랫드에서 신우황청심원의 급성 및 아급성독성시험

오승민,남혜윤,김준수,연제덕,신대희,이진영,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1,500 and 3,000 ㎎/㎏. Body weights were significantly decreased at 540 ㎎/㎏ dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal LD_50 of NWCH was 812.3 ㎎/㎏ in male and 872.3 ㎎/㎏ in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 ㎎/㎏/day in this study.

식품 중의 아크릴아마이드

오상석,김혜영,박재영 이화여자대학교 생활환경대학 인간생활환경연구소 2004 인간생활환경연구소 논집 Vol.- No.2

Swedish National Food Administration reported that acrylamide was detected in heat treated starch rich food products in April.2002. Acrylamide is considered as potential carcinogen and genotoxicant. It is noticed that formation of acrylamide in potato products was greater than other food products. It may be due to high concentration of asparagine and glucose in potato products comparing to that of other food products resulting in Maillard reaction during heat treatment. Research on acrylamide formation during food processing has been hot issue among other research groups. In this study, general issues on acrylamide in food products including risk assessment, mechanism, toxicity, anallfical method and reduction are discussed.

난소 기형종에 동반된 직장후방 기형종

오보영,이령아,구혜수,문혜성 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

乾癬患者 臨床報告

吳恩英,朴惠宣,池鮮渶,具德謨 동의대학교 한의학연구소 2001 동의ㆍ경산 한의학 학술대회 Vol.5 No.-

A Reports were done on proriasis which were treated by medications of Sasang Constitution and Constitution-Acupunture in Dept. surgery, opthalmology &tolaryngology, college of Oriental Medicine, Kyungsan University, Pohang, Korea, from May 30. 2000 to JUN 30 2001. we gave score and checked involvement, plaque, erythematous popules, invasiveness according to psoriasis area and severity index. The results were as follows: 1. Sasang Constitution classification was Soyanggin 14(93.33%), Taeumgin 1(6.67%) in the 15 cases. Hyungbangsabaeksan is used in 9 cases(60%), Yanggeuksanhoatang is used in 3 cases(13.11%), Geopungchunggisan is used in 3 cases(20%), Hyungbangdojucksan is used in 1 case(6.57%). 2. In the 9 cases, we checked for over 4 weeks, clinical severity of involvement, plaque, total score(psoriasis area and severity index) was siginificantly decreased(p<05). clinical severity of erythematous popules, itching was decreased but lt is not siginificant(p>05). 3. The mean duration of treatmemt was 73.3 days, result of Excellent or Good improvement was showed on over 120 days. These resilts indicate that Sasang Constitution and Constitution-Acupuntuer treatment is effetive on psoriasis and the more study is needed.

외음부에 발생한 혈관근육섬유아세포종 1례

오혜근,구자봉,김동출,심재영,박정훈,박영균,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

We present a case of angiomyofibroblastoma of the vulva in a 32-year-old woman. The asymptomatic lesion measured 4×3cm and appeared as a gray-white myxoid mass on cut sections Histologically, it appeared as a relatively well-circumscribed spindle cell proliferation with alternating hypercellular and hypocellular areas and proliferation of thin-walled blood vessels. Immunohistochemically, the stromal cells expressed vimentin, CD34 and progesterone receptor, but not desmin, α-smooth muscle actin, S-100 protein and estrogen receptor. These features were similar to those of angiomyofibroblastoma as previously reported in the vulva except negativity for desmin A case of pathologically proven very rare tumor of angiomyofibroblastoma of the vulva is presented with a literature review

분노조절 프로그램이 시설아동의 공격성에 미치는 효과

오영현,송영혜 대구대학교 특수교육재활과학연구소 2009 再活科學硏究 Vol.27 No.1

본 연구는 공격성향의 시설아동을 대상으로 분노조절 프로그램을 실시하여 공격성의 변화를 보는 것이다. 연구대상은 K군 소재 청소년의 집에서 생활하는 초등학교 6학년 아동으로 선정방법은 ‘공격성 진단 검사’와 ‘공격욕구검사’로 공격성의 정도가 심한 아동 6명을 선정하여 실험집단과 통제집단에 각각 3명씩 무선배정 하였다. 프로그램은 이완활동, 문제해결훈련을 지도하는 토론, 회기 목표와 관련된 구조화된 활동, 자유놀이 단계로 구성되었다. 프로그램의 참여도를 높이고 최상의 학습 상태를 받아들일 수 있도록 하기 위해 프로그램 초반에 이완활동으로 신체적&#8228;정서적 긴장을 해소하고 즐거움을 주는 신체놀이를 했다. 분노조절을 위해 사회적 기술훈련, 인지-행동적 접근, 자기교시훈련, 자기주장훈련과 문제해결 기술훈련, 긴장이완훈련의 보편적인 방법을 사용하였고, 프로그램의 진행은 한 회기 60분, 주 2회, 총 10회기 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 분노조절 프로그램은 공격성 검사에서 공격성을 감소시켰고 하위영역의 공격행동(신체적, 언어적, 우회적공격성, 부정성, 흥분성, 적의성)을 모두 감소시켰다. 둘째, 회기 내에서 시설아동의 공격행동(신체적, 언어적, 우회적공격성, 부정성, 흥분성, 적의성)을 감소시켰다. The aim of the study is to examine changes in aggression level of the aggressive children residing in an institution by applying an anger control program. Children residing in an Institution for Minor in K county who were in the sixth grade of the elementary school were subjected to an 'aggression diagnose test' and a 'desire for aggression test.' Total six children with high aggression scales were selected by the test, and three were randomly assigned in a control group and the rest three in a test group. The program was comprised of relaxation activity, discussion to guide problem solving ability, structured activity related to a goal specific to each session, and free play. To encourage an active participation in the program and enable an optimal reception of the learning, a relaxation activity with fun physical play was conducted at the beginning of the program for releasing physical and emotional tension. A universal method was used to control anger including cognition-behavioral approach and training for social skill, self-instruction, self assertion, problem solving skill, and tension release. The program was implemented twice a week for 60 minutes per session for ten weeks in total. The research tasks were as follows: first, to examine whether the anger control program reduces aggression of the children in an institution; second, whether the program reduces physical, verbal, and indirect aggression, denial, rage, or hostility as sub-categories of the aggression; and third, whether the program reduces aggressive behavior of the institutionalized children within a session. Changes of the aggression according to the research tasks were measured and compared before, after, and as a follow up of the program. To measure aggressive behavior such as physical, verbal, indirect aggression, denial, rage, and hostility, frequency of such aggression was recorded in a free play environment. The results of the study are as follows. First, the anger control program reduced the aggression according to the aggression test. It also reduced all aggressive behaviors such as physical, verbal, indirect aggression, denial, rage, and hostility. Second, it reduced aggressive behavior of the institutionalized children within a session such as physical, verbal, indirect aggression, denial, rage, and hostility. Although the study was a case study of a relatively small number of participants with limitations for a generalization, the results of the study showed that the anger control program had a positive effect on reducing the aggression of the children in an institution.

면접조사를 통한 초등학생의 영양교육 실태 및 실천도 조사

오유진,이영미,김정현,안홍석,김정원,박혜련,서정숙,김경원,권오란,박혜경,이은주,성현이 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study investigated the experience and practice of elementary school students on nutrition education. The data were collected from 217 male and female students attending 5-6th grade elementary schools in Seoul and Kyunggi-Do from March to June 2007, interviewing face to face by a nutrition teacher and 3 interns of a nutrition teacher. The results were as follows: 86.5% of the subjects learned about ‘Table etiquette’, ‘Reasons for eating fruits and vegetables’ (78.7%), ‘Food waste and environment’ (72.3%), ‘Healthy snacks’ (55.7%), ‘Food sanitation’ (52.3%), ‘Food culture of foreign countries’ (48.1%). Nutrition education experience was significantly different by gender. A total of 43.5% boys responded that they never learned about ‘basic food preperation’ (p < 0.01). They had learned ‘Nutrients for body’ and ‘Food waste and environment’ in school, ‘Healthy weight loss’, ‘Food culture of foreign countries’, ‘Food circulation’ on television, Most content (‘Table etiquette’, ‘Simple cooking’, ‘Food sanitati n’, ‘Eating behaviors for health’, ‘Reasons for eating fruits and vegetables’, ‘Healthy snacks’) was learned from parents. The practice after nutrition education was higher in ‘Table etiquette’ (2.14), ‘Eating fruits and vegetables’ (2.07) than others compared with education experience. The most reason of non-practice on nutrition information was ‘Troublesome’. In ‘Nutrients for body’, a boy answered ‘Difficult for practice’ 20.0%, a girl answered ‘Difficult to understand’ 32.6%, showing a significant difference between the gender groups (p < 0.001). They remembered the ‘Nutrients for body’ (49.6%), ‘Food sanitation’ (44.5%) because of ‘important content’,‘Basic food preparation’ (40.6%), ‘Food culture of foreign countries’ (36.3%) because of ‘interesting content’, ‘Healthy weight loss’ (52.0%), ‘Eating behavior for health’ (44.5%) and ‘Healthy snacks’ (33.7%) because of ‘need for my health’.

유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

193 nm 용 화학 증폭형 감광제 시뮬레이션을 위한 노광 후 지연 효과에 대한 연구

이영미,오혜근 한양대학교 이학기술연구소 2001 이학기술연구지 Vol.3 No.-

The deprotection of 193 run chemically amplified resist is amplified by photo-generated acid during post exposure bake. The acid concentration is changed through reactions such as diffusion, evaporation and acid neutralization with atmospheric base contaminations during post exposure delay. Since the acid concentration greatly affects the final critical dimension, it is very important to control post exposure delay time. In this paper the characteristics of the post exposure delay effect on photoresist profiles was studied. We measured the transmittance and thickness change of the 193 run chemically amplified resist with respect to post exposure delay time. From this result the imaginary refractive index change with post exposure delay time was also obtained. This post exposure delay effect was included in our simulator, LUV (Lithography for Ultra-Violet), and the resulting resist profiles were obtained. 193 nm 용 화학 증폭형 감광제(Chemically Amplified Resist)는 노광(Exposure)을 하면 PAG(Photo Acid Generator)에 의해 산이 생성되고 노광 후 열처리 (Post Exposure Bake) 동안 비보호 (deprotection)반응이 일어나게 된다. 그런데 빛에 의해 만들어진 산은 노광을 하고 노광 후 열처리를 하기까지의 지연 시간 동안 확산, 증발, 그리고 대기중 염기와의 중화반응 등에 의해 농도가 변할 수 있다. 노광과 노광 후 열처리뿐만 아니라 노광 후 지연 (Post Exposure Delay)에 의해 변한 산의 농도가 현상 후 최종 선폭에 막대한 영향을 끼치게 된다. 따라서 본 논문에서는 노광 후 지연 시간에 따른 193 nm 용 양성 화학 증폭형 감광제의 투과율과 두께 변화를 측정하여 노광 후 지연 시간에 따른 하수 굴절률을 얻었고, 그 결과를 노광 후 열처리시 비보호 고분자 영역의 농도와 관련시켜 선폭에 미치는 영향을 연구하였으며 자체 제작한 시뮬레이터 LUV(Lithography for Ultra-Violet)에 적용하였다.