간호 지식관리시스템 개발

민효숙,문원희,김미자,김선미,황윤신,황관옥,심희숙 충남대학교 간호과학연구소 2006 충남대 간호학술지 Vol.9 No.1

The purpose of this study were to develop Knowledge Management System for the nurse and to identify its effectiveness. The program was developed in development of the contents and programing. And the system was operated to 85 nurse for three weeks. Data collection were performed during the period of May 1, 2005 to December 30, 2005. The data was collected from 85 nurses using questionnaires. In order to ascertain the validity of clinical application of the system, Prior experience of the computer mediated communication, user satisfaction and utilization were analyzed. The instruments for the study were satisfaction(Kim, 2000), utilization(Kim, 2002). The collected data were analysed by descriptive statistics, using SPSS WIN 11.0 program. The results showed average score which is the satisfaction(6.09) showed middle satisfaction scores. It is concluded that if Nursing Knowledge Management System is operated considering all the above factors, It wound be one of the best qualified continuing clinical method for nurses.

적조생물구제농도의 Sodium Hypochlorite (NaOCl)의 노출에 따른 조피볼락 및 바지락의 조직학적 영향

한조희,김영석,허민도,정해진,박관하 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2

In a previous study by Kim et al. (2000), sodium hypochlorite (NaOCI) has been demonstrated to be effective against algae that cause red tides. To secure the environmental safety of the chemical in practical use, effect of NaOC1, at concentrations. required for algicidal activity, on the histology of rockfish and little neck clam was examined. When the animals were exposed to NaOCI at concentrations of 0.5 or 2 ppm for I hr, there was no exposure-associated histological change in either animal. As the experimental exposure condition was set in consideration of the use, our results provide safety information necessary for practical application to marine fields.

Water glass로부터 ZSM-5의 합성

우훈희,홍지숙,서정권,이관영,이정민 한국공업화학회 2002 응용화학 Vol.6 No.2

In order to seek optimum conditions for ZSM-5 formation in the absence of organic template,the effects of both starting composition and water glass as silica source were examined. Water glass was most inexpensive among silica sources, but this was difficulty in reactant control because of contained much alkali ingredient, Considering environmental problem and economic performance,chose alkali drawing-out method to use methanol newly to remove alkali ingredient of waterglass. Characterization of ZSM-5 was carried out by means of XRD, SEM.

국소성 피질이형성증의 외과적 치료

조관국,김형일,이민철,김근수,김연희,정창오,Neto, Pedro R. 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.12

Corticai Dysplasia(CD) is increasingly recognized as a cause of intractable epilepsy since it can be easily diagnosed with high resolution magnetic resonance imaging(MRI). We analyzed 24 consecutive cases with cortical dysplasia who underwent resective surgery at our institute between September. 1992 and December. 1995. MRI was demonstrated to be a decisive tool to identify CD in 16 cases(66.7%). However, the remaining 8 cases(93.9%) were confirmed to have CD based on histological examination. Location of the lesion included temporal(n=9), central(n=5), multilobar(n=5), and frontal(n=5). Intracranial EEG recording was performed to delineate the epileptogenic zons in 16 cases : subdural grid(10 cases) and depth electrode(6 cases). Resection was performed in temporal(n=9), frontal(n=7), central(n=5). parietal(n=1), and muitilobar(n=1). Complete resection was possible in 15(62.5%) and partial resection in 9(37.5%). Histological examination revealed dyslamination of cortical layers only(n=9), additional dysplastic neurons(n=7), and additional balloon cells(n=8). Surgical outcome was graded as seizure free(n=14 : 58.3%), rare seizures(n=3 : 12.5%). <50% reduction of seizure frequency(n=2 : 8%), and no change(n=5 : 20.8%) after mean follow-up of 12.7 months. The most influencing factor on the surgical outcome was the degree of completeness of resection(p<0.05). However. detectability of CD on MRI, severity of histological findings, age of seizure onset, and duration of seizure were not significantly related with the surgical outcome High suspicion is required to detect the CD among the patients with intractable epilepsy and surgical strategies should be well-planned to improve the surgical outcome in the patients with CD.

정신분열증에서 신경증적 증상의 임상적 의의에 관한 연구

박병관,신석철,강민희,신윤오 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To investigate the clinical significance of the neurotic symptoms in schizophrenia, the author applied PSE(Present State Examination) on Screening Schedule to 153 schizophrenic patients who were fit for the aim of this study. The patients were divided into two groups to grasp the phenomenological characteristics as the group with neurotic symptoms (100 cases) and the group without neurotic symptoms(53 cases). Among 91 items except neurotic symptoms in PSE, 14 items were selected as significant under X²-test, and tried factor analysis with 14 items using SPSS/PC+. The results of this study were summarized as follows. 1. In the group with neurotic symptoms, 4 factors were extracted as slowness of speech and behavior and blunted affect factor, inappropriate answer and affect factor, delusion factor, and restricted and poverty of speech factor. In the group without neurotic symptoms, 5 factors were extracted as slowness speech and behavior and incoherence factor, inappropriate and poverty speech and self-neglect factor, delusion factor, inappropriate affect factor, and loss of affect factor. In the group of total patients, 4 factor were extracted as restricted and slowness of speech and behavior and blunted affect factor, delusion factor, inappropriate and poverty of speech and inappropriate affect factor, and incoherence factor. 2. In the group with neurotic symptoms, slowness of speech and behavior, inappropriate answer, blunted and inappropriate affect were the major symptoms and inappropriate answer and affect, delusion, restricted and poverty of speech were the minor symptoms. Among these symptoms, slowness restriction, poverty of speech and behavior, inappropriate answer and characteristic blunted affect were characterized by negative symptoms(i.e. defect state) which were frequent in chronic schizophrenia. 3. In the group without neurotic symptoms, slowness of speech and behavior, incoherence, and self-neglect were the major symptoms and inappropriate and poverty of speech, delusion, inappropriate and loss of affect were the minor symptoms. Among these symptoms, slowness and inappropriateness of speech and behavior, and characteristic incoherence and self-neglect were characterized by positive symptoms which were interpreted as less distorted reality than the group with neurotic symptoms in the process of schzophrenia. 4. In the group of total patients, restricted and slowness of speech and behavior, blunted affect and delusion were the major symptoms and inappropriateness, poverty and incoherence of speech, and inappropriate affect were the minor symptoms, which were composed of the major and the minor symptoms of the group with neurotic symptoms and without neurotic symptoms. These symptoms can be seen frequently in the diagnostic criterias and clinical practice and thought to be the result of the major symptoms common in schizophrenia regardless of he presence of neurotic symptoms.

복합트레이닝이 수영경기력 및 근력에 미치는 영향

이정숙,안민호,이은희,신옥연,김영준,이윤관 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.6

This study was aimed to find what impacts the combined training of circuit weight training and swimming training can give to the competing power of swimming athletes and their respiratory functions and to provide the basic data for preparing the desirable training program to shorten swimming records through 14 girl swimming athletes, a group of 7 athletes in circuit weight training and another 7 in swimming training and the following conclusions were obtained: 1. Swimming and Circuit training groups showed, before and after 12 week training, the changes of muscular strength: grasping power (p<.001), back muscle (p<.01), arm extensor (p<.05), leg extensor (p<.05), leg curl extensor (p<.01), broad jump (p<.05) increased espectively than those of swimming training group and which were more effective. 2. In the comparison between groups, the meaningful difference appeared in swimming training groups, showing grasping power (p<.01), back muscular strength (p<.01), arm extensor (p<.05), leg extensor (p<.01), leg extensor (p <.01) 3. In the changes of competition record, in swimming and circuit training group, before and after 12 week training, meaningful increases appeared by 50m record(p<.05), 200m record (p<.05) 4. In the changes of competition record, as for the comparison between groups, meaning ful increases, 50m record (p<.05), 200m record (p<.05) appeared.

재발성 류마티즘 환자에서 발작의 유발인자

주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.

진성 복압성 요실금 환자에서 복강경하 방광경부현수술의 유용성: 타술식과의 비교 연구

김용태,엄민식,이석영,신관희,서정원,윤석중,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 진성 복압성 요실금의 치료법으로서 복강경을 이용한 Burch 수술을 타수술법과 비교하여 그 유용성을 알아보고자 하였다. 대상 및 방법: 진성 복압성 요실금을 주소로 본원 비뇨기과에서 수술을 시행받은 44명의 환자를 수술법별로 분류하여 수술법에 따른 성공률, 수술 시간, 입원 기간 및 합병증의 빈도를 비교 분석 하였다. 결과: 전체 환자에서 수술 성공률은 86.4% 였으며 이들 중 복강경을 이용한 Burch 수술군에서는 성공률이 100% 이었다. 복강경을 이용한 Burch 수술군은 타수술군에 비하여 입원 기간이 짧았다. 복강경을 이용한 Burch 수술군은 합병증이 매우 경미하였으며 전체 환자의 31.8%에서 단기간의 배뇨곤란을 호소하였으나 장기간의 배뇨곤란은 없었으며 슬링 수술군에서는 3례(16.7%)에서 심한 절박성 요실금을 호소하였다. 결론: 복강경을 이용한 Burch 수술은 높은 치료 성공률과 낮은 합병증의 빈도를 나타내어 진성 복압성 요실금의 치료에서 매우 우수한 수술법으로 사료된다. Purpose: We performed this study to investigate the usefulness of laparoscopic Burch colposuspension as a treatment of genuine stress incontinence compare to other anti-incontinence operation. Materials and Methods : We analyzed success rate, operation time, admission day, and complication rate of various anti-incontinence operations in 44 genuine stress incontinence patients who have been received operation in our hospital. Results : Overall success rate was 86.4%, but laparoscopic Burch coposuspension showed 100% success rate. Laparoscopic Burch colposuspension required shorter admission day compared to other anti-incontinence oparations. Complication rate was lower in laparoscopic Burch colposuspension group. Short-term voiding problems were identified in 31.8% of total patients but 3 patients(16.7%) who have received sling operation complained severe urge incontinence. Conclusion : Laparoscopic Burch colposuspension is considered as an effective surgical method for genuine stress incontinence due to high success rate and low complication rate.

일측성선조체의 6-OHDA손상 후 도파민효능약물 투여로 발현된 회전운동의 특성

이순철,문민선,이수정,유민,윤철호,유관희 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-

The present study examined the characteristics of behavior induced by dopamine agonists following treatment with 6-hydroxydopamine(6-OHDA) unilaterally into left striatum in rats. 6-OHDA was administered at doses of 8.16 and 24 ㎍/2㎕(in 0.1% ascorbic acid) into dopaminergic neurons in left striatum of 7 weeks old rat under anesthetic. Locomotor activity was significantly decreased at 1 week following 6-OHDA-administration in 7 weeks old rats. The contralateral circling behaviour was inducd by apomorphine(5 ㎎/㎏, I.p.) after 1 week following 6-OHDA(24 ㎍/2㎕) treatment, and was further increased by repeated administration of apomorphine at 2, 3 and 4 weeks. The contralateral circling behavior was also induced by lisuride and 1-dopa in a dose dependent manner, but not by SK & F 82526 in 7 weeks old rats treated with 6-OHDA, The contralteral circling behavior ws significantly higher in 21 weeks old rats but significantly lower in 35 weeks old rats when compared with 7 weeks old rats. The contralateral circling behavior induced by apomorphine did not differ significantly in and 35 weeks old male and female rats. These results suggest that 6-OHDA treatment into left striatum causes remarkable destruction of intrastriatal dopaminergic neurons leading to dopaminergic receptor supersensitivity. Thus, the contralateral circling behavior induced by apomorphine may be used as indicator for neurodegenerative diseases.

Rat Brain cDNA Library로부터 SNAP-25 유전자의 클로닝

조애리,지영미,유민,이순철,유관희 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.1

SNAP-25는 presynaptic plasma membrane에 위치하는 단백질로서 synaptic vesicle의 docking과 fusion에 있어서 매우 중요한 역할을 한다. 생쥐 SNAP-25 유전자와 99%의 높은 homology를 갖고 있는 Z2 cDNA를 probe로 사용하여 쥐의 뇌 cDNA library에서 SNAP-25 유전자를 screening 하였다. 그 결과 6개의 양성 클론을 분리해 냈으며, 이들 각각을 S1, S2, S3, S4, S5, S6으로 명명하였다. 이중에서 생쥐 SNAP-25와 가장 높은 homology를 보여 주고 있는 S5 클론을 선택하여 염기서열을 분석하였다. 2,100 bp의 염기서열로 구성된 쥐 SNAP-25 cDNA는 206개의 아미노산을 coding하는 618 bp의 open reading frame을 가지고 있으며, ORF는 209∼211 bp에 위치하는 AUG codon에서 시작하여 827∼829 bp에 위치 하는 stop codon TAA에서 끝난다. 3' untranslated region에서는 28과 19개의 CA 반복 염기서열을 보여주고 있었으며, SNAP-25 peptide sequence에서 4개의 cystein residues는 84∼91에 위치하고 있었으며, amino terminus부분에서 amphipathic α-helix를 형성하고 있는 것을 볼 수 있었다. 사람과 쥐의 SNAP-25 유전자는 88%, 생쥐와 쥐의 경 우는 97%의 homology를 보여 주고 있었다. 그리고 사람과 쥐의 ORF에서 염기서열은 94%, 생쥐와 쥐의 ORF에서 염기서열은 100%의 homology를 보여주고 있었으며 사람, 생쥐, 그리고 쥐 의 ORF에서 아미노산 서열은 100%의 homology를 보여 주고 있었다. SNAP-25 was first investigated as a neuron-specific protein preferentially expressed in CA3 pyramidal neurons of mouse hippocampus. It is a presynaptic plasma membrane protein in the nerve cell and plays an important role in the synaptic vesicle membrane docking and fusion pathway. We have recently isolated SNAP-25 cDNA from a rat brain cDNA library using a probe of Z2 cDNA. It consisted of 2,101 bp and an open reading frame (ORF) was identified between nucleotides (nt) 209 and 827. The AUG codon (nt 209∼211) was surrounded by CTACCATGG, which corresponded to the consensus sequence of ribosomal binding site. The ORF was terminated by TAA (nt 827∼829) to encode a polypeptide of 206 amino acid residues. The 3'-untranslated region contained two extensive stretches of repeated (CA)28 and (CA)19 at positions 925∼980 and 1645∼1682. It is noteworthy that cysteine residues were clustered in the span of amino acid residues 84∼91 : Cys-Gly-Leu-Cys-Val-Cys-Pro-Cys. Rat SNAP-25 showed 88% and 97% identity in nucleotide sequences to that of human and mouse, respectively. Amino acid sequence of rat SNAP-25 showed 100% identity to that of mouse and human SNAP-25.