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레진 배양액의 생체내 및 실험실 세포독성에 미치는 영향
임미경,김은철,유수경,김강주 원광대학교 생체재료·매식연구소 1992 원광생체재료·매식 Vol.2 No.1
To know the in vitro and the in vivo cytotoxicity of resin solution, resin solution was applied to cultured fibroblast and was injected into the mouse. The cytotoxic effect of resin solution was measured by MTT assay and in vivo cytotoxicity was examined after Hematoxylin and Eosin staining. The cell activity of resin solution in the concentration of 59% was significantly decreased compared to control group and 5% group. In histopathologic study of resin solution, there were severe inflammatory cell infiltration, mild interstitial edema, trace hemorrhage, and moderate or severe muscle destruction in resin injected group. These results suggested that there might be some differences between the cel viability of fibroblast and in vivo cell cytotoxicity. Further study is needed to clarify the cytotoxicity by direct implanting of resin mass.
수종 플레이트의 재료학적 특성과 실험실 비방사선 강도 검사를 이용한 생체적합성 비교
이동근,이용근,이의석,양희창 원광대학교 생체재료·매식연구소 1996 원광생체재료·매식 Vol.5 No.2
The method of rigid internal fixation with miniplate is an acceptable procedure for the treatment of oral & maxillofacial trauma and orthognathic reconstructive surgery. With the goal of osteosynthesis tha is stable during function, an osteosynthetic union was developed for treatment of mandibular fractures which does justice to the particular anatomic and functional conditions in the mandibular region in its construction. This study was to compare used miniplate with new miniplate at the point of elastic modulus, maximum force. We studied various patterns of plate fixation. The obtained results were as follows. 1. There was no significant difference between new miniplates and used miniplates in elsatic modulus, maximum force, displacement at maximum force, fracture force, displacement at fracture force and work up to fracture(p>0.05). 2. New miniplates showed higher modulus of elasticity than used miniplates, but there was no difference in the patterns of fracture of plate fixation. 3. New miniplates showed higher maximum force than used minoplates, but no difference in the patterns of fracture of plate fixation. 4. There were no difference in the patterns of plate fixation and the displacement at maximum force between new miniplates and used miniplates. 5. There were no difference in the patterns of plate fixation and the fracture force between new miniplates and used miniplates. 6. There were no difference in the patterns of plate fixation and the displacement at frature force between new miniplates and used miniplates. 7. There were no difference in the patterns of plate fixation and the work up to fracture between new miniplates and used miniplates.
Cyclic AMP analog와 PGE2가 마우스 조골세포의 활성에 미치는 영향
김형룡,김장숙 원광대학교 생체재료·매식연구소 1996 원광생체재료·매식 Vol.5 No.2
To maintain its functional integrity, bone is continuously remodelled by a process involving resorption by osteoclasts and bone formation by osteoblasts. In order to respond to changes in the physical environment or to trauma with the relevant action, this process is strictly regulated by locally synthesized or systemic fators. Prostaglandin E_2(PGE_2) is perhaps one of the best studied of these factors, having been known to affect bone cell function for several decades. PGE_2 has both anabolic and catabolic activities. Excess levels of PGE_2 have been implicated in a number of pathological states associated with bone loss such as a number of chronic inflammatory conditions such as periodontal disease and rheumatoid arthritis. PGE_2 and other arachidonic acid metabolites have been shown to be potent stimulators of osteoclastic bone resorption in organ culture. The anabolic effects of PGE_2 were first noticed when an increase in periosteal woven bone formation was seen after the infusion of PGE_2 into infants in order to prevent closure of the ductus arteriosus. The cellular basis for the catabolic actions of PGE_2 has been well characterized. PGE_2 increase osteoclast recruitment in bone marrow cell cultures. PGE_2 also has a direct action on osteoclast serving to inhibit activity and can also indirectly activate osteoclast via other cells in the vicinity, presumably osteoblast. The cellular mechanisms for the anabolic actions of PGE_2 are not nearly so well understood. The purpose of this paper is to study the anabolic actions of PGE_2 on osteoblastic clone MC3T3E1 cells. The effects of DBcAMP and PGE_2 on the induction of alkaline phosphatase(ALP) was investigated in osteoblastic clone MC3T3E1 cells cultured in medium containing 0.4% fetal bovine serum. DBcAMP and PGE_2 stimulated ALP activity and MTT assay in the cells in a dose-dependent manner at concentrations of 10-500ng/ml. Cycloheximide, protein synthesis inhibitor, inhibited the stimulative effect of PGE_2 and DBcAMP on ALP activity in the cells. PGE_2 also increased the intracellular cAMP content in a dose-dependent fashion with a maximal effect at 500ng/ml. Our present results suggest that PGE_2 stimulate the differentiation of osteoblasts and are involved in bone formation in vivo, as well as in bone resorption.
김요숙,김상철 원광대학교 생체재료·매식연구소 1999 원광생체재료·매식 Vol.8 No.1
The purpose of this study was to investigate the relationship between the space discrepancy of the mandibular dentition and carniofacial morphology in adults with good Angle class I occlussion. Dental casts of normal group, crowded group and spaced group were selected on the basis of dental crowing and spacing. Subjects with excessive space to accomodate the lower teeth were classified as spaced group(39). Subjects with a space discrepancy of more than 4mm were classified as crowded group(45). Normal subjects had little or no dental crowding and spacing(40). Various skeletodental measurements in lateral cephalograms were evaluated and compared by ANOVA, Pearson correlation analysis and multiple stepwise regression analysis. The results were as follows: 1. ANB angle was larger in crowded group than in spaced group. 2. Maxilla and mandible in crowded group were inclined more downward and forward than in spaced group, so crowded group was found to have vertical tendency. 3. Anterior cranial base length and mandibular body length were longer in spaced group than in crowded group. 4. According to the multiple stepwise regression analysis with space discrepancy as dependent variable, 40% of variance of space discrepancy could be explained by ANB angle, anterior facial height and ramus height. Multiple regression equation was as follows space discrepancy = 46.51 - 2.51ANB - 0.58AFH + 0.65RH