비호지킨씨 림프종에서 COPBLAM-V 복합화학요법의 치료효과

송홍석,정화영,남계윤 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2

1989년 3월부터 1992년 6월사이에 계명대학교 의과대학 내과학교실에서 stage II, III 및 IV의 intermediate-grade 림프종환자 29례를 대상으로 COPBLAM-V 복합화학요법으로 치료한 결과 다음과 같은 결과를 얻었다. 총 29례 환자 중 18례(62.1%)에서 완전관해,11례(37.9%)에서 부분관해로 총관해율은 100%였고, 나이 조직형 병기 B증상유무에 따른 차이는 없으나 남자는 완해율을 보였다. 전체환자의 중앙생존기간은 36.8개월로 1년, 2년, 3년 4년 생존율은 각기 68.0%, 68.0%, 54.4%, 40.8%였고, 조직형에 따른 생존율의 차이는 없으나 남자와 여자(P 0.025), stage II III IV (p 0.001), Stage A와 B(p 0.001)사이는 유의한 차이를 나타내어, 여자이거나 나이가 많거나 진행병기 그리고 B증상이 동반된 경우 생존율이 낮았다. 각 약제의 RDI는 Cyclophosphamide 0.722, oncovin 0.773, dexamethasone o.785, bleomycin o.763, adriamycin 0.720, procarbazine 0.776로 남녀 연령 조직형 B증상유무 재발유무 및 치료반응에 따른 각 약제의 RDI의 차이는 없었고, RDI와 생존기간과는 서로 상관관계가 없었으나 총림프구수와 생존기간 사이에는 유의한 (p 0.001) 상관관계를 나타내었다. COPBLAM-V치료후 grade III 및 IV의 부작용은 빈혈 13.6%, 백혈구감소증 44.9%, 구토 22.8%, 탈모증 34.5% 그리고 간기능저하와 감염이 각기 3.4%에서 동반되었으며, 이 중 1례에서 패혈증으로 인하여 사망하였다. Between March 1989 and June 1992, 29 patients with advanced stage, intermdiate-grade non Hodgkin's lymphoma were treated with a COPBLAM-V regimen including cyclophosphamide, oncovin, prednisolone, bleomycin, adriamycin, procarbazine. Median age was 45.7 years and 5 patients were 60 years or old. 18 patients(62.1%) achieved a complete response(CR) and 11 patients(37.9%) had a partial response. Of the 18 CRs, 7 patients(38.9%) suffered a relapse. The median survival time was 36.8 months, and 4-year survival rate was 40.8% ad disease free survival for CRs was 55.2% with a median follow-up of 18.6 months. Male gender was negatively associated with respones rate and age greater than 60 years, female sex, stage Ⅲ and Ⅳ, B symptoms, decreased lymphocyte count significantly decreased survival rate. But relative dose intensity of drugs did not influence the outcome. Overall toxicity was acceptible with 1 treatment- related death due to sepsis. The incidence of nonfatal infection was 17.2%.

두피에 발생한 악성림프종 1례

정화영,송홍석,정강호 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

A case of primary non-Hodgkin's lymphoma of scalp is presented. The patient is 16-year-old male who has develped 10×15cm huse scalp tumor on left frontal head with both cervical lymph node enlagement. The CT presentation of slightly isodense soft tissue mass lesion without rim enhancement on left scalp was found. Magnetic resonance imaging of head showed that tumors invaded outer table of the skull focally. There were no other extra cutaneous manifestations. Biopsy of tumor revealed diffuse poorly differentiated lymphocytic type of malignant lymphoma. The patient was treated with six cycles of COPBLAM-V chemotherapy that resulted in complete remission. Four months after the completion of chemotherapy, the left preauricular lymph node was enlarged. Biopsy revealed same pathology with that of scalp. Again he obtained a complete response with combination chemotherapy.

결핵군 55 kDa 항원의 면역학적 분석

김화중,김홍성,임재현,조은경,송창화,박정규 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Identification and characterization of mycobacterial antigens are critical for evaluation of their role in diagnosis, vaccination, and pathogenesis of mycobacterial diseases. An attempt has been made to immunologic characterize the 55 kDa protein antigen of Mycobacterium tuberculosis H37Rv which attracted our interest because it is present in high concentration in 50-80% ammonium sulfate fraction of the culture filtrate. Two monoclonal antibodies (MAbs) directed to 55 kDa antigen were produced. MAbs MT55-1 and MT55-2 reacted with a single 55 kDa protein band. On examination of degree for cross-reactivity with other mycobacterial species by enzymelinked immunosorbent assay (ELISA) and immunoblotting, these antibodies reacted strongly with M. tuberculosis and M. bovis BCG, and reacted weakly with M. marinum and M. smegmatis. To investigated the subcellular distribution of MAbs defined epitopes in the 55 kDa antigen within the mycobacterium, we isolated three major subcellular factions of M. tuberculosis, namely, cell wall, cytoplasmic membrane, and cytosol, by a simple fractionation procedure. MAb MT55-1 reactive cpitope was found in the cytosol when tested by immunoblotting. A sandwich ELISA was initially developed for detecting 55 kDa antigen using MT55-1 MAb in mycobacterial culture filtrate before detecting it in clincal specimens. The minimal detectable concentration was 1.0 ㎍/m1 for M. tuberculosis culture filtrate and 100 ㎍/ml for sonic extracts of M. bovis BCG and M. marinum, respectively. But the 55 kDa antigen was not detected in sonic extracts of other mycobacterial species examined. Although further evaluations are required, this study suggests that the 55 kDa antigen may be of interest as potential diagnostic reagent.

여성의 브래지어 착용에 관한 연구 : 대구시내를 중심으로 The centering Taegu city

오화자,이송자,홍정민,김정원 대구효성가톨릭대학교 1988 연구논문집 Vol.37 No.1

The purpose of this study was to obtain the material for a right selecting buying, care of brassier, and for a right production of brassier. The questionaires in this study were administered to a sample of 10 age -50 age women in Taegu city. The result were as follows; 1. In the degree of wearing the brassier, the old age was lower than the younger age. The first time of wearing is around fifteen. The number of brassier for each a person is 4∼5. 2. In the degree of wearing the brassier as a rule the older age was lower than the younger age on the other hand at the time going out, the degree of wearing the brassier was high. 3. Most of women was wearing a round type brassier, and teen-age and twenty age prepared to asid strech type brassier and thirty age, fourty age, fifty age prepared to a cup side stretch type brassier, semi-long brassier in order. 4. In the feeling of wearing the brassier, the best brassier was round type brassier, semi-long type brassier, cup side stretch type brassier, tape type in order. 5. The reason of wearing the brassier was for a maintenance of figure, habit courtesy, harmony of out of garment in order. 6. The case of knowing of one's bust size and one's brassier size was about 40%. 7. In the place of buying the brassier, there was no difference between department and market, agency In a brassier, buying point was material, maker, advertsement, price in order. 8. The washing of brassier was per a 2 day∼3 day, not only summer but winter after washing, the change of brassier was change of lace, color fastness, twist of abuld strap, change of figure of cup in order. 9. The reason of abandonment of brassier was change of lace, discomfort, color fastness in order.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

거대 점오염원이 주변 대기질에 미치는 영향에 관한 연구

김유근,이화운,전병일,장은숙,홍정혜,문윤섭,원경미,송정희 부산대학교 환경문제연구소 1996 環境硏究報 Vol.14 No.1

In order to show the effect of a vast point pollutant source on air quality of Pusan Thermoeletric Power Plant and its surrounding area, air quality around Pusan Thermoeletric Power Plant was simulated by ISCLT-2 which was supplied by EPA. For this purpose the emission amount of SO_2, NO_2 and TSP was calculated and atmospheric stability was classified for a recent decade(1985~1994) in Pusan. A result of the emission amount showed that much amount of NO_2, NO_2 and TSP are emitted from industrial area. It was clear that NO_2 is much emitted from line source and industrial area. And as a result of classification of atmospheric stability, neutral, stable and unstable state were 58%, 24.1% and 17.9%, respectivly. The result of ai quality simulation by ISCLT-2 showed that Pusan Thermoeletric Power Plant is affecting on the increse of 2.0ppb, 3.0ppb and 5.0㎍/㎥, SO_2, NO_2, and TSP respectively at its surrounding area, site A-3 which was located westward 2.2㎞ distance from Plant

난소종양으로 오진된 골반후복막 신경집종 1예

박연진, 홍승화, 지일운, 정은환, 최송이, 김학순 충북대학교 의학연구소 2012 忠北醫大學術誌 Vol.22 No.2

본문참고

타타늄의 열처리 조건에 따른 동전위 양극분극특성 및 표면 미세구조 변화

주동현,이용렬,정영화,양홍서,박상원,이도재,송호준,박영준 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.2

The corrosion resistance of metallic implants is essential for successful implant osseointegration. Moreover, the implant surface should have appropriate surface roughness for the attachment of the osteoblast and collagen fibrils. When titanium is exposed to air a thermodynamically very stable oxide film is formed at once. This oxide is very thin and yet it protects the metal from corrosion instantaneously. However, the oxide would not be ideal, and it would be supposed that the state of oxide film would be various by the different conditions when it is formed. The objective of this study was to evaluate the electrochemical properties and surface microstructural changes of titanium after passivation treatment or exposure to high heat (in vacuum or in air). ASTM grade 2 commercially pure titanium (Ti) disks of 10㎜ diameter were wet ground and polished with 240 and 600 grit SiC, and then ultrasonically cleaned with distilled water and ethanol. Cleansed as-received samples (As-R group) were passivated with 30% nitric acid solution at 50℃ for 15 minutes to make the Pas group. The Std-V samples were made by treating the Ti disks in vacuum quartz tube (10^-8 Torr) at 530℃ for 40 min for stress relieving, followed by annealing at 700℃ for 90 min, and then slow cooling to room temperature. The Std-A samples undergo identical procedure as the Std-V group except that it is done in air. For 530℃-V samples, Ti disks were heated at 530℃ for 40 minutes and slow cooled to room temperature. The 1000℃-V samples were produced by heating Std-V specimens again at 1000℃ for 2 hr, followed by cooling to room temperature. 530℃-A and 1000℃-A samples were also prepared. Potentiodynamic anodic polarization measurement, SEM, AFM and XRD analysis were performed to evaluate the effects of the various treatments. The difference in the mean values of E_corr between groups showed statistically significant difference (P<0.05), but that of I_corr did not show significance (P>0.05). When Ti surface was passivated there was a shift of corrosion potential (E_corr) in the noble direction and a lower corrosion current density (I_corr) value. Std-A samples showed most noble E_corr value among the tested groups. 530℃-V samples showed more noble E-corr than other tested groups except Std-A group. 1000℃-V samples showed more noble E-corr than those of Std-V sample. In the case of Std-, 530℃- and 1000℃-groups, -A sub-groups showed better corrosion resistant characteristics than -V sub-groups in regard to E-corr and I_corr values. In the SEM observations, the surfaces of the As-R samples showed only scratch line on smooth surface. In Pas samples, thick oxide layer covered the surface under high magnification observation. 530℃-A samples were covered by oxide granules, and Std-A samples had 25~50 nm-thick acicular oxides. The 1000℃-A samples were covered by coarse oxide crystals with a granule diameter of 0.1~0.6 μm having a gross appearance of milky white color, which was identified by XRD as a rutile. On the other hand, 1000℃-V samples showed an Widmansta¨tten structrue of which the orientation of the lattice is formed along crystallographic planes of the parent crystals. On the AFM observation, 530℃-A samples showed RMS roughness of 79.38 nm which is 5 times rougher than those of the As-R samples. Std-A sample had a roughness of 330.47 nm which is about 20-times rougher than that of the As-R sample. 1000℃-A samples were covered by coarse granular oxides and the roughness were about 0.56 μm. Vacuum sub-group samples showed a more smooth surface than air sub-group samples, and the oxide film was more dense. Due to variability of the surface treatment and heat treatment conditions, the process of the oxide formation seems to be affected thereby making the corrosion properties and surface micro-morphology different. However, more various electrochemical analysis together with surface analysis, and an investigation for the effects of those on the osteoblast cell adhesion and calcium phosphate apposition are needed for the improvement of the osseointegration rates of the titanium implants.