요골신경과 폐장을 지배하는 미주신경간의 반사회로

진춘조,나흥식,남숙현 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

This experiment was performed to determine the influence on the impulse discharge of vagal efferents to lung with electrical stimulation of the radial nerve. The results are surlnlarled as follows: 1. The impulse discharges of vagal efferents resulted from electrical stimulation of the radial nerve were divided into two groups, that is increasing group and decreasing group. The duration of increasing period was longer than that of decreasing period and the changes of the impulse discharge was more evident on the lower voltage than the higher voltage. 2. The resting impulse discharge rate (spontaneous activity) before the electrical stimutation were 4. 9 to 5.8 counts per second in the increasing group, and were 4.7 to 5.0founts per second in the decreasing group. 3. The electrical stimulation of the ferloral nerve were elicited the changes of the impulse discharge, that is increment or decrement of impulse discharges on the vagal efferents to the lung.

반복적 장폐쇄 증상을 보인 Crohn병 1예

진춘조,유태석,성무경,박형석,조화상,유광하,조영일,허원만 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.1

Crohn's disease is a rare inflammatory bowel disease in Korea which requires a differential diagnosis with intestinal tuberculosis. In the early stages of Crohn's diseaae, the combiation of bowel wall edema and spasm produces intermittent obstructive manifestations, so the usual subjective symptoms were appeared long standing diarrhea, low grade fever and abdominal pain and distension. We recently experienced a case of Crohn's colitis with repeated bowel obstruction in female adult who underwent surgical resection.

근육운동후 골격근내의 젖산탈수소효소 활성도의 변화

진춘조,남숙현 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1

Recent investigation have shown that lactate dehydrogenase (LDH) activity was changed by strong muscular exercise in animal and man. Changes in activity of LDH was studied in rat, Performing maximal exercise of 30 minutes. The muscle samples were obtained at rest and different time intervals in the recovery periods. Activity of dehyrogenase was measured by Cabaud and Wroble'wski method. Control value (mean±S.E.) for muscle LDH was 4406±343 unit. At the termination of exercise 6hr., 12hr., and 24hr. after exercise the LDH activity was 3726±524 unit, 4375±915 unit, 6235±1045 unit and 5643±897 unit respectively.

정상 십이지장 구부에서 발견된 Bezoar 1예

진춘조,조영권,허태행,전혜정,박동립,윤상애 대한소화기내시경학회 1998 Clinical Endoscopy Vol.18 No.3

A 50-year-old man who had suffered from chronic indigestion complained of upper abdominal pain and vomiting which had persisted for 4 days. Consequently, he had eaten two persimmons before sleeping detected each day for five days. An irregular multinodular villous filling defect was in the duodenal bulb on, the UGI series, which had its location and changed its position. It was difficult to differentiate a papillary gastric polyp or villous tumor from the duodenal bezoar, but the patient's history of having eaten persimmons was helpful. The endoscopic and pathologic study confirmed a phytobezoar which was located in the normal duodenal bulb. Subsequently we are reporting this case having reviewed the related literature of the phytobezoar which was found in the normal duodenal bulb.

폐쇄성 황달을 유발한 비기생충성 간낭종 1예

진춘조,박형석,조화상,유광하,유종길,이경영,임형래,이순일 대한소화기학회 1998 대한소화기학회지 Vol.32 No.1

Cystic disease of the liver is observed with increasing frequency because of the common use of computed tomography and ultrasonography. Hepatic cyst does not present particular symptoms. However, depending on its size and location, symptoms like abdominal distension, or pressure effects on adjacent organs including bile ducts causing intermittent jaundice could appear. Patients with hepatic cyst usually show no elevation of liver enzyme, bilirubin, or liver function tests. Jaundice usually can occur in the patients when the cyst becomes large enough to cause exrtahepatic blocking of bile duct. We receotly experienced a 57-year old female complaining of generalized pruritus, which was diagnosed as non-parasitic liver cyst with obstructive jaundice. The diagnosis was confirmed by abdominal US, CT, ERCP and operation. Unroofing of hepatic cyst was performed, and 3 months later, she was asyrnptomatic and total bilirubin was normalized. We report this case with a review of the relevant literatures.

유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력

진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.

소화성 궤양 환자에서의 Helicobacter pylori의 감염률과 박멸에 관한 연구

박형석,공수정,진춘조 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.6 No.-

Recent studies have shown that there is a strong association between Helicobacter pylori and chronic gastritis, duodenal ulcer or gastric ulcer. The aims of this study are to evaluate the prevalence of H.pylori infection in chronic superficial gastritis, duodenal ulcer and gastric ulcer patients by using rapid urease test(?? test) and to evaluate the efficacy of antibiotic therapy using colloidal bismuth subcitrate, metronidazole and amoxicillin in recurrent duodenal ulcer patients. Rapid urease test was done in 346 patients with chronic superficial gastritis, 66 patients with duodenal ulcer and 50 patients with gastric ulcer. Triple therapy was done in 24 patients with recurrent duodenal ulcer and positive Helicobacter pylori infection. Laboratory tests were done prior and after treatment and 6 weeks later, re-examination was done to find the rate of ulcer healing and eradication of Helicobacter pylori. The results were as follows: 1) The prevalence of H.pylori infection in duodenal ulcer patients(89.4%) was significantly high compared with that of chronic superficial gastritis(56.4%) and gastric ulcer(64.0%). 2) There was no relation between infection and sex or age in chronic superficial gastritis. 3) Follow-up examination revealed that ulcer was healed in 19 patients(100%) and eradication rate of H.pylori was 94.7%. 4) Eighteen patients who were ?? negative have been followed in 9 months and ulcer recurrence was not noted.

기능성 소화불량 환자에서 Helicobacter pylori의 발현 및 균 박멸이 임상 증상에 미치는 효과

진춘조,이재동,이수인,송기호,박형석,윤호상,김석,이승철 건국대학교 의과학연구소 1999 건국의과학학술지 Vol.8 No.-

This study was designed for the assessment of the prevalence of Helicobacter pylori and the effect of its eradication on clinical symptoms in patients with functional dyspepsia. We enrolled 51 patient with dyspepsia more than 3 months. The patients, who had no organic lesion in endoscopy into 4 groups: A (Helicobacter pylori infected and eradication group), B (Helicobacter pylori infected and non-eradicated group), C (Helicobacter pylori not infected and proton-pump inhibitor and free radical scavenger administration group), and D (Helicobacter pylori not infected and free radical scavenger only group). And follow-up the patients on 10th day and 30th day, when we score the dyspeptic symptom and frequency. 24 out of 51(47.1%) were CLO positive. There were much improvements at 30th day dyspepsia score in eradicated group(A) but not in non-eradicated group. And the difference between two groups was statistically significant (p<0.001). There was no difference between group C and D. In conclusion, Helicobacter pylori has a role in functional dyspepsia and the eradication of Helicobacter pylori in patients with functional dyspepsia improve the clinical symptoms of dyspepsia.

위내시경으로 진단된 소화성궤양의 임상적 고찰

진춘조,박형석 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

A clinical analysis was performed on 1958 patients with peptic ulcer who were diagnosed by gastroduodenoscopy at Kon-Kuk University Min-Joong Hospital from Jan. 1983 to Dec. 1992. The results were as follows: 1) Of the total 1958 cases, duodenal ulcer were 1055 cases, gastric ulcer 750 cases, and combined ulcer 153 cases respectively. The mean age of gastric ulcer(46.4) was statistically higher than that of duodenal ulcer(38.3)(p<0.05). The male to female ratio of gastric ulcer was 3.3 : 1, duodenal ulcer 3.5 : 1, and combined ulcer 5.1 : 1 respectively. 2) The proportion of gastric ulcer among the peptic ulcer decreased from 49.2% to 33.6% during the period of 1983 to 1992, and that of duodenal ulcer increased from 43.7% to 60.0%. 3) The most frequent symptom was epigastric pain(78.7%). Duodenal ulcer patients complained hunger pain more frequently than gastric ulcer patients(21.5% vs 15.3%) but it was not statistically significant(p>0.05). 4) The most prevalent site of gastric ulcer ws lesser curvature(52.1%) and antrum(34.1%). The most favorable site of duodenal ulcer was anterior wall of bulb(41.0%). 5) Among the gastric ulcer, active stage was 66.3%, healing stage 28.0%, and scarring stage 5.7% respectively, and the commonest shape was round(38.3%). 6) Among the duodenal ulcer, active stage was 58.6%, healing stage 22.7%, and scarring stage 18.7% respectively, and commonest shape was ovoid(37.5%). 7) The complications of peptic ulcer were hemorrhage(7.3%), stenosis(1.7%), and perforation(0.1%).

당뇨가 위장관 운동에 미치는 영향

박형석,진춘조 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

The application of new measurement techniques in patients with diabetes mellitus has demonstrated a high prevalence of disordered motility in all segments of the gastrointestinal tract. In the past these were invariably considered a consequence of autonomic neuropathy, but acute hyperglycemia can now be seen to be a major reversible influence at every level of the gastrointestinal tract that has been studied. Conversely, gastrointestinal function affects glycemic control; approaches to modify the rate of gastric emptying are being Investigated for their utility In the management of diabetes.