젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구

이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1

Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.

濟州道 住民 蟯蟲感染의 疫學的 硏究

李根泰,李範珪,盧英俊,任世旭,李在興 醫藥係社 1955 綜合 醫學 Vol.12 No.12

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

중ㆍ고년여성의 하지 근 기능과 요부 및 대퇴근 횡단면적의 상관관계

김창근,이수경,권영우,박정배 한국체육대학교 체육과학연구소 2001 국제학술대회논문집 Vol.20 No.1

The purpose of the present study was to investigate the relationship between isokinetic muscle function and muscle cross-sectional area (CSA). Twelve women participated in the present study, divided young (n=6, 23.7±1.9 year) and elderly women (n=6, 60.3±6.8 year). Isokinetic strength (power, strength, endurance) and CSA (psoas major and thigh muscles) measured with dynamometer and computerized tomograph, respectively. Cross-sectional area of psoas major muscle in elderly group revealed markedly smaller than in young group, but thigh muscle was not the case. Muscle CSA in young women correlated between power and endurance and psoas major muscle, as well as between muscle strength and CSA of thigh muscle. But no correlation occurred between strength and cross sectional area, except endurance which was highly correlated between CSA and endurance. In conclusion, aging decreases muscle function and CSA. Partially muscle strength correlated with muscle CSA in young women, but no correlation occurred in elderly women. Further study needed to elucidate the exact mechanism related to aging muscle with muscle density and neuromuscular function.

감마선(^60Co) 조사에 의한 항진균 세균의 돌연변이체 유도

정혜영,이영근,김재성,조규성,이영복 한국환경농학회 2002 한국환경농학회지 Vol.21 No.3

항진균 세균의 특성 및 기능변화 가능성을 조사하기 위하여 버섯폐배지, 온천수, 해조류 및 삼림토양으로부터 식물병원성 진균에 대한 8 종의 항진균 활성 균주를 분리하였고 감마선(^60Co)을 이용하여 LD_95 에 돌연변이체를 유도하였다. Bactllus circulans K1, Burkholderia gladioli K4와 Bacillussubtilis YSl은 12 종의 식물병원성 진균에 대go 항진균 활성을 보였다. 이들 균주의 방사선감수성 조사결과 B. gladioliK4는 감마선에 대한 높은 감수성을 보였으며, D_10 값은 0.11kGy 였다. 감마선에 의해 유도된 Kl-1004와 YSl-1009는Botryosphaeria dothidea에 대해 항진균 활성이 증가되었다. B.subtilis YS1의 돌연변이체인 YSl-1006과 YS1-1009는 tebuconazol과 copper hydroxide에 대해 농약 저항성을 나타냈다. SAR535, SAR5108 과 SAR5l18 돌연변이체는 야생형 균주인 Streptomyces sp. SAR01에 비해 5 종의 식물병원성 진균에 대해 항진균 활성이 없었다. 연구결과, 방사선을 이용하여 다양한 기능의 돌연변이체 유도가 가능하였다. 이를 이용하여 항진균 활성 관련 유전자 연구 및 균주개량이 가능할 것으로 사료된다. In order to evaluate the antifungal activity of bacteria against plant pathogenic fungi, 8 bacteria were isolated from mushroom compost, hot spring, seaweed, and forest soil and mutants from them were induced by LD_(95) gamma radiadon(^(60)Co). Bacillus circuluns K1, Burkholderia gladioli K4 and Bacillus subtilis YS1 showed wide antifungal spectrum against 12 kinds of plant pathogenic fungi. From the radiation sensitivity test, R gladioli K4 was very sensitive to gamma radiation and its D_(10) value was 0.11 kGy. Antifungal activities of B. circulans K1-1004 and B. subtilis YS1-1009, which were induced by the radiation of ^(60)Co increased against Botryosphaeria dothidea. The mutant strains, B. subtilis YS1-1006 and B. subtilis YS1-1009 were resistant to tebuconazole and copper hydroxide. SAR535, SAR5108, and SAR5118 mutated from Streptomyces sp. SAR01 were antifungal activity deficient mutants against 5 kinds of plant pathogenic fungi compared to wild strain, so that they could be supposed to be model strains for studying antifungal mechanism. It is suggested that various functional types of mutants could be induced by gamma radiation and applied usefully.

겉보기 탄성계수와 탄성이론해를 이용한 터널안정성 평가

이재호(Lee Jae Ho),정윤영(Jeong Yun Young),박영화(Park Young Hwa),권근철(Kwon Keun Cheol) 대한토목학회 2009 대한토목학회 학술대회 Vol.2009 No.10

비혈연간 동종골수이식에 의해 치료된 중증 재생불량성빈혈 1예

김현중,이홍기,이방훈,이창근,이종태,정현식,김원석,윤성수,강원기,박근칠,김대식,고영혜,박찬형 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

비혈연간 동종골수이식은 혈연간 동종골수이식이 불가능한 환자에서 기존의 면역역제요법으로 효과가 없었던 경우나 재발한 경우에 적응증이 될수 있다. 이식 거부와 이식편대숙주병의 발생이 골수 이식의 성공률을 감소시키므로, 보다 강력한 conditioning regimen의 사용과 T cell이 제거된 골수를 사용하는 것이 필요하다. 기존의 high dose corticosteroid나 cyclosporine에 대하여 불응성인 이식편대숙주병의 치료를 위해서 ATG와 Mycophenolate mofetil (Cellcept®) 의 사용이나 Tacrolimus, Methotrexate와 같은 다른 면역억제제치료를 고려해 볼 수 있다. It is known that allogenic bone marrow transplantation is the most effective treatment for aplastic anemia. However, this treatment is only applicable to a minority of patients because the proportion of patients who have HLA-matched siblings about 25% to 30% of all the aplastic anemia patients. In the case of the absence of HLA-matched donor, unrelated allogenic bone marrow transplantation is considered. However, (because of severe acute and chronic GVHD and graft failure) the success rate of this approach is only 20~30%. Recently, it was reported that increased immunosuppressive condition combined with T cell depletion of the marrow graft would result in greater success. There was no case of successfully treated aplastic anemia patient by unrelated allogenic bone marrow transplantation in Korea. Here, we report a case of severe aplastic anemia successfully treated with unrelated allogenic bone marrow transplantation.

청소년의 인터넷 중독 정도에 따른 정신과적 공존질환 및 행동 양상에 관한 연구

이준영(June-Young Lee),박이진(E-Jin Park),조근호(Keun-Ho Joe),채숙희(Suk-Hi Chai),김성벽(Sung-Byuk Kim),이창욱(Chang-Uk Lee),김대진(Dai-Jin Kim) 한국중독정신의학회 2010 중독정신의학 Vol.14 No.1

Objectives:This study aimed to clarify the differences in psychiatric comorbidities and, behavioral patterns correlating with the severity of Internet addiction in adolescents. Methods:We assessed 321 adolescents recruited from an Internet rescue school, psychiatric outpatients, and 4 schools in Seoul and Gyeonggido. We divided them into a non-addicted group, a potential-risk group, and a high-risk group according to Young’s Internet Addiction Test (IAT). We evaluated their psychiatric comorbidities and behavioral patterns via psychiatric clinical interview, the Children’s Depression Inventory (CDI), the State-Trait Anxiety Inventory (STAI), and a self-report questionnaire about behavioral pat-terns. Results:There were significant differences in CDI and STAI scores among the 3 groups. The IAT, CDI, and STAI scores correlated positively with each other. There were differences in psychiatric comorbidity distributions between the potential-risk and high-risk groups, but only “other mood disorder” showed a significant difference. There were also significant differences in behavioral patterns among the 3 groups. Conclusion:This study suggests that there are psychiatric comorbidity and behavioral pat-tern differences according to Internet addiction severity in adolescents. We expect further studies will reveal more profound understandings of these relationships.

Interfacial Characteristics of Epoxy Composites Filled with γ-APS Treated Natural Zeolite

이재영,이상근,김상욱,Lee, Jae-Young,Lee, Sang-Keun,Kim, Sang-Wook 한국접착및계면학회 2001 접착 및 계면 Vol.2 No.3

${\gamma}$-APS (${\gamma}$-aminopropyltriethoxysilane)로 표면처리된 천연제올라이트와 에폭시 수지 복합 재료의 표면 자유 에너지, 인상강도 및 계면 모폴로지에 대해 연구하였다. 표면처리하지 천연제올라이트의 표면 자유에너지 성분 중에서 무극성 성분인 Lifshitz-van der Waals 성분, ${\gamma}{\frac{LW}{SV}}$는 $19.22mJ/m^2$이었고, 극성 성분인 Lewis acid-base 성분, ${\gamma}{\frac{AB}{SV}}$는 $15.27mJ/m^2$이 있다. ${\gamma}$-APS의 처리농도가 증가함에 따라 ${\gamma}{\frac{LW}{SV}}$값은 증가하였지만 ${\gamma}{\frac{AB}{SV}}$는 감소하였으며, 이는 ${\gamma}$-APS의 소수성 성분인 알킬기의 영향이 친수성 기인 아민이나 수산기의 영향보다 커지기 때문이다. 인장강도와 Young율은 ${\gamma}$-APS 처리에 의해 개선되었으며, SEM 분석에 의해 계면특성이 향상되었음을 확인하였다. Epoxy composites filled with natural zeolite was prepared to investigate the effects of silane coupling agent, ${\gamma}$-APS (${\gamma}$-aminopropyltriethoxysilane)on the surface free energy, tensile properties and interfacial morphology. The value of Lifshitz-van der Waals component, ${\gamma}{\frac{LW}{SV}}$ for polar was $19.22mJ/m^2$ and increased, while that of Lewis acid-base component, ${\gamma}{\frac{AB}{SV}}$ for polar was $15.27mJ/m^2$ and decreased with the increasing content of ${\gamma}$-APS treatment. It is due that the surface of the zeolite is more coated by hydrophobic of alkyl group than hydrophilic amine or hydroxyl group. The tensile strength and Young's modulus of epoxy system were improved by the treatment with ${\gamma}$-APS due to the strong interface bonding, which was confirmed by SEM.