정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)

김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.

Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

부산지역 수돗물과 지하수의 중금속 농도

김준연,손지언,김형수,김두희,원미숙,김인식,이혜령 동아대학교 산업의학연구소 2000 산업의학연구소 논총 Vol.- No.5

This study investigated mean airborne CO concention of 15 workplaces, suspected of CO exposure and conducted self-reported questionnaire completion and indirect COHb concentration measure using Micro II Smokerlyzer to healthy 702 adult subjects from 1999 May to 1999 September in order to find a relation of CO exposure and occupational factors, socioeconomic factors, and health related behaviors and confirm the related conditions in the screening test for CO exposure. The results of this study were summarized as follows : 1. In the CO exposed and non exposed group, COHb concentrations of the smokers were 2.55±0.96% and 2.21±0.97% and that got a statistically significant difference, There were not statistically significant differences in the age and total smoking index. Passed times after the last smoking, Working time/day, and working duration were statistically significant difference (p〈0.05). 2. In the CO exposed and non exposed group, COHb concentrations of non-smoking group were 0.94±0.35% and 0.68±0.47% and that got a statistically significant difference. There were not statistically significant differences in the age and working duration but Working time/day was a statistically significant difference(p〈0.05). 3. In the CO exposed group, r-square of multiple regression of the smokers was 38.5 % and passed time after the last smoking, working time/day, and job category were statistically significant differences (p〈0.05). And r-square in the CO non-exposed group was 38.3 % and age, passed time after the last smoking, and total smoking index were statistically significant difference. 4. In the CO exposed group, r-square of multiple repression of the non-smokers was 66.3% and job category and airborne CO concentration were statistically significant differences(p〈0.05). But r-square of non-smokers in the CO non-exposed group was 1.0% and there was not a statistically significant difference(p〈0.05). 5. In the smokers of CO exposed and non exposed groups, relation of COHb concentration and passed time after the last smoking was expressed as exponential function, Y = 2.9182e-0.0083x and r-square of this function was 37.4%. Therefore it was more than 150 minutes that passed time after the last smoking was when COHb concentrations were measured as less than 1%. In conclusion, variable, that was statistically significant to COHb concentraion in the both CO exposed and non-exposed smokers, was a passed time after the last smoking. We suggest that you have to restrict the smoking of smokers at least 150 minutes in the exposed and non exposed group before COHb concentration measure in order to exclude smoking effects

PSPICE를 이용한 수정된 Chua회로의 카오스 통신 시뮬레이션

김성곤,배준호,호인석,최희주,변건식 東亞大學校 附設 情報通信硏究所 1999 情報通信硏究所論文誌 Vol.7 No.1

Recently, there has been much interest in utilizing chaotic circuits to implement a secure communication. Although Chua's circuit is the simplest chaotic circuit, it has complex chaotic dynamic porperties. The modified Chua's circuit has two additional components more than Chua's cirecuit and makes the circuit equations become fore-dimensional instead of three-dimensional, it makes Chua's circuit more flexible. In this paper, we use two modified Chua's oscillators to simulation on the chaos control and synchronizaion. The simulation results show that the modified Chua's oscillator has good chaotic control and sunchronization. And we have successfully carried out the basic esperiment on the chaotic secure communication.

HPLC를 이용한 농약 Carbendazim의 측정법에 관한 연구

김준서,조만희,이상한,김창세 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

The measurements of pesticide Carbendazim were studied and following conditions were proposed as a most good methods; 1. There were detected at 204 nm by means of Hitachi 200-20 spectrophotometer. 2. Pesticide Carbendazim mesurement was performed by menas of ISCO model 2350, spherisorb ODS column, 70% acetonitrile as a solvent phase, flow rate 0.5 ml/min, chart speed 0.5 cm/min, and 25℃ oven temperature. 3. The relationships between the concentration and absorbance of pesticide Carbendazim were linear from 2.5 to 15 ppm. 4. It showed stable result in Folin-Wu, and the recovery rate was also good.

스타이렌 아이오노머의 기계적인 성질에 미치는 혼합 양이온의 영향

김희석,나연화,이용혁,이법원,유지강,박기주,김준섭 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.1

The styrene-co-methacrylate ionomers neutralized with Na +, Ba2 +, and mixed cation of both were prepared. The dynamic mechanical properties of two cation-containing ionomers were measured and compared to those of the ionomers neutralized with only one type of cations. We found that in the ionomers with one type of cations the difference in the type of cation does not change the glass transition temperatures. It was found, however, that the cluster Tg of the mixed cation ionomer is lower than that of the single cation ionomers. Thus it was postulated that in the two-cation system the two cations in a solution have sufficient dynamics to form new type of multiplet containing both cations, which may be slightly bigger than that found in the single cation multiplet. The mechanical properties also imply that the strength of ion interactions in the multiplets of the two cation ionomer is thought to be weaker than that of the one cation ionomers. These two effects are believed to contribute the lower in the cluster glass transition of mixed cation system.

스포츠시설 불만족 고객의 재구매 보상요인

김상대,이준희 한국스포츠산업경영학회 2000 한국스포츠산업경영학회지 Vol.5 No.1

본 연구는 스포츠시설의 최초 구매활동에서 불만족을 경험한 소비자가 구매단절을 하지 않고 재 구매를 할 경우 불만족에 대한 보상요인으로서 스포츠시설의 3대 구성요소를 스포츠시설의 입지조건, 설비수준, 인적서비스 등으로 분류하여 이것들이 인구통계변수와 이용유형에 따른 변화의 차이를 분석하기 위한 것이다. 이러한 목적에 의하여 부산시내에 소재한 6개 스포츠시설을 3개월 이상 계속하여 이용하고 있는 성인 600명을 대상으로 자기평가기입법에 의한 설문조사를 실시한 후 최초의 구매결과에서 불만족을 경험한 것으로 응답한 남자 105명, 여자 126명의 자료를 SPSS Win 7.5를 이용 통계처리 하였으며, 자료분석을 위하여 사용한 통계분석방법으로는 Pearson의 적률상관분석과 Fisher의 Z-score를 채택하였다. 이상의 연구절차를 통하여 얻은 결론은 다음과 같다. 첫째, 스포츠시설의 입지조건은 인구통계 변수 중 소득수준에서, 참가유형에서는 주로 참가하는 종목에 따라 보상받는 정도가 높게 나타났다. 둘째, 스포츠시설의 설비수준에서는 인구통계변수의 직업군 중 전문직, 학력에서는 대학원을 졸업한 집단을 제외한 나머지 집단에서 유의한 것으로 나타났다. 셋째, 인적 서비스에 의하여 불만족을 보상받는 경우는 인구통계변수 중 대졸집단에서, 이용유형에서는 헬스 및 에어로빅을 주로 하는 집단에서만 유의한 관계를 가지는 것으로 나타났다. 따라서 스포츠시설의 구성요소 중 설비수준이 불만족을 상쇄하는 정도가 전 집단에서 가장 유효한 것을 알 수 있었다. This study was aimed to understand the role in the three component factors of sports facilities as compensation factor for dissatisfaction in the case that customers who were not satisfied in the first purchase are keeping purchase, not stoping purchase. As the same aim, the condition of location . the level of equipment, and man service in the sports facilities are classified into three component factors in sports facilities, these results were analyzed the difference of changes according to statistics variables and using types. The counterparts of this study who have using over 3 months in sports facilities located in Pusan, have been not satisfied with the results of the first purchase, 105 male and 126 female, conducted the inquiries by self-administration method, that is dealt with the statistics package of SPSS Win 7.5. statistics analysis method used for analyzing data adopt Quantities correlation analysis of Pearson and Z-score of R.A. Fisher. The conclusion of this study are showed as followings: First, the degrees of compensation showed that location of sports facilities is affected by the level of income among population statistics condition of sport facilities, joining type is affected by the participating event. Second, the level of equipment showed significantly in professional among the groups of population statistics variables, and the rest group exclude the post graduated university. The last, in the case of having compensation against dissatisfaction owing to man-service, that showed significant relations in graduated university group in population statistics variables and the group which use mainly health center and/or aerobics in using type. In conclusion, the level of equipment in component factors in component factors in sports facilities showed the most significant with the degrees of compensation to decrease of dissatisfaction in every group.

비만 펩티드 백신의 효능에 영향을 미치는 구조적 요소

김형진,이희종,김효준 한양대학교 이학기술연구소 2007 이학기술논문지 Vol.10 No.-

Apo B-100 is a constitutive component of low density lipoprotein (LDL) of which functions in packaging, transport, and absorption of lipids. Extortive binding of anti B4-antibody onto Apo B-100 should inhibited the functions of Apo B-100. Previously, we had showed that the peptide B4 induced antibodies recognized Apo B-100 and thus elicited anti-obesity effect. In this study, we compared the efficacy of peptide vaccine against obesity and of antibody inducing immune response by introducing additional peptides fused to B₄ Peptide. Previously, we had constructed B₄T, introducing additional peptides fused to the C-terminal of B₄ peptide, and BTB, fused to the middle of B₄ peptide, with preS2 of HBV. Then we manufactured vaccines, and vaccinated on C57BL/6 mouse. We measured weight of mice 3 days a week and, after vaccinating, we gathered blood and performed ELISA in interval 2 weeks for indicating antibody inducing immune response. Among these two artificial vaccines, B₄T was better Vaccine against obesity than another. But BTB was batter efficient inducer of the antibody against B₄. These result explains that B₄ tetramer is very crucial structural factor to operate as an obesity vaccine. Apo B-100은 low-density lipoprotein의 구성 요소로서 지방의 패키징, 운송, 흡수를 담당한다. App B-100에 anti B4-antibody의 인위적 결합은 이러한 Apo B-100의 기능을 저해할 것이다. 선행 연구에서 B4 펩티드에 의해 유도된 antibody가 Apo B-100을 인지하고 그에 따라 비만억제 효과를 나타내는 것을 확인하였다. 본 연구는 비만에 대한 B cell epitope을 4번 반복한 B4 펩티드에 추가적인 펩티드를 연결한 두 가지의 백신을 사용하여 효능을 비교하였다. HBV의 preS2를 B4의 C-terminal에 연결한 B₄T와 중간에 삽입시킨 BTB를 제조하여 C57BL/6 마우스에 주사하였다. 일주일에 3회 마우스의 체중을 측정하였고, 백신 주사는 2주 간격으로 4회 실시하였으며, 백신 주사 후 2주 간격으로 혈액을 채취하여 면역 반응에 의해 유도된 antibody를 indirect Enzyme -Linked Immunosorbent Assay에 의해 측정하였다. 두 가지 백신 사이에서 체중 증가 억제율로 본 비만에 대한 백신효과는 B₄T가 더 우수하였다. 그러나 B₄T에 비해 BTB가 유도된 antibody의 titer와 혈중 지속 시간이 더 우수했다. 이런 결과는 B펩티드가 항체유도에 있어서 중요하지만, 비만억제 기능에 있어서 B₄ tetramer가 매우 중요한 인자임을 입증하였다.

자매에서 발생한 중증 마이코플라즈마 폐렴에서 스테로이드 치료

김도희,이경일,김명숙,윤유숙,황자영,임정우,강진한,이준성 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Numerous evidences support the pathogenesis that M. pneumonias pneumonia is associated with cell-mediat-ed immune reaction. We report 2 cases of severe M. pneumoniae pneumonia in previously healthy sisters, who were both admitted during an epidemic of M. pneumoniae pneumonia. The elder sister, who was 16 years old, was admitted with M. pneumoniae pneumonia. She showed no response to treatment with clarithroycin and levo-floxacin, and eventually progressed to severe ARDS, requiring mechanical ventilation. After treatment with hydrocortisone (200 mg/day), there were rapid improvements in clinical manifestations and chest radiographic findings. The younger sister, who was 14 years old, was admitted 10 days later, Presenting with fever but no pneumonic lesions on chest radiograph. Just like her sister, the infection showed no response to clarithromycin. Fever persisted and pneumonic consolidation with mild pleural effusion was noticed in the left lower lobe on the 5th hospital-day. After treatment with oral prednisolone (1 mg/kg), she showed rapid defervescence and on the 8th hospital day, no pneumonic lesions were detectable on chest radiograph. Given the fact that the pathogenesis of pneumonia and extrapulmonary manifestations in M. pneumoniae infection is immune-mediated, an immuno-suppressive therapy would be validated for selected patients with M. pneumoniae infections.