전기 기계적 해리로부터 회복된 쯔쯔가무시병에서의 급성 전격성 심근염

정영학,이민주,이경화,이지훈,김석형,이병권 이화여자대학교 의과학연구소 2016 EMJ (Ewha medical journal) Vol.39 No.1

Scrub typhus, caused by Orientia tsutsugamushi , is an acute febrile illness. Characteristics of tsutsugamushi disease are fever, rash and eschar. However, severe complications might rarely occur, such as acute fulminant myocarditis caused by scrub typhus. Thus, there are few reports of recovery from seriously complicated cases. We report on an adult male with scrub typhus complicated with acute fulminant myocarditis with no previous comorbid illness who recovered successfully with proper treatment including antibiotics, ventilator support, percutaneous cardiopulmonary support, and continuous renal replacement therapy.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)

김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2

Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.

The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

벼 무논골뿌림裁培時 播種期가 生育 및 收量에 미치는 影響

池在浚,朴裁成,朴成圭,李尙榮,洪性澤,孫錫龍 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

This study was carried out to determine the optimum seeding date for the rice(Oryza sativa L.) cultivation of the puddled-soil drill seeding, which is one of the efficient labor saving cultural methods, at the central part of Korea. Namweonbyeo, Anjungbyeo and Ilpumbyeo were seeded on four dates from April 10 to May 25, 1994 with the 15 day interval in the paddy field. In order to examine the adequate seeding date, the growth characters, yield components and yields were investigated. The coleoptile emerged 1 or 2 days earlier in Namweonbyeo than in Anjungbyeo and Ilpumbyeo, and later seeding resulted earlier coleoptile emergence. The number of seedling stands were higher in the order of Namweonbyeo, Anjungbyeo and Ilpumbyeo, was increased at the later seeding and was 81 to 88 seedlings on April 10 seeding. The plant height, number of leaves, number of tillers and dry weight at 50 days after seeding of all three cultivars were higher at later seeding. Leaf area index(LAI) were higher in the order of Ilpumbyeo, Anjungbyeo and Namweonbyeo. LAIs at the heading stage, at 30 days after heading and at 30 days before heading were higher in that order. The dry matter weight at the 30 days before heading was higher in sheath and stem than that in leaf blade, while, at heading stage, it was higher in the order of sheath and stem, leaf blade and panicle. On the other hand, at 30 days after heading, it was higher in the order of panicle, sheath and stem and leaf blade. The number of panicles per m2 was greater in the order of Ilpumbyeo, Anjungbyeo and Namweonbyeo. The ratio of ripened grain was reduced as the later seeding date. Its ratio was higher in Namweonbyeo than in Anjungbyeo and Ilpumbyeo. Yield of Namweonbyeo was lower than those of Anjungbyeo and Ilpumbyeo. Yield was decreased as the seeding date was delayed. Namweonbyeo showed the highest yield at seeding on May 10, while Anjungbyeo and Ilpumbyeo showed at seeding on April 25. The seeding date was negatively correlated with the ratio of ripened grain. while the number of seedling stands was positively correlated with the number of panicle per m2.

CAI를 활용한 프로그램이 청각장애아동의 듣기 및 말하기 능력 향상에 미치는 효과

이지현,석동일 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.1

The purpose of this study was to find out whether a child's hearing disorder was improved through CAI program. The experiment was conducted on three children with hearing disorder for fourty minutes a session, three times a week. The experiment was performed using subjects that consisted of three stages: baseline stage, treatment stage and maintenance stage. The ability to improve hearing and speaking was evaluated. The results were as follows; Firstly, the ability of hearing on different words through CAI program was improved after the treatment on all subjects. The result persisted. Secondly, the ability of hearing on various sentences through CAI program was improved after the treatment on all subjects. The result persisted. Finally, the subjects ability on speaking through CAI program was improved after treatment in all subject. The result persisted. CAI(Computer Assisted Instruction)를 활용한 프로그램은 소프트웨어 형태로서 컴퓨터에 프로그램만 설치하게 되면, 물리적인 공간에 상관없이 동일한 자극을 반복해서 줄 수 있다. 따라서 아동이 집에서 공부할 때도 치료사와 공부했던 기억을 되살리는 데 많은 도움을 주게 되며, 부모가 가정에서 지도 시 치료사와 동일한 자료로 공부하게 됨으로써 가정에서 교육할 때 교재로 인한 부담감을 줄일 수 있다. 또한 물리적 환경의 약점을 보완해 줄 수 있으며, 아동의 흥미를 유발하는 것과 동시에 집중력을 높여주고, 즉각적인 피드백을 제공하며 아동 스스로 프로그램을 진행시키면서 학습할 수 있다는 데 본 연구의 필요성을 가진다. 이와 같은 필요성에 기초하여 본 연구에서는 CAI를 활용한 프로그램이 청각장애 아동의 듣기 및 말하기 능력에 미치는 효과를 밝히는데 목적을 두었다. 이 연구의 대상자는 대구 OO 치료실에 다니는 청각장애 아동 3명을 대상으로 하였으며, 사용한 CAI 프로그램은 언어치료실과 가정에서 사용할 수 있도록 Macromedia사의 Directer 8.5를 이용하여 CD-Title로 제작하였다. 이 연구는 세 명의 대상아동에 대한 CAI 프로그램의 효과를 평가하기 위해서 피험자 간 중다기초선 설계법(multiple baseline design)을 적용하였다. 본 연구는 CAI를 활용한 프로그램을 청각장애아동에게 적용시켰을 때, 단어수준 및 문장수준 듣기 능력 향상과 말하기 능력 향상에 대한 효과를 알아보기 위해서 실시하였다. 본 연구에서 얻은 주요 결과를 요약하면 대상 아동 모두에게서 단어수준과 문장수준에서 듣기 능력이 향상되었고, 아울러 말하기 능력도 향상되었다. 이 결과는 치료를 종결한 후에 실시한 유지평가에서도 유지되는 것으로 나타났다. 이런 결과에 비추어 CAI 프로그램은 청각장애아동 언어치료의 한계성을 극복할 수 있는 방법 중의 하나로 보여 진다.

鮟鱇網 漁具 漁法의 改良에 관한 硏究(Ⅱ) : 展開帆을 이용한 改良漁具 試驗(豫報)

李吉來,宋之浩,朴鍾洙,徐萬錫,趙鳳坤,朴正鎬,洪聖根,鄭公炘,裵錫悌,鄭與基,金鎭乾 군산대학교 1980 群山水産專門大學 硏究報告 Vol.14 No.1

Ordinarily stow net fisheries was used by floater beam and sinker beam for the purpose of spreading the mouth of net. But it was not only iuconvenient and dangerous but much defective. In this thesis, we have studied fundermental experiment of the improved stow net fishing gear using head rope, ground rope and otter sail instead of floater beam and sinker beam. From the result of this experiment, it has been succeeded for fishing work to achieve basically without any difficulty. The results obtained in this study were as follows. 1) The resistance of fishing gear was estimated R≒7V2 as possible as it is taken greatly. (R: Resistance V: the rate of current) 2) The interval of otter sail was spreaded smoothly. Being in normal condition, it was maintamed the width 37-38m. It was heared comparison with net mouth of ordinary gear, and the shearing force was enough. 3) The height of mouth was lower than we have anticipated to and seemed to have the supplement of buoyancy. But according to increasing the rate of current, the lowness of mouth height was little affected. 4) The height of otter sail was decreased at the rate of 30% by the rate of current, on the contrary, the height of wing was not decreased owing to sufficient buoyancy, 5) The adjustment of extention length of hanging wire(connected with fishing boat) and raising wire(with otter sail) was great important problem and it must be dealed with the most moderatly because of a corelation between the spreading of fishing gear and catching ability. 6) On the depth of 30m, it was taken 25 minuits to cast anchor and lines, 20 min cast net, 24 min haul net, 45 min haul lines and heave anchor, respectively. 7) The improved stow net with otter sail was cleared up the defects and difficult problems in ordinary gear using floater beam and sinker beam, and it have more advantages of fishing work than ordinary one. But there were involved in lots of problems in details to solve in the future.

반려동물의 기생충검사 이론 및 실제

이성호,박영석,박병권,김상기,정지윤,박수진,박창식,김병수 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

The aim of this article is to improve human health and that of companion animals by improving the diagnosis and control of parasitic diseases. This is achieved by research into parasites of veterinary significance including zoonoses and the use of comparative systems to increase our understanding of some human parasitic diseases. We should promotes learning and teaching through knowledge and operates a diagnostic unit that offers a service to pet owner for indigenous and exotic parasitic diseases of companion animals. We must diagnose and treat them early. Zoonotic parasites are very important because many of animal parasites are zoonoses and give pain and death to human. Parasites are divided Protozoa, Helminthes and Arthropods. There are many protozoa, about 65,000 species. Arthropods are the vector of another diseases, such as virus, bacteria, protozoa and nematodes. Helminthes are composed of Trematoda, Cestoda, Nematoda and Acanthocephala. The target of Veterinary Parasitology is to recognize the characteristics of these parasites and subsequently diagnose, treat and control them. This article is intended to familiarize you with the essential facts and concepts of companion animal parasitology. Emphasis is placed on fecal sample techniques (comparison of fecal examination techniques; frequently found artifacts in fecal smears; direct Smear; zinc sulfate flotation; etc.) We recommend that the study be done to more references on animal parasites.

법랑아세포종에서의 p53 및 MIB-1 발현 : 임상 및 병리학적 요인들간의 연관성 Correlation Between Clincopathologic Parameters

이수운,한지용,권창석,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Thirty five patinets' paraffin embedded biops block , which was previously diagnosed ameloblastoma and obtained from oral and maxillofacial surgery dept. of pusan paik hospital and OMS dept of collage dentistry, pusan national university hospital, from January 1994 to march 1999, were performed immunohistochemistry with p-53 and MIB-1. On investigating the expression, correlation between clinical and histologic factor and correlation between prognosis and moleculopathologic property were examined. And we obtained the following results; 1. Age over forty, recurrence rate was 58.5%. 91.4% of the tumor was developed on mandibule, recurrence rate of maxilla area tumor was 66.7% On radiologic and histologic feature, multilocular and follicular type has high recurrence rate but no significance statistical difference was found 2. Expression of p-53 was 25.7%, When underage of forty. location on mandibule, multilocular and plexiform type, the expression of p-53 was somewhat higher and recurred cases of tumor, expression rate was 12.5%. 3. MIB-1 expression rate was 77.1%. When location on mandibule, unilocular, plexiform type tumor and previously recurred case, MIB-1 expression was 87.5% which was somewhat higher than no recurrence case of 74.1%. 4. 33.3.% of positive on MIB-1 have expression of p-53 and all p-53 positive case express MIB-1 positive. All p-53 positive case have high cell proliferation rate. From this result, age and location have closely related with the prognosis of tumor, histologic feature and MIB-1 expression has related with the prognosis of tumor. But p-53 has highly expressed on cell proliferation area, not closely related with the prognosis of tumor.

딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향

이승우,감성훈,홍지웅,최기송,박은석,지상철 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50∼90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.