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김홍성 한국기계가공학회 2005 한국기계가공학회지 Vol.4 No.1
In this study, A controlled auto-ignition (CAI) single cylinder gasoline engine is considered, focusing on the extension of operating conditions. The fuel is injected indirectly into electrically heated inlet air flow. Investigated are the engine performance characteristics under the wide range of operating conditions such as 32 to 63 in the air-fuel ratio, 1000 to 1800 rpm in the engine speed, and 150 to 180 in the inlet-air temperature. A controlled auto-ignition gasoline engine which has the super ultra lean-burn with self-ignition of gasoline fuel can be achieved by heating inlet air.
Poly(vinylpyrrolidone-g-acrylonitrile) 블렌드의 자외선 흡수특성에 관한 연구
김홍성,이신희 한국섬유공학회 1998 한국섬유공학회지 Vol.35 No.3
Ultraviolet radiation (UV) absorption- ability of poly (vinylpyrrolidone-g-acrylonitrile) blend and the effect of adsorption of UV-absorbers into the polymeric substrate were discussed in chemical interaction between UV-absorbers and poly (vinylpyrrolidone-g-acrylonitrile) blend as a substrate. The blend has chemical groups to interact with UV absorbers and has high visible transparency and radiation-durability. The results showed that the chemical and molecular structural character of UV absorber and of polymeric substrate affects sensitively the absorptionability of UV radiation and the adsorption-ability of UV-absorber into its substrate materials. The interaction system of 2- or 4-hydroxy in benzenoid with carbonyl in phenone or pyrrolidone was mainly investigated by UV spectrometer and FT-IR spectrometer. The blend prepared under proper constituent and condition shows excellent UV-shielding property.
Acrylonitrile과 Methyl acrylate의 수계 Redox 공중합에 있어서 Polyvinylpyrrolidone의 영향
김홍성,이신희 한국섬유공학회 1996 한국섬유공학회지 Vol.33 No.3
The kinetics of copolymerization of acrylonitrile with methyl acrylate initiated by aqueous sulite-chlorate redox system were studied in the presence of polyvinylpyrrolidone (PVP) as an emulsifier. The PVP was found to affect the polymerization rate, conversion, and relative molecular mass of polyacrylonitrile copolymer. The PVP in the polymerization solution was found to increase the polymerization rate particularly by reducing radical induction periods and the polymerization activation energy. A suitable kinetic scheme has been proposed and discussed to account for the experimental data.
액체암모니아에 의한 면 셀룰로오스 I과 II의 결정구조의 변화
김홍성,배소영 한국섬유공학회 1995 한국섬유공학회지 Vol.32 No.2
The crystal transformation, degree of crystallinity, and crystallite size of cotton cellulose, treated with liquid ammonia and dried by evaporation, wert investigated. The quantification of crystalline content was carried out by resolution of X-ray scattering intensity distribution on the assumption that all digracted intensities take the form of symmetrical Gauss distribution centering at its Bragg angle. The treatment of liquid ammonia transformed part of cellulose I and II crystals into III crystals, thereby making it a polymorphic structure. The m crystals transformed from I and II crystals, IIIa, and IIIb, had a very close lattice type mutually, but showed a considerable difference on the transformational extent, crystalline disruption behavior, and reversional ability to original crustal.
Gene Expression Profiling in Osteoclast Precursors by Insulin Using Microarray Analysis
김홍성,이나경 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.11
The balance between bone formation by osteoblasts and destruction of mineralized bone matrix by osteoclasts is important for bone homeostasis. The increase of osteoclast differentiation by RANKL induces bone diseases such as osteoporosis. Recent studies have shown that insulin is one of main factors mediating the cross-talk between bone remodeling and energy metabolism. However, the systemic examination of insulin-induced differential gene expression profiles in osteoclasts has not been extensively studied. Here, we investigated the global effects of insulin on osteoclast precursors at the level of gene transcription by microarray analysis. The number of genes that were up-regulated by 1.5 fold after insulin treatment for 6 h, 12 h, or 24 h was 76, 73, and 39; and 96, 83, and 54 genes were down-regulated, respectively. The genes were classified by 20 biological processes or 24 molecular functions and the number of genes involved in ‘development processes’ and ‘cell proliferation and differentiation’ was 25 and 18, respectively, including Inhba, Socs, Plk3, Tnfsf4, and Plk1. The microarray results of these genes were verified by real-time RT-PCR analysis. We also compared the effects of insulin and RANKL on the expression of these genes. Most genes had a very similar pattern of expressions in insulin- and RANKL-treated cells. Interestingly, Tnfsf4 and Inhba genes were affected by insulin but not by RANKL. Taken together, these results suggest a poten-tial role for insulin in osteoclast biology, thus contributing to the understanding of the pathogenesis and development of therapeutics for numerous bone and metabolic diseases.
Anti-tumor Effect of 4-1BBL Modified Tumor Cells as Preventive and Therapeutic Vaccine
김홍성 대한의생명과학회 2022 Biomedical Science Letters Vol.28 No.4
We have previously reported that genetically modified tumor cells with 4-1BBL have anti-cancer effects in a CT26 mouse colorectal tumor model. In this study, genetically modified tumor cells with 4-1BBL were evaluated for their potential as candidates for preventive and therapeutic cancer vaccine. To identify the effect of preventive and therapeutic vaccine of genetically modified tumor cells with 4-1BBL, tumor growth pattern of CT26-4-1BBL as a cancer vaccine was examined compared to CT26-beta-gal. In therapeutic vaccination, CT26-WT was inoculated into mice and then vaccinated mice with doxorubicin (Dox)-treated CT26-beta-gal and CT26-4-1BBL (single or three times). Triple vaccination with Dox-treated tumor cell inhibited tumor growth compared to single vaccination. Vaccination with CT26-4-1BBL showed an efficient tumor growth inhibition compared to vaccination with CT26-beta-gal. For preventive vaccination, Dox-treated CT26-beta-gal and CT26-4-1BBL was vaccinated into mice with three times and then administered mice with CT26-WT. Preventive vaccination with CT26-4-1BBL showed no tumor growth. Preventive vaccination with CT26- beta-gal also led to tumor-free mice. These results suggest that genetically modified tumor cells with 4-1BBL can be used as therapeutic or preventive cancer vaccine.
니트릴기의 가수분해 반응을 이용한 흡수성 아크릴 혼방사의 물성
김홍성 한국섬유공학회 2002 한국섬유공학회지 Vol.39 No.1
Super-absorbent hydrogel fiber was prepared from polyacrylonitrile(PAN)-based acrylic fiber by hydrolyzing its nitrile groups. Chemical reaction of PAN and physical properties of hydrolyzed acryl/cotton blended yarn were analyzed using FT-IR spectrophotometer, wide angle X-ray diffractometer, differential scanning calorimetry, universal testing machine, and static honestmeter to discuss nitrile group substitution mechanism, microstructure of the hydrolyzed fiber, and other physical properties. Most nitrile groups of PAN were hydrolyzed to ionic groups such as carboxyl group err And the crystalline phase of the acrylic fiber was disrupted to amorphous phase after processing, but the fiber retained its original shape. Water-absorption ratio and antistatic resistance of the hydrolyzed acryl/cotton blended yarn increased greatly, but tensile strength decreased by half.
IEEE 929-2000 단독운전 시험조건 하에서 단상 계통연계형 PV 시스템의 Anti-Islanding을 위한 RPV 방식 및 AFD방식의 해석 및 설계
김홍성,최규하,김재철,최영호,김한구 전력전자학회 2007 전력전자학회 논문지 Vol.12 No.1
To detect islanding mode when the grid is being tripped is a major safety issue in utility interactive PV(UIPV) system. Widely used techniques among various active methods to detect islanding mode are Reactive power variation (RPV)method and Active frequency drift(AFD) method. In this paper, analytical design method is suggested for AFD and RPV method under IEEE recommended islanding test condition. And in order to show the validity of proposed method, EMTP based simulation was done for UIPV system with RPV method and AFD method. Results shows proposed method is very useful. 계통연계형 PV 시스템의 중요한 보호기능인 단독운전 검출기능은 시스템의 안전성 및 전기적 안정성 측면에서 매우 중요하다. 단독운전 검출기법으로는 크게 수동적 방식과 능동적 방식으로 분류되는 다양한 기법들이 있다. 본 연구에서는 IEEE 929-2000에서 제시하는 단독운전 시험조건 하에서 현재 널리 사용되는 능동적 방식 중 무효전력 변동 방식(RPV method)과 능동적 주파수 변동 방식(AFD method)을 채용한 시스템의 연계점에서 주파수 변동 특성을 해석하였다. 그리고 해석결과를 바탕으로 RPV 방식 및 AFD 방식의 설계법을 제시하였다. EMTP를 이용한 시스템 시뮬레이션을 통하여 제안된 해석 및 설계법의 타당성 및 유효성을 검증하였다.