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박동식,남희승,정현오,이상억,김동현 대한재활의학회 2009 Annals of Rehabilitation Medicine Vol.33 No.4
Objective: To evaluate the usefulness of infrared thermography in the diagnosis of unilateral carpal tunnel syndrome (CTS). Method: Thirty six patients confirmed electrodiagnostically as CTS and fifteen adults with normal electrodiagnostic study were included in this study. For the thermographic diagnosis, we measured the skin temperature of the palmar area of all 5 fingers, thenar area, hypothenar area and volar area of forearm bilaterally. We compared the interside peak temperature difference between median nerve innervated area and noninnervated area in three different groups (normal control, mild CTS and moderate to severe CTS groups). Results: Thermography of the CTS patients showed significant temperature differences in more than one area of the median vasomotor nerve territory, and no significant temperature difference in all the areas that were not innervated by the median vasomotor nerve. When we considered interside temperature differences of more than 0.3°C as abnormal findings, the sensitivity of thermography was 2.7% and the specificity was 86.6%. With more than 0.6°C as abnormal, the sensitivity was 25% and the specificity was 66.6%. With more than 1.0°C, the sensitivity was 8.3% and the specificity was 73.3%. There was no significant interside peak temperature difference in all groups. Conclusion: This study suggests that infrared thermography has low sensitivity and specificity, which implies that it is not useful for the diagnosis of CTS.
Nitric oxide integrated polydopamine capsule
박동식,김원종 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.1
The nitric oxide (NO) participates in various therapeutic process in vivo such as anti-restenosis, wound healing and antibacterial activity. Therefore, diverse NO delivery platforms have been reported, however, there have been continuous opinions which point out the question about the biocompatibility of the materials and NO capacity. Herein, we exploit bio-inspired polydopamine (pDA) to develop biocompatible nanocapsule-based NO delivery platform. pDA shows biocompatibility in vivo and includes a lot of secondary amine groups for conjugating the diazeniumdiolates, one of the NO-releasing moiety. Moreover, the capsule platform was expected to provide the cavity for keeping various bioactive molecules for further study. Based on these rational designs, the pDA-NO capsule was developed. The successful fabrication of pDA-NO capsule was confirmed and its NO-releasing properties and biomedical potential were evaluated.