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Clinical implication of crescentic lesions in immunoglobulin A nephropathy
Lee, Mi Jung,Kim, Seung Jun,Oh, Hyung Jung,Ko, Kwang Il,Koo, Hyang Mo,Kim, Chan Ho,Doh, Fa Mee,Yoo, Tae-Hyun,Kang, Shin-Wook,Choi, Kyu Hun,Lim, Beom Jin,Jeong, Hyeon Joo,Han, Seung Hyeok Oxford University Press 2014 Nephrology, dialysis, transplantation Vol.29 No.2
<P><B>Background</B></P><P>To date, there has been much controversy about the role of crescentic lesion as a significant prognostic factor in immunoglobulin A nephropathy (IgAN). This study evaluated whether crescentic lesions predict adverse renal outcomes in IgAN patients.</P><P><B>Methods</B></P><P>A total of 430 patients with biopsy-proven IgAN between January 2000 and December 2009 were included. Histological variables of the Oxford classification (Oxford-MEST) and the presence of crescents were assessed. The primary endpoint was a 50% decline in estimated glomerular filtration rate.</P><P><B>Results</B></P><P>Of the 430 patients, 81 (18.8%) had a crescentic lesion. During a mean follow-up of 61 months, the primary outcome occurred in 19 (23.5%) patients with crescents compared with 40 (11.5%) patients without crescents (P = 0.01). A Kaplan–Meier plot showed that the 10-year renal survival rate was significantly lower in patients with crescents than patients without crescents (P = 0.01). However, in a multivariable Cox analysis which included clinical factors and the Oxford-MEST, crescents were not significantly associated with an increased risk of developing the primary outcome [hazard ratio: 0.71, 95% confidence interval (CI) 0.36–1.41, P = 0.33]. Furthermore, adding crescents to the Oxford-MEST did not improve the discriminative ability for the prediction of renal outcomes [<I>c</I>-statistic: 0.86 (0.81–0.91) vs. 0.86 (0.80–0.91), P = 0.21].</P><P><B>Conclusion</B></P><P>Crescentic lesion was not an independent prognostic factor, suggesting that crescents have limited value in predicting renal outcomes of IgAN.</P>
Macaulay, E,Nichol, R C,Bacon, D,Brout, D,Davis, T M,Zhang, B,Bassett, B A,Scolnic, D,Mö,ller, A,D’Andrea, C B,Hinton, S R,Kessler, R,Kim, A G,Lasker, J,Lidman, C,Sako, M,Smith, M,Sullivan, M,Abbo Oxford University Press 2019 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.486 No.2
<B>ABSTRACT</B><P>We present an improved measurement of the Hubble constant (H0) using the ‘inverse distance ladder’ method, which adds the information from 207 Type Ia supernovae (SNe Ia) from the Dark Energy Survey (DES) at redshift 0.018 < z < 0.85 to existing distance measurements of 122 low-redshift (z < 0.07) SNe Ia (Low-z) and measurements of Baryon Acoustic Oscillations (BAOs). Whereas traditional measurements of H0 with SNe Ia use a distance ladder of parallax and Cepheid variable stars, the inverse distance ladder relies on absolute distance measurements from the BAOs to calibrate the intrinsic magnitude of the SNe Ia. We find H0 = 67.8 ± 1.3 km s−1 Mpc−1 (statistical and systematic uncertainties, 68 per cent confidence). Our measurement makes minimal assumptions about the underlying cosmological model, and our analysis was blinded to reduce confirmation bias. We examine possible systematic uncertainties and all are below the statistical uncertainties. Our H0 value is consistent with estimates derived from the Cosmic Microwave Background assuming a ΛCDM universe.</P>
The Oxford classification as a predictor of prognosis in patients with IgA nephropathy.
Kang, Seok Hui,Choi, Sun Ryoung,Park, Hoon Suk,Lee, Ja Young,Sun, In O,Hwang, Hyeon Seok,Chung, Byung Ha,Park, Cheol Whee,Yang, Chul Woo,Kim, Yong Soo,Choi, Yeong Jin,Choi, Bum Soon Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.1
<P>In 2009, the Oxford classification was developed as a pathological classification system for immunoglobulin A nephropathy (IgAN) to predict the risk of disease progression. The aim of this retrospective study was to evaluate the clinical and pathologic relevance of the Oxford classification in Korean patients with a pathologic diagnosis of IgAN.</P>
Woo, Joo Yong,Jeong, Kwang Ju,Kim, Young Jin,Paek, Kyung-Hee Oxford University Press 2016 Journal of experimental botany Vol.67 No.19
<▼1><P><B>Highlight</B></P><P><I>CaLecRK-S.5</I>, a positive regulator of priming, plays a critical role in plant immunity to broad-spectrum pathogens.</P></▼1><▼2><P>In Arabidopsis, several L-type lectin receptor kinases (LecRKs) have been identified as putative immune receptors. However, to date, there have been few analyses of LecRKs in crop plants. Virus-induced gene silencing of <I>CaLecRK-S.5</I> verified the role of <I>CaLecRK-S.5</I> in broad-spectrum resistance. Compared with control plants, <I>CaLecRK-S.5</I>-silenced plants showed reduced hypersensitive response, reactive oxygen species burst, secondary metabolite production, mitogen-activated protein kinase activation, and defense-related gene expression in response to <I>Tobacco mosaic virus</I> pathotype P<SUB>0</SUB> (TMV-P<SUB>0</SUB>) infection. Suppression of <I>CaLecRK-S.5</I> expression significantly enhanced the susceptibility to <I>Pepper mild mottle virus</I> pathotype P<SUB>1,2,3</SUB>, <I>Xanthomonas campestris</I> pv. <I>vesicatoria</I>, <I>Phytophthora capsici</I>, as well as TMV-P<SUB>0</SUB>. Additionally, β-aminobutyric acid treatment and a systemic acquired resistance assay revealed that <I>CaLecRK-S.5</I> is involved in priming of plant immunity. Pre-treatment with β-aminobutyric acid before viral infection restored the reduced disease resistance phenotypes shown in <I>CaLecRK-S.5</I>-silenced plants. Systemic acquired resistance was also abolished in <I>CaLecRK-S.5</I>-silenced plants. Finally, RNA sequencing analysis indicated that <I>CaLecRK-S.5</I> positively regulates plant immunity at the transcriptional level. Altogether, these results suggest that <I>CaLecRK-S.5</I>-mediated broad-spectrum resistance is associated with the regulation of priming.</P></▼2>
Jung, Joo Eun,Kim, Hong Sook,Lee, Chang Seok,Park, Dae-Hun,Kim, Yong-Nyun,Lee, Min-Jae,Lee, Jung Weon,Park, Jong-Wan,Kim, Myung-Suk,Ye, Sang Kyu,Chung, Myung-Hee Oxford University Press 2007 Carcinogenesis Vol.28 No.8
<P>Tumor angiogenesis is required for tumor development and is stimulated by angiogenic inducers like VEGF (vascular endothelial growth factor). Our previous study demonstrated that STAT3 (signal transducer and activator of transcription 3) up-regulates HIF-1alpha (hypoxia inducible factor-1alpha) protein stability and enhances HIF-1-mediated VEGF expression in hypoxic solid tumor cells, thus suggesting that the inhibition of STAT3 signaling may have clinical applications. In this study, we examined in vitro and in vivo, whether caffeic acid (CA) or its derivative CADPE [3-(3,4-dihydroxy-phenyl)-acrylic acid 2-(3,4-dihydroxy-phenyl)-ethyl ester] exert anticancer activity by targeting STAT3. It was found that CA or CADPE significantly inhibit STAT3 activity, and that this in turn down-regulates HIF-1alpha activity. Consequently, sequential blockade of STAT3 and HIF-1alpha resulted in the down-regulation of VEGF by inhibiting their recruitment to the VEGF promoter. In mice bearing a Caki-I carcinoma, both CA and CADPE retarded tumor growth and suppressed STAT3 phosphorylation, HIF-1alpha expression, vascularization and STAT3-inducible VEGF gene expression in tumors. Taken together, our results demonstrate that CA and CADPE are potential inhibitors of STAT3 and that they suppress tumor angiogenesis by inhibiting the activity of STAT3, the expression of HIF-1alpha and VEGF.</P>
Bae, Hyun Won,Kim, Dockyu,Choi, Ki Young,Kwon, Na Ra,Chae, Jong Chan,Zylstra, Gerben J.,Koh, Sung-Cheol,Lee, Choong-Hwan,Kim, Eungbin Oxford University Press 2007 FEMS microbiology letters Vol.266 No.1
<P>We identified a p-cumate degrading gene cluster (designated cmt) with a novel organization in our genomic studies of the terpene-degrading Rhodococcus sp. strain T104. The mutant strain SN140, isolated for the inability to grow on p-cumate, accumulates 2,3-dihydroxy-p-cumate as identified by liquid chromatography-mass spectrometry and 300 MHz proton nuclear magnetic resonance spectroscopy. Reverse transcriptase polymerase chain reaction experiments showed that the cmt genes are operonic and induced specifically by growth on p-cumate. This report is the first example of identifying the genes for p-cumate degradation in a gram-positive organism based on functional data.</P>