판막 질환에서의 심근 섬유화 : 심근 조직을 이용한 형태학적 연구 및 혈청 생화학적 지표의 분석

강수진,박덕우,송재관,박경민,송종민,강덕현,한기훈,송현,이재원,주석중,송명근,김정선 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

다핵균 및 단핵균으로부터 고protease 생산균주의 Screening

송상호,임현수,최명락,유은정,김성영 여수대학교 1998 論文集 Vol.13 No.2

4 multinucleate and 7 mononuclear fungi were investigated for screening of high protease productive strains. The protease activity of mononuclear strains was generally greater than that of multinucleate strains. For acid proteinase, Aspergillus awamori AOK 1007 and Asp. oryzae shoyu 2 as mononuclear strains were selected in glucose-polypeptnoe medium. For acid carboxypeptidase, two mononuclear strains were screened as Asp. awamori AOK 1007 and Asp. usamii mut. shirousami AOK 1011 in glusose-sodium glutanate medium. In this result, mononuclear fungi appeared higher protease production than that of multinuclear fungi. So, mononuclear fungi may gave many merits to improve protease activity by using of mutation or cell fusion technology.

有限要素法을 이용한 過壓密粘土의 壓密沈下豫測

현상락,류제천,김송만,박춘수 충남대학교 산업기술연구소 2002 산업기술연구논문집 Vol.17 No.1

Consolidation is the time-dependent settlement of soils resulting from the expulsion of water from the soil pores. When a saturated compressible clay layer is subjected to a stress increase, consolidation settlement occurs greatly. Because the hydraulic conductivity of clay is significantly small, the excess pore water pressure generated by loading gradually dissipates over a long period. The settlement caused by consolidation in clay may be several times greater than the immediate settlement. A number of researches are carried out to predict the consolidation behavior in field, however, most of researches show the discrepancies between the prediction and the field settlement data. Therefore, the estimation of consolidation rate is one of the important factors in the construcion on soft clayey deposits. In this paper, laboratory tests have analyzed to apply accurately the soil parameters that executed the plan of stage construction. This study analyzes consolidation behavior of overconsolidated clay with two-dimensional consolidation analysis program by use of the numerical method. By using this program, the time dependent consolidation behavior of soft deposits can be analyzed appropriately. Elastic and elastic-plastic finite element analysis are compared with Terzaghi's theory of one-dimensional consolidation.

貝類의 冷凍에 關한 硏究 : 4. 오분자기의 凍結貯藏溫度에 따른 品質의 變化 4. Quality Changes of Abalone, Haliotis diversicolor japonica, by the Freezing Storage Temperatare

宋大鎭,河璡桓,金洙賢 濟州大學校 海洋資源硏究所 1985 해양과환경연구소 연구논문집 Vol.9 No.-

오분자기를 보다 效果的으로 利用하기 위한 基礎資料를 얻기 위하여 오분자기를 脫殼, 凍結한 후 凍結貯藏中의 品質의 變化를 實驗하였다. 凍結貯藏中 pH는 거의 變化가 없었고 drip量 조금씩 增加하였으며 揮發性鹽基窒素도 조금씩 增加하였으나 -35℃의 경우 3個月까지는 좋은 鮮度를 維持하였다. 保水力은 점차 減少하여 貯藏 3個月후에는 -10℃에서 貯藏한 경우가 10%, -35℃는 약 7%까지 減少하였다. hardness는 -10℃와 -35℃ 다 같이 1個月까지 增加하다가 以後 급격하게 減少하였으며 toughness는 계속 減少하였다. cohesiveness는 -10℃의 경우 큰 變化가 없었으나 -35℃의 경우는 2個月에 급격히 減少하였으며 elasticity는 -10℃와 -35℃의 경우 모두 큰 變化가 없었다. 色調의 變化에서 a값은 큰 變化가 없었으나 L값은 계속 減少하였고 b값과 ΔE값은 계속 增加하였다. 組織學的 觀察의 結果 貯藏溫度가 높은 것일수록 氷結晶의 成長과 근속끼리의 응집이 현저함이 確認되어졌다. To obtain the basic data for utilizing abalone, Haliotis diversicolor japonica more effectively the quality changes as pH, drip, water holding capacity (WHC), texture, color difference and histological observation in shelled and frozen products during storage were carried out. It was noticed that the pH of frozen products (-10℃ and -35℃) were not changed markedly, thaw exudate (drip) and volatile basic nitrogen (VBN) were slightly increased as the storing period prolonged but fairly good freshness was maintained until 3 months in the storage of -35℃. The water holding capacity for all frozen products were steadily decreased to show 10% and 7% down at -10℃ and -35℃ respectively with 3 months storage on the base of raw materials. With all frozen products it was observed that hardness was increased up until the 1 month storage period and then suddenly dropped while toughness was decreased steadily. NO significant changes in cohesiveness with the -10℃ storage were observed but with -35℃, it was dropped rapidly after 2 months storage while elasticity was not changed markedly for all frozen products. The color difference expressed as a value was not changed markedly while the L value was decreased steadily. The b and ΔE value were increased continually as the frozen period was extended. It was confirmed that both the growth of ice crystal and aggregates of muscle bundle were prominent at the higher storage temperature in histological observation.

뇌동맥류의 진단에 대한 전산화단층촬영 뇌혈관조영술과 고식적 뇌혈관조영술의 비교

송상현,윤수한,안영환,안영민,조기홍,조경기,김선용,서정호 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

Cerebral angiography has been essential for the diagnosis of the intracranial aneurysms but. is sometimes accompanied by serious complications. Resolution of CT angiography was up-graded greatly to represent the three-demensional structure of vesseles since helical CT had been introduced. We have compared 26 cases of CT angiography and 28 cases of conventional angiography in terms of specificity and sensitivity for the diagnosis detectable aneurysm diameter. configurational diagnosis and diagnostic confidency. All results showed no statistical difference between CT angiography and conventional angiography. These should suggest that CT angiography could be replaced with conventional angiography for the diagnosis of ruptured aneurysms and even of unruptured aneurysms. resulting in the introduction of first screening modality of unruptured aneurysms.

정상 성인의 말초 혈액 림프구에 표현된 Humkv325-derived κ 경쇄에서의 N-region addition

송준현,이찬희,이지수,이수곤 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

Complementarity determining region(CDR3) of immunoglobulin is the center of antigen binding site. Changes in the number of amino acids of CDR3 may result in change in antigen binding specificity and affinity. The majority of immunoglobulin x chain has 9 or 10 amino acid co-dons in the CDR3 region. Immunoglobulin x chain containing CDR3 with 11 amino acid codons cannot be made without N-region addition. The aims of this study were to evaluate the presence of immunoglobulin x light chain with 11 amino acid codons in its CDR3 domain expressed in the peripheral blood lymphocytes(PBLs) of normal individuals and to correlate amino acid codon length in CDR3 region with age and sex. RNA was isolated from PBLs of normal individuals and x chain was PCR amplified. Amino acid length of CDR3 region was determined by polyacrylamide gel electrophoresis. A low but constant expression of immunoglobulin x chain with 11 amino acid codons in CDR3 region in normal individuals was found (mean±SD=11.72±1.80%). Significant correlation was not found between amino acid length in CDR3 region of x chain and age or sex. These findings suggest that the concept that N-region addition in x light chain does not occur due to absence of terminal deoxynucleotidyl transferase (TdT) needs to be reconsidered. The existence of long CDR3 K chain in PBLs of normal individuals may reflect that CDR diversity in is quite common. Amino acid length of x chain CDR3 is not regulated during development and there is no influence of sex on the expression of x chain containing CDR3 with 11 amino acids.

개별환경제어(PEM)시스템의 운용에 따른 건물의 에너지절약성에 관한 연구

송인춘,구현덕,김기세,나기태,김병수 忠南大學校 産業技術硏究所 1999 산업기술연구논문집 Vol.14 No.1

The building energy conservation possibility by introducing personal environment module(PEM)system was analyzed by DOE-2.1E building energy analysis program on the 6 stories office building. The results showed energy consumption of the building with PEM system could be increased more than the conventional VAV system when the occupant was not decreased. But the energy consumption rate in the building with PEM could be equal to VAV system when approximately 20% of the occupant is decreased. As a result, basically PEM system can consume more about 9.2%energy than the VAV system, but it can also have the possibility to save energy about 11.4% if it is operating with energy conservative way.

태양열 온수급탕 시스템에 관한 연구 : 아파트를 중심으로 With relevance to Apartment

송인춘,김기세,구현덕,김병수,나기태 忠南大學校 産業技術硏究所 1999 산업기술연구논문집 Vol.14 No.1

This work was carried out to propose a model of the most effective layout and installation for applying the Solar Hot Water system to apartment and to offer the basic data for promoting the destribution of this Solar Hot Water system in the country. For this purpose, the performed experiments are as followings: 1)Measurement and analysis of the amount of hot water adn the cost of water used in apartment of which the area is 30 to 40 pyung. 2)to esimate the efficiency of Solar Hot Water System in accordance with an angle of inclination. 3) Analysis of economical efficiency the annual expected saving cost produced by replacing the existing hot water system with the Solar Hot Water System. 4)Proposal of the best model for installing the Solar Hot Water System in apartment by considering the place and sunshine,and compaison of merit and demerit of this system.

패류의 동결에 관한 연구 : 1. 소라의 동결

송대진,김수현,하진환 제주대학교 해양연구소 1984 해양자원연구소연구보고 Vol.8 No.-

To obtain the basic data for utilizing topshell, the changes of quality as pH, drip, free water content, water holding capacity, texture and color difference in shelled and frozen products during storage was studied. It was noticed that the pH of all frozen products (-10℃ and -35℃) were not changed markedly. Thaw exudate(drip) and free water content were increased as the storing period prolonged. The content of thaw exudate was risen slightly while free water content for all frozen products was increased notably marked 2.5 times in comparison with raw ones after 3 months storage. The water holding capacity for all frozen products were fell down steadily, it showed down 10% level at final stage of storage on the base of raw materials. It was revealed that the hardness and toughness were leveled up until the time of 2 months storage and then decreased moderately. There was not a significant change in elasticities and the degree of cohesiveness droped for all frozen storing periods. The color differences, expressed as L value mere reduced, the values of a and b were not changed markedly while the values of ΔE was increased as the frozen peried was extended.