위암 환자의 복강내 투여를 위한 Activated Charcoal-Alginate Bead 제형으로부터 Mitomycin C의 용출 거동

이진호,최선웅,서중기,김동민,정경수,오정연,김진향,노승무,민병무,김용백,김창식,박근성,강대영,송규상,양준묵,조준식,정현용,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherapy seems a logical choice for cancer chemotherapy. In this study, Mitomycin C (MMC)-activated charcoal (CH)-alginate (ALG) beads were prepared by the mixtures of CH particles adsorbed with MMC as an anti-cancer drug and aqueous alginate solution. The alginate is recognized as biodegradable, nontoxic, and biocompatible. The release of MMC from the beads in 0.1 M Tris buffer was stable and continuous until about 1 week. The MMC-CH-ALG beads can be applied in the peritoneal cavity for intraperitoneal chemotherapy since they provide a good adhesiveness on the tissue and controlled release pattern of the drugs.

낙동강유역의 연최대 일강우량에 대한 적정 분포형의 결정

이정식,이재준,신창동 金烏工科大學校 1992 論文集 Vol.13 No.-

This study discusses several statistical tests which may be applied to probability distributions to examine their goodness of fit. It moves on to present the results of a comprehensive study of the feature of 7 frequency distributions applied to annual daily maximum rainfall data in the Nagdong River watershed. Four tests-difference, modified difference, Chi-square and Kolmogorov-Smirnov test-are used in this study to determine the fitting performance of the distributions. The best fit type of distributions is chosen on the basis of comparison for goodness of fit. Results presented here indicate that the Log Pearson Type-Ⅲ and Type-Ⅲ extremal distribution are superior in the analysis of annual daily maximum rainfalls in the Nagdong River watershed.

다구치법에 의한 고 규소 내산주철의 용해주조공정 최적화

신제식,이상목,문병문,김정철,한동운,백승한 대한금속재료학회 2005 대한금속·재료학회지 Vol.43 No.2

In this study, Taguchi method, one of the design tools of experiments, was applied to optimize casting process parameters of the high silicon corrosion-resistant iron. Three casting process parameters such as melting temperature, rare earth metal (mischmetal) addition, and pouring temperature were chosen. Using SN (signal-to-noise) ratio calculated from ultimate tensile strength of each experimental casting run, the relationship between the casting parameters and mechanical properties was statistically evaluated. The casting condition of a melting temperature of 1,650℃, 0.2% rare earth metal addition, and a pouring temperature of 1,350℃ led to an excellent ultimate tensile strength above 11 kgf/mm², which is beyond the industrial criterion. The effects of the casting parameters on mechanical properties and corrosion resistance were further confirmed by combined analysis of fractography, hydrogen content determination, microscopic test, and acid resistance test. (Received August 23, 2004)

정상인에서의 교감신경피부반응의 전도속도

정광익,김혜경,박동식 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.4

발생원인에 따른 도시지역 강우의 시간분포 분석

이정식,신창동 금오공과대학교 2006 論文集 Vol.27 No.-

The objective of this study is to analyze the temporal pattern characteristics of rainfall in urban areas for origins of rainfall occurrence. A origins of rainfall occurrence were defined as Changma, Typhoon, Severe rain storm, Frontal storm. The rainfall data from 1595 event-rainfalls during 44 years in Seoul, Busan, Daegu and Daejeon have been used to determine the statistical factor of the type of temporal pattern of rainfall by the Huff's 4th quartile distribution and Yen and Chow triangular hyetograph method. Also, the results of this study compared with result of research work Korea Institute of Construction Technology(l989) and Ministry of Construction & Transportation (2000). The conclusions of this study are as follows; (1) In the method of rainfall type by the Huff's 4th quartile distribution, Changma and Severe rain storms and Frontal storm is found second-quartile storms, and Typhoon is found third-quartile storms. (2) Also, In the case by Yen and Chow method, similar to the result of Huff's method was produced. (3) Comparative analysis of the results shows that shapes of the dimensionless cumulative curves and values are different from those of existing researches.

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

Bacillus sp. LJ-25가 생성하는 extracellular chitinase의 정제 및 특성

주동식,조덕제,이정석,조만기,이응호 동서대학교부설연구소 1997 연구소 논문집 Vol.2 No.-

The extracellular chitinase from Bacillus sp. LJ-25 was pruified Sephadex G-100 gel filtration, DEAE-Cellulose and CM-Spephadex C25 column chromatography. The pruified chitinase showed a single band on disc and SDS polyacrylamide gel electrophoresis and the molecular weight was estimated to be about 50KDa. The Optimum pH and temperature for the activity of the purified extracellular chitinase were 7.5 and 35℃, respectively. The activity of chitinase was strongly inhibited by metal ions such as Zn²+, Ba²+, Co²+, Mn²+ and Cu²+. The purified chitinase did not hydrolyze N,N??-diacetylchitobiose, N,N, N'-triacetylchitotriose and p-nitrophenol-N-acetyl-β-D-glucosaminide, which are known to be the substrates of exo-type chitinase. The products in hydolysis of colloidal chitin with the chitinase were N-acetylglucosamine, N,N'-diacetylchitobiose and N,N,N'-triacetylchitotriose.

글리코 써머얼 법에 의한 나노 산화아연 분말 합성 및 특성

김정원,김선욱,김명호,배동식 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

ZnO nanoparticles were prepared under glycothermal condition by precipitation from metal nitrates with aqueou ammonium hydroxide. The nanoparticles were obtained at temperatures between 230 and 250℃. The microstructure and phase of the Synthesized particles were studied by SEM(FE-SEM) and XRD. The properties of the ZnO powder were studied as a function of various processing parameters such as reaction temperature, reaction time and solute concentration. The average particle sizes of the ZnO increased with increasing reaction temperature. The average sizes of the systhesized ZnO nanoparticles which prepared at 230℃ for 4 h were about 20-30 nm.

美國의 邊境精神과 韓國의 새마을運動精神과의 比較硏究

郭東憲,李瑛雨,李廷彬,申址湜 경북대학교 1988 새마을 硏究論叢 Vol.9 No.-

망간페라이트 나노 분말의 수계분산거동 및 특성

배동식,김은정,한경섭 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-

Dispersion stability of nanosized MnFe₂O₄ powders which was produced by glycothermal process were studied in aqueous suspension using ESA(Eletrokinetic Sonic Amplitude). The average particle size of the synthesized MnFe₂O₄was about 30±10nm. The dispersion and rheological behavior of MnFe₂O₄nanoparticles aqueous suspension was investigated using MnFe₂O₄as a disperse agent. The colloidal stability of nanosized MnFe₂O₄aqueous suspensions at different pH values has been investigated by means of zeta potential, sedimentation, average particle size and microstructure of green body. The isoelectric point of MnFe₂O₄powders is at pH around 5.5 and the value of zeta potential is at its maximum near pH 11.