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      • KCI등재

        조직 내 모호성의 존재론적 이해: 프라이빗 뱅킹 비즈니스를 중심으로

        조성환,박정은,김상준 한국중소기업학회 2025 중소기업연구 Vol.47 No.2

        This study seeks to approach the salience of ambiguity in organizations and its factors from a phenomenological perspective. The concept of ambiguity has been dealt with for a long time, but our knowledge on this is fragmented. Identifying the ontology of ambiguity can provide significant theoretical implications in the area of management. This study investigates what ambiguity appears in private banking businesses and what factors cause the ambiguity to appear. Based on a qualitative analysis in a phenomenological perspective, we found that in the context of Korean PB businesses, four major factors to cause organizational ambiguity were identified: bureaucratic structure, ambivalence of PB-related identity, under-developed performance management systems suitable for PB, and human resource development separate from career development. In addition, social ambiguity arising from social demands and technical ambiguity arising from changes in the technological environment were additionally captured. By specifying the organizational ambiguity and its factors to appear, this study provides theoretical implications on how organizations, ex ante, prevent themselves from making organizational ambiguity salient and, ex post, establish valid management strategies for any contingencies the organization can encounter regarding organizational ambiguity.

      • 지방간의 병리학적 소견과 초음파검사의 연관성에 관한 연구

        조성환,박이천,박남영,노지훈,윤병철,한병훈,이상욱 고신대학교(의대) 고신대학교 의과대학 학술지 2006 고신대학교 의과대학 학술지 Vol.21 No.1

        BACKGROUND Fatty liver is a common disease characterized by diffuse accumulation of neutral fat(triglycerides) more than 5 percent in liver. Ultrasonography has used to be a diagnostic tool for fatty liver, because of cost-effective and non*invasive study. But the sensitivity and specificity of ultrasonography for diagnosis of fatty liver are variable. Thus, we conducted a retrospective study to investigate correlation between histology and sonographic findings of fatty change in liver. METHODS We collected data from 47 patients who were diagnosed as fatty liver by liver biopsy and ultrasonography from January, 1994 to December, 1997. We compared a sonographic finding with the histologic grade of fatty liver and analysed the data retrospectively by SAS program. RESULTS Major cause of fatty liver is alcohol. The mean consumption of alcohol during 1 day is 64,1 gram,and the mean duration of alcohol drinking is 16.5 years, Degree of fatty infiltration in ultrasonography was significantly correlated with degree of fatty accumulation of Iiver(p=0.001), But, though it was diagnosed as normal by ultrasonography, 19.1% of total patients was fatty liver by needle biopsy, CONCLUSION We think that liver biopsy is needed for further management and follow-up, if liver function test is abnormal,though the finding of ultrasonography is normal

      • F-110 : Free Paper Presentation ; NCOA7 Act as a Co-factor for the AhR-mediated Signaling Pathway

        조성환,박신영,이은정,홍윤기,한선숙,이승준,김우진 대한결핵 및 호흡기학회 2013 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.116 No.-

        Background: Ncoa7, as a co-activator, enhances the transcriptional activities of several nuclear receptors involved in the co-activation of different nuclear receptors, such as ESR1, THRB, PPARG and AhR. Recent studies have demonstrated that regulation of AhR (aryl hydrocarbon receptor) action and the activities of other members of the nuclear receptor superfamily are dependent on interactions with other nuclear proteins including both co-activator and co-repressor proteins that are important tissue/cell-specific mediators of nuclear receptor function. However, as a co-factor of AhR, the function of Ncoa7 isoform 4 in human is still unknown. Materials & Methods: Ncoa7 isoform4 was cloned, verified and used to generate recombinant protein for interaction between Ncoa7 isoform4 and AhR. Quantification of cytokine expression in Beas-2B cell line was performed using real-time reverse transcriptase (RT-PCR). Results: Protein-protein interaction analysis showed that the Dioxin (TCDD) mediated Ncoa7 isoform 4 was interaction with the Aryl-hydrocarbon receptor (AhR) and activate AhR-induced inflammatory cytokines. Both endogenous and enhanced green fluorescent protein (EGFP)-fused Ncoa7 proteins were detected in the nucleus. Ncoa7 was associated with Xenograft response elements (XREs) and induced activation of IL6, IL1b, and IL8. Conclusion: We conclude that the AhR complex interacts with the Ncoa7 isoform 4 and induces its transcriptional activity by associating with the transcriptional complex formed on AhR-responsive promoters.Background: Ncoa7, as a co-activator, enhances the transcriptional activities of several nuclear receptors involved in the co-activation of different nuclear receptors, such as ESR1, THRB, PPARG and AhR. Recent studies have demonstrated that regulation of AhR (aryl hydrocarbon receptor) action and the activities of other members of the nuclear receptor superfamily are dependent on interactions with other nuclear proteins including both co-activator and co-repressor proteins that are important tissue/cell-specific mediators of nuclear receptor function. However, as a co-factor of AhR, the function of Ncoa7 isoform 4 in human is still unknown. Materials & Methods: Ncoa7 isoform4 was cloned, verified and used to generate recombinant protein for interaction between Ncoa7 isoform4 and AhR. Quantification of cytokine expression in Beas-2B cell line was performed using real-time reverse transcriptase (RT-PCR). Results: Protein-protein interaction analysis showed that the Dioxin (TCDD) mediated Ncoa7 isoform 4 was interaction with the Aryl-hydrocarbon receptor (AhR) and activate AhR-induced inflammatory cytokines. Both endogenous and enhanced green fluorescent protein (EGFP)-fused Ncoa7 proteins were detected in the nucleus. Ncoa7 was associated with Xenograft response elements (XREs) and induced activation of IL6, IL1b, and IL8. Conclusion: We conclude that the AhR complex interacts with the Ncoa7 isoform 4 and induces its transcriptional activity by associating with the transcriptional complex formed on AhR-responsive promoters.

      • KCI등재

        미래 한국디자인 혁신을 위한 예술적 디자인 방법의 고찰 - 오브제아트가 현대 디자인에 미친 영향을 중심으로 -

        조성환,김병수 한국디지털디자인학회 2010 디지털디자인학연구 Vol.10 No.2

        The origin of Italian design, the main stream of contemporary design, can be explained by recovery of human spirit, which pursuing arts in industrial and capitalistic zeitgeist. However, dominant industrial environment of design in Korea, the reason of its logical and scientific standard is making a mistake with interpret the main currentof contemporary design. In anticipation of art period by future trend, together with design emphasis,there are growing calls of criticism, resistance and self-examination against the design. These are the needs of the times to raise the value to the spiritual life which is a new understanding of the human subject and rediscovery of human nature. The art is the only activity concern with human philosophy and mind. The object art as a modern formative art, it completed reperception of human subjects and rediscovery of human nature as a new art through the study of philosophical relationship between human being and objects. Moreover, it made artistic sublimation to conflict between human being and technology not compromising to industry but overcoming mental horizon against material civilization. The purpose of present article is to point out that contemporary design doesn't get out of perception of industrial society and to explore the creative remedy about it. By considering the influence modern formative art on main current of contemporary design of Italian design, present article was to point out a mistake of existing scientific and methodological approach and to present the alternative point of viewof innovation of future design. 현대디자인의 주류인 이탈리안 디자인의 원천은 산업과자본귀속적인 시대정신에 예술이 추구하는 인간정신의회복으로 설명될 수 있다. 그러나 우리나라의 산업지배적인 디자인 환경은 과학적이고 논리적인 잣대만으로현대 디자인의 주류를 해석하는 오류를 범하고 있다. 미래 트렌드로 예술의 시대가 예견되어지면서 디자인의중요성과 함께 디자인에 대한 저항과 비판, 자성의 목소리도 높아지고 있다. 그것은 문명 비판을 통한 인간 주체의 재인식과 인간성의 재발견이라는 정신세계의 삶으로 그 가치를 상승시키려는 시대적 요구라 할 수 있다. 인간의 철학과 정신을 다루는 인간 활동은 예술의 영역이 유일하다. 현대조형예술로서의 오브제아트는 인간과사물과의 철학적 관계의 탐구를 통해 현대 문명 속에서인간 주체의 재인식과 인간성의 재발견을 새로운 미술양식으로 완성하였으며, 인간과 기술의 대립을 산업과의타협이 아닌 인간정신이 물질문명을 극복하는 예술적승화를 이루었다. 이에 본 논문은 오늘날 우리 디자인이 산업시대의 통념에서 벗어나지 못하고 있는 현실의 창조적 탈피 방안으로 현대조형예술이 이태리 디자인의 현대 주류 화에 미친 영향의 고찰을 통해 종래의 과학적, 방법론적 접근의오류를 지적하고 미래 디자인혁신의 대안적 시각을 제시하였다.

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