길거나 갑상선기능이 낮을수록 갑상선의 섬유화가 심하였고 여포성분의 감소를 보였다. 갑상선의 기능상태와 옥소섭취율 혹은 갑상선주사상의 섭취율은 역 상관관계를 보였다. 임상단계의 초기에 발견된 환자들은 기능항진증의 증상을 보였다가 기능저하증의 양상을 보인 후 회복되는 이형적인 경과를 보였다. 임상단게의 후기에 발견된 환자들은 4명중 3명이 기능저하증을 보였는데, 이는 경과로 보아 질환의 최종단계로 생각되었다. $quot; 8 cases of subacute thyroiditis was diagraiosed amormg 108 needle biopsy of the thyroid during the period from April 1976 to August 1978. Correlation of the histologic findings with the clinical staging proposed by Czernick was relatively well matched; cases with long clinical course or low thyroid hormone levels showed greater fibrosis and reduction of follicular elements in thyroid. Thyroid (131)^I uptake or the uptake as seen on the thyroid scanning correlated inversely with the thyroid hormone levels. The clinical course of the patients seen in their initial stage of disease followed the classical pattern; hyperthyroid-like, hypothyroid-like and recovery. 3 among the 4, who were seen in their later clinical course showed hypothyroidism, which seemed the final outcome of their diseases.

간경변증에서의 혈역학적 변화에 관한 연구

김정일,이정상,고창순 대한핵의학회 1970 핵의학 분자영상 Vol.4 No.2

간경변증 환자 29예에서 혈장량, 심박출량 및 신혈장류량을 동시에 측정하여 혈역학적 변화를 관찰하였으며 다음과 같은 결론을 얻었다. 1) 평균 혈장량은 3793±895ml로 정상보다 증가된 것을 보았고 혈액량 (5266±1222ml) 및 체중 kg당 혈액량 (95.7±23.41ml)도 역시 증가되어 있었다. 체중 kg당 혈장량 (69.1±19.1ml)은 증가하는 경향을 보였고 혈액량과 혈장량의 차, 즉 적혈구질량은 26.4±7.05ml로 정상범위내에 있었다. 2) 평균 심박출량은 7708±2652ml/min로 증가되어 있었으며 심계수(4924±1998ml/min/M2) 심박동량 (96.2±34.2ml/beat), 심박동계수 (62.3±27.34ml/M2) 및 분별심계수 (1.54±0.577)도 모두 증가함을 보았다. 전말초저항은 1664±753.8 dynes sec cm-5M2로 정상보다 감소되어 있었다. 3) 평균 신혈장류량은 537±146.8ml/min/1.73M2로 정상 내지는 감소된 것을 보였고, 평균 creatine clearance는 66.7±23.0ml/min/1.73M2로 현저한 저하를 보았다. filtration fraction은 일정치 않았으나 대부분의 예에서 감소되었다. 심박출량의 신분별치는 상대적으로 감소하여 있었다. 4) 신혈장류량은 전반적으로는 정상 또는 저하되어 있었으나 creatine clearance가 60ml/min/1.73M2 이하인 군과 치료에 저항하는 복수군 및 공소혈증이 있는 예에서 현저한 감소를 보였다. 5) 본실험에서 관찰한 사구체 여과율의 감소, filtration fraction의 저하 및 심박출량의 신분별치의 감소등은 신장의 수입세동맥저항의 상승을 뒷받침한다. 6) 간경변증에서 신순환 장애는 공소혈증이나 핍뇨에 선행하여 일어남을 알 수 있었다. 7) 임상상이나 간기능 성적은 이들 혈역학 변화와 상관관계가 없었고 다만 식도 정맥류가 심박출량이 증가된 예에서 관찰되었다. 8) 신혈역학 변화와 혈장량 혹은 심박출량 간에도 상관관계는 없었다. $quot;Cardiac output, plasma volume and renal plasma flow were determined to evaluate hemodynamic changes in 29 patients with cirrhosis of the liver. The results obtained were as follows. 1) The mean plasma volume was 3793±895ml and it was significantly higher than the normal controls. The mean blood volume (5266±1222ml) and blood volume per kg body weight (95.7±23.41ml) were also increased significantly. The mean plasma volume per kg body weight (69.1±19.1ml) showed increased tendency and the mean difference between blood volume and plasma volume per kg body weight (26.4±7.05ml) was in lower limit of normal range. 2) The mean cardiac output was 7708±2652ml/min and it was significantly increased. The mean cardiac index (4924±1998ml/min/M2), stroke volume (96.2±34.2ml/beat), stroke index (62.3±27.34ml/beat/M2) and fractional cardiac index (1.54±0.577) were also increased significantly. The mean total peripheral resistance was 1664±753.8 dynes sec cm-5 M2 and it was significantly lower than the normal conte mean renal plasma flow was 537±146.8ml/min/1.73M2 and it was normal to decreased tendency. The mean endogenous creatinine clearance (66.7±23.0ml/min/1.73M2) was significantly decreased. Filtration fraction was variable, but it was slightly lower than normal in most cases. The mean renal fraction of cardiac output (11.4±6.27%) was relatively decreased. 4) Although renal plasma flow was normal or decreased in general, it was definitely diminished in patients with creatinine clearance less than 60ml/min/1.73M2, resistant ascites, and signs of azotemia (elevated BUN and serum creatinine). 5) Diminished glomrular filtration rate with low filtration fraction and decreased renal fraction of cardiac output observed strongly supported increased renal afferent arteriolar resistance. 6) Renal circulatory impairment preceded azotemia or oroliguria in cirrhosis. 7) Clinical findings and liver function were not correlated with hemodynamic changes, except for esophageal varices associated with high cardiac output obser. 8) No definite correlation of renal hemodynamics with plasma volume or cardiac output was found. $quot;