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(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향
오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4
Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.
Hyesook Chang(장혜숙) , Eun Kyung Choi최은경) , Jeong Gill Cho(조정길) , Tae-Hwan Lim(임태환) , Tae-Keun Lee(이대근) ,Yun Yi(이윤) ,Young Joo Cho(조영주) , Gon Sup Kim(김곤섭) 대한방사선종양학회 1991 Radiation Oncology Journal Vol.9 No.1
2-DDG가 쥐의 섬유육종(FSall)에 미치는 영향에 대한 연구로 에너지 신진대사는 체내에서의 ³¹P - 자기공명 분광기를 이용하여 관찰하였고 세포 증식 능력은 유세포 분석기를 사용하여 연구하였다. 성장속도는 개의 세포를 C₃Hj/Sed 쥐의 발등에 이식한 후 3차원적으로 측정하여 관찰하였다. 2-DDG를 투여한 경우에는 이식후 12일에 복강내로 주사하였다. 이식후 12일의 종양의 평균 크기는 250㎣이었다. FSall 종양의 성장속도는 semilog graph의 기울기와 종양의 doubling time으로 측정하였다. 2-DDG를 투여한 후 성장속도가 감속되었다. 5~12일 사이의 성장속도의 기울기가 0.828, 종양의 Idubling time이 0.84일이고 대조군에서는 13~28일 사이의 기울기가 0.218, doubling time이 3.2일인 반면 2-DDG 투여군에서는 성장속도의 기울기가 0.135이고 doubling time이 5.1일이었다. ³¹P-자기공명 분광기를 이용하여 2-DDG의 영향을 분석해 본 결과 2-DDG 투여후 종양증식 속도의 감속과 더불어 phosphomonester (PME)와 inorganic phosphate (Pi)의 증가속도가 감소하였다. 이것은 2-DDG 투여후 세포의 괴사가 감소하였다는 의미가 있다. 유세포 분석기를 이용하여 종양의 증식 능력을 분석한 결과는 2-DDG 투여후 S-phase와 G₂+M phase의 DNA 분포가 크게 증가하였다. 이것은 2-DDG 투여후 세포가 좀더 방사선에 민감한 cycle로 진행함을 의미하는 것으로 해석할 수 있다. 이에 저자들은 2-DDG가 FSall 종양세포에 미치는 흥미있는 결과를 토대로 방사선 치료에 미치는 영향과 실제 이용 가능성에 대하여 더 연구하고자 한다. The effect of 2-deoxy-d-glucose (2-DDG) on C₃H mouse fibrosarcoma(FSall) was studied, Metabolic status, especially for energy metabolism, was studied using in vivo P-MRS, prolifer-ative capacity was observed on flow cytometry(FC) and growth rate was measured after trans-plantation of viable tumor cells in the dorsum of foot of C₃Hf/Sed mice. One gram of 2-DDG per kg of body weight was injected intraperitoneally on 12th day of implantation. Average tumor size on 12th day of implantion was 250㎣. Growth rate of FSall tumor was measured by tumor doubling time and slope on semilog plot. After 2-DDG injection, growth rate slowed down. Tumor doubling time between tumor age 5-12 days was 3.2 days with slope 0.218 in control group. After 2-DDG injection, tumor doubling time was elongated to 5.1 days with slope 0.136. The effect of 2-DDG studied in vivo P-MRS suggested that the increase of phosphomonoes-ter (PME) and inorganic phosphate (Pi) by increasing size of tumor, slowed down after 2-DDG injection. Flow cytometry showed significantly increased S-phase and G₂ + M phase fraction suggesting increased proliferative capacity of tumor cells in the presence of 2-DDG. Authors observed an interesting effect of 2-DDG on FSall tumor and attempt to utilize as an adjunct for radiotherapy.
억제대 적용지침 개발을 통한 불필요한 억제대 적용율 감소활동
곽경선,김성은,배은경,이은숙,이은혜,최윤정,이윤경 한국의료QA학회 2009 한국의료질향상학회지 Vol.15 No.2
문제: 억제대 적용에 대한구체적 적용지침 없이 의례적으로 억제대를사용함으로 인해 환자들의 신체적 또는 정신적 안전을 위협할 수 있다. 목적: 완전 진정상태 이거나 근력이 약하여 발관능력이 없는 환자에 대한 예방적 적용, 바빠서 환자를볼수 없 는경우, 간호사본인의 판단이 없이 타인의 요구에 따르는등의 불필요한 억제대 적용이 증가하는 원인을 파악하여 중환자실의 특수성에 맞는 억제대 적용및 제거 지침을 마련하고자 한다. 의료기관: 인천광역시에 소재한 의과대학 소속병원의 집중치료실 개선효과: 억제대 적용에 대한중환자실 간호사에게 미치는 영향을 보면 태도 정도 p=0.09(p<0.1), 올바른 수행 능력은 p= 0.005 (p <0.0히로통계적으로유의한것으로 나타났다. 지식 정도 p=0.172(p<0.05) 통계적으로 유의 하지는 않지만 모든항목이 개선 활동전 에 비해 2,3차 개선 활동후에 향상한 것으로 나타났다. 개선활동전에 8.1%였던 간호 기록, 0.7%였던 간호중재, 0%였던 의사처방율이 3차 개선 활동 후 3가지 모두 100% 달성되었다. 이는 억제대 적용율 갑소 및 부적절한 억제대 적용율은 유의하게 감소하였다. 교훈: 중환자실 간호사의 억제대 적용에 대한태도, 지식, 올바른 간호 수행 능력은 지속적으로 재평가 되어지고, 교육내용은좀더 나은 간호제공을 위하여 개발 되어져야 할 것이다. 억제대 적용 기준과 제거 기준을 Check List 하여 객관성의 유지를 위한 개선 활동은계속적으로 Feedback 되어야 할 것이다.
Thiopental Sodium, Propofol(Diprivan^�) 및 Midazolam이 안압에 미치는 영향
최정은,서경덕,서동선,최세진 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1
Intraocular pressure(IOP) were measured during induction of anesthesia with thiopental sodium(n = 10), propofol(n=10), and midazolam(n=10). IOP were measured using a Schioetz tonometer before and after induction, and 1min and 3min after endotracheal intubation. All patients were divided into three groups as follows ; Group Ⅰ(n=10) : thiopental sodium 5mg/kg was administered intravenously for induction of anesthesia Group Ⅱ(n=10) : propofol 2mg/kg was administered intravenously for induction of anesthesia Group Ⅲ(n=10) : midazolam 0.2mg/kg was administered intravenously for induction of anesthesia Succinylcholine 1mg/kg were administered intravenously for endotracheal intubation in all groups. The results were as follows ; 1) Induction of anesthesia with propofol and thiopental sodium are associated with a significant reduction in IOP. 2) Induction of anesthesia with propofol is associated with more significant reduction in IOP than thiopental sodium. 3) Induction of anesthesia with midazolam is not associated with reduction in IOP. From above results, propofol can be used as effectively as thiopental sodium for general anesthesia in patients who undergo ophthalmic surgery.
K대학 여대생을 대상으로 한 치아우식활성검사 비교조사 연구
최은미,송윤신,장희경,최정이 경복대학 2002 京福論叢 Vol.6 No.-
본 연구는 치아우식증 발생요인 중 타액요인을 집중적으로 분석하고자 타액분비율, 타액점조도, 타액완충능, 스나이더, 구강내 포도당잔류검사를 조사하였으며, 특히 20내 남성의 치아우식증 발생요인에 대한 연구자료와 타액분비율과 타액내 pH 변화에 대한 조사 및 스나이더검사 간의 임상적 비교 조사 등의 연구를 통하여 자료를 비교 분석할 수 있었다. 또한 구강내 포도당잔류검사를 조사한 결과 등 수종의 실험연구의 경험적 연구 결과를 가지고, 한국의 여대생들과 상호관계를 비교 분석하고자 하였다. 본 연구의 조사대상은 여대생 160명을 대상으로 하였으며, 수집된 자료는 빈도, 백분율 분석으로 유의성을 검증하였다. 본 연구에서 조사된 결과는 다음과 같다. 1. 전체 조사대상자의 우식치아 수는 평균 3.23개로 조사되었고, 발거치아는 0.22개로 조사되었으며, 충전치아는 5.06개로 나타났다. 2. 전체 조사대상자의 평균 영구치 우식경험치아는 8.52개로 조사되었고, 평균 완충능력은 10.54로 나타났다. 3. 구강내 포도당잔류시간을 측정한 결과 평균 12.36 분으로 조사되었다. 4. 스나이더 검사방법 결과 조사대상자의 평균 치아우식활성 정도는 35.43 시간으로 판정기준에 의하여 중등도 활성으로 나타났다. 5. 자극성 타액분비량 및 타액점조도와 진행중인 치아우식증 보유집단과 집단간의 비교에서는 차이가 있음을 볼 수 있었다(P<0.01). 6. 비자극성 타액분비량, 자극성 타액분비량 및 구강내 포도당잔류시간 측정검사와 치아우식활성집단간에는 유의한 수준으로 나타났다(P<0.01). 7. 타액점조도에서도 치아우식활성집단간에는 유의한 수준으로 나타났다(P<0.05). 이와 같은 절과를 볼 때, 향후 연구논제에 세계보건기구(WHO)에서 기초조사로 조사되는 연령군인 12세 아동의 치아우식증과 치아우식활성과의 관계를 규명하고자 하는 노력이 있다면 치아우식증 발생요인을 구체적으로 제시할 수 있으리라 사료된다. This study was performed to investigate saliva flow rate, saliva buffer capacity, snyder test, glucose residuum test in the oral cavity in order to analyze 'saliva factor' intensively among the causing factor of dental caries. Especially through study data on causing factor of dental caries in male twenties, examination on pH changing rate in the saliva and saliva flow rate, clinical comparative study between Snyder tests, we have made a comparative analysis. Also, based on many kinds of exparimental study results from examination on glucose residuum test in the oral cavity, etc, we have intention to analyze comparatively interactive relationship of korean female college students. The subject of this study is 160 female college students, and we verified the confidence of our study data by the frequency, centesimal analysis. The results were as follows ; 1. Among the total subjects, the average of caries teeth were 3.23, extracted teeth 0.22, filling teeth 5.06. 2. Among the total subjects, the average of permanent teeth with experience of dental caries were 8.52, average buffering capacity 10.54. 3. The average minutes of glucose residual time in the oral cavity were examined 12.36 minutes. 4. On the result of Snyder examination method, the average activative degrees of dental caries were 35.43 hours rated medium level by the standard of decision. 5. There are some differencies between stimulative saliva flow, saliva adherence degree and the group of dental caries in progress. 6. There are significant results between non-stimulative saliva secretion, stimulative saliva flow, glucose remaining time test in the oral cavity and the group of dental caries in activation. 7. There are significant results between groups of dental caries in activation about saliva adherence degree. According to the results, if there is any effort in the future study theme to investigate the relationship between 12 year-old children's dental caries whose age WHO has made a basic surveying subject and activation of dental canes, we can present the causing factor of dental caries concretely.
다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
Choi,Eun Jeong,Park,Myonghwa 한국노인간호학회 2021 노인간호학회지 Vol.23 No.3
Purpose: The purpose of this study was to identify interprofessional competencies for the integrated community care of older people. Methods: This study used a methodological approach, and the specific process aimed to identify the components of interprofessional competencies for integrated community care using a scoping review and validating the identified competencies with the Delphi method. The scoping review first identified relevant studies through the following electronic databases: PubMed, CINAHL, Embase, and the Cochrane Library. We then selected studies that met the inclusion criteria and analyzed their results to identify a draft version of the competencies. Expert panels validated the list of competencies through two rounds of the Delphi survey. Results: The two rounds of the Delphi survey revealed a consensus. Finally, we developed an interprofessional competency for integrated community care comprising 19 interprofessional core competencies, 20 integrated core care competencies for community care administrators, 13 integrated core care competencies for care coordinators, 13 integrated core care competencies for local service providers, and 12 integrated core care competencies for community health leaders. Conclusion: This study can help inform job descriptions, evaluate relevant professionals’ performances, and develop a competency-based curriculum for better practice.
햄스터 구강암 발생 과정에서 Heat Shock Protein에 관한 면역조직화학적 연구
최규환,이동근,김은철,정창주 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2
A IMMUNOHISTOCHEMICAL STUDY ON HEAT SHOCK PROTEIN IN ORAL CARCINOGENESIS IN HAMSTER Heat shock protein (HSP) expression is unto·emulated in tumor cells and, HSP expression is likely marker of the malignant potential of oral epithelial lesion. Furthermore, the 70kDa HSP is implicated in the degree of tumor differentiation, the rate of tumor proliferation and the magnitude of the anti-tumor Immune response. Accordingly, the distribution and intensity of HSP70 and HSP47 expression was assessed in the DMBA induced oral carcinogenesis in hamster. Golden Syrian hamsters which were 3 months-age and 90∼120g were collected. 9,10-dimethyl -1,2-ben-zanthracene (DMBA) in a 0.5% solution in mineral oil was painted on the buccal pouch mucosa 3 times per week in the study group. In each control and experimental groups of 6, 8, 10, 12, 14, 16, 18, 20 weeks, specined for immunohistochemical study with anti-HSP47 and anti-HSP70 antibody. The following results were obtained. 1.HSP47 positive cells were race or negative of normal oral mucosa, increased mildly in basal and suprabasal basal layer, and spinous cell layer after experimental 6 weeks (dysplastic or CIS stage). In CIS stage, HSP47 expression is prominent in dysplastic free or normal adjacent epithelium. 2.HSP47 positive cells in connective tissue were mainly inflammatory cells, which is gradually increased from control to precancerous and cancer stage. But HSP47 positive cells after 14 weeks were decreased, especially normal and cancer adjacent epithelium. 3.The positive staining cells of HSP70 in control, dysplastic, and CIS stage were not seen. But they were mild findings in basal layer and moderate findings in spinous layer after experimental 14 weeks (cancer stage). 4.HSP70 positive cells were increased in precancerous and cancer stage than control group in connective tissue. After experimental 16 weeks, we could not find the HSP expression in cancer cells according to cancer differentiation or cancer stage. It is concluded that HSP70 or HSP47 expression is not a definitive marker of oral malignancy or malignant potential. However, with further development, HSP immunoreactivity may be valuable as an adjunct to conventional histology for assessing the malignant potential of oral mucosal lesions.