뜬 바닥구조용 완충재의 동탄성계수 측정에 관한 연구

김하근,김명준,이병권 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

The aim of this study is to suggest the method of measuring the dynamic stiffness and the loss factor of materials used under floating floors in dwellings by Korea standard (KS F 2868) We measured and compared those of 18 resilient materials in several conditions such as the size of test specimens, the type of excitation methods, pick-up locations and so on in the first result, there's no differences of natural frequency according to vibration pick-up location in the second result, the dynamic stiffness by using sinusoidal signal of exciter is higher than that by using impulse signal of Impact hammer Finally, in case of measuring dynamic stiffness of material which has higher stiffness or is easy to change by bending moment, It should be measured with great care

수목추출물의 생리활성에 관한 연구(Ⅸ) : 아까시나무 심재의 항산화활성 물질 Antioxidative Compounds from Heartwood of Robinia pseudo-acacia

최돈하,이학주,이성숙,김윤근,강하영 한국목재공학회 2002 목재공학 Vol.30 No.4

항산화활성이 우수한 아까시나무 심재 에탄올 조추출물로부터 항산화물질을 탐색할 목적으로 4종의 화합물을 단리하였으며, MS, NMR 등의 분광학적 방법에 의해 그 화학적 구조를 3-β-stigmast-5-en-3-ol(daucosterol)를 비롯하여 스틸베노이드 화합물인 3,3' ,4' ,5-tetrahydroxystilbene과 후라보노이드인 3,3' ,4' ,5' ,7-pentahydroxyflavone(robinetin) 및 3,3' ,4' ,7-tetrahydroxyflavanone(fustin)으로 각각 동정하였다. 단리된 화합물의 프리라디칼 소거능을 측정하여 항산화활성을 검정한 결과, 페놀성 수산기가 5개인 3,3' ,4' ,5' ,7-pentahydroxyflavone은 천연항산화제 및 합성항산화제보다 높은 항산화활성을 나타내어 단리화합물 중 가장 항산화활성이 높은 것으로 나타났다. 또한, 페놀성 수산기가 4개인 3,3' ,4' ,5-tetrahydroxystilbene과 3,3' ,4' ,7-tetrahydroxyflavanone도 천연항산화제인 α-tocopherol보다 높은 항산화활성을 나타내었으나 3-β-stigmast-5-en-3-ol은 항산화활성이 없는 것으로 나타나 프리라디칼 소거능에 의한 항산화활성은 화합물의 페놀성 수산기수에 크게 좌우되는 것으로 판단되었다. 이상의 결과 아까시나무의 높은 항산화활성은 3,3' ,4' ,5' ,7-pentahydroxyflavone. 3,3' ,4' ,5-tetrahydroxystilbene 및 3,3' ,4' ,7-tetrahydroxyflavanone에 기인하는 것으로 사료되었다. Antimicrobial and antioxidative activities on heartwood extractives of domestic species were investigated to develop a natural fungicide or preservative. One steroid, stilbene derivatives and two flavonoids were isolated from heartwood of Robinia pseudo-acacia which has been selected due to its high antioxidative activity among the tested species. The structures were determinded as : 3-β-stigmast-5-en-3-ol(daucosterol), 3,3',4,5-tetrahydroxystilbene, 3,3',4',5',7-pentahydroxyflavone(robinetin) and 3,3',4',7-tetrahydroxyflavanone(fustin) respectively on the basis of spectroscopic data and chemical correlations. According to the results of free radical scavenging activity, 3,3',4',5',7-pentahydroxyflavone was evaluated as the highest antioxidative compound among the four compounds and showed higher radical scavenging activity than those of α-tocopherol and butylated hydroxytoluene(BHT), one of the strongest synthetic antioxidants. 3,3',4',5-Tetrahydroxystilbene and 3,3',4',7-tetrahydroxyflavanone showed higher antioxidative activities than that of α-tocopherol. However, 3-β-stigmast-5-en-3-ol did not show free radical scavenging activity. In this regard, it could inferred that high antioxidative activity of extractives of R. pseudo-acacia was derived from 3,3',4',5',7-pentahydroxyflavone, 3,3',4',5-tetrahydroxystilbene and 3,3',4',7-tetrahydroxyflavanone.

방음터널 단면형상에 따른 소음저감 특성 평가 : 터널 내부소음을 중심으로

이원열,김하근,오양기,주문기 대한건축학회 2004 대한건축학회논문집 Vol.20 No.2

It seems inevitable for residential buildings to be high-rise and allocated near traffic roads due to the crowdedness in urban areas. Acoustic environments in those areas have been seriously deteriorated by the increase of traffic vehicles. But sound barriers have a limitation in controlling noise due to diffraction noise from sound barriers. Hence sound barrier is not effective to protect the high-rise apartment from traffic noise. This work aims at evaluating characteristics of noise reduction according to the tunnel section shapes by using 1/5 scale model. We carried out a number of field measurements for 1/5 scale model of noise barrier tunnels with various sectional shapes. The results were as follows 1) The level difference was ranged from 0㏈ to 1.2㏈ according to the opening in the ceiling 2) The level difference was ranged from 0.4㏈ to 2.3㏈ when sound-absorbing materials were increased up to 45% of all surface areas. 3) There was generally good agreement between prediction results and the measurement results.

방음터널 단면형상에 따른 소음저감 예측 및 특성 평가 : 터널 외부소음을 중심으로

오양기,김하근,이원열 대한건축학회 2004 대한건축학회논문집 Vol.20 No.8

Noise emitted from urban arterial roads is getting more serious problem in the environmental quality of living. Though noise barrier is one of measures to mitigate noise levels at housing area, it has a limited effect especially on apartment units high around the roads. Noise barrier tunnel may be another effective device for noise reduction even to high rise apartments. On these basis, this study aims at providing a number of possible sectional shapes of noise barrier tunnels, measuring their effects on noise reduction with 1 to 5 scale model measurements, and proposing/validating a prediction technique of their effects. According to a number of measurements with various sectional shapes or the scaled model, 1)the proposed sectional shapes have affirmative effects on noise reduction, 2)the difference in noise levels between in and out of tunnel are about 10dB whether there is opening in the ceiling or not. 3)results from predictions and the measurements show generally good agreements within 0.3∼3.6 dB(A).

양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여

지익성,신석철,왕성근,이선우,신용재,김충수,김상국,최하석,오승용,류택근,이영호 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3′UTR

Kim, Min Young,Park, Jungyun,Lee, Jong Joo,Ha, Dae Hyun,Kim, Jonghwan,Kim, Chan Gil,Hwang, Jungwook,Kim, Chul Geun Oxford University Press 2014 Nucleic acids research Vol.42 No.11

<P>Requiem (REQ/DPF2) was originally identified as an apoptosis-inducing protein in mouse myeloid cells and belongs to the novel Krüppel-type zinc finger d4-protein family of proteins, which includes neuro-d4 (DPF1) and cer-d4 (DPF3). Interestingly, when a portion of the REQ messenger ribonucleic acid (mRNA) 3′ untranslated region (3′UTR), referred to as G8, was overexpressed in K562 cells, β-globin expression was induced, suggesting that the 3′UTR of REQ mRNA plays a physiological role. Here, we present evidence that the REQ mRNA 3′UTR, along with its <I>trans</I>-acting factor, Staufen1 (STAU1), is able to reduce the level of REQ mRNA via STAU1-mediated mRNA decay (SMD). By screening a complementary deoxyribonucleic acid (cDNA) expression library with an RNA–ligand binding assay, we identified STAU1 as an interactor of the REQ mRNA 3′UTR. Specifically, we provide evidence that STAU1 binds to putative 30-nucleotide stem–loop-structured RNA sequences within the G8 region, which we term the protein binding site core; this binding triggers the degradation of REQ mRNA and thus regulates translation. Furthermore, we demonstrate that siRNA-mediated silencing of either STAU1 or UPF1 increases the abundance of cellular REQ mRNA and, consequently, the REQ protein, indicating that REQ mRNA is a target of SMD.</P>

A Novel PCR Primers HPU185 and HPL826 Based on 16S rRNA Gene for Detection of Helicobacter pylori

Kim, Jong-Bae,Kim, Geun-Hee,Kim, Hong,Jin, Hyun-Seok,Kim, Young-Sam,Ha, Soo-Hyun,Lee, Dong-Ki The Korea Society for Microbiology 2000 大韓微生物學會誌 Vol.35 No.4

The PCR primer set JW21-JW22 of Weiss et al. (19), which was reported to amplify a 139-bp fragment of the l6S rRNA gene of Helicobacter pylori, has been recently used for the detection of H. pylori in clinical specimens. However, when we applied JW21-JW22 PCR to other members of the genus Helicobacter and unrelated microorganisms, all of these bacteria produced a 139-bp PCR product. Therefore, we designed a novel primer set, HPU185-HPL826, which produced a 642-bp amplicon of the l6S rRNA gene of H. pylori. Then we further examined the specificity of the novel PCR assay using Southern blot hybridization with an internal probe, HPP225. The PCR assay described in this study was shown to be highly sensitive and specific only to the H. pylori 16S rRNA gene sequences.

Sa1556 Endoscopic Grading of Gastroesophageal Flap Valve Helps Predict Proton Pump Inhibitor Response in Patients With Gastroesophageal Reflux Disease

Kim, Gwang Ha,Cheong, Jae Hoon,Moon, Ji Yoon,Lee, Bong Eun,Ryu, Dong Yup,Kim, Dong Uk,Choi, Seok-Reyol,Song, Geun Am Elsevier 2011 Gastrointestinal endoscopy Vol.73 No.4

제2형 당뇨병 환자에서 발생한 자발적 안구마비 2예

김기훈,최지훈,계영하,장근영,김지웅,김태현,김경희,박병현,형근영,조정구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

Diabetics are predisposed to certain acute mononeuropathies, including a cranial neuropathy involving ocular motor nerves. Oculomotor nerve palsy is the most common cranial neuropathy in diabetes mellitus. Affection of several nerves in one eye can occur, rarely. Such as, the third and the sixth or the third and the fourth. The clinical characteristics of diabetes-associated ophathalmoplegia include abrupt onset, frequent occurrence of short-lived ipsilateral pain, sparing of pupillary reflex, resolution in most cases within a few months. Clinicopathological studies have suggested that diabetic ophathalomoplegia results from microvascular ischemia of an oculomotor nerve in its subarachnoid, cavernous segment or mid brain. Pupillary sparing is a single feature of diabetic third nerve palsy, and it has been widely used to distinguish diabetic oculomtor palsy from extrinsic compressive lesion of the third nerve, such as an aneurysm in the carotid siphon. No specific treatment is necessary. We experienced two cases of diabetic spontaneous ophthalmoplegia, one affected oculomotor nerve and the other affected partially oculomotor nerve and trochlear nerve, so we report these cases with review of the literatures.