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현탁액중 수크랄페이트 , 노이시린 , 히드로탈사이트에 의한 방부제의 흡착
지상철,이기준,박은서,정병기 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4
In order to screen appropriate preservatives for the suspension containing sucralfate, neusilin and hydrotalcite, the patterns and mechanism of the adsorption and desorption of several preservatives on these antacids were studied. The employed preservatives were parabens(methyl, propyl, butyl), chlorhexidine diacetate and sorbic acid. While none of parabens were adsorbed on three antacids, chlorhexidine diacetate was strongly adsorbed on all the antacids employed, especially on hydrotalcite. Sorbic acid was not adsorbed on nesilin and hydrotalcite, however, 65% of sorbic acid was adsorbed on sucralfate. The adsorption of chlorhexidine diacetate on neusilin and hydrotalcite was partly physical and partly chemical, while its adsorption on sucralfate was almost chemical. Sorbic acid was completely desorbed from sucralfate. In all cases, the adsorption isotherms were fitted well to both Freundlich equation and Langmuir equation. Based on these results, parabens and sorbic acid were the preservatives of choice for the suspension containing sucralfate, neusilin and hydrotalcite.
지상철,이윤석,박은석 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.3
The bioequivalence of two nabumetone tablets was evaluated in 16 normal male volunteers (age 21∼30 yrs) following oral administration. Test product was "Nacton tablet" made by Jin Yang Pharmaceutical Co. and reference product was "Unimeton tablet" made by Dong Kwang Pharmaceutical Co.. After one tablet containing 500 ㎎ of nabumetone was administered, blood was taken at predetermined time intervals and the concentration of 6-methoxy-2-naphthylacetic acid, active metabolite of nabumetone, in plasma was determined with an HPLC method using fluorescence detector. AUC, C_(max) and T_(max) were calculated and statistically analyzed for the bioequivalence of the two products. The results showed that the differences in AUC, C_(max) and T_(max) between two products were 3.66%, 6.87% and 1.85%, respectively. The powers(1-β) for AUC. C_(max) and T_(max) were 91.4%, 88.9% and 81.1%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%. All of these parameters met the criteria of FDA for bioequivalence, indicating that "Nacton tablet" is bioequivalent to "Unimeton tablet".