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        • 흡입물질이 흰쥐 Lactate Dehydrogenase와 Cholinesterase 활성변화에 미치는 영향

          윤수홍,박병윤,하헌,박은주 한국환경독성학회 1995 환경독성보건학회지 Vol.10 No.1

          The effects of volatile substances inhalation on lactate dehydrogenase and cholinesterase in rats were investigated. Male Sprague-Dawley rats were exposed to marketed odorant, ethyl acetate and ethyl ether for 15 days. Enzyme activities were measured in serum and several tissues such as liver, lung, brain, heart, kidney and muscle to find differences of effects according to the organ. Cholinesterase activity in serum and most of tissues revealed time-dependent decrease in the case of marketed odorant inhalation. Especially in heart and kidney significant decrease was observed. Ethyl acetate exposure to rats revealed also decrease in serum and all tissues by 40% to 60%. Ethyl ether inhalation showed significant decrease by 30% to 50°,%. Lactate dehydrogenase activity was markedly increased in serum and similarly in heart, brain and kidney by exposure to marketed odorant. No changes were observed in liver. Ethyl acetate exposure to rats revealed increase in serum by about 200%, compared to normal group and in other tissues by 40% to 70% except in liver and muscle. Ethyl ether inhalation showed significant increase in serum by about 100%. There was no change in liver and slight increase in muscle.

        • 환경 오염 물질에 의한 효소 활성 변화에 관한 연구(제1보)

          尹水弘 영남이공대학 1980 論文集 Vol.9 No.-

          The variation of cholinesterase activities of rat scrum, lung, brain, muscle, heart, kidny and liver after 3 hours administrated LD50 of D. D. V.1'. parathion and malathion investigated with using Rappaport method and then the effects of organic phosphates on cholinesterase are as follows; 1. The cholinesterase activities of rat scrum, lung, brain. muscle, heart, kidny and liver was inhibited owing to the oral administration of organic phosphates. 2. Organic phosphates inhibited more cholinesterase then acetyleholinesterase 3. Organic phosphates containing the groaner sulphur inhibite the more effectively cholinesterase.

        • 지렁이의 造血成分에 關한 硏究

          尹水弘 영남이공대학 1977 論文集 Vol.6 No.-

          In above experiment, we research for general compoment and inorganic cornpoment of earthworm. The results are following; 1. About 38 percentage, protein and 16 percentage lipid are separated in earthworm so We can utilize source of protein. 2. As large amounts of inorganic content arc much more than other foods. It is proper for cliet of hematosis and treatment of anemia.

        • 家兎의 酵素生化學的 硏究

          尹水弘 영남이공대학 1977 論文集 Vol.6 No.-

          Lactatedchydrogenase isozymes in the brain, lung, liver, heart, kidney, pupil, muscle, pancreas and siminal vesicle of adult male rabbit were separated by Cellulose acetate electrophoresis. Lactatedehydrogenase isozymes patterns were differnt each other between tissues. LDH1 were superior in aerobic tissues such as brain, lung, heart, seminal vesicle. pancreas and kdney. LDH6 were superior in anaerobic tissues such as liver and mscle.

        • 당뇨성 모델에서 차전초의 간보호 및 지질개선효과

          윤수홍,하헌 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.3

          The antihepatic and hypolipidemic activities and total lipid levels of water extract of Plantaginis Herba, used for respiratory and renal disorder in folk medicine, were evaluated in streptozotocin-induced diabetic rats. Diabetes was induced by a single injection of streptozotocin (50 mg/kg, i.p.). Water extract of Plantaginis Herba recovered enzyme activities such as GOT, GPT, ALP and LDH increased by streptozotocin (STZ) treatment. This crude drug also suppressed the enhanced production of lipid in hyperglycemia. These results strongly suggest that Plantaginis Herba be a promising liver-protective and hypolipidemic agent.

        • 지렁이의 營養成分에 關한 硏究 (第二報) : 지렁이의 amino acid 組成에 對하여 A study on the amino acid component in Earth Worm

          尹水弘 영남이공대학 1981 論文集 Vol.10 No.-

          In above experiment, we research for amino acid component of Earth Worm. The results are following: The essential amino acid are separated in Earth Worm, we can utilize source of protein.

        • 일차 배양한 간세포에서의 권백의 간보호효과의 Screening Test

          윤수홍,이주영,하헌 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.2

          Selaginellae Herba has been used as folk medicine for antineoplastics, coagulants, antidotes and invigorants. To find an in vitro screening method for liver protective effect of Selaginellae Herba in benzo(a)pyrene intoxicated injury were examined in primary cultured rat hepatocytes. Using MTT assay, herba concentration showed dose dependently viability. The lowest concentration of benzo(a)pyrene giving cytotoxicity revealed around 50μM. The hepatoprotective effect of Selaginellae Herba in both water and chloroform extracts was also increased dose dependently.

        • Benzo(a) pyrene에 의해 유도된 간장해에 미치는 황련 수침액의 영향

          윤수홍,하헌,서민지 한국환경독성학회 1993 환경독성보건학회지 Vol.8 No.1

          The present study was undertaken to find a protective effect of Coptis Rhizoma Extract on liver injury induced by benzo (a)pyrene in rats. This crude drug significantly suppressed the increase of several biochemical parameters such as transaminase, lactate dehydrogenase and alkaline phosphatase in serum and liver and total cholesterol. But there were little changes in elevated serum phospholipid level. The results suggested that Coptis Rhizoma prevent bezo (a)pyrene-induced hepatic injury.

        • 有機燐系 殺蟲劑가 흰쥐의 Cholinesterase 活性에 미치는 影響

          윤수홍,김신희,박병윤 한국환경독성학회 1987 환경독성보건학회지 Vol.2 No.1

          본 硏究는 흰쥐에 有機燐系 농약인 malathion과 DDVP의 投與에 의한 血淸, 腦 및 肝臟의 ChE活性, 電氣泳動에 의한 ChE isozyme pattern 및 病理組織學적 상태의 변화를 조사하였다. 血淸, 腦 및 肝臟의 ChE활성은 malathion과 DDVP 投與群에서 농도와 시간이 증가함에 따라 저하하였으며, 血淸 및 腦 ChE활성은 7일째는 저하하였으나 시간이 경과함에 따라 다소 회복되는 경향을 나타내었다. ChE isozyme은 血淸 및 肝臟에서는 전기영동상 많은 band가 관찰되었고 腦에서는 소수의 band만이 나타났으며 농약의 투여 농도 및 시간의 경과에 따라 band의 수와 선명도가 감소되었다 肝臟의 病理組織學적 檢査는 malathion 投與群에서는 central vein과 portal area사이의 midzonal necrosis가 관찰되었으며, DDVP 投與群에서는 portal area에 국한된 portal necrosis가 주된 所見이었다. Changes in cholinesterase (ChE) activity, electrophoretic pattern of ChE and histopathologic state on the mice serum, brain and liver by administration of organophosphorous insecticides were studied. The mice ChE activities on serum, brain and liver decreased by increasing of concentration and time both administration of malathion and DDVP, whereas on serum and brain the activities of the 7 days after administration decreased, and then presented the gradually slight recovery in course of time. The ChE on serum and liver showed many isozyme bands by polyacrylamide gel electrophoresis but several on brain. And isozyme bands disappeared and diffused by administration of organophosphorous insecticides and development of time. The mice liver with administration group of malathion on histopathologic test showed midzonal necrosis between central vein and portal area, and with administration group of DDVP mainly presented portal necrosis on location of potal area.

        • Butane gas가 흰쥐 혈청과 조직의 Lactatedehydrogenase 및 Cholinesterase에 미치는 영향

          윤수홍,박은주,조수열,최현태 한국환경독성학회 1991 환경독성보건학회지 Vol.6 No.2

          Acute poisoning with organic solvents and other volatile compounds now usually follows deliberate inhalation (volatile substance abuse) or ingestion of these compounds. The effect of butane gas inhalation was analyzed for serum, liver, brain, lung and muscle. And the observations are revealed on rat cholinesterase activity, lactatedehydrogenase activity and electrophoretic pattern of lactatedehydrogenase isozyme. The results are as follows: 1. The rat cholinesterase activity on serum, liver and muscle show the decreased by increasing of inhalation time of butane gas in particular the lung cholinesterase activity was greatly affected. 2. Butane gas inhalation brought out the lactatedehydrogenase activity increased of the serum and the tissues and had an important effect especially in both the liver and muscle lactatedehydrogenase activities. 3. Each tissue was found to have a characteristic distribution of lactatedehydrogenase isozymes on celluloseacetate electrophoresis and the development of inhalation time is shown the disappearance and diffusion of band. The toxicity of butane gas inhalation was most prominence in the liver and lung toxicity was occurred also.

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