정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

RELATIONSHIP BETWEEN THE WIENER INTEGRAL AND THE ANALYTIC FEYNMAN INTEGRAL OF CYLINDER FUNCTION

Kim, Byoung Soo Chungcheong Mathematical Society 2014 충청수학회지 Vol.27 No.2

Cameron and Storvick discovered a change of scale formula for Wiener integral of functionals in a Banach algebra $\mathcal{S}$ on classical Wiener space. We express the analytic Feynman integral of cylinder function as a limit of Wiener integrals. Moreover we obtain the same change of scale formula as Cameron and Storvick's result for Wiener integral of cylinder function. Our result cover a restricted version of the change of scale formula by Kim.

RELATIONSHIP BETWEEN THE WIENER INTEGRAL AND THE ANALYTIC FEYNMAN INTEGRAL OF CYLINDER FUNCTION

Byoung Soo Kim 충청수학회 2014 충청수학회지 Vol.27 No.2

Cameron and Storvick discovered a change of scale for-mula for Wiener integral of functionals in a Banach algebra S on classical Wiener space. We express the analytic Feynman integral of cylinder function as a limit of Wiener integrals. Moreover we obtain the same change of scale formula as Cameron and Storvick s result for Wiener integral of cylinder function. Our result cover a restricted version of the change of scale formula by Kim.

Koebner 현상이 동반된 전신성 광택태선 1예

김기준,김시용,김영조,최규철,정병수 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

Lichen nitidus is a rare chronic dermatitis of unknown etiology. It is characterized by round, flat-topped, flesh-colored papules 2 to 3 mm in diameter that may occur in groups but do not coalesce. The lesions of lichen nitidus are usually localized to the upper extremities, genitalia, chest, and abdomen, but less commonly, they may be generalized. Although the eruption is usually asymptomatic, it is sometimes mild pruritic, and the Koebner phenomenon may be observed very exceptionally. We reported a case of generalized lichen nitidus with Koebner phenomenon.

기존 축열벽 시스템과 투명단열 축열벽 시스템의 열성능 평가 실험 연구

김병수,윤종호,윤용진,이진숙 대한건축학회 2003 대한건축학회논문집 Vol.19 No.10

TI-wall is an Mass-wall with TIM used instead of an usual single, double and triple glassed windows. The aim of this study is to analyze the thermal performance through Test-Cell of TI-wall in domestic climate. This study is carried out as follows: 1) Test-cells of TI-wall and Mass-wall are designed through the investigation of previous paper and work. The type of the TIM used in test-cell is small-celled(diameter 4㎜ and thickness 50㎜) capillary and cement brick(density 1500㎏/㎥) is used by thermal mass. 2) individual and combination test with various variants, such as thickness(190㎜, 380㎜) and surface absorption(60%, 95%) of thermal mass wall, measured for winter and spring, and the thermal effects are analyzed. Finally, as results indicated that the peak point time of the temperature of in-and-out surface is cut down approximately by an hour when the surface absorption of thermal mass wall is changed from 60% to 95% In case of applying for 1B(190㎜) in thickness of thermal mass wall. In case of applying for 2B(380㎜) in thickness of thermal mass wall, the temperature difference between in-and-out surface is showed about 23℃ in terms of Spring and Autumn. It means that the heat could not be delivered enough because the distance for heat transmission is too far. Therefore, in case of more than being 2B in thickness of thermal mass wall, it is not right for heating in Winter, Spring and Autumn. Experiment in term of su㎜er, the thermal mass wall is heated enough by outside temperature and solar radiation, the temperature difference between in-and-out surface is indicated 10℃. Also, inside temperature is sustained more than average 28C. Therefore, radical temperature rising will be released by changing its thickness, but the inside temperature still remains in high.

국내 프로농구 선수들의 요인별 운동상해 형태

김종언,안병수 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study examines the parts, symptoms, causes, period and treatment of injuries of man and woman pro basketball players according to their sex and injury positions in order to provide the basic information and materials for improving their athletic capacity and understanding the basic causes of the injuries with 164 man and woman Professional basketball players. It obtains the following conclusions. 1. It is found that according to the parts of injuries by exercises, injuries of the lower limbs, the upper limbs and the trunk were found frequently and according to the athletes' position, center, forward and guard showed high injuries in their lower, upper limbs and the trunk. 2. It is known that according to athletic technique in injuries, man athletes had most injuries in jumping and landing, followed by defense blocking and rebound, and female athletes had most injuries in jumping and landing, followed by ball catching and defense blocking. 3. It is found that in the injured parts, male athletes had most injuries in joint, muscle, tendon and skin in order and female athletes had most injuries in muscle, tendon, nerve and skin in order. According to athletes' position, center player had more joint, muscle and tendon, forward player had joint and nerve and guard player had muscle, tendon, nerve and joint. 4. It is understood that in the season of sport injuries, both male and female athletes had more injuries during group training and individual training in order and they had frequent injuries in winter and summer. Center, forward and guard players had more injuries during group training and in winter. 5. It is considered that the causes of injuries were mainly excessive and radical training and chronic fatigue in both male and female athletes and all their positions. 6. It is shown that according to the treatment and place of sport injury, all players had injuries in team compulsory training and they used their clinics for treating their injuries.

여드름 환자에서 adapalene 겔과 tretinoin 크림의 split-face 비교 연구

김영조,선정우,정병수,최규철 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1

Background : Adapalene is a new synthetic naphtholic acid derivative with potent retinoid and antiinflammatory properties, developed for the topical treatment of acne vulgaris. Objective : This study was designed to compare the efficacy and safety of 0.1% adapalene gel with tretinoin cream(0.025% and 0.05%) in the treatment of grade I to V facial acne vulgaris. Methods : Forty acne patient volunteers were enrolled in this investigatormasked, left-right comparison, randomized, controlled, intraindividual study. 0.1% adapalene gel and tretinoin cream(0.025% or 0.05%) were applied once a day to one halfface by the volunteers for 30 consecutive days. Efficacy and cutaneous tolerance were accessed at baseline and week 1, 2, 3, and 4. Efficacy was determined by investigator counts of inflammatory papules and pustules, and non-inflammatory open and closed comedones, as well as global improvement. Clinical signs(erythema, desquamation, dryness) and subjective symptoms(pruritus, burning) were evaluated and scored weekly. Result : 0.1% Adapalene gel was more effective in treating acne lesions than tretinoin cream(p<0.05). Cutaneous side effect was limited to a mild retinoid dermatitis occurring in all treatment groups. However, patients treated with adapalene gel tolerated this therapy significantly better than those treated with tretinoin cream. Conclusion : 0.1% adapalene gel applied once daily was significantly more effective in reducing acne lesions and was better tolerated than tretinoin cream in the treatment of acne vulgaris.

Narrow Band UVB로 치료한 진행성 반상 저색소증 1예

김병대,정예리,이근수,한승경 대한피부과학회 2003 대한피부과학회지 Vol.41 No.12

Progressive macular hypomelanosis is an idiopathic acquired hypopigmentary disorder first descri-bad in 1988. The disorder is characterized by ill-defined, non-scaly, round to oval, hypopigmented patches symmetrically localized on the trunk. No clinical symptoms have been observed. Currently, diagnosis is made on clinical grounds and any histological, laboratory investigations are not diagenositc. This disorder does not respond to conventional treatment and its clinical course is variable. We experienced a case of progressive macular hypomelanosis that was successfully treated with narrow band UVB phototherapy. (Korean J Dermatol 2003;41(12):1664~1666)

급성 단핵구성 백혈병에서 발생한 피부 백혈병 1예

김영조,홍문희,정병수 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

연골양 한관종 1예

김기준,김영조,정병수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

Chondroid syringoma, also called cutaneous mixed tumor, is a solitary, well-demarcated, firm intradermal or subcutaneous nodule which mainly occurs on the head and neck. Histopathologically, the tumor is composed of pleomorphic components of both epithelial and mesenchymal elements. Chondroid syringoma has been argued about, with differentiation toward eccrine or apocrine units. We report a case of chondroid syringoma in a 51-years-old male patient who has a solitary, 1.0 × 0.7㎝ in sized, firm, erythematous nodule on his nose.