정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

노인전문병원의 재활의학부 치료부문 기본계획을 위한 조사 연구

윤수진,채철균 한국의료복지시설학회 2007 의료·복지 건축 Vol.13 No.2

Rehabilitation medicine is an area which tries to help people who have physical inconvenience in everyday activities to live like healthy people as much as possible by training programs. As society gets more advanced and as the standard of living continuously rises, the need of the "Rehabilitation medicine" is also increasing. Also as we are entering into the aging society, especially geriatric rehabilitation medicine is getting more and more attention as a method to maintain the healthy lives of the elders. However, the standards related to medical care space for rehabilitation medicine is not thoroughly prepared. Although requirement for geriatric hospital is increasing, the standard of geriatric hospital is not following up to regulate them properly. Therefore, in this study, I will propose a'suitable planning'needed in geriatric rehabilitation by analyzing the rehabilitation sections of 5 general hospitals and 1 geriatric hospital.

삶의 질 향상을 위한 가정체육 실태조사

진윤수,김일곤,정문현 忠南大學校體育科學硏究所 1997 體育科學硏究誌 Vol.15 No.1

The research on the condition of family's health and physical exercise was made by three thousand families in Thaejon and in Chungnam. In the questionnaire, there were questions about health condition, existing physical exercises at home, quality of life, and a developmental plan for domestic exercises. And the report runs as follows. 1. In most of families, they feel happy. They believe that the most important thing to decide their happiness is their job. So they consider working more importantly than leisure for family happiness. 2. The health conditions of families are good. The bad factors that injure their health were fatness, irregular habit, ill balanced nutrition, and lack of exercise. They are taking exercise for health of family. 3. They keep on exercise to promote health. And they think that new programs of family physical education should be made continuously. As a usual, every husband in the families decides what kind of exercise to do. They spend about thirty or sixty minutes per one exercise. 4. It is necessary for husbands and wives to exercise together. They can not exercise because they don't have enough time. The couples prefer public sports facilities in the park because they are convenient to use anytime. 5. It is necessary for family to exercise together. Most of them exercise once a week at most. They prefer public sports facilities in the park because of their convenience. 6. They think that it is necessary to exercise with their neighbors. They have participated in exercise with neighbors once and less. When they exercised with neighbors, most of them used to do so in the nearest park. 7. When they exercise, most of couples play tennis. They usually go mountain climbing for family exercise. Badminton is prefered for an exercise with neighbors. 8. They want lots of family physical education programs to be developed and supplied by the support of government, And it is necessary to inspire people with new consciousness about family physical education to develop family exercise. And the financial problems should be supported by national treasury and a loc al tax.

스포츠 두부 손상

윤영설,진동규,김긍년,장진우,김영수 대한스포츠의학회 1999 대한스포츠의학회지 Vol.17 No.1

Head injury is the most frequent direct cause of death in sports. Furthermore, injury to the head takes an singular importance when we realise the brain is neither capable of regeneration nor, unlike many other body parts and organs, of transplantaion. Every effort must be made to protect the athlete's head as injury can lead to dementia, epilepsy, paralysis and death. There are three distinct types of stress that can be generated by an acceleration force to the head : compressive, tensile and shearing forces. The differential diagnosis with a head injury includes cerebral concussion, intracranial hemorrhage, postconcussion syndrome, second impact syndrome, malignant brain edema. 90 to 95% of all head injuries are cerebral concussions and more than 90% all cerebral concussions fall into mild categories. With a head injury the ABCs of first aid must be followed and then a neurological examination will be followed. In the case of the intracranial hematoma. definite surgical evacuation is indicated and in cases of the closed head injuries and most severe degree of concussion. observation is appropriate, with careful neurological monitoring. Over the last 20 years there has been a dramatic decrease in the most serious head injuries due to multiple factors. There are five areas that can affect a reduction in head injuries. The first two involve rules and coaching technique changes. The other three areas involve improvements in conditioning (especially of the neck), equipment, and finally medical supervision. The reduction in incidence and severity of athletic head injury gas been the results of changes and improvements instituted following constant study and research. And also, for the reduction in incidence of athletic head injury every effort or team physician, athletic trainer, physical trainer and team coaches should be necessary.

국가 수준의 중학교 '기술·가정 1'교과의 멀티미디어 교육자료 개발 연구

윤인경,김진수,이수정,신순인 한국 가정과 교육 학회 2003 한국가정과교육학회지 Vol.15 No.1

A purpose of this study is to develop multimedia materials of "Technology and Home Economics" subject matter in a national level. Researchers, writers, examiners, deliverers and developers in order to develop multimedia materials were organized of us with 40 people. First, we analyzed the textbooks of "Technologyㆍ Home Economics" subject matter and made the idea design. Second we got storyboards based on the idea design. Finally, we developed the 1021 multimedia materials based with storyboards. The developed materials were uploaded to the Edunet website. If the materials developed in this study are utilized, students of middle school will be get easily educational motive, and teachers are able to use the multimedia materials to the Technologyㆍ Home 1" subject instruction.

體育行政過程의 理論的 考察

陳潤洙,鄭在慶 忠南大學校體育科學硏究所 1990 體育科學硏究誌 Vol.8 No.1

The purpose of this study was to find out proces of physical education administration and the nature of administration with development of administration process. The results of this study were as followings : 1. The factors of constitution in process of physical education administration make up planning, decision-making, organizing, stimulating, coordinating, budgeting and evaluating. 2. The process of physical education administration belong to process of nature of administration and education administration but the process of physical education administration has charateristic of administrative. On the basis of this analysis, this paper attempts to demarcate the proper areas of physical education administration.

실업배구경기의 활성화 방안

진윤수,김용성 忠南大學校體育科學硏究所 2002 體育科學硏究誌 Vol.20 No.1

The porpose of this study is to define the best method which can make the professional games boom. The subjects were members of professional and university volleybell teams and the leaders of those teams and high school teams. To analyze the questions concerned with subjects' background. Frequency Analysis was used. To analyze the different views about 4PsC of players and leaders, T-test was used. ANOVA(analysis of variance) and T-test were used to analyze the different views about 4PsC according to subjects' background. Duncan's Multiple Range Test and Scheffe was used to study the similarities among all the group. The package used for this study was SAS(Statistical Analysis System) Program. The conclusion was as following: First, there was little difference between players' importance about Product, Place, Promotion, and Price and those of leaders' There were only some differences in customer management item. Second, there were a few differences about 4PsC according to four items of their background. 1) Only in Promotion, gender created some differences in the importance of 4PsC. 2) Only in Promotion, age made some differences in the importance of 4PsC. 3) In Product and Price, there were differences of 4PsC according to the subjects' educational background. 4) Only in Product, their background of carrer made difference of 4PsC.

1997학년도 新入生 實態調査 硏究

尹永植,李壽進 순천대학 학생생활연구소 1997 學生生活硏究 Vol.16 No.-

정신분열증에서의 청력장애

윤진상,이수형 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.1

To evaluate the possible relationship between hearing impairment and schizophrenic disorder, pure tone audiometry was administered to 195 hospitalized schizophrenics meeting the criteria of DSM-Ⅲ and a control group of 307 normal people. Some aspects concerning the assessment of hearing impairment (age of onset, duration, type, class and severity of hearing impairment) were investigated. Neither the congenitally or prelingually deaf patients nor the eldery adults over 45 years old were included in both groups. Schizophrenics were subdivided into two subgroups of those with hearing impairment (N=17) and those with normal hearing (N=178) and then the onset, subtype (paranoid or non-paraniod) and duration of schizophrenia plus the experience and persistence of auditory hallucination were compared between the subgroups. The results were as follows : 1) Hearing impairment (hearing loss of greater than 25 ㏈ as pure tone average in one or both ears) was identified in 17 cases (8.7%) of the schizophrenic group and 8 cases (2.6%) of the control group (p<0.01). 2) Mean loss of hearing in both ears was more severe in hearing impaired patients of the schizophrenic group than in hearing impaired patients of the control group (p<0.05). 3) Onset of schizophrenia was later in schizophrenics with hearing impairment than in schizophrenics with normal hearing (p<0.05). 4) The long standing or persistant auditory hallucination occured more often in schizophrenics with hearing impairment than in schizophrenics with normal hearing (p<0.01).

膨化보리쌀의 消化性 硏究

윤수홍,이명진 대구효성가톨릭대학교 1987 연구논문집 Vol.35 No.1

As one of use and processing expansion methods of Barley, we investigated the digestive properties of puffed barley. Using α-amyase as a starch digestive enzyme, we experimented in artifical gastric juice (pH 1.2) and artificial intestinal juice(pH 6.8). And we analyzed the structure of puffed barley compared with that of raw barley by X-Ray Diffractometer. The following results were obtained. 1. In artificial gastric juice (not contained α-amylase), the hydrolysis of starch by acid was very weak. In α-amylase added artificial intestinal juice, the starch-digestive power of puffed barley increased about three times of rawbarley, one and half to two times of boiled barley. 2. From X-Ray Analysis, the crystallization degree of raw barley was 27.5%, but that of puffed barley was 9.1% In conclusion, it was thought that the starch-digestive power of puffed barley increased by the considerable destruction of the micelle structure of starch when barley was puffed.