당뇨병환자에서 뇨증 Fibronectin농도의 증가에 관한 연구

한승범,조준승,손건영,서성문,박근용,조성래,박규영,박정모,이인규,여준기 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Plasma fibronectin is an α₂-glyoprotein, which is produced by vascular endothelial cells. Raised level of plasma fibronectin has been observed in diabetic patients particularly in the presence of microvascular complications. However, no available data exist about urine level of this glycoprotein in diabetic patients. We measured urine fibronectin level by ELISA methods in 54 diabetic patients who have microvascular comlications or not. The following results were obtained. 1) Urine fibronectin level(㎍/g creatinine) in diabetic group(1740.0±678.0) is increased compaired with those in normal control group(471.0±59.0). but this results were not significantly different among two groups(P>0.05). 2) Urine fibronectin level(㎍/g creatinine) was significantly increased in patients with nephropathy (6188.0±3144.0) compared with those in normal control group(471.0±59.0) and patients without nephropathy(645.0±251.0)(P<0.001). 3) There were a significant correlation between BUN, creatinine, creatinine clearance, 24hr urine total protein and urine fibronectin level in diabetic patients. Our data suggest that urine fibronectin excretion level might be used as a sensitive guide for diabectic nephropathy.

Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

닭의 乾燥 筋胃粘膜 粉末 投與가 Egg Type Fowl에 미치는 效果에 對한 硏究 : 第Ⅰ報 增體 및 羽毛量에 미치는 影響에 關하여 Ⅰ. The effect of body weight gainand feather weight

文勝式,朴玉潤 진주산업대학교 1981 論文集 Vol.19 No.-

This experiment was conducted to investigate the effect of Fowl Gizzard Mucouse Membrane Power treatment on body weight gain and feather weight with the data obtained from 60 pieces egg type fowls Babcock (B 380, 24 days-age) fed and allotted 4 treatments at the rate of 0%(C), 1%(T_1), 2%(T_2) and 3%(T_3) of FGM during the experimental period of 56 days from September 17, 1981 to December 12, the same year at Department of Animal Science, Jin Ju Agricultural and Forestry Junior Technical College. The results obtained are summarized as follows: 1. Average body weight gain at each experimental plot was 847.63g(T_2), 842.07(T_1), 828.94(T_3) and 815.83(C). The effect of FGM in the cody weight gain was nonsignificant for all the experimental plots. Feed conversion at each experimental plot was 3.65(T_2), 3.67(T_1), 3.75(C) and 3.77(T_3). 2. Average feather weight at each experimental plot was 105.84±10.13g(T_3), 90.78±13.55(T_2), 89.06±4.66(T_1) and 88.06±7.55(C). The effect of FGM in the only feather weight of T_3 plot was significant(p<.0.01).

여성의 사회교육 참여에 따른 생활만족도와 만족도에 미치는 요인 분석

문태영,박승환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

The purpose of this study was to examine how much women's life satisfaction was affected by social education and what factors impacted on that. The subjects in this study were 300 women who had participated in social-education programs provided by two women's centers for one year or longer period of time. A survey was conducted in August and September 2003 with self-administrated questionnaires on their life satisfaction and to what extent they received social education, and the responses from 286 women were selected for analysis, except for incomplete answer sheets. For data handling, statistical data on frequency and percentage were obtained, and t-test was implemented. Besides, regression analysis was carried out to identify what factors affected their satisfaction with social education. The findings of this study were as follows: First, among demographic variables, which were background variables, the health status of the respondents was significantly different according to age, education, family income and subjective health. By age, the older women were more contented with their lives and participated in more social-education programs. The older women preferred music and sports programs, and those who stopped at high school and school of lower grade favored music classes. The college graduates preferred art programs, and monthly mean income and subjective health made no significant differences. Second, their participation in social-education programs made a significant difference to their life satisfaction. Those who learned Samulnoli and singing found their lives most satisfactory, and the women who took computer classes were less pleased with their lives than those who took the other classes. The gap between them was significant.

닭의 乾燥筋胃粘膜 粉末投與가 Mouse의 發育效果에 미치는 實驗的 硏究 : 第1報. 增體에 미치는 影響에 關하여 1. The Effect of the Body Weight Gain

文勝式,朴玉潤 진주산업대학교 1980 論文集 Vol.18 No.-

本 試驗은 닭의 筋胃粘膜粉末을 3%(T_0),6%(T_1), 9%(T_2) 水準으로 配合飼料에 添加給與 했을 때 Mouse의 增體에 미치는 영향을 살펴보고자 1980年 10月 19日∼同年 11月 29日에 걸쳐 Mouse(dd Strain) 生後 8週 40首(♀20, ♂20)를 供試하여 晋州農業專門大學에서 實施한 結果는 다음과 같다. 1. ♀의 平均體重은 25.80g(24.23∼27.56(정도였고 ♂는 26.05g(24.14∼27.36)이었다. 2. ♀의 平均增體量은 C(2.91), T_0(3.57), T_1(5.26) 및 T_2(5.47) 順으로 처리구가 좋은 편이었으며 유의차가 있었다.(P<0.05). 3. ♂의 平均增體量은 C(3.77), T_0(5,81), T_1(6.02) 및 T_2(6.39) 順으로 처리구가 좋은 편이며 유의차가 있었다 (P<0.05). 4. ♀의 各 臟器의 평균 무게는 881.45㎎(간), 137.7㎎(심장), 336.9㎎(심장), 215.7㎎(폐), 246.8㎎(비장)이었다. 5. ♂의 各 臟器의 平均 무게는 902.0㎎(간), 152.7㎎(심장), 374.3㎎(신장), 267.6㎎(폐), 217.0㎎(비장)이었다. This experiment was conducted to determine the effect of Fowl gizzard mucouse menbrane dry powder treatment on growth of mice 20 heads male and 20 heads female of mice(dd strain)were alloted 4 treatments according to the levels of Fowl 0%(C), 3%(T_0), 6% (T_1)and 9%(T_2) per rations, respectively. During the period of 60 days from October 19.1980 to December 29.1980 on experiment had been carried out at Jinju Agricultual and Forestry Junior Technical Collage to compare body weight gain, The results obtained were summerized as fallows; 1. Average body weight was 25.80g(24.23∼27.56)in female and 26.05g(24.14∼27.38)in male. 2. Average body weight gains were 2.91g±.376(C), 3.57±.509(T_0) 5.26±.624(T_1) and 5.47±.624(T_2)in females, and statistical differences between treatments were found(P<0.05) 3. Average body weight gains were 3.77±.400(C), 5.81±.547(T_0)6.02±.715(T_1) and 6.39±.254(T_2) in males and statistical differences between treatments were found(P<0.05) 4. Each organs weight was 881.49㎎(liver). 137.7㎎(heart), 336.9㎎(kideny), 215.7㎎(lungs) and 246.8㎎(spllen)in females. 5. Each organs weight in male was 902.0㎎(liver), 152.7㎎(heart), 374.3㎎(kideny), 267.6㎎(lungs) and 217.0㎎(spllen).

닭의 乾燥 筋胃粘膜 粉末 投與가 Egg Type Fowl에 미치는 效果에 對한 硏究 : 第Ⅲ報 初産日令 및 質에 미치는 影響에 對하여 Ⅲ. The effect of First laying age in a day egg quility

文勝式,朴玉潤,宋瑛敏 진주산업대학교 1982 論文集 Vol.20 No.-

This experiment was conducted to investigate the effects of the additions at the level of 0(C), 1(T_1), 2(T_2) and 3%(T_3) of Fowl Gizzard Mucouse Membrane Powder in the formula feed on the average day at first laying and egg quality with a total of 40 pieces laying hens for 4 treatments during the experimental period of 84 days from Feb.1, 1982 to April 25, the same year at the brooding laboratory, Dept. of Animal Science, Jin Ju Agricultural and Forestry Junior Technical College. The average obtained are summarized as follows: 1. The average day at first laying day was long in the order of T_1(158.8±8.30), T_2(159.9±10.13), T_3(162.6±3.53) and C(164.3±7.04) and the average weight at first laying(kg), heavy in the order of T_1(2.10±0.16), T_2(2.11±0.19), T_2(2.13±0.08) and C(2.27±2.25)(P>0.05). The egg weight at first laying(g) was heavy in the order of T_2(47.5±5.09), T_3(48.15±4.13), T_1(48.9±4.93) and C(51.99±2.13)(P>0.05) 2. The average egg weight(g) was heavy in the order of C(59.66±2.06), T_1(59.74±2.56), T_2(60.70±5.23) and T_3(62.64±3.67) and the egg shell, thickness in the order of T_3(0.362±0.036), C(0.370±0.038), T_1(0.378±0.022) and T_2(0.382±0.034)(P>0.05). The yolk and albumen weight(g) was heavy in T_2(18.20±1.57), C(18.35±.95), T_3(18.60±0.97) and T_2(18.92±1.05), T_1(33.61±1.94), C(34.32±1.65), T_2(35.37±3.77) and T_3(36.64±2.62) in those order(P>0.05).

艾葉粉末의 添加給與가 肉鷄에 미치는 影響

文勝式,朴玉潤,宋瑛敏 진주산업대학교 1985 論文集 Vol.23 No.-

本 試驗은 1985년 9월 20일 孵化된 肉鷄用(Hubbard) 병아리 120首를 各區當 30首씩 4개區로 나누어 晋州農林 專門大學 養鷄場에서 3주간(1985.10.19~11.8)에 걸쳐 艾葉을 C(0%), T_1(1%), T_2(2%), T_3(3%)水準으로 飼料에 添加하여 給與試驗을 하였던 바 다음과 같은 성적을 얻었기에 報告하는 바이다. 1. 增體量은 T_1區(1296.32g), C區(1274.70g), T_3區(1264.32g) 및 T_2區(1259.64g)의 순으로 나타났다(p>0.05). 2. 飼料攝取量은 C區(2715. 13g), T_1區(2738.60g), T_2區(2754.16g) 및 T_3區(2811.46g)의 순으로 나타났고 飼料要求率은 T_1區(2.113), C區(2.130), T_2區(2.178) 및 T_3區(2.232)의 순으로 나타났다(p>0.05). 3. 産肉指數는 T_1區(306.48), C區(303.01), T_2區(293.38) 및 T_3區(284.86)의 순으로 나타났다. 4. 屠體率은 ♀는 T_1區(69.45), T_2區(69.30), T_3區(67.58) 및 C區(66.45)의 순이였고 ♂은 T_3(70.03), T_2區(69.13), T_1區(67.85) 및 C區(66.58)의 순이였다. 5. 臟器重量은 대조구와 처리구간에 차이를 볼 수 없었다. 6. 經濟性을 분석한 結果 各 區別 수당수익은 T_1區(613원), C區(590원), T_2區(583원) 및 T_3區(572원)의 순으로 나타났다. This experiment was all located to 4 plots by 30 chickens per each plot with 120 chickens of broiler-Hubbard hatched at the 20th of September, 1985 and the formula feed added in the levels of 0(C plot), 1(T_1 plot), 2(T_2 plot) and 3%(T_3 plot) of Artemisia was supplied for these of each plot during 3 weeks from October, 19 to November, 8, 1985 at the poultry house, Chinju Agricultral & Forestry Technical College. The results found out the effect of Artemisia meal addition on the growth of broiler-Hubbard were as follows: 1. The weight gain(g) was heavy in the order of T_1(1296.32), C(1274.70), T_2(1264.32) and T_3(1259.64) and non significant (p>0.05) between plots. 2. Feed consumption(g) was heavy in the order of C(2715. 13), T_1(2738.6), T_2(2754.16) and T_3(2811.46) and feed conversion, T_1(2.113), C(2.130), T_2(2.178) and T_3(2.232) (p>0.05). 3. Point spread was high in the order of T_1(306.48), C(303.01), T_2(292.38) and T_3(284.86). 4. Dressing percent of female ws high in the order of T_1(69.45), T_2(69.30), T_3(67.58) and C(66.45), and of male, T_3(70.03), T_2(69.13), T_1(67.85) and C(66.58). It was generally higher in the Artemisia meal addition plot than in the control. 5. Internal organies weight was non significant differences(p>0.05) between treatment plots and control. 6. In economical analysis, net income(won) per bird of each plot was 613(T_1), 590(C), 583(T_2) and 572(T_3).

말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull

박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.

마약길항제의 방출 제어형 제제 (제2보) : 나록손 이식제제의 생체적합성 및 약물속도론적 평가 Biocompatibility and Pharmacokinetics of Naloxone Implant

문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.