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비호지킨씨 림프종에서 COPBLAM-V 복합화학요법의 치료효과
송홍석,정화영,남계윤 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2
1989년 3월부터 1992년 6월사이에 계명대학교 의과대학 내과학교실에서 stage II, III 및 IV의 intermediate-grade 림프종환자 29례를 대상으로 COPBLAM-V 복합화학요법으로 치료한 결과 다음과 같은 결과를 얻었다. 총 29례 환자 중 18례(62.1%)에서 완전관해,11례(37.9%)에서 부분관해로 총관해율은 100%였고, 나이 조직형 병기 B증상유무에 따른 차이는 없으나 남자는 완해율을 보였다. 전체환자의 중앙생존기간은 36.8개월로 1년, 2년, 3년 4년 생존율은 각기 68.0%, 68.0%, 54.4%, 40.8%였고, 조직형에 따른 생존율의 차이는 없으나 남자와 여자(P 0.025), stage II III IV (p 0.001), Stage A와 B(p 0.001)사이는 유의한 차이를 나타내어, 여자이거나 나이가 많거나 진행병기 그리고 B증상이 동반된 경우 생존율이 낮았다. 각 약제의 RDI는 Cyclophosphamide 0.722, oncovin 0.773, dexamethasone o.785, bleomycin o.763, adriamycin 0.720, procarbazine 0.776로 남녀 연령 조직형 B증상유무 재발유무 및 치료반응에 따른 각 약제의 RDI의 차이는 없었고, RDI와 생존기간과는 서로 상관관계가 없었으나 총림프구수와 생존기간 사이에는 유의한 (p 0.001) 상관관계를 나타내었다. COPBLAM-V치료후 grade III 및 IV의 부작용은 빈혈 13.6%, 백혈구감소증 44.9%, 구토 22.8%, 탈모증 34.5% 그리고 간기능저하와 감염이 각기 3.4%에서 동반되었으며, 이 중 1례에서 패혈증으로 인하여 사망하였다. Between March 1989 and June 1992, 29 patients with advanced stage, intermdiate-grade non Hodgkin's lymphoma were treated with a COPBLAM-V regimen including cyclophosphamide, oncovin, prednisolone, bleomycin, adriamycin, procarbazine. Median age was 45.7 years and 5 patients were 60 years or old. 18 patients(62.1%) achieved a complete response(CR) and 11 patients(37.9%) had a partial response. Of the 18 CRs, 7 patients(38.9%) suffered a relapse. The median survival time was 36.8 months, and 4-year survival rate was 40.8% ad disease free survival for CRs was 55.2% with a median follow-up of 18.6 months. Male gender was negatively associated with respones rate and age greater than 60 years, female sex, stage Ⅲ and Ⅳ, B symptoms, decreased lymphocyte count significantly decreased survival rate. But relative dose intensity of drugs did not influence the outcome. Overall toxicity was acceptible with 1 treatment- related death due to sepsis. The incidence of nonfatal infection was 17.2%.
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남계윤,정화영,전영준,송홍석,차순도,김택훈,김옥배 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.3
Serum copper levels have been found to be elevated in the presence of certain neoplstic process such as leukemia, Hodgkin's disease, malignant lymphoma, sarcoma, lung cancer, cervical cancer, and carcinom of the digestive tract. It was found to be great value in assessing disease activity, prognosis, and therapy in these patients. From Nov. 1987 to Mar. 1989, the serum copper levels were checked by plasma scanner of Labtann in previously untreated, pathologically confirmed gynecologic tumor patients; cervical cancer in 126, breast cancer in 6, endometrial cancer in 5, ovary cancer in 11, uterine myoma in 7, and normal control in 57. 1) Mean serum copper levels were significantly higher values in cervical cancer (103.5±42.4㎍/㎗) and normal control(70.5±43.8㎍/㎗). 2) In cervical cancer, mean serum copper level was higher in advanced stage and difference between stage 0 vs. IV(p<0.05), stage I vs. II and stage III vs. IV(p<0.01), and stage I vs. III & IV, stage II and IV(p<0.005) was significantly different, but there was no significant differences between pre- and post-radiation value(102.2 vs. 94.1㎍/㎗) in successfully irradiated 42 patients.
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신장이식 환자에서 발생한 폐 Nocardiosis 1 예
김현철,박성배,한창엽,남계윤 대한내과학회 1992 대한내과학회지 Vol.43 No.3
Nocardiosis is a rare disease in healthy individual but is seen frequently in patients whose immunity is com- promised by the longterm use of corticosteroid therapy, and immunosuppressive agents. Nocardiosis is a gram positive aerobic bacilli and is weakly acid fast. It often lives in soil. Clinically, it has been known to cause pulmonary infection, subcutaneous nodules and brain abscesses. We have seen one case of pulmonary nocardiosis in a renal transplant patients and we are reporting this case togethet with a review of literature.
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황석순,이헌영,전석구,남계윤,전영준 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
Broncholithiasis has been recognized in medicall literature for centuries. Because of the relative infrequency, broncholithiasis has often been neglecteed in the differential deagnosis of bronchial obstruction. In this case, we could remove the broncholith obstructing the right middle lobar bronchus with the fiberoptic bronchoscope in a 37-year old man without any complications and the complete resolution of the pneumonia was followed.
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