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- 저자 : 윤수한 (검색결과 313 건)
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삼차신경 감각핵내 치수신경세포의 분포와 수 종 약물의 진통작용에 관한 연구
윤수한,이종흔,김중수,오석배 대한구강생물학회 1992 International Journal of Oral Biology Vol.16 No.1
This experiment was performed to clarify the relay site of primary afferent nerve of dental pulp in trigeminal sensory nucleus complex and to evaluate the analgesic effect of some ions and drugs on dental pain. Deep cavity was prepared on labial surface of lower canine to apply the ions or drugs and ipsilateral inferior alveolar nerve was exposed to record the action potential of single nerve fiber or a pair of wire electrode for record of digastric EMG was inserted into the ipsilateral muscle under genral anesthesia. In order to confirm the neural tracts in trigeminal sensory nucleus, animal was fixed to stereotaxic apparatus and caudal brainstem was exposed. Extracellular neural activity of trigeminal sensory nucleus responded to electrical stimulation of dental pulp was recorded by glass-coated tungsten microelectrode. Tested materials in this experiment were calciun chloride, calcium hydroxide, potassium chloride, eugenol, zic oxide eugenol and extract of Zingiberis rhizoma and Asiasari radix. Drug was applied into dental cavity for 15~45 minutes and neural activity and digastric EMG were recorded before application, after application and removal of drugs. Primary afferent of lower canine pulp was projected to all part of trigeminal sensory nucleus. But Aβ-fiber ended in only rostral part of nucleus, Aδ-fiber projected to rostral and caudal part and C-fiber ended in caudal part nucleus. Calcium chloride increased the threshold intensity of dental pulp significantly but calcium hydroxide showed slight effect on neural activity. Eugenol applied to cavity completely inhibited neural ativity after 45 minutes and decreased digastric EMG. Hypertonic potassium chlorde revealed the spontaneous activity of inferior alveolar nerve and minimum inhibitory effect. Extracts of Zingiberis rhizoma and Asiasari radix decreased the latent period of digastric EMG evoked by noxious stimulation of dental pulp.
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윤수한 大韓齒科保存學會 1993 Restorative Dentistry & Endodontics Vol.18 No.2
Sealapex was comparied with a zinc oxide euaenol sealer over a 24-wk interval to examine solubility in an in vitro situation. After obturation with gutta percha and the appropriate sealer, speciemens were immediately immersed in a saline solution to challenge the solubility oh the sealers. The solutions were changed weekly to allow for a continued dissolution of the sealers. Aget immersed in methylene blue solution for 3 days, the speiemens were made transpatent by a clearing process. Microscopic examination was used to determine the lenear penetration of dye for each speciemen. Result revealed that sealapex had no greater dissolution than ZOE. Key words : Z.O.E., Sealapex, Solubility, Clearing process, Dissolution
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낭성 두개인두종 치료를 위한 종양내 Bleomycin 주입
윤수한,최중언,김은영 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.11
Surgical excision or irradiation of craniopharyngioma is problematic because both are often associated with high risk of complications. Three cases of cystic craniopharyngioma were subtotally removed by surgery and followed by repeated injection of bleomycin into the remaining trumor cavity as postoperative adjuvant therapy. With bleomycin injection, tumors were shrunk postoperatively in two cases out of three but in one case cyctic portion became increased in size progressively which needed second operation and irradiation. Bleomycin injection could be considered as one of the reasonable alternative adjuvant therapies for incompletely removed cystic craniopharyngioma before radiation therapy.
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수아세포종 : 치료결과와 예후인자에 대한 연구 Outcome and Prognostic Factors
윤수한,이규성,박용구,최중언,정상섭,이규창 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.2
43 patients with medulloblastoma of the posterior fossa were treated at the Department of Neurosurgery Yonsei University College of Medicine from 1981 to 1991. Major treatment were surgery, irradiation chemotherapy or combination. Mean follow-up was 30 months(range, 1 to 120 months). Kaplan-Meier actuarial survival for all patients 59% at 3 years. Disease free survival was 53% at 3 years. Radiation and treatment period(before 1986 vs after 1986) affected outcome significantly. But other prognosic factors such as age, extent of surgical resection and chemotherapy did not affect outcome statistically. Follow-up more than 3 years showed very low recurrence rate.
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온도변화(溫度變化)에 따른 치질(齒質)의 구조적변화(構造的變化)
윤수한,Yoon, Soo-Han 대한치과보존학회 1976 Restorative Dentistry & Endodontics Vol.2 No.1
16 healthy teeth extracted have been selected and their color and structural change have been observed at the fixed temperatures of $200^{\circ}F$., $400^{\circ}F$., $600^{\circ}F$., and $800^{\circ}F$. respectively at the intervals of 10min. 30min and 60min. The results were as follows: 1) $200^{\circ}F$ Groop: At the 60 minutes interval, crown surface shows pattern simliars to mottled teeth and roots take on light yellowish colar and interglobular dentin tends to be rough. 2) $400^{\circ}C$ Groop: at the 30 minutes interval, cracks begin to show in the direction of long axis of the teeth and crown surface have been observed on the verge of fracture at the 60 minutes interval. 3) $600^{\circ}F$ Groop: Crowns take on grayish-white color thoroughout 10, 30 and 60 minutes intervals and roots reveal black color. Moreover the seperation of enamel from dentin has been confirmed at the 60 minutes interval and inner dentin has changed black. 4) $800^{\circ}F$ Groop: Crowns take on the same grayish-white color as at the $600^{\circ}F$ at the 10, 30 and 60 minutes intervals and roots reveal gray color at the 30 and 60 minutes intervals, while parts of the crown have fractured at the 10 minutes interval. Inner dentin has turned gray at the 60 minutes interval.
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윤수한,허승곤,이규창 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.1
The author analyzed 66 cases of intracranial arteriovenous malformations treated in the Department of Neurosurgery of Yonsei University Hospital from 1977 to 1985. The results are summarized as follows: 1) The ratio of male to female was 2:1 and 75.8% or 50 cases were distributed between the 2nd and 4th decade. 2) The common presenting symptoms were either seizure alone (14%) or various symptoms resulting from hemorrhage (75%). 3) Arteriovenous malformations were suggested in 93.3% and were diagnosed in about half of the cases with the brain CT scan. Enhanced tubular shadow was the most important finding and hyperdensity of the lesion on precontrast brain CT scan was the most common finding. 4) The most common site of involvement was the supratentorial subcortical region with 75.4%, followed by the supratentorial deep region with 14.8%, and the infratentorial and dural region with 4.8%. 5) When compared to small(<2㎝) and larger (>4㎝) lesions, there was less chance of hemorrhage in medium sized lesion (>2㎝ to <4㎝). When the subcortical and deep regions of the supratentorial lesion were compared, there was no difference in incidence of hemorrhage. 6) According to angiographic findings, 46.6% was grade Ⅰ lesions. The anterior cerebral artery and the middle cerebral artery were most commonly involved. 7) After craniotomy, total resection was performed in 34 of 43 cases or 79.1 %. Due to either size or location, 14.4% or 7 of 43 cases were inoperable. 8) Immediate postoperative neurological deficits were noted in 12.5 % or 6 of 48 cases. Non-hemorrhagic patients showed postoperative deficits more frequently than hemorrhagic patient did. 9) Regardless of treatment modality, there was a significant increase in number of patients who could be classified as grade Ⅰ at discharge. 10) Long-term follow-up was carried out on 19 craniotomy cases. Neurological improvement was noted in 63.2% of these 19 cases. Among this group, there was no case of neurological deterioration.
RISS
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