Fabrication of Advanced Biomaterials Using a Simple Fluidic Device

Sung?Wook Choi 한국생물공학회 2010 한국생물공학회 학술대회 Vol.2010 No.10

노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

4극 이방성 Sr페라이트·플라스틱자석의 제조에 관한 연구

최희태,문현욱,신용진,진성빈 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

This thesis deals with the fabrication of 4 poles anisotropic Sr ferrite plastic magnets. After Polyamide6 and polyamide12 are kneaded respectively with Sr ferrite powder, silane coupling and calcium stearate of lwt% are added for coating and pelleting. The pelleted specimen injection-moulded under magnetic field using 4 poles mould. In the case of using polyamide6 as a binder, for 4 poles anisotropic Sr ferrite plastic magnets the surface magnetic flux density distribution is +943.8∼-943.8kG and the deviation is 5.2%, polyamide12, the distribution is +1040.9∼-1040.9KG and the deviation is 5.4%.The magnet distribution shows stability. As the results of experiments, we find 4 poles anistropic Sr ferrite plastic magnets have properties as the materials appropriate for manufacturing magnet type synchronous motors.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

입상활성탄의 자연발화 특성에 관한 연구

최재욱,김상렬 東亞大學校 大學院 1993 大學院論文集 Vol.18 No.-

The characteristics of critical spontaneous ignition of granulated activated carbon were investigated at a constant ambient temperature and sinusoidally varying ambient temperatures. As the results of the experiments, the critical spontaneous ignition temperature at the sinusoidally varying ambient tem-peratures was generally lower than that at the constant ambient temperature. At the critical spontaneous ignition temperature decreased as the period increased. The critical Frank-Kameneskii's parameter δ?(εω) was determinded from the results. δ?(εω) = δ?{1-379 exp (-0.935·ω?)} δ?(εω) = δ?{1-381 exp (-0.930·ω?)} δ?(εω) = δ?{1-388 exp (-0.929·ω?)}

복합레진의 수리 시 표면처리가 결합강도에 미치는 영향

최정인,김영재,김정욱,이상훈,김종철,한세현,장기택 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

본 연구의 목적은 표면처리가 기존의 레진과 새로운 레진 사이의 전단결합강도에 미치는 영향을 평가하는 것이다. 준비된 레진 시편을 6군으로 임의로 배분하여 각각의 표면처리를 한 후 수리용 레진을 축조하였다. 일주일간 보관 후 전단결합강도를 측정하였고 일원분산 분석법으로 통계처리하여 다음과 같은 결과를 얻었다. 1. 3군과 4군(air abrasion)은 1군(산부식)에 비해 전단결합강도가 유의하게 높게 나타났다(p<0.005). 5군과 6군(diamond bur)은 1군(산부식)에 비해 높은 전단결합강도를 나타냈으나 통계적으로 유의하지 않았다(p<0.005). 2. 2군(자가부식 접착제)은 1군(산부식)에 비해 전단결합강도가 낮게 나타났으나 유의한 차이는 없었다(p<0.005). 3. 3군(air abrasion)과 4군(air abrasion +산부식)에서 전단결합강도의 차이는 유의하지 않았다(p<0.005). 4. 5군(diamond bur)과 6군(diamond bur+산부식)에서 전단결합강도의 차이는 유의하지 않았다(p<0.005). 결론적으로,복합레진의 수리 시 air abrasion으로 표면처리를 했을 때의 결합강도가 가장 높았고,산부식 방법과 처리여부는 수리강도에 유의한 영향을 미치지 않았다. The purpose of this study was to evaluate the effect of surface treatment on the shear bond strength between new and old composite resin. The prepared resin specimens were separated 6 groups, and each group then received a different surface treatment. Then the repair material was added. Shear bond strengths for repair were measured after 7 days and the results were analyzed by using one way ANOVA. The results were as follows ; 1. Group 3, 4(air abrasion) showed significantly higher shear bond strength than Group l (phosphoric acid)(p<0.05). Group 5, 6(diamond bur) showed higher bond strength than Group l(phosphoric acid) but not significantly different(p<0.05). 2. Group 2(self-etching adhesive) showed lower shear bond strength than Group 1 (phosphoric acid) but not significantly different (p<0.05). 3. There was no statistically significant difference between Group 3 (air abrasion) and Group 4(air abrasion + etching). 4. There was no statistically significant difference between Group 5(diamond bur) and Group 6(diamond bur+etching). In conclusion, the surface treatment with air abrasion resulted in higher repair bond strength than other methods. Repair bond strength was not significantly affected by acid etching.

하악과두에 발생한 호산구육아종

최문경,허경회,이원진,오성욱,이삼선 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

The present study reports a case of eosinophilic granuloma of the mandibular condyle. Eosinophilic granulomas on the mandibular condyle are very rare, but there are several common clinical and radiographic presentations. The clinical presentations involve swelling on preauricular area, limitation of opening, TMJ pain, etc. The radiographic presentations involve radiolucent lytic condylar lesion with or without pathologic fracture. Sometimes new bone formations are observed. The purpose of the article is to add new cases to the literatures.

골수강내 금속정 및 나사못 맞물림을 이용한 경골의 치료

최창혁,권굉우,김신근,이상욱,강창진 대구효성카톨릭대학교 1997 연구논문집 Vol.56 No.2

Fracture of the tibial shaft is the most common among the long bone fractures, and it is difficult to treat because of a high incidence of delayed union, nonunion and malunion. Interlocking Intramedullary mailing is considered to be valuable method in treating long bone fracture such as tibial fracture these days because it enables rigid fixation, early joint motion exercise and weight bearing. Between April 1993 and March 1997, we treated 63 cases of tibia fractures with interlocking intramedullary nailing. The results were as follows: 1. Among the 63 cases, 51 cases were closed fractures and 12 cases were open fractures. 2. Static interlocking nailing was done in all cases and dynamization was done in 7 cases in postoperative 13 weeks. 3. Average union time was 19.9 weeks, 19 weeks with closed tibia fracture and 2.4 weeks with open tibia fracture. According to fracture site, 22 weeks with proximal tibia fracture, 19.2 weeks with mid-tibia fracture and 21.4 weeks with distal tibia fracture. According to the Winquist-Hansen classification, Type I was 19.8 weeks, Type Ⅱ was 20.4 weeks, Type Ⅲ was 22 weeks and Type Ⅳ was 26 weeks. 4. Weight bearing was started at the time of subsidence of pain and tenderness of the fracture site, 11.5 weeks with closed fracture and 12.3 weeks with open fracture. 5. According to the functional result of Klemm and Borner, 44 cases were excellent, 9 cases were good, 7 cases were fair and 3 cases were poor.

Langmuir-Blodgett 초박막의 전기적 특성

최병호,김성진,정순욱 金烏工科大學校 1998 論文集 Vol.19 No.-

Ultrathin film of 100Å-order is fabricated by Langmuir-Blodgett technique. By measure of UV-vis spectra and capacitance, deposition status was confirmed together with the thickness of natural oxidized aluminum film inside a device and dielectric constant of (N-docosyl pyridinium)-TCNQ(1:2) complex. The conductivity of this film measured by the direction of either vertical or horizontal axis is results in a quite different value.