HCV, Alcoholic : PE-096 ; Clinical and histopathological features of acute onset autoimmune hepatitis

( Min Young Rim ),( Soo Yong Park ),( In Ku Yo ),( Min Su Ha ),( Ju Seung Kim ),( Ju Won Lee ),( Young Kul Jung ),( Dong Hae Chung ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Joo Choi ),( Ju Hyun Kim1 ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Autoimmune hepatitis (AIH) is a progressive inflammatory liver disease of unknown etiology that is reported to be a consequence of aberrant autoreactivity. Several studies which reported the acute presentation of AIH have different clinical course and histologic features. In this study, we compared acute presentation of AIH and chronic presentation of AIH. Methods: We retrospectively reviewed the medical records of patients with autoimmune hepatitis from January 2003 to June 2011 at Gachon University, Gil Hospital. A total of 29 patients were enrolled, 7 patients were diagnosed with acute presentation of AIH. Results: There was no difference between two group in age, gender, and score system of AIH. Patients with acute presentation had higher serum levels of total bilirubin, lower serum levels of albumin in clinical feature (p<0.05), and higher frequency of zone 3 necrosis in histologic feature. The cumulative incidental rate of the normalization of serum AST and ALT levels with prednisolone treatment was similar between patients with acute presentation and chronic presentation in clinical course. Conclusions: Higher AST, ALT and, bilirubin were clinical specific feature, and zone 3 necrosis is a histological characteristic of autoimmune hepatitis with acute presentation.

광주·전남지역 초등학교 6학년 아동의 흡연실태

김경주,강혜영 韓國學校保健學會 2002 韓國學校保健學會誌 Vol.15 No.1

The purpose of this descriptive study was to investigate the smoking behaviors and their related factors of the 6th graders from 25 primary schools in Gwangju City and Chonnam province. The total number of subject were 882 children(2% of total 44,088 persons). The instrument consisted of 14 for sociodemographic and smoking-related characteristics and 12 for smoking behaviors-related factors. The survey was conducted with the help of school nurses from August 20th to September 30th, 200, and the data were analyzed with SAS program. The results were as follows: 12.8% of the 6th graders had once and more smoking experiences and 0.9% of them are current smoking. The number of children who have smoking experience were significantly more in the male group, unsatisfying group in school life, lower in school performance(p< .001); and of lower level of father's education(p< .05), of children of working mothers, and of relatively unhappy family atmosphere(p< .01). There were number of children who have smoking experience were significant in the group of having smoking friends, of frequent buying cigarette, and of having smoking siblings(p< .001) and relatives(p< .05). It is concluded that smoking experience of primary school children in Gwangju and Chonnam area were relatively lower than that of other provinces and foreign countries but starting age of smoking was tended to be lower gradually.

全北任實方言 硏究

金海正,孫周一,李氣銅 又石大學校 1982 論文集 Vol.4 No.-

Through collecting some basic dialects in Im-sil district, we are going to find their characteristics in phonology, syntax, and lexicography. We've collected and investigated about 720 lexical items. The investigation method we adopted is the direct question & answer between investigators and informants. Our informants' average age is over sixty, and they have lived there all their lives. The results are as follows; 1. Phonology. A. Their phonological system is found to be almost similar to that of central dialects. We can confirm their vowel system is composed of ten vowels, distinguishing /e/ from /ε/. This phenomenon is different from our common knowledge about it. B. Every single vowel alternates actively in all the vowels. The alternative phenomena between /e/ and /ε/ occur in accordance with back vowel and umlaut respectively. C. Their umlaut phenomena are extensive and similar to those of both central and kyoung-sang dialects. D. Diphthongs with consonant in the initial syllable usually alternates with single vowel. E. We find their palatalization more various than that of central dialects. This phenomena are sure to occur when the condition is given in the first and second syllable. F. Glottalized phenomenon is more productive than aspirated phenomenon. Ⅱ. Syntax. A. The form" -(h??) d??e" is the predicate of matrix sentence which dominates the complementrary structure. B. The form "-jad??i" has a [+Active] as syntactic property while the forms "-d??i" and "d??e" don't C. The forms "a/??rau" and "-d??irau" can be integrated with the form "-ja d??i" but can't be integrated with the form "(h??) d??e" naturally. D. The form "-d??i" is pronounced with rising intonation and assumed to be tag-question usage for the moment. D. While the form "-d??i" with explanatory final ending is used as a Korean general form as a converbum, the form "-jad??e" isn't. F. The purpose of this paper is to point out the general fallacy of classifying the form "-had??i" and "-had??e" as a traditional distinctive features of dialect form (allomorph) in Im-sil dialect, when collecting data of dialect syntax with a special criteria. Ⅲ. Lexicology. Aiming to establish lexical system of subdialect, lexical category is limited within a scope of semantic method and posture. We investigate it with pure and unconfused semantic approach. We describe them synchronically; the meanings of Im-sil dialects based on informents' detailed expressions. We contrast them with standard language. Any particular expression, if necessary, is selectively accounted in the main body.

알코올이 면역체계에 미치는 영향

김주현,정소형,강혜경 東國專門大學 1999 金龜論叢 Vol.7 No.1

술은 식품, 약품 또는 중독성 물질로 분류되며 기분 전환제 또는 정신자극 약품으로 작용한다. 술은 국민의 신체적 정신적 건강을 해치는 물질로 계속적으로 주목을 받고 있으며 이를 상습 하는 사람의 경우 영양장애뿐 아니라 간, 췌장, 소화기관, 뇌, 심장, 근육과 생식기관등 신체의 모든 기관에 손상을 입힌다고 한다. 술의 남용은 결핵(tuberculosis), 기회감염(oppotunistic infections), 뇌와 목의 종양, 자가면역질환(autoimmune disease)의 발생 정도가 높으며, 면역체계와의 관련성 역시 제기되고 있다. 알코올에 의한 면역부진은 세포 매개성 면역(cell-mediated immminity)에서 가장 두드러지며, 이로 인해 결핵의 이환이나 간염과 인체면역결핍바이러스(HIV infection)과 같은 비루스에 의한 감염이 쉽게 일어날 수 있다. 알코올에 의해 T cell의 기능은 손상되거나 분비 이상이 초래될 수 있으며, Natural killer cell의 활성이 감소되는 등의 면역 기능의 손상을 가져올 수 있다. 이러한 면역기능의 손상은 간질환, 암, 기타 감염에 쉽게 노출될 수 있는 환경을 제공하게 된다. 결국 알코올 섭취와 관련된 특정질환에서 알코올은 immnomodulator로서 작용하여 여러 질환의 원인 물질로 작용될 수 있다.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

전신성 홍반성 루푸스 환자에서 발생한 다발성 피부섬유종 1예

김용주,김정은,김애리,손상욱,송해준,오칠환 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

병렬 기구 공작 기계의 가공 정밀도 평가에 관한 연구

김기욱,고해주,정윤교 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-

Recently, In the advanced countries have been studied on the Parallel Kinematic Machine Tool(PKMT). PKMT has merits to reduce a machining error while switch position of workpiece for 5-plane machining. Main spindle & moving plat-form to chain many links may increase mechanical stiffness because it takes tensile & compressed strengths instead of getting bending moment. Even though there are little studies on the PKMT & evaluation of machining accuracy. In this paper introduces a test work-piece & method for evaluation of machining accuracy with PKMT.

청소년의 스마트폰 중독과 우울 및 불안과의 관계

김경은,김필송,민주연,박수경,신서인,이지은,정해인,조호정,최정원,최정인 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to investigate the relationships between the degree of smart phone addiction among adolescents and their depression and anxiety levels. Method: In this study, 379 high school students were selected using the convenient sampling method. The instruments used for this study were smart phone addiction measure, the CES-D (Center for Epidemiological Studies-Depression Scale), and the STAI (State-Trait Anxiety Inventory). Data were analyzed using the SPSS 20.0 program with descriptive statistics, t-test, ANOVA with Scheffe test, and Pearson’s correlation coefficient. Result: The mean score for smart phone addiction was 40.45±17.27, depression was 36.56±9.58, state anxiety was 44.00±9.61, and trait anxiety was 45.70±9.75. There were significant differences between the degree of smart phone addiction and the following variables: gender (t=-4.953, p<.001), hours of smart phone use per day (F=12.259, p<.001), types of frequently used features (F=3.485, p=.008), and satisfaction level for smart phone (F=5.18, p<.001). There were statistically significant relationships (p<.001) among degree of smart phone addiction, depression level, and state and trait anxiety levels. Conclusion: The results of this study suggested that there was a significant relationship between smart phone addiction and mental health, specifically, depression and anxiety among adolescents. Further research is needed to develop nursing strategies to provide care for adolescents who frequently utilize smart phones.

컴퓨터를 활용한 음악과의 감상·작곡 수업 방법에 관한 연구

김현경,변혜주 부산대학교 예술대학 2003 藝術論文集 Vol.17 No.-

Music Education has been part of experience from very being of the time: Since nomadic peoples first sang, music has described, defined and deepened human experience. I believe that music enriches our own ways of thinking habits of mind as rich and different from each other botany is different from philosophy, and music is embedded in our daily life often so deeply or subtly that it is part of our subconsciousness. School classes are changing everyday along with developing technology. The transforming power of technology is a force not only in the economy but in the music field as well. Therefore, my thesis is teaching music by using Computer. Appreciating is not only a simple listening activity, but also a field of learning. This means appreciation is so important that it should be a theoretical background for music teaching and learning through recognizing and grasping the essence of appreciation teaching Composing is so easy for students to make music using software. It is so enjoying to the students and helps them approach music. As I develop some skills of music appreciation and composing by using lots of web and software, I discovered several benefits, First, students are interested in music through the Computer teaching than without it. Second, students can learn more easier by himself/herself more information and knowledge through Computer. Third, students can concentrate, feel enthusiastic about their learning, and access music information much more quickly. Forth, music and computers are central to the growth of cultural diversity. Finally, intermediate Computer-use teachers approached Computer as an integrated system to present course materials effectively. Where as, expert Computer - use teachers to seem to value how to search, organize, and synthesize information, and use of technology of communicate each others. Above all, for subject teachers, they need practical training relating to use of Computer in their subject areas.

Berberine의 항생제 내성 황색포도구균에 대한 항미생물 효과

김해경,차정단,유용욱,김강주,이동근 원광대학교 생체재료·매식연구소 2000 원광생체재료·매식 Vol.9 No.1

Antibiotic-resistant Staphylococcus aureus (S. aureus) emerged in many parts of the world and increased complex clinical problems. Therefore, new agents are needed to treat to antibiotic-resistant S. aureus. Some natural products are candidates of new antibotic substances. Previous reports showed that the extract of Coptidis Rhizoma and Phellodendri Cortex have antimicrobial effects. The main antibacterial substance of Coptidis Rhizoma and Phellodendri Cortex is berberine. In this study, we examined the antimicrobial activity of berberine to antibiotic-resistant S. aureus. We isolated the 13 strains of antibiotic-resistant S. aureus from the oral cavity of healthy children in a preschool, and investigated the antimicrobial activity of berberine. We examined the effects of berberine on the level of resistance to antibiotic-resistant S. aureus. We observed that the invasion of S. aureus into human gingival fibroblasts was blocked by berberine. Berberine inhibited the growth of antibiotic-resistant. S. aureus as a dose dependent maner. Minimum inhibition concentration (MIC) of berberine against antibiotic-resistant S. aureus was 50-100 ㎍/ml. The inhibition of S. aureus invasion was depended on the concentration of berberine in human gingival fibroblasts. The MIC of ampicillin against antibiotic-resistant S. aureus was 32 ㎍/ml. However, the MIC of ampicillin against antibiotic-resitant S. aureus in the presence of 50 ㎍/ml berberine was 1 ㎍/ml. These data indicate that the combination with berberine and β-lactam antibiotics resulted in the synergistic reaction. These results suggest that the berberine may have the antimicrobial activities to antibiotic-resistant. S. aureus, and the mechanism may be the inhibition of growth and intracellular invasion. and alteration of antibiotic-resistance level of antibiotic-resistant S. aureus.