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茵蔯蒿가 흰쥐 肝조직내 Na^+·K^+ -ATPase 活性에 미치는 영향
金柱賢,申國鉉,趙台淳 成均館大學校 科學技術硏究所 1987 論文集 Vol.38 No.2
In order to investigate the effects of Artemisia on bile flow, the bile volume and the activities of Na^+·K^+-ATPase in liver plasma membrane and liver homogenate were examined in rats orally administered methanol extract of Artemisiae messer-schmidtiana Besser var. viridis Besser for 3 days. In the case of bile juice, the flow rate was increased 30∼70%. The activities of Na^+·K^+-ATPase was increased to 2.5 fold in liver homogenate and 2.1 fold in liver plasma membrane. On the other hand activities of Mg^++-ATPase was slightly increased in both liver homogenate and liver plasma membrane.
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The Role of Lysyl Oxidase-like 2 in the Odontogenic Differentiation of Human Dental Pulp Stem Cells
김주현,조제열,이은향,박혜정,박의균,권대근,신홍인 한국분자세포생물학회 2013 Molecules and cells Vol.35 No.6
Adult human dental pulp stem cells (hDPSCs) are a unique population of precursor cells those are isolated from postnatal dental pulp and have the ability to differentiate into a variety of cell types utilized for the formation of a reparative dentin-like complex. Using LC-MS/MS proteomics approaches, we identified the proteins secreted from the differentiating hDPSCs in mineralization media. Lysyl oxidase-like 2 (LOXL2) was identified as a protein that was down-regulated in the hDPSCs that differentiate into odontoblast-like cells. The role of LOXL2 has not been studied in dental pulp stem cells. LOXL2 mRNA levels were reduced in differentiating hDPSCs, whereas the levels of other LOX family mem-bers including LOX, LOXL1, LOXL3, and LOXL4, are increased. The protein expression and secretion levels of LOXL2 were also decreased during odontogenic differentiation. Recombinant LOXL2 protein treatment to hDPSCs resulted in a dose-dependent decrease in the early differentiation and the mineralization accompanying with the lower levels of odontogenic markers such as DSPP, DMP-1 and ALP. These results suggest that LOXL2 has a negative effect on the differentiation of hDPSCs and blocking LOXL2 can promote the hDPSC differentiation to odontoblasts.
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