宅配 業體와 電子商去來 業體間 서비스 要因의 認識에 대한 硏究

윤동현,박영재 한국물류학회 2006 물류학회지 Vol.16 No.1

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

당뇨병과 동반된 화농성 간농양의 임상상 및 예후인자

오은숙,강무일,이원영,오기원,임동준,이소영,이정민,고승현,김성래,안유배,손현식,윤건호,차봉연,이광우,손호영,강성구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

연구배경: 감염질환은 혈관질환과 함께 당뇨병의 중요한 사망원인의 하나이며, 혈당조절이 불량할수록 감염 빈도가 증가됨은 잘 알려져 있다. 간농양의 발생이 있어서도 당뇨병은 중요한 기저질환 중의 하나이다. 일반적으로 간농양의 가장 흔한 원인균은 Escherichi coli라고 알려져 있으나, 최근 당뇨병을 가진 간농양 환자에서 Klesiella pneumoniae의 검출이 증가되고 있다. 또 최근 연구에 의하면 K.pneumonie가 간농양의 가장 흔한 원인균이며, K. pneumoniae에 의한 간농양은 K.pneumoniae 이외의 균주에 의한 간농양보다 당뇨병과 밀접히 관련되어 있다고 보고된 바 있다. 이에 저자들은 간농양 환자를 대상으로 당뇨병환자의 빈도를 알아보고, 그 원인균 및 특징을 비당뇨병 환자들의 경우와 비교해 보고자 하였다. 방법: 1992년 1월부터 1999년 6월까지 방사선학적 검사 혹은 수술에 의해 간농양이 확인되거나, 경피적 천자나 수술을 통한 배농액 배양, 혹은 혈액 검사에서 원인균이 증명된 182명의 환자를 대상으로 후향적 임상고찰을 실시하였다. 결과: 화농성 농양을 가진 167명의 환자(남:94명, 여:73명)중 당뇨병을 가진 환자는 54명 (남:30명, 여:24명)으로 32.3%를 차지하였다. 환자의 평균나이는 당뇨군에서 62.1 ± 13.4세, 비당뇨군에서는 55.1 ±15.5세로 당뇨군에서 높았으며(p=0.0021), 남녀간의 평균나이 비교 시 두 군 모두 여성의 나이가 의미있게 높았다. 비당뇨군에 비하여 당뇨군의 경우 저알부민혈증의 빈도와 aspartate transaminase가 증가되어있었다. 원인균주는 K. pneumoniae (당뇨군54%, 비당뇨군 39.1%), E. coli(당뇨군 17.5%, 비당뇨군 18.8%), Pseudomonas aeruginosa, Streptococcus viridans, Enterococcus 순이었으며 두 군간의 의미는 차이는 없었으나 K. pneumoniae의 경우 다른 균종에 비해 단독감염의 빈도가 높았다(82.8%). 사망률은 당뇨군에서 16.7%, 비당뇨군에서 7.1%로 당뇨군에서 의미있게 높았으며(p=0.019), 당뇨군에서의 사망환자는 모두 패혈증이 동반되어 있었다. 당뇨환자의 사망군은 생존군에 비해 당뇨병 이환기간이 길고 혼합감염의 빈도가 높았다(p=0.046). 검사실 소견에서는 총 빌리루빈 및 알카리성 포스파타제의 증가가 관찰되어 있었다. 결론: E. coli가 간농양의 주된 원인균이라는 기존 보고와는 달리 당뇨군과 비당뇨군 모두 K. pneumoniae가 간농양의 주된 원인균이었다. 또한 당뇨 유병기간이 길고 당뇨조절이 불량한 환자에서 혼합감염이며 총 빌리루빈 및 알카리성 포스파타제의 증가등과 같은 위험인자가 존재할 경우 사망률이 증가될 수 있으므로 이들 군에서는 적극적인 치료가 필요할 것으로 사료된다. Background: Liver abscesses are commonly associated with underlying disease, particularly diabete mellitus. The number of the liver abscesses caused by Klebslella pneumoniae in diabetic patient has been increased in Korea nowadays. This study was conducted to clarify the clinical presentation and prognostic factors of pyogenic liver abscesses, especially in diabetic patients and to determine the proportion of K. pneunomiae as a pathogen in liver abscess in Korea. Methods: Medical records of 167 patients treated for pyogenic liver abscess from January, 1992 through June, 1999 were reviewed retrospectively in detail. Major Pathogenic organism, clinical manifestations, prognostic factors, the importance of diabetes mellilus as an underlying disease and its effect on clinical features and prognosis were analyzed. Results: Among 167 cases of pyogenic liver abscess, underlying diabetes mellitus was present in 32.3%. The mean age of patients was 62.7 13.4 years in diabetic liver abscess group and 55.1 15.5 years in non-diabetic liver abscess group. Most liver abscesses were cryptogenic in origin or secondary to the billary tree diseases. The clinical presentations among the two groups were not significantly different. When compared to patients without diabetes, patients with diabetes had significantly higher proportions of hypoalbuminemia and elevated aspartate transaminase level. The most common organism of the pyogenic abscess was K. pneumoniae in both groups. Percutaneous drainage of the abscess with appropriate antibiotics was the most commonly used therapeutic modality in liver abscess. The mortality rate of diabetic liver abscess is 16.1 % and 7.1% in nondiabetic liver abscess. Complications, especially septicemla, were found more frequently in patients with diabetes than in patients without diabetes (64.8% vs 28.3%, septicemia : 31.5% vs 9.7%). The factors influencing mortality in the diabetic liver abscess were disease duration, mixed infection, presence of septicemia, elevated bilirubin and alkaline phosphatase. Conclusions: In contrast to prior report that the E. coli was the most common pathogen in liver abscess, we found that K. pneumoniae was the most common organism cultured in liver abscess. Diabetic patients have more complications and higher mortality than patients without diabetes. Early detection and proper treatment are needed to improve the outcome for diabetic patient with liver abscess.

Analysis of metal(loid)s contamination and their continuous input in soils around a zinc smelter: Development of methodology and a case study in South Korea

Yun, Sung-Wook,Baveye, Philippe C.,Kim, Dong-Hyeon,Kang, Dong-Hyeon,Lee, Si-Young,Kong, Min-Jae,Park, Chan-Gi,Kim, Hae-Do,Son, Jinkwan,Yu, Chan Elsevier 2018 Environmental pollution Vol.238 No.-

<P><B>Abstract</B></P> <P>Soil contamination due to atmospheric deposition of metals originating from smelters is a global environmental problem. A common problem associated with this contamination is the discrimination between anthropic and natural contributions to soil metal concentrations: In this context, we investigated the characteristics of soil contamination in the surrounding area of a world class smelter. We attempted to combine several approaches in order to identify sources of metals in soils and to examine contamination characteristics, such as pollution level, range, and spatial distribution. Soil samples were collected at 100 sites during a field survey and total concentrations of As, Cd, Cr, Cu, Fe, Hg, Ni, Pb, and Zn were analyzed. We conducted a multivariate statistical analysis, and also examined the spatial distribution by 1) identifying the horizontal variation of metals according to particular wind directions and distance from the smelter and 2) drawing a distribution map by means of a GIS tool. As, Cd, Cu, Hg, Pb, and Zn in the soil were found to originate from smelter emissions, and As also originated from other sources such as abandoned mines and waste landfill. Among anthropogenic metals, the horizontal distribution of Cd, Hg, Pb, and Zn according to the downwind direction and distance from the smelter showed a typical feature of atmospheric deposition (regression model: <I>y</I> = <I>y</I> <SUB>0</SUB> + αe<SUP>−<I>βx</I> </SUP>). Lithogenic Fe was used as an indicator, and it revealed the continuous input and accumulation of these four elements in the surrounding soils. Our approach was effective in clearly identifying the sources of metals and analyzing their contamination characteristics. We believe this study will provide useful information to future studies on soil pollution by metals around smelters.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Several approaches were combined to identify metal(loid) contamination in soil. </LI> <LI> As, Cd, Cu, Hg, Pb, and Zn in soils were derived from the Zn smelter. </LI> <LI> As originated from multiple anthropogenic sources as well as from the Zn smelter. </LI> <LI> Lithogenic Fe can be an indicator for continuous input of anthropogenic metals. </LI> <LI> Soil contamination can be effectively investigated with our proposed approach. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Effects of L. plantarum Application on Chemical Composition, Fermentation Indices and Fatty Acid Profiles of Barley Silage

Dong-Hyeon Kim,Sardar M. Amanullah,Hyuk-Jun Lee,Young-Ho Joo,Hee Yun,Seong-Shin Lee,Young-Min Song,Hoi-Yun Kim,Sam-Churl Kim 경상대학교 농업생명과학연구원 2015 농업생명과학연구 Vol.49 No.5

This study was conducted to know effects of forage cutting height and inoculants application on chemical composition, fermentation characteristics and fatty acid profile of barley silage. Barley forage(Yuyeon hybrid) was harvested at two different cutting heights(5 vs. 15cm) and applied with or without Lactobacillus plantarum, and ensiled for 0, 2, 7, 28, 49 and 100days. On 0 to 49-d of ensiling, higher cutting height resulted rapid drop (p<0.05) in pH caused by higher lactate content. Crude protein (p<0.01) content of 100-d silage was decreased by inoculation, but increased by higher cutting height. However, neutral detergent fiber and acid detergent fiber contents were decreased (p<0.05) by both inoculation and cutting height. In vitro dry matter digestibility was improved by higher cutting height (p=0.01), while yeast and mold counts were reduced (p<0.0001). The C18:3n-3 content in barley silage was decreased (p=0.001) by inoculation, but increased (p=0.034) by higher cutting height. The DNA analysis indicated L. plantarum dominating fermentation in inoculated silages. The results showed that higher cutting height can improve silage quality in terms of increasing crude protein content and digestibility as well as reducing yeast and mold counts in barley silage.

Transition Metal-induced Apoptosis in Osteoblasts

Yun, Dong Hyeon,Kim, Dae Eop 원광대학교 치의학연구소 2002 圓光齒醫學 Vol.11 No.2

셀레늄, 카드뮴, 수은, 그리고 망간 둥과 같은 금속이온들은 골 대사를 직접 교란시키는 물질로 인식되어 왔다. 그러나 골 병소 형성과 관련한 기전은 아직 규명되지 않았다. 본 연구에서는 여러 금속 이온 즉, 셀레늄, 카드뮴, 수은, 그리고 망간 이온등에 노출된 MC3T3El 조골세포가 다량의 reactive oxygen species(ROS)를 만드는 것을 관찰하였다. 분비된 ROS는 acetyl cysteine (NAC), reduced glutathione(GSH), 흑은 superoxide dismutase(SOD) 와 같은 free radical scavenger에 의해 완전히 흡수되었다. 먼저, 셀레늄(10μM), 카드뮴(100 μM), 수은(100μM), 혹은 망간(1mM) 처리시 세포고사 현상과 유사한 DNA 분절, comatin 응축, 그리고 caspase-3-like cysteine pretense와 활성화가 유도되는것을 MC3T3El 조골세포 내에서 관찰하였다. N-acetyl cysteine(NAC), reduced glutathione(GSH), 흑은 superonide dismutase(SOD) 등과 같은 항산화제를 동시에 투여했을 때, 각 금속 이온들에 의한 고사는 현저히 억제되었다. Catalase 흑은 dimethylsulfoxide(DMSO)는 NAC, GSH, 혹온 SOD에 비해 고사 억제효과가 낮게 나타났다. 결과와 같이 nitroblue tetrazolium(NB 염색을 통해 각 금속 이온들이 MC3T3El 조골세포 내에서 자유기(free radical)의 잠재적 요인이 됨을 보여주고 있다. 셀레늄, 카드뮴, 수은, 그리고 망간 투여 후 MC3T3El 조골세포 내에서의 고사의 유발이 산화적 손상과 관련됨을 보여주고 있다.

Comparison of Three Plating Media for Enumerative Detection of Clostridium perfringens in Various Foods

Dong Hyeon Kim,Yun Gyeong Kim,Jung Whan Chon,Ji Yeon Hyeon,In Gyun Hwang,Hyo Sun Kwak,Sang Hyeon Yoon,Kun Ho Seo 대한수의학회 2011 대한수의학회 학술대회발표집 Vol.2011 No.-

덕트 유무에 따른 UAM 항공기의 낙뢰 간접 영향성 연구

김동현(Dong-Hyeon Kim),김윤곤(Yun-Gon Kim),조재현(Jae-Hyeon Jo),이학진(Hakjin Lee),명노신(Rho-Shin Myong) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.7

HIRF 환경에서의 UAM 항공기의 전자기 영향성 분석

김동현(Dong-Hyeon Kim),김윤곤(Yun-Gon Kim),조재현(Jae-Hyeon Jo),이학진(Hakjin Lee),명노신(Rho Shin Myong) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.11