생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

Kirschner wire를 사용한 과두하 골절의 구강내 접근법

김성일,김승룡,백진아,고승오,신효근 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

The treatment of mandibular subcondylar fractures is a matter of controversy. The majority of mandibular subcondylar fracture are treated by closed reduction, but the displaced or dislocated mandibular subcondylar fractures may be treated by open reduction. The characteristics of open reduction are the anatomical reduction, the functional restoration, the rapid function, the maintenance of vertical ramus dimension, the better appearance and the less resultant TMJ problem etc. When an open reduction is considered, the wire, miniplate, lag screw and Kirschner wire are available with internal fixation. Of these, Kirschner wire is a simple method relatively and correct positioning of the wire achieves rigid fixation. But many open reduction methods for mandibular subcondylar fractures require extraoral approach. The extraoral approach has some problems, the facial scar and the risk of facial nerve injury. On the other hand, the intraoral approach eliminates the potency of the facial scar and the facial nerve injury, but is difficult to access the operation site. Since the intraoral approach was first described by Silverman (1925), the intraoral approach to the mandibular condyle has been developed with modifications. The purpose of this article is to describe the intraoral technique with the Kirschner wire on mandibular subcondylar fractures. Conclusion : The intraoral reduction with Kirschner wire on mandubular subcondylar fractures avoids the facial scar and facial nerve injury and is simple method to the extraoral approach. And it has minimal morbidity and better esthetics.

진단방사선영역에서 Ho 여과판 사용시 피폭선량 감소와 화질개선에 관한 연구

김영근,이성길 광주보건대학 2000 論文集 Vol.25 No.-

This work was reduction of exposure dose and improvement of image quality by use of Ho filter in diagnostic fadiology, From the results of experimental evaluation, it was founded that in the case of the Ho filter, the variety of X-ray property with kVp was less than those of Cu and Al. And the ratio of transit to surface-dose and the load of X-ray tube were increased in the order Al, Cu, Gd and Ho. The contrast of X-ray image showed the higher value in the order of Cu, Al, Gd and Ho.

WLL 증폭기 불요방사 성능분석

김성철,송인근 우송대학교 1999 우송대학교 논문집 Vol.4 No.-

In this paper the system perfomance degradation resulting from nonlinear transmitter power amplifier which is essential to increase the efficiency is analyzed in a WLL-CDMA system. The power amplifier is modeled by its AM-AM, AM-PM characteristics. Through the investigation of the power spectrum density of the transmitted signal , spectral regrowth or sideband regrowth which is result from amplitude distortion can be seen. All these characteristics result in BER performance degradation due to other user interferences and intersymbol interference. The analysis technique described here applies not only to power amplifier but also to any other nonlinear components such as mixers and switches. Also the effects of adjacent channel interference and supurious emission can be analyzed between different systems.

다중 경로 채널에서의 ATC를 적용한 DMF 초기동기 장치의 성능분석

김성철,송인근 우송대학교 1998 우송대학교 논문집 Vol.3 No.-

To analyze the DS/SS reciever performance with respect to coed acquisition, multipath fading channel is characterized as a two-ray Rayleigh fading channel. In the code acquisition loop, the performance is evaluated in terms of the acquisition time and detection probability with the acquisition time is taken into account. To improve the performance, ATC (automatic gain control) algorithm is proposed. The simulation results show that high sampling rate improves the performance and in case of high SNR, the performance of the DMF acquisition system has a little difference between AWGN and Rayleigh fading channel.

방사선 촬영실내 세균 오염도에 관한 연구

김영은,이성길,김창복 광주보건대학 2004 論文集 Vol.29 No.-

As a result of measuring the bacterial contamination level of radiographic room, It was examined 27 of Gram (+) cocci, 1 of Gram (-) Bacillus was found in the air of a cubic meter (㎥) radiographic room. As a result of measuring the radiographic table, a large number of Gram (+) cocci was detected in the B, F and Gram (+) Bacillus was detected in the F, G hospital. as a result of measuring the radiographic cassette, a large number of Gram (+) cocci was detected in the B, G hospital and Gram (+) Bacillus was detected in the B, G and D, E hospital. After independent culturing and monitoring, it was clear up the D, E, F, G hospital Gram (+) cocci was the simple Gram (+) Bacillus. On the contrary, the D, G hospital appeared saprophytic Staphylococcus epidermis. This study verifies that a number of saprophytic bacteria can survive in the air of the radliographic room, radiogrphic table and radiograhic cassette. There was the hospital which is uncountable, and was very detected. These results notified all visiting person and patients could be infected from the baterial contamination in radiographic room. Also, it means that all visitors could be changed baterial transmitter. It is provides comfortable environment and better medical service to the disinfection that minor filming is indoor and personal hygiene in order to prevent this bacillary infection and must listen to the safe department of radiology on bacillary infection in ten thousand. This study verifies that common potentially pathogenic bacteria can survive in radiographic processing room. Therefore, effective cleaning regimens are of fundamental importance in controlling and preventing potential nosocomial transmission in the diagnostic imaging department

부분적 수면박탈이 주간 졸리움, 피로감과 반응시간에 미치는 영향

김상국,왕성근 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

The purpose of this study was to investigate the effects of early partial sleep deprivation on daytime sleepiness, fatigue and reaction time, measured by the multiple sleep latency test(MSLT), visual analogue scale(VAS) and reaction timer. The subjects were 10 healthy young male college students aged from 19 to 25 years, who had no histories of significant medical or psychiatric illness as well as sleep related problems. Subjects undergown experiment 4 nights and days in the laboratory. The data of the first night and day were baseline. The remaining experiment in the laboratory consisted of 1 hour, 3 hours, 5 hours sleep restriction night and day. Each experiment had intervals more than 3 days to eliminate possible cumulative effects of repetitive partial sleep deprivation. Subjects applied MSLT to investigate their objective daytime sleepiness, VAS to rate subjective feeling of sleepiness and fatigue, and reaction time to investigate visuo-motor performance. MSLT data scored according to the criteria of Rechtschaffen and Kales every 30 seconds, and applied paired-t-test. Sleep restrictions result in the increment of sleepiness index, VAS score, stage 2 sleep. However, sleep latency on MSLT and reaction times were shortened. One hour sleep restriction affects sleep latency on MSLT and visual analogue scale scores mostly. The results suggested that nocturnal sleep restriction may induce daytime sleepiness and fatigue as expected, and shortened reaction time was out of our expectation.