수면박탈이 각성 뇌파의 양수 리아프노프 지수에 미치는 효과에 관한 연구

김대진 ( Dai Jin Kim ),정재승 ( Jae Seung Jeong ),채정호 ( Jeong Ho Chae ),고효진 ( Hyo Jin Go ),김춘길 ( Choon Gil Kim ),김수용 ( Soo Yong Kim ),백인호 ( In Ho Paik ) 한국감성과학회 1997 연차 학술대회 논문집 Vol.1997 No.-

Sleep deprivation may affect the brain functions such as cognition and, consequently, dynamics of the EEG. We examined the effects of sleep deprivation on chaoticity of the EEG. Five volunteers were sleep-deprived over a period of 24 hours. They were checked by EEG during two days, the first day of baseline period and the second day of total sleep deprivation period. EEGs were recorded from 16 channels for nonlinear analysis. We employed a method of minimum embedding dimension to calculate the first positive Lyapunov exponent. For limited noisy data this algorithm was strikingly faster and more accurate than previous ones. Our results show that the sleep deprived volunteers had lower values of the first positive Lyapunov exponent at ten channels (Fp1, F4, F8, T4, T5, C3, C4, P3, P4, O1) compared with the values of baseline periods. These results suggested that sleep deprivation leads to decrease of chaotic activity in brain and impairment of the information processing in the brain. We suggested that nonlinear analysis of the EEG before and after sleep deprivation the role of sleep and the effects of sleep deprivation on the brain function.

주파수 가변 고속 디지털 MRI 모뎀 RF부 설계와 구현

김용철,박현대,김대진 전남대학교 전자통신기술연구소 2001 전자통신기술논문지 Vol.4 No.1

In this paper, we designed and made RF block of variable frequency digital modem for high speed MIRI system that can support not only multi-nuclei system but also any magnetic intensity(1.0T~3.0T). We executed simulation of fixed frequency digital modem using fixed band pass filter(BPF), variable frequency digital modem using variable band pass filter(tunable filter). Based on these simulations, variable band pass filter(tunable filter) named Micropole is ordered and manufactured. We designed and made RF block of variable frequency digital modem for high speed MRI system using variable band pass filter(tunable filter). And then we tested this board using PC and function generator and observed the output spectrum using spectrum analyzer. These spectrums are very clear and wide bandwidth about 500KHz and the level of main spectrum is 60~70dB more than harmonics or spurious. This difference of level is available for MRI system.

리아프노프 지수를 이용한 알쯔하이머형 치매 환자 뇌파의 비선형 역동 분석을 위한 예비연구

채정호,김대진,최성빈,박원명,이정태,김광수,정재승,김수용,Chae, Jeong-Ho,Kim, Dai-Jin,Choi, Sung-Bin,Bahk, Won-Myong,Lee, Chung Tai,Kim, Kwang-Soo,Jeong, Jaeseung,Kim, Soo-Yong 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

치매에서의 뇌파 연구는 주로 주파수 분석과 지형화 분석을 이용하여 정량화하는 것을 위주로 진행되어 왔으나, 이러한 선형적 분석은 뇌파와 같이 복잡한 신호를 분석하는 것에는 한계가 있었다. 최근 새로운 패러다임인 카오스 이론에 근거를 두고 뇌파를 비선형적으로 측정하는 방법이 소개되고 있다. 본 연구는 알쯔하이머형 치매 환자의 뇌파 신호를 최대 양수 리아프노프 지수를 이용하여 비선형적으로 분석하는 것이 가능한 가를 알아보고 그 결과를 대조군과 비교해보기 위하여 시도되었다. 3명의 알쯔하이머형 치매 환자와 3명의 대조군에서 뇌파 신호를 받아 디지털화한 후에 비선형 분석법 중 하나인 최대 양수 리아프노프 지수를 산출하였다. 알쯔하이머형 치매군은 전체 15개의 전극 부위 중 8곳의 전극 부위에서 대조군에 비하여 유의하게 낮은 최대 양수 리아프노프 지수를 나타내었다. 각 두뇌 영역별 및 반구별 분석에서도 알쯔하이머형 치매군이 대조군에 비하여 전 두뇌 영역에서 최대 양수 리아프노프 지수가 유의하게 낮았다. 이에 따라 알쯔하이머형 치매 환자의 뇌파를 비선형적 분석하여 조사한 이들 두뇌의 카오스적 성상이 감소되어 있다는 것을 확인할 수 있었다. 이 결과는 향후 뇌파의 비선형적 분석인 리아프노프 지수 산출이 두뇌 기능을 조사하는 데에 유용한 새로운 방법이 될 가능성이 있다는 것을 시사한다. The changes of electroencephalogram(EEG) in patients with dementia of Alzheimer's type are most commonly studied by analyzing power or magnitude in traditionally defined frequency bands. However because of the absence of an identified metric which quantifies the complex amount of information, there are many limitations in using such a linear method. According to the chaos theory, irregular signals of EEG can be also resulted from low dimensional deterministic chaos. Chaotic nonlinear dynamics in the EEG can be studied by calculating the largest Lyapunov exponent($L_1$). The authors have analyzed EEG epochs from three patients with dementia of Alzheimer's type and three matched control subjects. The largest $L_1$ is calculated from EEG epochs consisting of 16,384 data points per channel in 15 channels. The results showed that patients with dementia of Alzheimer's type had significantly lower $L_1$ than non-demented controls on 8 channels. Topographic analysis showed that the $L_1$ were significantly lower in patients with Alzheimer's disease on all the frontal, temporal, central, and occipital head regions. These results show that brains of patients with dementia of Alzheimer's type have a decreased chaotic quality of electrophysiological behavior. We conclude that the nonlinear analysis such as calculating the $L_1$ can be a promising tool for detecting relative changes in the complexity of brain dynamics.

중독 정신 병리의 이해 : 뇌영상 연구를 중심으로

민정아,김대진,Min, Jung-Ah,Kim, Dai-Jin 대한생물정신의학회 2011 생물정신의학 Vol.18 No.2

Substance addiction is a chronically relapsing disorder that has been characterized by a vicious cycle composed of intoxication, craving/anticipation, withdrawal, and response inhibition/bingeing. Here we summarize the findings from neuroimaging studies in addiction according to these behavioral components and suggest the integrated neurobiological model of drug addiction and related brain correlates. The roles of various prefrontal regions, thalamus, memory circuit, anterior cingulated, and insula were also suggested in addition to those of classical mesolimbic dopaminergic system and its responsivity. Limited studies of behavioral addiction demonstrated a similarity with substance addiction on the neurobiological basis. Based on the current understanding of neurobiology of addiction, further researches on interactions of behavioral components and their brain correlates, behavioral addiction, and therapeutic applications will be desired.

매개 모형을 통하여 고찰한 우울과 주의력결핍 과잉행동장애, 인터넷 게임장애 사이의 관계

이선규,김대진,조현,Lee, Seon-Gyu,Kim, Dai-Jin,Cho, Hyun 대한생물정신의학회 2019 생물정신의학 Vol.26 No.2

Objectives Internet gaming disorder (IGD) is associated with attention deficit/hyperactivity disorder (ADHD) or depression etc. We tried to examine the mediating effects of depression in the relationship between ADHD and IGD. Methods This study was conducted on 2000 people who participated in on-line survey among 14-39 year-old men and women in 2017. And we clarified the relationship among IGD, ADHD, and depression and tested the mediation model. The mean and standard deviation of the main variables were calculated and correlation analysis was performed to confirm the relationship among the main variables. In order to test the mediating effect of depression on the relationship between ADHD and IGD, the structural equation model was implemented using AMOS 21 (IBM). Results There were significant correlations among the variables; IGD, ADHD and depression. Depression had a mediating effect 0.23 (95% confidence interval : 0.17-0.28) in the relationship between IGD and ADHD. Conclusions This study showed that depression can mediate ADHD and IGD. Therefore, the evaluation and management of depression and ADHD should be included in the diagnosis and treatment of IGD.

알츠하이머형 치매 환자 뇌파의 비선형 역동 분석 - 상관차원을 이용한 예비적 연구 -

채정호,김대진,정재승,김수용,고효진,백인호,Chae, Jeong-Ho,Kim, Dai-Jin,Jeong, Jaeseung,Kim, Soo Yong,Go, Hyo Jin,Paik, In-Ho 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

치매에서의 뇌파 연구는 주로 주파수 분석과 지형화 분석을 이용하여 정량화하는 것을 위주로 진행되어 왔으나 이러한 선형적 분석은 뇌파와 같이 복잡한 신호를 분석하는 것에는 한계가 있었다. 최근 새로운 패러다임인 카오스이론에 근거를 두고 뇌파를 비선형적으로 측정하는 방법이 소개되고 있다. 본 연구는 알츠하이머형 치매환자의 뇌파 신호를 상관차원을 이용하여 비선형적으로 분석하는 것이 가능한가를 알아보고 그 결과를 대조군과 비교해보기 위하여 시도되었다. 3명의 알츠하이머형 치매 환자와 3명의 대조군에서 뇌파 신호를 받아 디지털 화한 후에 비선형분석법 중 하나인 상관차원 값을 계산하였다. 전체 15개의 전극부위 중 3곳을 제외하고는 모든 전극과 두뇌 영역별, 반구별 분석 모두에서 알츠하이머형 치매군의 상관차원값이 유의하게 낮았다. 본 연구 결과는 알츠하이머형 치매 환자에서 카오스 이론을 이용한 비선형적 전기신경생리학적 분석으로 알아낼 수 있는 두뇌의 복합성, 즉 두뇌의 카오스적 성상이 감소되어 있다는 것을 의미하며 향후 뇌파의 비선형적 분석이 두뇌 기능을 조사하는 데에 유용한 새로운 방법이 될 가능성이 있다는 것을 시사한다. The changes of electroencephalogram(EEG) in patients with dementia are most commonly studied by analyzing power or magnitude in certain traditionally defined frequency bands. However because of the absence of an identified metric which quantifies the complex amount of information, there are many limitations in using such a linear method. According to chaos theory, irregular signals of EEG can also result from low dimensional deterministic chaos. Chaotic nonlinear dynamics in the EEG can be studied by calculating the correlation dimension. The authors have analyzed EEG epochs from three patients with dementia of Alzheimer type and three matched control subjects. The multichannel correlation dimension is calculated from EEG epochs consisting of 15 channels with 16,384 data points per channel. The results showed that patients with dementia of Alzheimer type had significantly lower correlation dimension than non-demented controls on 12 channels. Topographic analysis showed that the correlation dimensions were significantly lower in patients with Alzheimer's disease on frontal, temporal, central, and occipital head regions. These results show that brains of patients with dementia of Alzheimer type have a decreased complexity of electrophysiological behavior. We conclude that the nonlinear analysis such as calculating correlation dimension can be a promising tool for detecting relative changes in the complexity of brain dynamics.

Multi-Pose Pedestrian Detection using HybridFeatures and AdaBoost

Yong Hyun Kim(김용현),Dai Jin Kim(김대진) 한국정보과학회 2014 한국정보과학회 학술발표논문집 Vol.2014 No.6

스트롱암 기반의 DTV 트랜스포트 스트림 발생기 설계 및 구현

박현대(Hyun Dai Park),장용석(Yong Seok Jang),최효정(Hyo Jung Choi),김대진(Dae Jin Kim) 대한전자공학회 2002 대한전자공학회 학술대회 Vol.2002 No.11

금연이 혈중 Leptin, Ghrelin, Glucagon-Like Peptide 1, Nerve Growth Factor의 농도에 미치는 영향

이희미,원왕연,김대진,Lee, Hee-Mi,Won, Wang-Youn,Kim, Dai-Jin 대한생물정신의학회 2011 생물정신의학 Vol.18 No.2

Objectives It is well-known that tobacco smoking is related to various disease entities including chronic obstructive pulmonary disease, inflammation, cardiovascular disease, and neoplasms. The prohibition of smoking is important for the protection of these health problems. Regarding leptin, ghrelin, glucagon-like peptide 1 (GLP-1), and nerve growth factor (NGF) levels, correlations with the smoking are suggested but the reports on the effects after smoking cessation are not sufficient. Method The changes of plasma levels of leptin, ghrelin, GLP-1, and NGF levels were analyzed after quitting smoking in Korean adults. Eleven participants succeeding in quitting smoking among 37 male smokers were included in the final analysis. The plasma levels of NGF, leptin, ghrelin, and GLP-1 were measured before and after 8-weeks period of smoking cessation. Results The plasma level of leptin increased after 4 weeks of smoking cessation. In addition, the plasma level of NGF increased after 8 weeks of smoking cessation (p < 0.05). Conclusion Our results suggested that smoking cessation induces increases in leptin and the NGF level after smoking cessation. Many toxic materials including nicotine in the cigarette may be related to these changes of plasma level of leptin and NGF, playing a key role in neurogenesis and synaptic plasticity.

MPEG 비디오의 통계적 특성을 이용한 검색 시스템

유영달,강대성,김대진,Yu, Young-Dal,Kang, Dae-Seong,Kim, Dai-Jin 대한전자공학회 2001 電子工學會論文誌-CI (Computer and Information) Vol.38 No.5

현재 많은 정보들이 비디오 데이터로 전송 또는 저장되고 있으며 고성능 PC의 보급과 internet과 같은 통신망의 대중화로 이런 비디오 데이터는 급속도로 증가하고 있다. 본 논문에서는 이런 비디오 데이터의 검색을 위하여 비디오 스트립을 분석하여 shot을 찾아내고 이들 중 key frame을 찾는 방법에 대하여 연구하고 이로서 사용자의 질의에 부합하는 비디오를 검색한다. 본 논문에서는 shot 경계 검출을 위해 객체의 움직임에 강인하면서 shot 내에서의 칼라의 변화에 둔감한 새로운 feature를 제안하고, shot frame에서 구한 각 feature들의 통계적 특성을 이용하여 스트립의 특징에 따라 weight를 부가하여 구해진 characterizing value의 시간 변화량을 구한다. 구해진 변화량의 local maxima와 local minima는 비디오 스트림에서 각각 가장 특정적인 frame과 평균적인 frame을 나타낸다. 이 순간의 short frame을 구함으로서 효과적이고 빠른 시간 내에 key frame을 추출한다. 추출되어진 key frame에 대하여 원 영상을 복원한 후, 색인을 위하여 다수의 parameter를 구하고, 사용자가 질의한 영상에 대해서 이들 parameter를 구하여 key frame들과 가장 유사한 대표영상들을 검색한다. 실험결과 일반적인 방법보다 더 나은 결과를 보였고, 높은 검색율을 보였다. Recently many informations are transmitted ,md stored as video data, and they are on the rapid increase because of popularization of high performance computer and internet. In this paper, to retrieve video data, shots are found through analysis of video stream and the method of detection of key frame is studied. Finally users can retrieve the video efficiently. This Paper suggests a new feature that is robust to object movement in a shot and is not sensitive to change of color in boundary detection of shots, and proposes the characterizing value that reflects the characteristic of kind of video (movie, drama, news, music video etc,). The key frames are pulled out from many frames by using the local minima and maxima of differential of the value. After original frame(not de image) are reconstructed for key frame, indexing process is performed through computing parameters. Key frames that arc similar to user's query image arc retrieved through computing parameters. It is proved that the proposed methods are better than conventional method from experiments. The retrieval accuracy rate is so high in experiments.