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이재준,김영수,정수련,정동섭,양지혁,성기익,김욱성,전태국,조양현 대한흉부외과학회 2021 Journal of Chest Surgery Vol.54 No.2
Background: The number of heart transplantations (HTx) is increasing annually. Due to advances in medical and surgical support, the outcomes of HTx are also improving. Ex- tracorporeal circulatory life support (ECLS) provides patients with decompensated heart failure a chance to undergo HTx. A medical approach involving collaboration among ex- perienced experts in different fields should improve the outcomes and prognosis of ECLS- bridged HTx. Methods: From December 2003 to December 2018, 1,465 patients received ECLS at Sam- sung Medical Center. We excluded patients who had not undergone HTx or underwent re- peated transplantations. Patients younger than 18 years were excluded. We also excluded patients who received an implantable durable left ventricular assist device before HTx. In total, 91 patients were included in this study. A multidisciplinary team approach began in March 2013 at our hospital. We divided the patients into 2 groups depending on whether they were treated before or after implementation of the team approach. Results: The 30-day mortality rate was significantly higher in the pre-ECLS team group than in the post-ECLS team group (n=5, 18.5% vs. n=2, 3.1%; p=0.023). The 1-year surviv- al rate was better in the post-ECLS team group than in the pre-ECLS team group (n=57, 89.1% vs. n=19, 70.4%; p=0.023). Conclusion: We found that implementing a multidisciplinary team approach improved the outcomes of ECLS-bridged HTx. Team-based care should be adapted at HTx centers that perform high-risk HTx.
이재준,정영기 한국생명과학회 1999 생명과학회지 Vol.9 No.6
The purpose of the paper is to explore the current knowledge on the nutritional evaluation, cholesterol-lowering effect and antitumor activity of kimchi and its ingredients(Korean cabbage, garlic, red pepper powder, ginger and onion). Kimchi contains high contents of nutrients such as vitamins(ascorbic acid, $\beta$-carotene and vitamin B complex), minerals(calcium, potassium, iron and phosphorous), essential amino acids and dietary fiber. Kimch also contains high levels of lactic acid bacteria, allicin, capsaicin, organic acid, phenol compounds, flavonoid and sulfur compounds. The dietary fiber and lactic acid bacteria isolated from kimchi are effective in improving intestinal microflora of human. Isoluble dietary fiber shows anticancer activity, but soluble dietary fiber shows hypocholesterolemic effect. Lactic acid bacteria isolated from kimchi acts as a hypocholesterolemic or anticancer agent. A major ingredient of kimchi is mainly cruciferous and allium family vegetables, which were also reported to prevent cancer and atherosclerosis. It is suggested that kimchi is important not only as one of the traditional fermented Korean food but also as therapeutic agent for carcinogenesis and hypercholesterolemic state.
이재준,김윤화,엄성인,고재욱,백종배,윤성렬 한국산업안전학회 1997 한국안전학회지 Vol.12 No.4
Demand of LPG and LNG will increase continuously due to high calories, clearness, and convenience for usage. These gases are used widely for power plants, industrial plants, and domestic fuel. But accidents related with gas are increasing in proportion to increment of gas usage. Especially, LPG has high ignitability due to weak dispersion to air and accumulation at low place because LPG is heavier than air. There are many hazards during transportation as well as production, storage, and usage of LPG. Commonly, tank lorry is used for inland transportation of LPG. If tank lorry were to raise leakage incidents and then LPG released during transporting, the accidents cause serious effects on the environment as well as human damage of surrounding area. In this study, therefore, hazards which cause LPG of tank lorry to leak during transportation were identified and risk of LPG transportation was assessed quantitatively. Also, the result of this study might be a useful measure for predicting damage and preparing safe transportation strategies of LPG tank lorry.
우리나라 경기변동의 안정성 분석: 서비스산업의 역할을 중심으로
이재준 한국개발연구원 2011 KDI Journal of Economic Policy (KDI JEP) Vol.33 No.2
본 연구는 거시경제적 변동성(macro- economic volatility)이 국가마다 다르게 나타나는 현상의 원인을 산업구조적 차원에서 실증분석을 통해 찾아보려는 시도이다. 특히 우리나라 경제에서 서비스산업이 차지하는 역할에 주목하여, 서비스산업이 경기변동성에 미치는 영향을 국내적인 산업구조 측면과 국가 간 비교를 통해 분석하였다. 분석 결과, 우리나라의 경기변동성은 국가위험도를 중심으로 과거에 비해 크게 개선되었으나 여전히 대내외적 충격의 영향에 노출되어 있으며, 이는 제조업 중심의 산업구조적 특성에 기인한 것으로 판단할 수 있다. 이러한 산업구조하에서는 우리 경제가 대외부문 충격(global sectoral shock)으로 인한 거시경제적 변동에 지속적으로 노출될 수밖에 없다는 것을 의미하며, 구조적으로 나타나는 변동요인을 완화시키기 위해서는 서비스업이 대부분을 차지하고 있는 비교역재 부문이 상대적으로 활성화되어야 함을 시사하고 있다. This study discusses the phenomenon behind various forms of macroeconomic volatility faced by countries in terms of industrial structure through empirical analysis, and in the process attempts to validate the role of the service industry. The analysis shows that economic fluctuations in Korea have been significantly improved, mainly due to the country risk. However, Korea is still exposed to the impact of external shocks, which is attributable to the manufacturing-centered industrial structure. Under such industrial structure, it is inevitable for the Korean economy to be continuously exposed to macroeconomic fluctuations caused by global sectoral shocks. So, in order to alleviate business fluctuations, it is necessary to enhance the role of non-tradable sectors that account for most of the service industry.
반응표면분석법을 이용한 새싹보리 마이크로웨이브 추출공정의 최적화
이재준,박대희,이원영 한국식품저장유통학회 2017 Food Science and Preservation Vol.24 No.7
This study attempted to find optimum extract range of active ingredient for barley sprouts (Hordeum vulgare L.). Extracts from Hordeum vulgare L. were made by microwave extraction method and total polyphenol content (TPC), total flavonoid content (TFC), DPPH radical scavenging activity (DPPH) were measured with extract of Hordeum vulgare L.. Response surface methodology (RSM) was applied to a extraction process, and central composite design (CCD) was also used for this process to examine the optimum condition. Independent variables (Xn) are concentration of ethanol (X1: 0, 25, 50, 75, 100%), microwave power (X2: 60, 120, 180, 240, 300 W), extraction time (X3: 4, 8, 12, 16, 20 min). Dependent variables (Yn) are TPC (Y1), TFC (Y2), DPPH radical scavenging (Y3). It is formed by sixteen conditions to extract. The R2 value of dependent variables is ranged from 0.90 to 0.97 (p<0.05). Experiments values within the optimal range (40% of ethanol concentration, 120 W of microwave power, 18 min of extraction time) were 3.74 mg GAE/g (TPC), 3.00 mg RE/g (TFC), 35.43% (DPPH), respectively. Under the optimized conditions, predicted value showed no significant difference comparing with the experimental values.
이재준,조은윤,고은경,조준훈,박하영,이정언,남석진,김덕환 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.6
Background: The p16INK4a gene methylation has been reported to be a major tumorigenic mechanism. Methods: We evaluated the methylation status of the p16INK4a genes in 231 invasive breast cancer and 90 intraductal carcinoma specimens using a methylation-specific polymerase chain reaction and p16 protein expression using immunohistochemistry. The quantity of cell-free methylated p16INK4a DNA in the plasma samples of 200 patients with invasive breast cancer was also examined using a fluorescence-based real-time polymerase chain reaction assay. Results: The frequencies of p16INK4a methylation in invasive and intraductal tumors were 52.8% (122/231) and 57.8% (52/90),respectively. The p16 protein was overexpressed in 145 of the 231 invasive carcinomas (62.8%) and 63 of the 90 intraductal carcinomas (70%). High p16 expression in invasive carcinomas correlated significantly with a high histologic grade, a negative estrogen receptor and progesterone receptor status, p53 immunoreactivity and high Ki-67 expression with immunohistochemistry. In addition, the methylation index of p16INK4a was significantly higher in the cancer patients than the normal controls (p<0.001). Conclusions: High p16 immunoreactivity correlated with a loss of differentiation in breast carcinomas and high frequency of p16INK4a promoter methylation in both invasive and intraductal carcinomas, suggesting it maybe involved in the pathogenesis of breast cancer.