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        한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

        김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

        Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

      • 안지오텐신 변환효소 억제제와 안지오텐신 II 수용체 차단제 투여 후 발생한 급성 신부전과 폐부종으로 전원된 선천성 단일신 환자의 치료 1예

        백두현,김경진,홍성철,강석형,송하응,김혜인,김수현,오현정,강혜원,김서우,유민아,류동열,최규복,강덕희 이화여자대학교 의과대학 2010 EMJ (Ewha medical journal) Vol.33 No.1

        Blockers of renin-angiotensin system(RAS) including ACE inhibitor or ARB are one of the most frequently prescribed medications for the treatment of hypertension, heart failure and proteinuria. One of the major side effects of these RAS blockers is the deterioration of renal function, mainly due to a reduction of intraglomerular pressure. Therefore, close monitoring of renal function is recommended when RAS blockers are initially prescribed, especially for the patients with impaired renal function. We report a patient who was transferred to our hospital due to the sudden development of oliguria and dyspnea after treatment for hypertension with ACEi and ARB. She was finally diagnosed as RAS blocker-induced acute renal failure with pulmonary edema complicated on congenital solitary kidney. After hemodialysis and conservative treatment, her renal function was recovered with maintenance of normal urine output. Conclusion:This case highlights the necessity of the functional and structural evaluation of kidney to prevent the serious complication such as acute renal failure before the administration of ACEi and/or ARB.

      • 미세혈관 협심증 환자의 임상상 및 지표에 관한 연구

        박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

        Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.

      • 저혈당성 뇌증환자에서 보인 복합 간질성 안구운동

        김영진,한선정,양현덕 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

        간질성 경련 환자에서 보이는 이상 안구운동으로는 안진, 공액성 안구 편위, 및 스큐변위 등이 있다. 대뇌의 일측성 병변에 의한 간질에서 나타나는 전형적인 수평성 안진과는 달리, 양측성 대뇌 병변에 따른 추적운동명령의 이상 조합은 다양한 방향으로 무질서한 안구 운동을 일으킬 수 있으나 이러한 안구 운동은 아직까지 문헌에 보고된 바는 없어 이를 보고하고자 한다. 당뇨를 앓고 있는 75세 여자 환자가 반복적인 전신성 강직간대 발작에 이은 반 혼수 상태로 내원하였다. 환자의 안구는 여러 방향으로 무질서하게 움직이는 공액성 운동을 간헐적으로 보였으며, 이러한 안구 운동은 페니토인 정주 후에 현저히 감소하였다. 뇌파검사에서 주기성 간질성 방전을 보였다. 대뇌의 추적운동 영역을 자극하면 서상의 안구 운동을 발생시킬 수 있으므로, 복합성 안구운동이 나타나는 기전은 양측 대뇌에서의 추적운동명령이 부적절한 조합을 이루기 때문이라고 유추할 수 있다. Epileptic eye movements usually occurs as nystagmus. Although it is theoretically possible that abnormal combination of pursuit commands from both hemispheres can generate multidirectional chaotic eye movements, this form of epileptic eye movement has not yet been described. We report an unusual case of complex epileptic eye movements associated with hypoglycemia. A 75-year-old diabetic woman presented with repeated episodes of generalized tonic-clonic seizures due to hypoglycemia. The patient's eyes showed conjugate, multidirectional and chaotic movements which occurred intermittently and ceased after infusion of phenytoin.

      • 풍력에 대한 합리적인 접근

        김덕현,한봉구 서울산업대학교 2005 논문집 Vol.54 No.2

        The state of the art on Wind Forces reported by the author in the year 1961 is presented herein. The flow of the air, which is the wind, is studied by Bernovilli equations. Both drag and lift forces are obtained by the use of the drag and lift coefficients. The variatio of velocities due to the height and the effect of shock wave are also included 모든 건설재료에는 치수의 한계가 있다. 현수선교나 사장교인 경우 강재를 사용하면 최대지간 거리 5000m~7000m가 가능하나, 유리섬유 복합재료를 사용하면 이의 2배, 탄소섬유 복합재료를 사용하면 이의 3배가 가능하다. 지간 거리가 20,000m가 되면 가장 중요한 하중은 바람 하중이다. 복합재료의 여러 장점 때문에 거대한 규모의 건물, 교량등 구조물이 건설될 때 구조 기술자는 풍(바람)하중을 구하고 다룰 수 있어야 한다. 이 논문에서는 구조 기술자가 풍 하중을구할 수 있게 기초이론과 기본기술을 제공하고 있다.

      • 서울지역 여대생들의 떡에 대한 인식 및 섭취 실태 조사

        김영순,오순덕,김향미,신지홍,김현경,배유미,조규영,조성환 高麗大學校 倂設 保健大學 保健科學硏究所 2003 保健科學論集 Vol.29 No.1

        This study conducted a survey of the improvement and popularization for Korea Rice Cakes, a Korean traditional food, on two hundred women students in five colleges in Seoul, Korea. It was investigated to get the information of the recognition, preference, and consumption patterns for the succession and improvement of Korean Rice Cakes. The results are as follows: 1. A portion of 41.5% among responders knows from three to six kinds of Korean Rice Cakes, and of 28% can make at least one among the kinds of Korean Rice Cakes. 2. A portion of 91% recognizes that Korean Rice Cakes are one of well-nourished food, but of 42% answers that Korean Rice Cakes cannot be replaced with the principle food. Also, there are no significant differences in the recognition of Korean Rice Cakes as the kinds of religions. 3. The frequency of purchase is about one or twice in a month (35.5%). Consumers (36.5%) intend to purchase Korean Rice Cakes for the commemoration of national holidays or anniversaries. 4. The reasons for the preference of other foods more than Korean Rice Cakes are the easiness of purchase (36.0%), the deliciousness (21.5%), the diverse kindness (17.5%), and the proper package (9.5%). It is important that constant and particular school / home education is need to improve and success Korean Rice Cakes.

      • 오리고기에 關한 硏究 (1) : 오리고기 蛋白質의 아미노酸 組成 Amino Acid composition of Duck-meat protein

        김동필,조덕봉,남현근 광주보건대학 1976 論文集 Vol.3 No.-

        Amino acids of duck-meat in Jeon-nam have been analyzed by gas chromatography. Through this analysis, the following results were obtained. 1. The quantities of general components in duck-meat were determined 13.61%∼21.19% protein, 17.23%∼4.92% fat, 0.56%∼1.03% ash, and 50.91%∼65.72% moisture. 2. The quantities of protein amino acids in duck-meat were determined 6.10% alanine, 2.75% valine, 7.13% glycine, 2.20% iso-leucine, 4.54%leucine, 4.90% proline, 5.80% threonine, 1.15% methionine, 3.20% hydroxy proline, 3.01% phenylalanine, 6.70% aspartic acid, 12.71% glutamic acid,. 4.95% lysine, 1.11% arginine, 5.60% histidine, 4.40% cystine+cystein, and serineand tyrosine in trace amount. 3. Except tryptophane, almost all the essential amino acids were analyzed.

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