제 2 형 당뇨병에서 미세혈관 합병증과 대혈관 합병증의 대비

강문호,이기영,정연실,김홍규,서찬종,송광식,박혜영,이원기 대한당뇨병학회 2001 Diabetes and Metabolism Journal Vol.25 No.2

Background: Type 2 diabetes is a heterogeneous disease. As to its complications, microangiopathy predominantly develop in some patients while macroangiopathy is more predominant in others. Therefore, this study was performed to identify the factors associated with such dissociation. Methods: Type 2 diabetic patients were classified into the macro and microangiopathy groups by carotid intima-medial thickness (IMT) and the presence of severe diabetic retinopathy. Patients with IMT ≤ 0.83 mm and severe NPDR or PDR were assigned to microangiopathy group; those with IMT 0.84 mm and no diabetic retinopathy were assigned to macroangiopathy group. Of 95 patients studied, 14 were classified as microangiopathy group and 20 as macroangiopathy group. Results: When the microangiopathy and macroangiopathy groups were compared, the microangiopathy group were significantly younger at the time of examination and at the onset of diabetes, and had longer duration of diabetes. Percentage of patients receiving insulin treatment was significantly higher and plasma C-peptide significantly lower in the microangiopathy group. However, HDL-cholesterol levels were significantly lower in the macroangiopathy group. Furthermore, the multiple logistic regression analyses revealed that younger onset of type 2 diabetes was an independent factor that was associated with the acceleration of microangiopathy. Conclusion: This study suggests that the age at onset of diabetes is an important independent risk factor that is associated with predominant development of microangiopathy in type 2 diabetic patients.

Mo 함유 Zr 합금의 인장 및 크리프 특성

이원식,권숙인,황선근,이창규,김명호,변재원 대한금속재료학회(대한금속학회) 2000 대한금속·재료학회지 Vol.38 No.5

One of the major reasons for utilizing Zr-base alloys in nuclear reactors is its good resistance to creep. Tension and creep deformation behaviors of Zr-1Nb-1Sn-0.1Fe alloy (0%Mo alloy) and Zr-1Nb-1Sn-0.1Fe-0.5Mo (0.5%Mo alloy) were evaluated to investigate the effect of Mo addition on mechanical properties and anisotropy. The addition of Mo increased the tensile strength through solid solution hardening. Room and high temperature tensile strength of TD(transverse direction) specimens were higher than those of RD(rolling direction) specimens. The TD specimen of 0.5Mo alloy showed higher elongation at room temperature than the RD specimen due to lattice rotation resulted from twin deformation. The stress exponent, n, obtained in creep test lied between 2.3 and 4.5 in both RD and TD specimens and the viscous glide was the predominant mechanism in creep deformation. The 0.5%Mo alloy showed higher creep resistance than the one without Mo.

췌장암에서 Cyclooxygenase - 2 발현의 역할

김은경,이용욱,이규택,최규완,박동일,백승운,이준행,이종균,고광철,이풍렬,이종철,김재준,김완선,공구 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3

Background/Aims: Accumulating evidence suggests that the use of NSAID may reduce the incidence of colorectal cancer. The likely mechanisms of these effects by NSAID is cyclooxygenase-2 (COX-2)-related inhibition of tumor proliferation and induction of apoptosis. The aim of our study was to examine possible roles and clinical significance of COX-2 expression in pancreatic cancer. Methods: Seventy-two pancreatic adenocarcinoma tissue specimens were obtained from surgical resection. After the immunohistochemical staining of the specimens, we examined proliferation activity (assayed by Ki-67 expression), apoptosis (by TUNEL stain), and microvessel density (by CD34 expression). We also investigated the relationship between the immunohistochemical expression of COX-2 and various clinicopathological characteristics. Results: The COX-2 positive rate in pancreatic epithelial cells was 41.7%. Proliferation index (PI) was significant higher in COX-2 positive specimens comparing to negative specimen (p=0.015) and the increase in intensity of COX-2 expression correlated with increasing PI (p=0.036). Apoptotic index (AI) was significantly higher in positivee COX-2 expression than in negative expression (p=0.044), but there was no significant difference in AI/PI between the COX-2 positive and negative specimens (p=0.44). The expression of COX-2 protein did not correlate with microvessel density, sex, age, differentiation, tumor size, stage, metastasis or patients survival. Conclusions: The expression of COX-2 enzyme in pancreatic cancer contributes to tumor proliferation, but is not related to apoptosis, angiogenesis or clinical characteristics. Further study is needed to examine the clinical usefulness of NSAID and COX-2 selective inhibitors.

인슐린 신호정달 경로

이문규,전병학 대한당뇨병학회 1993 Diabetes and Metabolism Journal Vol.17 No.4

벼 품종의 백엽고병 필리핀 균계에 대한 저항성 유전분석

이규성,구뎁에스쿠쉬 한국국제농업개발학회 2000 韓國國際農業開發學會誌 Vol.12 No.4

본 실험은 인디카 벼 4품종을 필리핀 흰잎마름병 6개 레이스 중 레이스 6에 대한 저항성 유전양식과 대립검정을 통한 기존 및 새로운 유전자를 밝히기 위하여 1999년 건기 및 우기에 필리핀 국제미작연구소 식물육종과 흰잎마름병 실험포장에서 수행하였다. 저항성 유전양식은 4품종 모두 필리핀 레이스 6을 지배하는 열성유전자를 갖고 있었으며, 이 유전자는 기존에 밝혀진 저항성 열성 유전자인 xa13과 비 대립관계인 것으로 나타났다. 한편 똑 같은 레이스 6을 지배하는 저항성 열성 유전자이나 xa13과 비 대립간에 있는 것으로 최근 밝혀진 xa24(t) 와의 대립검정에서도 4개 품종 중 ARC5756, Bazail 414 그리고 Bazail 980은 유전자의 비 대립간으로 밝혀졌으며, Bhadoia 648은 대립간으로 나타나 xa24(t)와 같은 유전자로 나타났다. 따라서, 3개 품종은 레이스 6을 지배하는 새로운 유전자일 가능성이 컸으며, 확인 검정을 위한 F₃후대 검정이 이루어지고 있다. The mode of inheritance and allelic relationship of the genes for resistance to bacterial blight using Philippine races of Xanthomonas oryzae pv. oryzae(Xoo) in four cultivars were studied. The results showed that four cultivars have at least a single recessive gene for resistance to race 6. Test for allelism of the genes revealed that a recessive gene conferring resistance to race 6 in four cultivars is non-allelic to xa 13. The allelic test of four cultivars with DV85 carrying xa24(t) showed that ARC5756, Bazai1414, and Bazai1980 are non-allelic while Bhadoia 648 is allelic to xa24(t). The further confirmation of new gene conferring resistance to race 6 is now being investigated.

하기도 감염증 환자의 치료에 있어서 Ceftibuten과 Cefaclor의 유효성 및 안전성 비교평가를 위한 임상시험

이홍렬,김세규,장준,김성규,이원영 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

Ceftibuten은 β-acyl side chain에 carboxye-thylidine moiety를 가진 aminothiazolyl cephalosporin으로, 전형적인 plasmid β-lactamase 및 새로운 TEM 효소에 대하여 구조적이 안정성과 경구 복용시의 흡수 정도가 향상되었다. 다른 3 세대 경구용 cephalosporin과 마찬가지로 항균력이 비경구용 cephalosporin와 비슷하고 약력학적으로는 더 우수하기 때문에 외래 환자들의 하부 호흡기계 감염에 비경구용 약제의 차선책으로 사용이 가능하다. 본 연구에서 병원외에서 발생한 하부 호흡기계 감염을 대상으로 ecftibuten과 cefaclor를 투여한 결과 임상 양상은 모두 치료후에 호전되었다. 임상적으로 유효한 cure와 improvement의 예는 ceftibuten군에서 89.7%, cefaclor군은 87.5%씩 이었고 양군간에 유의한 차이는 없었다. 세균학적으로 ceftibuten 군에서 elimination이 더 많았으나 역시 양군간에 유의한 차이는 없었다. Ceftibuten군중 3.0%, cefaclor군은 7.4%에서 부작용이 관찰되었다. 이상의 결과로써 ceftibuten은 병원외에서 발생한 하부 호흡기계 감염에 대하여 외래에서 효과적으로 사용할 수 있는 항생제라고 생각된다. Ceftibuten is the aminothiazolyl cephalosporin, which contains a carboxyethylidine moiety at position 7 of the β-acyl side chain. The provides β-lactamase stability against both the classic plasmid β-lactamases, and also the new TEM enzymes, and excellent absorption by the oral route. Because, similarly to other oral third-generation cephalosporins, ceftibuten has the expanded antimicrobial spectrum like parenteral third-generation cephalosporins and better pharmacokinetic properties, it may be a good alternative against lower respiratory tract infection, mainly in the outpatient setting. In this study, we examined the efficacy and safety of ceftibuten in the patients with the community-acquired lower respiratory tract infection. We administrated ceftibuten or cefaclor in randomized comparative manner. Clinical manifestations were improved in both groups and overall effective rates were 89.7% in ceftibuten group and 87.5% in ceftclor group with no significant difference. Most isolated pathogens were eliminated by ceftibution such as Haemophilus influenzae, Streptococcus pneumoniae and so on, even though cases were not sufficient. There was no serious adverse effect by ceftibuten. Conclusively, ceftibuten was thought to be an effective oral antobiotic against community-acquired lower respiratory tract infection in the outpatient setting.

Dieulafoy 양 병변에 의한 십이지장게실 출혈 1 예

김상현,김경환,이동현,송철수,정노원,박상제,김은규,하홍성,나일환,황윤이,성은영,최익수,신영기 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1

Duodenal diverticula are first reported by Chomel in 1710. Duodenal diverticula are relatively common in adults with a prevalence of 23% in SRCP. The most duodenal diverticulum is asymptomatic. Complications such as obstruction, cholangitis, blliary stones, ulceration, perforation and hemorrhage can occur in approximately 10%. However, relatively few cases of bleeding from a duodenal diverticulum have been reported. The cause of bleeding from a duodenal diverticulum is uncertain and various suspected etiologies were suggested, such as ectopic gastric mucosa, stasis-induced ulceration, erosion into major vessels, aortoenteric fistuias, intradiverticujar polyp, aspirin-induced erosion. We report a case of a bleeding duodenal diverticulum by a Dieulafoy-like lesion and suggest this 1esion as one of posslble causes of blee4ng in duodenal diverticulum.

그래파이트 표면에 증착된 자기결합 헤테로폴리산 단분자층의 STM 연구 : NDR 거동과 산화환원 반응성 NDR ( Negative Differential Resistance ) Behavior and Redox Activity

송인규,이화영,마무드카바,마크바토 한국화학공학회 1997 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.35 No.3

본 연구에서는 STM(scanning tunneling microscopy)에 의해 측정된 헤테로폴리산의 NDR(negative differential resistance) 거동과 헤테로폴리산의 산화환원력과의 상관관계에 대하여 살펴보았다. 이를 위해 양이온 및 배위원소가 헤테로폴리산의 NDR 거동에 미치는 영향을 조사하였다. 헤테로폴리산의 NDR 거동은 촉매의 전자적인 성질, 즉 촉매의 산화환 원능력과 밀접한 관련이 있는 것으로 나타났다. 산화환원능력이 우수한 헤테로폴리산일수록 낮은 음전압에서 NDR 거동이 나타났다. 또한 헤테로폴리산의 환원상태에 따른 산소이탈량은 NDR 전압 변화량과 밀접한 관련이 있는 것으로 나타났다. 따라서 STM에 의해 측정된 헤테폴리산의 NDR 거동은 촉매의 산화환원능력을 예측하는 지표가 될 수 있음을 알 수 있었다. A correlation between redox potential and NDR(negative differential resistance) behavior of heteropolyacid probed by STM(scanning tunneling microscopy) was examined in this work. The effects of counter cations and polyatoms on the NDR behavior of heteropolyacid were examined for this purpose. It was revealed that NDR behavior was closely related to the electronic property of heteropolyacid, and in turn to the redox potential of heteropolyacid. More reducible heteropolyacid showed NDR behavior at less negative voltage. It was also found that the amounts of oxygen loss from polyanion with respect to reduction state was related to the changes in NDR voltage. It was concluded that NDR behavior of heteropolyacid probed by STM could be a fingerprint for the prediction of redox potential of heteropolyacid.

성인에서 반복적인 위장관출혈로 발현한 공장 거대 중복성 낭종

김영호,이경수,이상수,문원,강태욱,최규완,박동일,도재혁,백승운,이풍렬,이종철,김재준,류민규 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Duplication of the alimentary tract is an unusual congenital anomaly which may occur at any level, from the oral cavity to the rectum. Jejunal duplication cyst is quite rare and most of them are presented in infancy with the symptoms of abdominal mass, obstruction, hemorrhage and perforation. But some cases has not been diagnosed till adult if duplication cyst was too small enough to cause symptoms. We report a case of a 28-year-old woman who presented with recurrent gastrointestinal hemorrhage as a result of an ulceration without ectopic mucosa in jejunal duplication cyst and was successfully treated with surgery.(Korean J Med 61:264-269, 2001)

논문 : 이홍기 편 ?조선전설집?(1944)에 대하여

이복규 ( Bok Kyu Lee ) 온지학회 2012 溫知論叢 Vol.0 No.30

이 글은 이홍기 편 ?조선전설집?(1944)의 존재 양상을 자세히 알리고,이것이 한국 최초의 우리말 전설집이라는 사실을 주장한 논문이다. 그간에는 최상수의 ?한국민간전설집?(1958)을 최초 전설집이라고 인식해왔는데 그렇지 않다는 새로운 주장을 펼쳤다. 최상수의 것에 비해 그 완성도가 떨어지기는 하지만 우리나라 사람이 우리말로 엮은 최초의 전설집인 것이 분명하며, 도별로 엮은 점, 초기의 구비문학 연구자 고정옥에게 적극 활용된 것도 명백한 사실임을 밝혔다. 이홍기의 전설집은 모두 167편의 전설을 싣고 있으며, 지역별로 자료를 배열하고 있다. 경기도 10편, 충청도 7편, 전라도 6편, 경상도 10편, 황해도 8편, 평안도 9편, 강원도 5편, 함경도 11편이다. 수록 전설의 유형을 분류한 결과, 지명(地名19편), 암석(8편), 고승(4편), 원령(怨靈4편), 씨족시조(3편), 총묘(塚墓3편), 불사연기(佛寺緣起3편), 용(3편), 수업(修業3편), 지소(池沼2편), 열녀(2편), 불상(佛像2편), 힘내기(힘경쟁담 2편), 보은형(2편), 용천(湧泉1편), 미혈(米穴쌀나오는 구멍 1편), 정자(亭子1편), 임진왜란(1편), 풍수(風水1편), 의견(義犬1편), 효자(1편), 기타(1편)이었다. 가장 많은 것이 지명전설(19), 그 다음이 암석전설(8)임을 알 수 있었다. 각각 전체의 28퍼센트, 12퍼센트를 차지한다. 이 같은 양상은 최상수의 책에 실린 전설의 유형 분류 결과와 유사하여 흥미롭다. 다른 자료집(북한에서 간행한 설화집 및 최상수가 펴낸 전설집)과 비교한 결과, 최상수의 전설집에는 없는 전설들이 이 전설집에 실려 있었다. 서로 중복되어 실려있는 자료라 할지라도 차이가 있었다. This paper aims to look into what Joseonjeonseoljip (1944), the anthology of Korean folklore compiled and edited by Lee Hong-gi, consists of and to establish the fact that it is Korea`s first Legends anthology written in Korean. A new claim is proposed against the Anthology of Korean Legends (1958) by Choi Sang-su that it is not the first anthology. Although compromising the degree of perfection, the collection is assuredly the first Legends anthology written in Korean and edited by a Korean, characterized by being compiled provincially and being actively quoted by Ko Jeong-ok, the first-generation scholar of oral literature. This book contains 167 stories in total, arranging them under the provincial titles: 10 stories for Gyeonggido, 7 for Chungcheongdo, 6 for Jeollado, 10 for Gyeongsangdo, 8 for Hwanghaedo, 9 for Pyeongando, 5 for Gangwondo, and 11 for Hamgyeongdo. To classify the types of folklore covered, there are 19 stories about geographical names, 8 about rocks, 4 about old monks, 4 about spirits with enmity, 3 about clan`s ancestors, 3 about graves, 3 about building a buddhistic temple, 3 about dragons, 3 about apprenticeship, 2 about bodies of water, 2 about fidelity, 2 about buddhistic statue, 2 about wrestling, 2 about gratitude, 1 about fountain, 1 about a hole for rice, 1 about pavilion, 1 about Imjin War, 1 about feng shui, 1 about a faithful dog, 1 about a filial pious son, and the rest. Legends about geography rank first, followed by those about rocks, which account for 28 percent and 12 percent respectively. This is interesting in that the classification is similar to that of Choi Sang-su. When compared with other collections such as the folklore anthology published in North Korea and that of Choi Sang-su, this book introduces more stories. Even the overlapped stories differ in textual terms. First of all, they differ in size as Lee`s stories are much longer. Secondly, Lee`s stories use more paragraphs. All these suggest that Lee and Choi very likely used different sources when they compiled their materials. The North Korean version turned out to copy virtually everything of Lee`s except that such surrealistic, much too fantastic, or superstitious elements as might contradict the North Korean ideology have been eliminated. This is a pioneering study of Lee Hong-gi`s Joseonjeonseoljip. Provided what the researcher claims in this study is valid, certain statements about ``the first folklore anthology`` ought to be corrected. Additionally, those issues should also be addressed properly such as who on earth Lee Hong-gi the compiler was and what value the stories themselves might retain.