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뇌척수액 배액환자에서 뇌실내 항생제 투여시 뇌척수액내에 항생제 농도
윤수한,안영환,안영민,조경기 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.5
Phamacokinetic study of the antibiotic concentrations in the cerebrospinal fluid was done with high pressure liquid chromatography of CSF samples from twelve patients who had various amount of continuous extra ventricular drainage during antibiotic administration. Five patients with isrge amount(over 150cc/day) of drainage had decreased CSF antibiotic concentrations dramatically below the effective concentration within 4 hours after intraventricular antibiotic administration. but six patients with small(less than 150cc/day) drainage maintained CSF antibiotic level above effective concentration even 24 hours after administration. In conclusion, repeated intra ventricular administration of antibiotic is necessary to maintain the effective drug level in the patient with CSF drainage over 150cc/day
Kerr sealer를 根管充塡材로 使用時 根管閉鎖性에 關한 實驗的 硏究
尹壽漢 大韓齒科保存學會 1980 Restorative Dentistry & Endodontics Vol.6 No.1
AbstractThe author has studied comparatively the sealing quality of conventional Z.O.E. cement, Kerr sealer and Nogenol sealer by means of penetration of 2% methylene blue solution through the root apex of human teeth in 72 cases as time elapsed.The results were as follows; 1. All the specimens, whose dye immersion time is two days, showed dye penetration of low degree unrelated to the kinds of root canal sealer. 2. Kerr sealer group, like conventional Z.O.E. group, showed dye penetration of high degree related to increased time of immersion in the dye. 3. In Nogenol group, there was slight increase in penetration related to increased time of immersion in the dye. 4. Kerr sealer group showed comparatively lower grade of dye penetration than conventional Z.O.E. and higher than Nogenet sealer.
호제근충재 Vitapex와 수산화칼슘이 근첨형성에 미치는 영향에 관한 연구
윤수한 大韓齒科保存學會 1985 Restorative Dentistry & Endodontics Vol.11 No.1
To compare calcium hydroxide with Vitapex paste in the effect of apical closure, apexification was done with two medicaments in the nine teeth of seven patients visiting at SNUDH, and then, after radiographic and clinical observation of at least six months, the author concluded the followings: 1. The significant differences between calcium hydroxide and Vitapex paste were not observed in the effect of apical closure. 2. In calcium hydroxide group, the resorption of the paste within the canal was not observed but in Vitapex group, observed. 3. In both calcium hydroxide group and Vitapex group, the progressive healing of apical lesion was observed. 4. The progressive resorption of Vitapex paste out of the apical foramen was observed.
변형된 액상 압력파 전달에 따른 뇌손상 모델에서 Laser Doppler에 의한 뇌혈류 측정 및 고삼투압제제에 의한 뇌혈류 변화 비교
윤수한,조기홍,조경기,안영민,안영환 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10
study of cortical blood flow changes using laser doppler was conducted in seven head injuried rate with subsequent intravenous administration of mannitol Cortical blood flow after head trauma by the fluid-percussion model was decreased in 6 cases and initially increased and then decreased in 1 case. Cortical blood flows were dramatically increased about three to six times after intravenous administration of mannitol. These results suggest that the modified fluid-percussion cortical injury system is more stable and consistent than the old fluid-percussion injury model. It therefore seems applicable to be used as experimental models for head trauma.
만니톨 투여에 의한 혈뇌장벽의 개방은 All-or-None Phenomenon인가?
윤수한,조기홍,조경기,안영민,안영환 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.9
We evaluated the effect of mannitol-induced blood-brain-barrier disruption(BBBD) in 20 rats of the routine-dose mannitol group(1.75g/㎏). 7 rats of the small-dose mannitol group(0.87g/㎏), and 10 rats of the saline control group. Radioactivity ratios of brain section to plama in the routine dose mannitol group revealed a wide variation of 0.0134 to 0.1747 which was compared to the small dose mannitol group of 0.0107-0.0275 in the plasma albumin space and to the saline control group of 0.0051-0.0174. This result suggest that mannitol-induced BBBD may not be threshold event of all-or-none phenpomenon, but progressive graded reacton with various sensitivity.
수아세포종 : 치료결과와 예후인자에 대한 연구 Outcome and Prognostic Factors
윤수한,이규성,박용구,최중언,정상섭,이규창 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.2
43 patients with medulloblastoma of the posterior fossa were treated at the Department of Neurosurgery Yonsei University College of Medicine from 1981 to 1991. Major treatment were surgery, irradiation chemotherapy or combination. Mean follow-up was 30 months(range, 1 to 120 months). Kaplan-Meier actuarial survival for all patients 59% at 3 years. Disease free survival was 53% at 3 years. Radiation and treatment period(before 1986 vs after 1986) affected outcome significantly. But other prognosic factors such as age, extent of surgical resection and chemotherapy did not affect outcome statistically. Follow-up more than 3 years showed very low recurrence rate.