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김치로부터 분리한 Exopolysaccharide생성 유산균 Leuconostoc kimchii GJ2의 마우스에 대한 급성독성
이재준,이유미,장해춘,이명렬,Lee, Jae-Joon,Lee, Yu-Mi,Chang, Hae-Choon,Lee, Myung-Yul 한국생명과학회 2007 생명과학회지 Vol.17 No.4
본 연구는 김치로부터 분리한 EPS생성 유산균 Leu. kimchii GJ2에 대한 급성독성시험을 위하여 복강 및 경구로 1회 시료물질을 최고 용량(복강: 2,500 mg/kg, 경구: 5,000 mg/kg)으로, 10마리 ICR계통 암수 마우스에게 투여한 후 14일간의 일반증상, 사망률, 체중, 임상증상 및 육안적 소견을 관찰하였다. 복강 및 경구투여한 후 24시간 이내에 일부 시료투여군에서 부분적으로 사망례가 관찰되었으나 나머지 시험동물은 계속 생존하여 평균치사량을 산출할 수 없었다. 복강 혹은 경구투여한 후 마우스의 체중변화에 있어서도 암수 모두 대조군과 시료물질 투여군 사이에 유의성 있는 차이는 보이지 않았으며, 생존동물의 부검결과에서도 내부장기의 육안적 이상 소견도 관찰되지 않았다. 이상의 결과로부터 시험물질인 Leu. kimchii GJ2는 복강 및 경구투여 시 마우스에서 독성학적인 변화가 관찰되지 않았으며, $LD_{50}$은 복강투여가 2,500 mg/kg, 경구투여가 5,000 mg/kg 이상인 저독성의 안전한 물질로 사료된다.
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이재준,김윤화,엄성인,고재욱,백종배,윤성렬 한국산업안전학회 1997 한국안전학회지 Vol.12 No.4
Demand of LPG and LNG will increase continuously due to high calories, clearness, and convenience for usage. These gases are used widely for power plants, industrial plants, and domestic fuel. But accidents related with gas are increasing in proportion to increment of gas usage. Especially, LPG has high ignitability due to weak dispersion to air and accumulation at low place because LPG is heavier than air. There are many hazards during transportation as well as production, storage, and usage of LPG. Commonly, tank lorry is used for inland transportation of LPG. If tank lorry were to raise leakage incidents and then LPG released during transporting, the accidents cause serious effects on the environment as well as human damage of surrounding area. In this study, therefore, hazards which cause LPG of tank lorry to leak during transportation were identified and risk of LPG transportation was assessed quantitatively. Also, the result of this study might be a useful measure for predicting damage and preparing safe transportation strategies of LPG tank lorry.
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재발 시 MN1-ETV6 유전자재배열을 동반한 급성골수성백혈병 첫 증례 보고
이재준,조하은,박경선,김영진,조선영,한재준,이우인,박태성 대한진단검사의학회 2021 Laboratory Medicine Online Vol.11 No.2
MN1-ETV6 rearrangement is rarely detected in patients with myeloid neoplasms, such as acute myeloid leukemia, myelodysplastic syndrome, and myelodysplastic/myeloproliferative neoplasms. Usually, MN1-ETV6 rearrangement is found at diagnosis. Here, we report the first Korean AML patient with MN1-ETV6 gene rearrangement in a case of relapse exhibiting normal karyotype at early diagnosis. MN1-ETV6 유전자재배열은 급성골수성백혈병, 골수형성이상증후군을 포함한 골수구계종양(myeloid neoplasm) 환자에서 매우 드물게 검출되며 일반적으로 진단 당시에 검출된다. 저자들은 급성골수성백혈병 진단 당시에는 정상 핵형이었으나, 항암치료 후 재발 시 MN1-ETV6 유전자재배열을 동반한 국내 첫 증례를 경험하였기에 이를 보고하고자 한다.
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이재준,김영수,정수련,정동섭,양지혁,성기익,김욱성,전태국,조양현 대한흉부외과학회 2021 Journal of Chest Surgery Vol.54 No.2
Background: The number of heart transplantations (HTx) is increasing annually. Due to advances in medical and surgical support, the outcomes of HTx are also improving. Ex- tracorporeal circulatory life support (ECLS) provides patients with decompensated heart failure a chance to undergo HTx. A medical approach involving collaboration among ex- perienced experts in different fields should improve the outcomes and prognosis of ECLS- bridged HTx. Methods: From December 2003 to December 2018, 1,465 patients received ECLS at Sam- sung Medical Center. We excluded patients who had not undergone HTx or underwent re- peated transplantations. Patients younger than 18 years were excluded. We also excluded patients who received an implantable durable left ventricular assist device before HTx. In total, 91 patients were included in this study. A multidisciplinary team approach began in March 2013 at our hospital. We divided the patients into 2 groups depending on whether they were treated before or after implementation of the team approach. Results: The 30-day mortality rate was significantly higher in the pre-ECLS team group than in the post-ECLS team group (n=5, 18.5% vs. n=2, 3.1%; p=0.023). The 1-year surviv- al rate was better in the post-ECLS team group than in the pre-ECLS team group (n=57, 89.1% vs. n=19, 70.4%; p=0.023). Conclusion: We found that implementing a multidisciplinary team approach improved the outcomes of ECLS-bridged HTx. Team-based care should be adapted at HTx centers that perform high-risk HTx.
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